ISCS - ECOLI - GREMLIN Contacts

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ISCS - Cysteine desulfurase IscS

UniProt:	P0A6B7	Sequences: MKLPIYLDYSATTPVDPRVAEKMMQFMTMDGTFGNPASRSHRFGWQAEEAVDIARNQIADLVGADPREIVFTSGATESDNLAIKGAANFYQKKGKHIITSKTEHKAVLDTCRQLEREGFEVTYLAPQRNGIIDLKELEAAMRDDTILVSIMHVNNEIGVVQDIAAIGEMCRARGIIYHVDATQSVGKLPIDLSQLKVDLMSFSGHKIYGPKGIGALYVRRKPRVRIEAQMHGGGHERGMRSGTLPVHQIVGMGEAYRIAKEEMATEMERLRGLRNRLWNGIKDIEEVYLNGDLEHGAPNILNVSFNYVEGESLIMALKDLAVSSGSACTSASLEPSYVLRALGLNDELAHSSIRFSLGRFTTEEEIDYTIELVRKSIGRLRDLSPLWEMYKQGVDLNSIEWAHH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12677
Length:	404 (344)
Sequences:	26730 (18083)
Seq/√Len:	975.0

ECOLI - ISCS CSDA SUFS SERC DCEB DCEA
BACSU - ISCS ISCS2 ISCS1 SUFS YCBU PUCG SERC
HALSA - CSD Q9HR11 Q9HMR6 MFNA
SULSO - Q97WK1 Q97VM5 Q97ZK0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
276_R	367_D	3.615	1.00
280_G	370_I	3.400	1.00
276_R	363_E	3.362	1.00
152_H	184_S	3.351	1.00
96_H	122_T	3.328	1.00
167_G	177_Y	3.122	1.00
57_Q	257_R	3.031	1.00
162_D	165_A	3.025	1.00
138_E	169_M	2.842	1.00
181_A	200_M	2.816	1.00
101_K	125_A	2.670	1.00
254_E	257_R	2.546	1.00
202_F	215_A	2.489	1.00
96_H	142_R	2.472	1.00
191_D	194_Q	2.456	1.00
138_E	172_A	2.406	1.00
245_P	248_Q	2.389	1.00
96_H	120_E	2.278	1.00
24_M	28_T	2.238	1.00
148_V	170_C	2.217	1.00
170_C	175_I	2.202	1.00
284_I	374_R	2.196	1.00
280_G	367_D	2.181	1.00
164_A	194_Q	2.171	1.00
276_R	280_G	2.164	1.00
63_G	191_D	2.156	1.00
136_E	139_A	2.152	1.00
355_F	369_T	2.146	1.00
272_G	363_E	2.139	1.00
17_P	21_E	2.131	1.00
96_H	145_T	2.112	1.00
280_G	283_D	2.026	1.00
318_K	375_K	1.976	1.00
290_N	304_S	1.943	1.00
79_D	106_A	1.930	1.00
20_A	24_M	1.917	1.00
136_E	140_A	1.906	1.00
122_T	140_A	1.888	1.00
288_Y	304_S	1.888	1.00
17_P	28_T	1.871	1.00
95_K	144_D	1.866	1.00
127_Q	131_I	1.858	1.00
125_A	136_E	1.858	1.00
168_E	172_A	1.844	1.00
150_I	166_I	1.839	1.00
73_S	77_E	1.799	1.00
57_Q	253_G	1.790	1.00
164_A	168_E	1.779	1.00
368_Y	372_L	1.774	1.00
133_D	136_E	1.766	1.00
60_D	260_K	1.747	1.00
318_K	372_L	1.738	1.00
20_A	28_T	1.727	1.00
179_V	197_V	1.715	1.00
68_E	220_R	1.714	1.00
170_C	177_Y	1.653	1.00
288_Y	306_N	1.639	1.00
134_L	169_M	1.627	1.00
72_T	78_S	1.620	1.00
277_L	357_L	1.610	1.00
204_G	252_M	1.608	1.00
197_V	200_M	1.589	1.00
96_H	144_D	1.575	1.00
269_R	273_L	1.527	1.00
79_D	178_H	1.527	1.00
302_N	352_S	1.526	1.00
21_E	25_Q	1.516	1.00
23_M	251_G	1.510	1.00
57_Q	260_K	1.505	1.00
95_K	146_I	1.504	1.00
75_A	182_T	1.491	1.00
113_Q	231_H	1.483	1.00
165_A	168_E	1.473	1.00
82_A	199_L	1.472	1.00
141_M	169_M	1.465	1.00
153_V	297_A	1.459	1.00
275_N	279_N	1.455	1.00
84_K	231_H	1.452	1.00
22_K	254_E	1.447	1.00
169_M	173_R	1.442	1.00
171_R	198_D	1.441	1.00
267_M	271_R	1.439	1.00
21_E	24_M	1.424	1.00
171_R	196_K	1.419	1.00
147_L	178_H	1.409	1.00
280_G	374_R	1.406	1.00
207_I	252_M	1.399	1.00
65_D	220_R	1.399	1.00
22_K	25_Q	1.391	1.00
32_T	46_Q	1.390	1.00
101_K	123_Y	1.386	1.00
135_K	138_E	1.382	1.00
264_A	268_E	1.377	1.00
163_I	179_V	1.375	1.00
282_K	293_L	1.361	1.00
99_T	111_C	1.359	1.00
53_I	57_Q	1.357	1.00
54_A	253_G	1.351	1.00
271_R	275_N	1.350	1.00
168_E	196_K	1.347	1.00
278_W	301_L	1.331	1.00
124_L	140_A	1.330	1.00
210_P	251_G	1.328	1.00
363_E	367_D	1.326	1.00
134_L	165_A	1.318	1.00
199_L	218_V	1.313	1.00
56_N	60_D	1.309	1.00
274_R	278_W	1.306	1.00
127_Q	133_D	1.287	1.00
98_I	140_A	1.285	1.00
138_E	173_R	1.284	1.00
169_M	172_A	1.275	1.00
135_K	139_A	1.275	1.00
50_A	250_V	1.274	1.00
167_G	196_K	1.272	1.00
99_T	123_Y	1.258	1.00
86_A	176_I	1.256	1.00
208_Y	358_G	1.245	1.00
18_R	258_I	1.244	1.00
98_I	145_T	1.238	1.00
10_S	300_I	1.237	1.00
309_E	312_S	1.236	1.00
16_D	258_I	1.235	1.00
277_L	366_I	1.234	1.00
53_I	253_G	1.229	1.00
120_E	142_R	1.223	1.00
67_R	220_R	1.223	1.00
184_S	200_M	1.221	1.00
268_E	272_G	1.215	1.00
61_L	185_V	1.213	1.00
78_S	201_S	1.212	1.00
185_V	202_F	1.208	1.00
153_V	184_S	1.208	1.00
372_L	375_K	1.205	1.00
262_E	265_T	1.204	1.00
322_V	353_I	1.197	1.00
148_V	175_I	1.195	1.00
129_N	292_D	1.195	1.00
362_T	365_E	1.193	1.00
94_G	146_I	1.190	1.00
137_L	166_I	1.174	1.00
15_V	20_A	1.173	1.00
368_Y	371_E	1.172	1.00
58_I	215_A	1.171	1.00
150_I	177_Y	1.171	1.00
137_L	148_V	1.171	1.00
278_W	282_K	1.165	1.00
150_I	163_I	1.163	1.00
49_E	53_I	1.161	1.00
63_G	193_S	1.156	1.00
370_I	374_R	1.152	1.00
69_I	217_Y	1.133	1.00
316_A	376_S	1.132	1.00
160_V	188_L	1.132	1.00
273_L	366_I	1.123	1.00
56_N	59_A	1.120	1.00
134_L	138_E	1.119	1.00
102_T	161_Q	1.118	1.00
51_V	249_I	1.111	1.00
279_N	282_K	1.106	1.00
152_H	200_M	1.106	1.00
56_N	66_P	1.103	1.00
142_R	145_T	1.101	1.00
167_G	171_R	1.094	1.00
280_G	371_E	1.092	1.00
192_L	217_Y	1.088	1.00
189_P	264_A	1.087	1.00
279_N	283_D	1.077	1.00
178_H	201_S	1.076	1.00
283_D	374_R	1.069	1.00
149_S	178_H	1.061	1.00
97_I	111_C	1.057	1.00
253_G	257_R	1.056	1.00
138_E	142_R	1.046	1.00
57_Q	60_D	1.032	1.00
303_V	355_F	1.031	1.00
87_A	119_F	1.030	1.00
112_R	115_E	1.029	1.00
262_E	266_E	1.028	1.00
176_I	199_L	1.016	1.00
171_R	177_Y	1.007	1.00
371_E	375_K	1.007	1.00
138_E	165_A	1.005	1.00
286_E	306_N	1.004	1.00
61_L	256_Y	1.004	1.00
109_D	112_R	1.000	1.00
153_V	298_P	0.998	1.00
269_R	272_G	0.996	1.00
141_M	145_T	0.996	1.00
84_K	113_Q	0.987	1.00
152_H	195_L	0.985	1.00
367_D	371_E	0.982	1.00
265_T	268_E	0.979	1.00
277_L	369_T	0.976	1.00
254_E	258_I	0.975	1.00
10_S	356_S	0.974	1.00
134_L	137_L	0.971	1.00
108_L	123_Y	0.965	1.00
65_D	68_E	0.955	1.00
257_R	261_E	0.953	1.00
58_I	256_Y	0.946	1.00
142_R	173_R	0.946	1.00
198_D	219_R	0.944	1.00
107_V	149_S	0.943	1.00
191_D	195_L	0.937	1.00
170_C	173_R	0.936	1.00
274_R	301_L	0.934	1.00
83_I	111_C	0.933	1.00
148_V	166_I	0.932	1.00
62_V	202_F	0.922	1.00
278_W	289_L	0.917	1.00
277_L	301_L	0.915	1.00
357_L	366_I	0.915	1.00
62_V	217_Y	0.914	1.00
42_R	46_Q	0.912	1.00
364_E	367_D	0.911	1.00
265_T	269_R	0.906	1.00
290_N	352_S	0.905	1.00
290_N	302_N	0.902	1.00
314_I	324_S	0.898	1.00
204_G	213_I	0.898	1.00
20_A	27_M	0.895	1.00
266_E	359_R	0.894	1.00
113_Q	116_R	0.892	1.00
19_V	255_A	0.887	1.00
65_D	193_S	0.886	1.00
266_E	269_R	0.886	1.00
86_A	90_Y	0.886	1.00
304_S	351_S	0.881	1.00
192_L	195_L	0.878	1.00
361_T	366_I	0.878	1.00
95_K	120_E	0.877	1.00
207_I	256_Y	0.875	1.00
151_M	155_N	0.875	1.00
266_E	270_L	0.869	1.00
43_F	321_A	0.866	1.00
213_I	249_I	0.863	1.00
320_L	372_L	0.852	1.00
122_T	142_R	0.852	1.00
59_A	64_A	0.845	1.00
277_L	355_F	0.843	1.00
152_H	190_I	0.843	1.00
213_I	248_Q	0.840	1.00
312_S	316_A	0.840	1.00
204_G	209_G	0.837	1.00
125_A	140_A	0.835	1.00
54_A	57_Q	0.830	1.00
170_C	174_G	0.828	1.00
364_E	368_Y	0.824	1.00
86_A	199_L	0.821	1.00
164_A	195_L	0.818	1.00
152_H	163_I	0.818	1.00
320_L	369_T	0.816	1.00
91_Q	95_K	0.815	1.00
53_I	257_R	0.814	1.00
190_I	194_Q	0.812	1.00
297_A	300_I	0.811	1.00
273_L	363_E	0.810	1.00
320_L	368_Y	0.810	1.00
178_H	199_L	0.809	1.00
277_L	370_I	0.801	1.00
84_K	229_Q	0.799	1.00
64_A	68_E	0.798	1.00
131_I	161_Q	0.796	1.00
46_Q	49_E	0.796	1.00
79_D	201_S	0.795	1.00
82_A	216_L	0.792	1.00
23_M	27_M	0.792	1.00
284_I	287_V	0.791	1.00
101_K	126_P	0.787	1.00
185_V	207_I	0.786	1.00
185_V	256_Y	0.775	1.00
313_L	373_V	0.767	1.00
100_S	150_I	0.765	1.00
167_G	195_L	0.763	1.00
70_V	81_L	0.759	1.00
181_A	185_V	0.755	1.00
281_I	303_V	0.754	1.00
369_T	373_V	0.753	1.00
141_M	175_I	0.753	1.00
62_V	192_L	0.748	1.00
26_F	50_A	0.748	1.00
189_P	194_Q	0.748	1.00
98_I	122_T	0.748	1.00
280_G	284_I	0.747	1.00
287_V	305_F	0.745	1.00
185_V	190_I	0.741	1.00
18_R	261_E	0.741	1.00
284_I	370_I	0.740	1.00
54_A	249_I	0.738	1.00
312_S	315_M	0.738	1.00
219_R	222_P	0.736	1.00
189_P	192_L	0.736	1.00
64_A	217_Y	0.733	1.00
278_W	293_L	0.732	1.00
61_L	260_K	0.731	1.00
27_M	247_H	0.730	1.00
137_L	141_M	0.729	1.00
276_R	366_I	0.729	1.00
299_N	302_N	0.728	1.00
141_M	173_R	0.727	1.00
282_K	292_D	0.726	1.00
208_Y	359_R	0.723	1.00
57_Q	256_Y	0.717	1.00
227_E	231_H	0.714	1.00
12_T	33_F	0.714	1.00
18_R	254_E	0.713	1.00
176_I	198_D	0.713	1.00
196_K	219_R	0.711	1.00
361_T	365_E	0.711	1.00
112_R	123_Y	0.709	1.00
151_M	161_Q	0.708	1.00
99_T	149_S	0.707	1.00
122_T	145_T	0.706	1.00
13_T	208_Y	0.705	1.00
297_A	301_L	0.702	1.00
371_E	374_R	0.700	1.00
58_I	71_F	0.700	1.00
369_T	372_L	0.700	1.00
97_I	147_L	0.699	1.00
25_Q	32_T	0.699	1.00
257_R	260_K	0.697	1.00
189_P	267_M	0.689	1.00
25_Q	28_T	0.688	1.00
99_T	121_V	0.687	1.00
301_L	304_S	0.684	1.00
51_V	246_V	0.684	1.00
18_R	21_E	0.681	1.00
272_G	276_R	0.678	1.00
152_H	160_V	0.678	1.00
313_L	376_S	0.676	1.00
184_S	188_L	0.675	1.00
140_A	143_D	0.675	1.00
50_A	53_I	0.675	1.00
358_G	361_T	0.674	1.00
113_Q	117_E	0.674	1.00
127_Q	136_E	0.673	1.00
57_Q	61_L	0.672	1.00
229_Q	233_G	0.672	1.00
229_Q	232_G	0.671	1.00
241_S	244_L	0.669	1.00
163_I	177_Y	0.668	1.00
134_L	166_I	0.666	1.00
269_R	363_E	0.665	1.00
92_K	95_K	0.665	1.00
48_E	52_D	0.664	1.00
317_L	322_V	0.664	1.00
21_E	28_T	0.663	1.00
304_S	348_L	0.662	1.00
68_E	193_S	0.662	1.00
75_A	79_D	0.660	1.00
17_P	20_A	0.660	1.00
190_I	195_L	0.660	1.00
41_H	44_G	0.658	1.00
55_R	236_E	0.656	1.00
68_E	219_R	0.656	1.00
176_I	222_P	0.655	1.00
111_C	121_V	0.654	1.00
230_M	233_G	0.654	1.00
268_E	271_R	0.651	1.00
215_A	252_M	0.649	1.00
270_L	299_N	0.648	1.00
16_D	359_R	0.646	1.00
278_W	297_A	0.646	1.00
192_L	196_K	0.645	1.00
120_E	144_D	0.644	1.00
22_K	26_F	0.643	1.00
111_C	149_S	0.642	1.00
182_T	203_S	0.641	1.00
166_I	177_Y	0.640	1.00
22_K	250_V	0.639	1.00
322_V	355_F	0.639	1.00
37_A	244_L	0.635	1.00
16_D	19_V	0.634	1.00
82_A	178_H	0.633	1.00
167_G	197_V	0.632	1.00
367_D	370_I	0.632	1.00
181_A	184_S	0.631	1.00
277_L	281_I	0.631	1.00
53_I	56_N	0.628	1.00
124_L	136_E	0.628	1.00
228_A	231_H	0.628	1.00
105_K	109_D	0.628	1.00
167_G	179_V	0.623	1.00
99_T	103_E	0.621	1.00
62_V	185_V	0.616	1.00
18_R	262_E	0.616	1.00
77_E	230_M	0.614	1.00
222_P	225_R	0.613	1.00
165_A	169_M	0.613	1.00
206_K	354_R	0.611	1.00
17_P	24_M	0.610	1.00
108_L	112_R	0.609	1.00
228_A	232_G	0.609	1.00
152_H	179_V	0.608	1.00
114_L	119_F	0.607	1.00
38_S	41_H	0.601	1.00
168_E	171_R	0.598	1.00
91_Q	119_F	0.598	1.00
34_G	37_A	0.596	1.00
52_D	55_R	0.594	1.00
80_N	84_K	0.593	1.00
259_A	266_E	0.592	1.00
75_A	201_S	0.592	1.00
314_I	317_L	0.589	1.00
153_V	160_V	0.587	1.00
138_E	141_M	0.587	1.00
263_M	267_M	0.584	1.00
296_G	300_I	0.581	1.00
77_E	81_L	0.581	1.00
241_S	246_V	0.580	1.00
76_T	80_N	0.579	1.00
231_H	234_G	0.579	1.00
325_G	328_C	0.579	1.00
259_A	263_M	0.578	1.00
298_P	301_L	0.576	1.00
300_I	304_S	0.576	1.00
74_G	214_G	0.575	1.00
124_L	137_L	0.574	1.00
164_A	196_K	0.573	1.00
102_T	126_P	0.572	1.00
14_P	33_F	0.572	1.00
320_L	323_S	0.572	1.00
264_A	267_M	0.572	1.00
276_R	370_I	0.571	1.00
300_I	356_S	0.567	1.00
277_L	280_G	0.567	1.00
314_I	322_V	0.567	1.00
242_G	247_H	0.566	1.00
221_K	224_V	0.566	1.00
299_N	303_V	0.566	1.00
129_N	293_L	0.565	1.00
19_V	23_M	0.564	1.00
240_R	246_V	0.563	1.00
15_V	27_M	0.562	1.00
59_A	66_P	0.561	1.00
82_A	86_A	0.560	1.00
308_V	313_L	0.560	1.00
167_G	170_C	0.560	1.00
25_Q	50_A	0.559	1.00
114_L	117_E	0.559	1.00
281_I	287_V	0.559	1.00
298_P	303_V	0.558	1.00
26_F	250_V	0.557	1.00
204_G	207_I	0.557	1.00
311_E	315_M	0.555	1.00
14_P	208_Y	0.555	1.00
100_S	103_E	0.554	1.00
305_F	377_I	0.553	1.00
98_I	124_L	0.552	1.00
281_I	370_I	0.552	1.00
305_F	373_V	0.550	1.00
189_P	263_M	0.550	1.00
107_V	111_C	0.548	1.00
131_I	159_V	0.548	1.00
179_V	200_M	0.547	1.00
171_R	175_I	0.546	1.00
19_V	254_E	0.546	1.00
327_A	330_S	0.545	1.00
281_I	373_V	0.543	1.00
139_A	143_D	0.543	1.00
320_L	324_S	0.543	1.00
276_R	279_N	0.542	1.00
228_A	233_G	0.542	1.00
200_M	217_Y	0.541	1.00
280_G	366_I	0.540	1.00
73_S	76_T	0.539	1.00
189_P	193_S	0.539	1.00
110_T	231_H	0.538	1.00
60_D	63_G	0.538	1.00
137_L	169_M	0.537	1.00
115_E	123_Y	0.536	1.00
253_G	256_Y	0.536	1.00
190_I	200_M	0.535	1.00
273_L	357_L	0.535	1.00
230_M	234_G	0.535	1.00
256_Y	260_K	0.534	1.00
51_V	244_L	0.534	1.00
137_L	170_C	0.533	1.00
267_M	270_L	0.532	1.00
207_I	259_A	0.531	1.00
284_I	377_I	0.529	1.00
141_M	148_V	0.529	1.00
273_L	361_T	0.527	1.00
300_I	303_V	0.525	1.00
272_G	275_N	0.525	1.00
198_D	221_K	0.523	1.00
190_I	193_S	0.523	1.00
12_T	205_H	0.522	1.00
52_D	56_N	0.521	1.00
16_D	262_E	0.521	1.00
298_P	302_N	0.520	1.00
77_E	80_N	0.520	1.00
33_F	37_A	0.517	1.00
220_R	224_V	0.517	1.00
83_I	110_T	0.516	1.00
81_L	229_Q	0.515	1.00
199_L	216_L	0.515	1.00
208_Y	259_A	0.514	1.00
119_F	146_I	0.513	1.00
258_I	359_R	0.513	1.00
228_A	234_G	0.513	1.00
372_L	376_S	0.512	1.00
236_E	240_R	0.511	1.00
326_S	330_S	0.511	1.00
236_E	243_T	0.511	1.00
34_G	41_H	0.509	1.00
50_A	253_G	0.508	1.00
26_F	247_H	0.507	1.00
64_A	192_L	0.507	1.00
83_I	107_V	0.506	1.00
151_M	154_N	0.506	1.00
305_F	313_L	0.504	1.00
87_A	91_Q	0.501	1.00
193_S	196_K	0.500	1.00
55_R	71_F	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3lvmA	2	0.9728	100	0.382	Contact Map
3a9zA	2	0.9307	100	0.416	Contact Map
3vaxA	2	0.8663	100	0.421	Contact Map
4isyA	2	0.9257	100	0.423	Contact Map
4hvkA	2	0.9084	100	0.433	Contact Map
1eg5A	2	0.8911	100	0.433	Contact Map
3e9kA	2	0.8713	100	0.438	Contact Map
1kmjA	2	0.9059	100	0.44	Contact Map
4q75A	2	0.9183	100	0.443	Contact Map
1t3iA	2	0.9059	100	0.451	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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