GREMLIN Database
ALR1 - Alanine racemase, biosynthetic
UniProt: P0A6B4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10001
Length: 359 (348)
Sequences: 4890 (3629)
Seq/√Len: 194.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_L234_V3.5381.00
158_S191_I3.4131.00
287_P294_E3.1391.00
268_G310_L2.8261.00
252_P257_G2.8161.00
246_E266_R2.8021.00
179_N205_F2.7671.00
241_L268_G2.7561.00
15_H232_Q2.7351.00
64_L93_Q2.6851.00
252_P260_V2.6841.00
194_S213_I2.6531.00
248_K264_D2.6431.00
294_E333_R2.5891.00
323_I328_G2.5491.00
238_T321_P2.5191.00
267_L298_V2.4611.00
63_A95_F2.4411.00
20_L213_I2.4321.00
246_E264_D2.3841.00
50_P73_K2.3571.00
9_N12_A2.2761.00
90_I97_T2.2551.00
295_V313_Q2.2321.00
7_V238_T2.2281.00
258_T300_R2.2231.00
28_K53_D2.1991.00
259_W265_T2.1711.00
128_H251_E2.1531.00
254_G302_A2.1091.00
288_V308_V2.0731.00
239_S270_V2.0651.00
247_H261_S2.0601.00
30_V207_W2.0441.00
124_D128_H2.0381.00
32_V56_G2.0311.00
237_L272_M2.0231.00
175_L203_S2.0161.00
249_A264_D1.9851.00
241_L316_D1.9671.00
263_R312_P1.9361.00
173_K177_I1.9351.00
118_T151_R1.9351.00
217_V346_I1.9241.00
217_V342_A1.9171.00
349_L353_V1.9151.00
19_R22_E1.8911.00
182_C189_R1.8831.00
170_A257_G1.8561.00
331_V346_I1.8441.00
291_N320_D1.8421.00
43_L69_G1.8321.00
278_Y324_L1.8221.00
15_H19_R1.8161.00
36_N351_S1.8131.00
14_R48_T1.8101.00
132_V140_F1.7691.00
98_A157_V1.7641.00
162_R257_G1.7281.00
31_A214_L1.7061.00
317_K320_D1.6951.00
5_T238_T1.6761.00
176_A180_T1.6151.00
96_H154_V1.6141.00
175_L205_F1.5881.00
248_K261_S1.5871.00
106_A143_R1.5811.00
248_K251_E1.5791.00
244_V310_L1.5751.00
290_V308_V1.5701.00
279_P348_R1.5461.00
17_L214_L1.5271.00
50_P55_F1.5241.00
197_I210_P1.5171.00
42_L65_R1.5051.00
332_E342_A1.5051.00
30_V56_G1.4971.00
120_W190_S1.4861.00
290_V295_V1.4801.00
109_E147_C1.4801.00
123_L181_F1.4771.00
269_V307_C1.4701.00
189_R206_D1.4571.00
33_V46_A1.4411.00
162_R171_T1.4411.00
289_L329_L1.4381.00
12_A232_Q1.4281.00
192_A203_S1.4091.00
162_R165_E1.4021.00
270_V306_I1.4001.00
265_T309_D1.3971.00
13_L45_T1.3901.00
43_L65_R1.3841.00
265_T311_G1.3821.00
24_A27_S1.3781.00
6_V353_V1.3731.00
289_L323_I1.3721.00
46_A66_L1.3631.00
235_M325_W1.3581.00
302_A307_C1.3521.00
304_D352_R1.3511.00
94_H115_E1.3251.00
175_L179_N1.3211.00
289_L328_G1.3081.00
270_V322_V1.3071.00
28_K54_A1.2971.00
4_A272_M1.2951.00
286_T297_I1.2781.00
102_E106_A1.2741.00
44_E357_Y1.2681.00
261_S265_T1.2681.00
163_A195_G1.2591.00
258_T284_S1.2481.00
192_A204_H1.2461.00
31_A52_A1.2451.00
40_H235_M1.2421.00
116_P151_R1.2401.00
102_E143_R1.2381.00
10_R357_Y1.2381.00
251_E261_S1.2251.00
44_E47_R1.2241.00
244_V318_A1.2131.00
172_E202_Q1.2111.00
172_E176_A1.2061.00
138_E184_G1.2051.00
118_T154_V1.2041.00
55_F73_K1.1931.00
30_V54_A1.1901.00
109_E143_R1.1881.00
17_L52_A1.1861.00
15_H230_G1.1851.00
134_P180_T1.1631.00
267_L307_C1.1571.00
6_V237_L1.1571.00
170_A252_P1.1511.00
247_H253_V1.1491.00
17_L29_M1.1481.00
258_T283_P1.1321.00
192_A196_G1.1271.00
68_A93_Q1.1271.00
168_C199_L1.1181.00
278_Y334_I1.1161.00
4_A239_S1.1161.00
173_K176_A1.1151.00
241_L244_V1.1121.00
175_L191_I1.1121.00
20_L210_P1.1121.00
262_E265_T1.1121.00
177_I180_T1.1071.00
35_A275_G1.1011.00
325_W331_V1.1001.00
237_L353_V1.0941.00
289_L294_E1.0931.00
13_L49_L1.0891.00
66_L71_I1.0821.00
106_A110_E1.0791.00
89_T93_Q1.0781.00
109_E149_N1.0711.00
179_N183_E1.0671.00
21_R53_D1.0661.00
213_I231_C1.0651.00
287_P296_P1.0631.00
88_P92_A1.0581.00
103_E318_A1.0571.00
240_S321_P1.0561.00
50_P72_T1.0551.00
278_Y297_I1.0511.00
301_V306_I1.0471.00
49_L214_L1.0461.00
310_L316_D1.0431.00
272_M324_L1.0381.00
133_R251_E1.0311.00
124_D245_R1.0271.00
10_R48_T1.0271.00
201_P204_H1.0221.00
77_L95_F1.0211.00
64_L68_A1.0211.00
105_L144_L1.0101.00
5_T356_K1.0101.00
96_H118_T1.0061.00
54_A96_H1.0061.00
338_T345_L1.0061.00
241_L310_L1.0001.00
171_T200_W0.9951.00
74_P96_H0.9951.00
29_M210_P0.9850.99
288_V306_I0.9840.99
263_R311_G0.9770.99
326_G329_L0.9730.99
137_A181_F0.9630.99
330_P333_R0.9630.99
6_V235_M0.9600.99
17_L49_L0.9540.99
197_I208_V0.9540.99
122_K130_L0.9520.99
287_P337_M0.9490.99
89_T92_A0.9490.99
238_T323_I0.9470.99
179_N202_Q0.9450.99
243_A318_A0.9430.99
310_L313_Q0.9360.99
165_E168_C0.9270.99
43_L47_R0.9230.99
270_V288_V0.9220.99
24_A204_H0.9170.99
99_V105_L0.9160.99
162_R170_A0.9150.99
51_D73_K0.9130.99
250_G261_S0.9120.99
295_V311_G0.9120.99
265_T298_V0.9080.99
99_V119_V0.9080.99
235_M349_L0.9060.99
335_A340_V0.9030.99
270_V308_V0.9030.99
31_A49_L0.9020.99
130_L269_V0.9010.99
212_I343_Y0.9000.99
7_V356_K0.8990.99
241_L290_V0.8920.99
67_R75_V0.8860.99
295_V308_V0.8820.99
134_P177_I0.8770.99
188_Q206_D0.8730.99
279_P338_T0.8700.99
239_S271_A0.8670.99
281_A339_K0.8650.99
189_R205_F0.8590.99
130_L305_M0.8570.99
281_A338_T0.8450.98
329_L333_R0.8420.98
41_G357_Y0.8410.98
308_V322_V0.8400.98
54_A74_P0.8360.98
5_T240_S0.8360.98
160_F196_G0.8350.98
28_K188_Q0.8320.98
94_H118_T0.8290.98
160_F191_I0.8290.98
266_R315_Q0.8280.98
162_R256_G0.8280.98
197_I204_H0.8260.98
4_A353_V0.8220.98
158_S205_F0.8220.98
54_A207_W0.8150.98
253_V265_T0.8140.98
210_P213_I0.8140.98
14_R18_Q0.8120.98
247_H251_E0.8110.98
91_S117_V0.8100.98
282_A337_M0.8100.98
290_V322_V0.8090.98
47_R69_G0.8030.98
295_V312_P0.7970.98
142_H146_Q0.7960.98
291_N316_D0.7960.98
217_V331_V0.7950.98
293_R313_Q0.7940.98
254_G307_C0.7910.98
178_F189_R0.7910.98
123_L137_A0.7910.98
18_Q51_D0.7900.98
10_R44_E0.7890.98
20_L29_M0.7880.98
253_V307_C0.7860.97
103_E106_A0.7850.97
6_V40_H0.7840.97
250_G264_D0.7820.97
6_V349_L0.7770.97
293_R312_P0.7760.97
67_R94_H0.7760.97
155_N190_S0.7730.97
120_W155_N0.7720.97
188_Q207_W0.7710.97
105_L140_F0.7700.97
212_I217_V0.7700.97
102_E136_Q0.7670.97
138_E142_H0.7660.97
154_V187_G0.7640.97
263_R309_D0.7640.97
128_H133_R0.7630.97
195_G219_P0.7630.97
119_V150_V0.7600.97
252_P261_S0.7600.97
8_I357_Y0.7580.97
66_L75_V0.7580.97
172_E200_W0.7570.97
45_T49_L0.7570.97
242_I271_A0.7550.97
143_R147_C0.7550.97
128_H247_H0.7550.97
151_R187_G0.7550.97
290_V316_D0.7540.97
156_I182_C0.7520.97
278_Y286_T0.7500.97
280_R344_E0.7500.97
23_L27_S0.7490.97
272_M306_I0.7490.97
76_L120_W0.7480.97
33_V55_F0.7480.97
45_T234_V0.7470.97
164_D256_G0.7470.97
313_Q316_D0.7450.97
253_V267_L0.7420.96
291_N317_K0.7400.96
77_L90_I0.7390.96
236_S323_I0.7380.96
175_L192_A0.7370.96
291_N315_Q0.7340.96
278_Y306_I0.7340.96
316_D320_D0.7330.96
280_R341_S0.7320.96
161_A170_A0.7320.96
288_V324_L0.7290.96
32_V78_L0.7290.96
60_L90_I0.7280.96
19_R230_G0.7250.96
10_R45_T0.7240.96
279_P345_L0.7220.96
261_S264_D0.7200.96
8_I234_V0.7180.96
63_A93_Q0.7180.96
84_A107_A0.7150.96
247_H267_L0.7150.96
9_N236_S0.7150.96
56_G207_W0.7130.96
36_N42_L0.7120.96
218_S229_F0.7110.95
249_A262_E0.7090.95
282_A338_T0.7080.95
3_A240_S0.7060.95
212_I342_A0.7060.95
239_S306_I0.7050.95
76_L96_H0.7050.95
178_F191_I0.7010.95
99_V108_L0.7000.95
333_R336_E0.6990.95
162_R168_C0.6980.95
136_Q139_A0.6980.95
137_A141_Y0.6970.95
191_I205_F0.6960.95
321_P328_G0.6960.95
123_L156_I0.6950.95
91_S111_A0.6940.95
195_G212_I0.6940.95
306_I324_L0.6920.95
198_L229_F0.6910.95
82_F97_T0.6880.95
12_A15_H0.6870.95
46_A71_I0.6870.95
283_P286_T0.6860.95
331_V342_A0.6860.95
81_F100_H0.6780.94
325_W345_L0.6780.94
86_D89_T0.6770.94
221_E336_E0.6760.94
43_L71_I0.6730.94
112_S117_V0.6690.94
232_Q327_E0.6690.94
140_F144_L0.6690.94
168_C200_W0.6650.94
288_V322_V0.6640.94
168_C172_E0.6640.94
21_R29_M0.6620.93
237_L349_L0.6590.93
7_V236_S0.6590.93
133_R136_Q0.6580.93
42_L275_G0.6560.93
91_S112_S0.6550.93
243_A269_V0.6550.93
295_V316_D0.6540.93
11_R14_R0.6530.93
49_L55_F0.6520.93
9_N327_E0.6490.93
266_R312_P0.6480.93
102_E139_A0.6460.93
12_A231_C0.6450.93
237_L325_W0.6440.92
65_R351_S0.6430.92
60_L63_A0.6400.92
139_A143_R0.6390.92
28_K207_W0.6390.92
253_V298_V0.6390.92
125_T174_Q0.6380.92
286_T337_M0.6380.92
293_R315_Q0.6370.92
100_H243_A0.6360.92
133_R245_R0.6320.92
155_N188_Q0.6300.92
72_T94_H0.6280.92
144_L153_P0.6270.91
31_A55_F0.6250.91
180_T183_E0.6240.91
83_D86_D0.6230.91
45_T48_T0.6230.91
199_L220_L0.6210.91
19_R23_L0.6190.91
29_M208_V0.6180.91
285_G337_M0.6180.91
148_K151_R0.6180.91
15_H18_Q0.6180.91
291_N313_Q0.6160.91
103_E107_A0.6160.91
27_S208_V0.6150.91
54_A76_L0.6150.91
56_G78_L0.6120.90
332_E336_E0.6120.90
139_A142_H0.6120.90
342_A346_I0.6120.90
295_V310_L0.6120.90
156_I187_G0.6120.90
276_D352_R0.6110.90
262_E296_P0.6070.90
340_V345_L0.6070.90
312_P316_D0.6070.90
287_P333_R0.6040.90
279_P282_A0.6010.90
58_A304_D0.5990.89
64_L89_T0.5980.89
242_I305_M0.5940.89
35_A352_R0.5910.89
105_L109_E0.5910.89
297_I306_I0.5900.89
18_Q21_R0.5880.89
282_A286_T0.5880.89
91_S113_L0.5870.89
37_A42_L0.5860.88
266_R310_L0.5830.88
244_V266_R0.5830.88
246_E265_T0.5820.88
65_R69_G0.5810.88
253_V261_S0.5810.88
30_V76_L0.5800.88
323_I326_G0.5780.88
297_I308_V0.5780.88
297_I301_V0.5760.88
196_G200_W0.5750.88
334_I345_L0.5740.87
75_V95_F0.5730.87
33_V215_Y0.5710.87
18_Q22_E0.5690.87
138_E141_Y0.5680.87
46_A55_F0.5680.87
50_P53_D0.5670.87
180_T184_G0.5620.86
325_W349_L0.5610.86
212_I346_I0.5580.86
259_W298_V0.5570.86
323_I329_L0.5570.86
164_D300_R0.5560.86
164_D280_R0.5560.86
210_P214_L0.5550.86
19_R229_F0.5550.86
12_A234_V0.5530.85
81_F90_I0.5530.85
11_R15_H0.5530.85
52_A55_F0.5520.85
137_A140_F0.5490.85
104_Q108_L0.5470.85
105_L147_C0.5470.85
121_M141_Y0.5460.85
71_I74_P0.5450.85
37_A47_R0.5450.85
9_N232_Q0.5420.84
175_L200_W0.5420.84
253_V259_W0.5400.84
76_L98_A0.5400.84
176_A179_N0.5380.84
218_S332_E0.5360.84
294_E329_L0.5360.84
20_L197_I0.5350.84
276_D304_D0.5350.84
4_A237_L0.5340.83
81_F97_T0.5340.83
120_W154_V0.5340.83
53_D74_P0.5330.83
60_L64_L0.5310.83
24_A208_V0.5310.83
333_R337_M0.5310.83
290_V310_L0.5310.83
158_S171_T0.5280.83
108_L117_V0.5280.83
112_S115_E0.5270.83
325_W334_I0.5250.82
125_T161_A0.5250.82
249_A263_R0.5230.82
35_A304_D0.5210.82
191_I196_G0.5210.82
286_T334_I0.5210.82
10_R14_R0.5190.82
112_S150_V0.5190.82
134_P181_F0.5180.82
275_G350_T0.5170.81
160_F203_S0.5170.81
13_L214_L0.5160.81
197_I213_I0.5160.81
25_P204_H0.5140.81
168_C171_T0.5140.81
133_R248_K0.5140.81
19_R232_Q0.5120.81
343_Y347_T0.5110.81
143_R146_Q0.5100.81
92_A115_E0.5100.81
244_V268_G0.5090.80
292_G328_G0.5090.80
5_T321_P0.5090.80
125_T177_I0.5060.80
265_T312_P0.5060.80
218_S230_G0.5060.80
43_L46_A0.5050.80
274_Y303_M0.5040.80
54_A188_Q0.5040.80
336_E339_K0.5040.80
269_V305_M0.5040.80
218_S223_R0.5030.80
181_F184_G0.5030.80
54_A73_K0.5020.80
275_G352_R0.5020.80
282_A334_I0.5010.79
290_V313_Q0.5000.79
160_F192_A0.5000.79
200_W203_S0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1bd0A 2 0.9861 100 0.236 Contact Map
3hurA 4 0.9777 100 0.245 Contact Map
3e5pA 2 0.9805 100 0.249 Contact Map
4bhyA 2 0.9387 100 0.252 Contact Map
2rjgA 2 0.9972 100 0.252 Contact Map
1rcqA 2 0.9889 100 0.258 Contact Map
2vd8A 2 0.9415 100 0.259 Contact Map
3co8A 2 0.9777 100 0.264 Contact Map
4a3qA 2 0.9164 100 0.266 Contact Map
3s46A 2 0.9777 100 0.268 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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