ALR1 - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

ALR1 - Alanine racemase, biosynthetic

UniProt:	P0A6B4	Sequences: MQAATVVINRRALRHNLQRLRELAPASKMVAVVKANAYGHGLLETARTLPDADAFGVARLEEALRLRAGGITKPVLLLEGFFDARDLPTISAQHFHTAVHNEEQLAALEEASLDEPVTVWMKLDTGMHRLGVRPEQAEAFYHRLTQCKNVRQPVNIVSHFARADEPKCGATEKQLAIFNTFCEGKPGQRSIAASGGILLWPQSHFDWVRPGIILYGVSPLEDRSTGADFGCQPVMSLTSSLIAVREHKAGEPVGYGGTWVSERDTRLGVVAMGYGDGYPRAAPSGTPVLVNGREVPIVGRVAMDMICVDLGPQAQDKAGDPVILWGEGLPVERIAEMTKVSAYELITRLTSRVAMKYVD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10001
Length:	359 (348)
Sequences:	4890 (3629)
Seq/√Len:	194.5

ECOLI - ALR1 ALR2
BACSU - ALR2 ALR1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
13_L	234_V	3.538	1.00
158_S	191_I	3.413	1.00
287_P	294_E	3.139	1.00
268_G	310_L	2.826	1.00
252_P	257_G	2.816	1.00
246_E	266_R	2.802	1.00
179_N	205_F	2.767	1.00
241_L	268_G	2.756	1.00
15_H	232_Q	2.735	1.00
64_L	93_Q	2.685	1.00
252_P	260_V	2.684	1.00
194_S	213_I	2.653	1.00
248_K	264_D	2.643	1.00
294_E	333_R	2.589	1.00
323_I	328_G	2.549	1.00
238_T	321_P	2.519	1.00
267_L	298_V	2.461	1.00
63_A	95_F	2.441	1.00
20_L	213_I	2.432	1.00
246_E	264_D	2.384	1.00
50_P	73_K	2.357	1.00
9_N	12_A	2.276	1.00
90_I	97_T	2.255	1.00
295_V	313_Q	2.232	1.00
7_V	238_T	2.228	1.00
258_T	300_R	2.223	1.00
28_K	53_D	2.199	1.00
259_W	265_T	2.171	1.00
128_H	251_E	2.153	1.00
254_G	302_A	2.109	1.00
288_V	308_V	2.073	1.00
239_S	270_V	2.065	1.00
247_H	261_S	2.060	1.00
30_V	207_W	2.044	1.00
124_D	128_H	2.038	1.00
32_V	56_G	2.031	1.00
237_L	272_M	2.023	1.00
175_L	203_S	2.016	1.00
249_A	264_D	1.985	1.00
241_L	316_D	1.967	1.00
263_R	312_P	1.936	1.00
173_K	177_I	1.935	1.00
118_T	151_R	1.935	1.00
217_V	346_I	1.924	1.00
217_V	342_A	1.917	1.00
349_L	353_V	1.915	1.00
19_R	22_E	1.891	1.00
182_C	189_R	1.883	1.00
170_A	257_G	1.856	1.00
331_V	346_I	1.844	1.00
291_N	320_D	1.842	1.00
43_L	69_G	1.832	1.00
278_Y	324_L	1.822	1.00
15_H	19_R	1.816	1.00
36_N	351_S	1.813	1.00
14_R	48_T	1.810	1.00
132_V	140_F	1.769	1.00
98_A	157_V	1.764	1.00
162_R	257_G	1.728	1.00
31_A	214_L	1.706	1.00
317_K	320_D	1.695	1.00
5_T	238_T	1.676	1.00
176_A	180_T	1.615	1.00
96_H	154_V	1.614	1.00
175_L	205_F	1.588	1.00
248_K	261_S	1.587	1.00
106_A	143_R	1.581	1.00
248_K	251_E	1.579	1.00
244_V	310_L	1.575	1.00
290_V	308_V	1.570	1.00
279_P	348_R	1.546	1.00
17_L	214_L	1.527	1.00
50_P	55_F	1.524	1.00
197_I	210_P	1.517	1.00
42_L	65_R	1.505	1.00
332_E	342_A	1.505	1.00
30_V	56_G	1.497	1.00
120_W	190_S	1.486	1.00
290_V	295_V	1.480	1.00
109_E	147_C	1.480	1.00
123_L	181_F	1.477	1.00
269_V	307_C	1.470	1.00
189_R	206_D	1.457	1.00
33_V	46_A	1.441	1.00
162_R	171_T	1.441	1.00
289_L	329_L	1.438	1.00
12_A	232_Q	1.428	1.00
192_A	203_S	1.409	1.00
162_R	165_E	1.402	1.00
270_V	306_I	1.400	1.00
265_T	309_D	1.397	1.00
13_L	45_T	1.390	1.00
43_L	65_R	1.384	1.00
265_T	311_G	1.382	1.00
24_A	27_S	1.378	1.00
6_V	353_V	1.373	1.00
289_L	323_I	1.372	1.00
46_A	66_L	1.363	1.00
235_M	325_W	1.358	1.00
302_A	307_C	1.352	1.00
304_D	352_R	1.351	1.00
94_H	115_E	1.325	1.00
175_L	179_N	1.321	1.00
289_L	328_G	1.308	1.00
270_V	322_V	1.307	1.00
28_K	54_A	1.297	1.00
4_A	272_M	1.295	1.00
286_T	297_I	1.278	1.00
102_E	106_A	1.274	1.00
44_E	357_Y	1.268	1.00
261_S	265_T	1.268	1.00
163_A	195_G	1.259	1.00
258_T	284_S	1.248	1.00
192_A	204_H	1.246	1.00
31_A	52_A	1.245	1.00
40_H	235_M	1.242	1.00
116_P	151_R	1.240	1.00
102_E	143_R	1.238	1.00
10_R	357_Y	1.238	1.00
251_E	261_S	1.225	1.00
44_E	47_R	1.224	1.00
244_V	318_A	1.213	1.00
172_E	202_Q	1.211	1.00
172_E	176_A	1.206	1.00
138_E	184_G	1.205	1.00
118_T	154_V	1.204	1.00
55_F	73_K	1.193	1.00
30_V	54_A	1.190	1.00
109_E	143_R	1.188	1.00
17_L	52_A	1.186	1.00
15_H	230_G	1.185	1.00
134_P	180_T	1.163	1.00
267_L	307_C	1.157	1.00
6_V	237_L	1.157	1.00
170_A	252_P	1.151	1.00
247_H	253_V	1.149	1.00
17_L	29_M	1.148	1.00
258_T	283_P	1.132	1.00
192_A	196_G	1.127	1.00
68_A	93_Q	1.127	1.00
168_C	199_L	1.118	1.00
278_Y	334_I	1.116	1.00
4_A	239_S	1.116	1.00
173_K	176_A	1.115	1.00
241_L	244_V	1.112	1.00
175_L	191_I	1.112	1.00
20_L	210_P	1.112	1.00
262_E	265_T	1.112	1.00
177_I	180_T	1.107	1.00
35_A	275_G	1.101	1.00
325_W	331_V	1.100	1.00
237_L	353_V	1.094	1.00
289_L	294_E	1.093	1.00
13_L	49_L	1.089	1.00
66_L	71_I	1.082	1.00
106_A	110_E	1.079	1.00
89_T	93_Q	1.078	1.00
109_E	149_N	1.071	1.00
179_N	183_E	1.067	1.00
21_R	53_D	1.066	1.00
213_I	231_C	1.065	1.00
287_P	296_P	1.063	1.00
88_P	92_A	1.058	1.00
103_E	318_A	1.057	1.00
240_S	321_P	1.056	1.00
50_P	72_T	1.055	1.00
278_Y	297_I	1.051	1.00
301_V	306_I	1.047	1.00
49_L	214_L	1.046	1.00
310_L	316_D	1.043	1.00
272_M	324_L	1.038	1.00
133_R	251_E	1.031	1.00
124_D	245_R	1.027	1.00
10_R	48_T	1.027	1.00
201_P	204_H	1.022	1.00
77_L	95_F	1.021	1.00
64_L	68_A	1.021	1.00
105_L	144_L	1.010	1.00
5_T	356_K	1.010	1.00
96_H	118_T	1.006	1.00
54_A	96_H	1.006	1.00
338_T	345_L	1.006	1.00
241_L	310_L	1.000	1.00
171_T	200_W	0.995	1.00
74_P	96_H	0.995	1.00
29_M	210_P	0.985	0.99
288_V	306_I	0.984	0.99
263_R	311_G	0.977	0.99
326_G	329_L	0.973	0.99
137_A	181_F	0.963	0.99
330_P	333_R	0.963	0.99
6_V	235_M	0.960	0.99
17_L	49_L	0.954	0.99
197_I	208_V	0.954	0.99
122_K	130_L	0.952	0.99
287_P	337_M	0.949	0.99
89_T	92_A	0.949	0.99
238_T	323_I	0.947	0.99
179_N	202_Q	0.945	0.99
243_A	318_A	0.943	0.99
310_L	313_Q	0.936	0.99
165_E	168_C	0.927	0.99
43_L	47_R	0.923	0.99
270_V	288_V	0.922	0.99
24_A	204_H	0.917	0.99
99_V	105_L	0.916	0.99
162_R	170_A	0.915	0.99
51_D	73_K	0.913	0.99
250_G	261_S	0.912	0.99
295_V	311_G	0.912	0.99
265_T	298_V	0.908	0.99
99_V	119_V	0.908	0.99
235_M	349_L	0.906	0.99
335_A	340_V	0.903	0.99
270_V	308_V	0.903	0.99
31_A	49_L	0.902	0.99
130_L	269_V	0.901	0.99
212_I	343_Y	0.900	0.99
7_V	356_K	0.899	0.99
241_L	290_V	0.892	0.99
67_R	75_V	0.886	0.99
295_V	308_V	0.882	0.99
134_P	177_I	0.877	0.99
188_Q	206_D	0.873	0.99
279_P	338_T	0.870	0.99
239_S	271_A	0.867	0.99
281_A	339_K	0.865	0.99
189_R	205_F	0.859	0.99
130_L	305_M	0.857	0.99
281_A	338_T	0.845	0.98
329_L	333_R	0.842	0.98
41_G	357_Y	0.841	0.98
308_V	322_V	0.840	0.98
54_A	74_P	0.836	0.98
5_T	240_S	0.836	0.98
160_F	196_G	0.835	0.98
28_K	188_Q	0.832	0.98
94_H	118_T	0.829	0.98
160_F	191_I	0.829	0.98
266_R	315_Q	0.828	0.98
162_R	256_G	0.828	0.98
197_I	204_H	0.826	0.98
4_A	353_V	0.822	0.98
158_S	205_F	0.822	0.98
54_A	207_W	0.815	0.98
253_V	265_T	0.814	0.98
210_P	213_I	0.814	0.98
14_R	18_Q	0.812	0.98
247_H	251_E	0.811	0.98
91_S	117_V	0.810	0.98
282_A	337_M	0.810	0.98
290_V	322_V	0.809	0.98
47_R	69_G	0.803	0.98
295_V	312_P	0.797	0.98
142_H	146_Q	0.796	0.98
291_N	316_D	0.796	0.98
217_V	331_V	0.795	0.98
293_R	313_Q	0.794	0.98
254_G	307_C	0.791	0.98
178_F	189_R	0.791	0.98
123_L	137_A	0.791	0.98
18_Q	51_D	0.790	0.98
10_R	44_E	0.789	0.98
20_L	29_M	0.788	0.98
253_V	307_C	0.786	0.97
103_E	106_A	0.785	0.97
6_V	40_H	0.784	0.97
250_G	264_D	0.782	0.97
6_V	349_L	0.777	0.97
293_R	312_P	0.776	0.97
67_R	94_H	0.776	0.97
155_N	190_S	0.773	0.97
120_W	155_N	0.772	0.97
188_Q	207_W	0.771	0.97
105_L	140_F	0.770	0.97
212_I	217_V	0.770	0.97
102_E	136_Q	0.767	0.97
138_E	142_H	0.766	0.97
154_V	187_G	0.764	0.97
263_R	309_D	0.764	0.97
128_H	133_R	0.763	0.97
195_G	219_P	0.763	0.97
119_V	150_V	0.760	0.97
252_P	261_S	0.760	0.97
8_I	357_Y	0.758	0.97
66_L	75_V	0.758	0.97
172_E	200_W	0.757	0.97
45_T	49_L	0.757	0.97
242_I	271_A	0.755	0.97
143_R	147_C	0.755	0.97
128_H	247_H	0.755	0.97
151_R	187_G	0.755	0.97
290_V	316_D	0.754	0.97
156_I	182_C	0.752	0.97
278_Y	286_T	0.750	0.97
280_R	344_E	0.750	0.97
23_L	27_S	0.749	0.97
272_M	306_I	0.749	0.97
76_L	120_W	0.748	0.97
33_V	55_F	0.748	0.97
45_T	234_V	0.747	0.97
164_D	256_G	0.747	0.97
313_Q	316_D	0.745	0.97
253_V	267_L	0.742	0.96
291_N	317_K	0.740	0.96
77_L	90_I	0.739	0.96
236_S	323_I	0.738	0.96
175_L	192_A	0.737	0.96
291_N	315_Q	0.734	0.96
278_Y	306_I	0.734	0.96
316_D	320_D	0.733	0.96
280_R	341_S	0.732	0.96
161_A	170_A	0.732	0.96
288_V	324_L	0.729	0.96
32_V	78_L	0.729	0.96
60_L	90_I	0.728	0.96
19_R	230_G	0.725	0.96
10_R	45_T	0.724	0.96
279_P	345_L	0.722	0.96
261_S	264_D	0.720	0.96
8_I	234_V	0.718	0.96
63_A	93_Q	0.718	0.96
84_A	107_A	0.715	0.96
247_H	267_L	0.715	0.96
9_N	236_S	0.715	0.96
56_G	207_W	0.713	0.96
36_N	42_L	0.712	0.96
218_S	229_F	0.711	0.95
249_A	262_E	0.709	0.95
282_A	338_T	0.708	0.95
3_A	240_S	0.706	0.95
212_I	342_A	0.706	0.95
239_S	306_I	0.705	0.95
76_L	96_H	0.705	0.95
178_F	191_I	0.701	0.95
99_V	108_L	0.700	0.95
333_R	336_E	0.699	0.95
162_R	168_C	0.698	0.95
136_Q	139_A	0.698	0.95
137_A	141_Y	0.697	0.95
191_I	205_F	0.696	0.95
321_P	328_G	0.696	0.95
123_L	156_I	0.695	0.95
91_S	111_A	0.694	0.95
195_G	212_I	0.694	0.95
306_I	324_L	0.692	0.95
198_L	229_F	0.691	0.95
82_F	97_T	0.688	0.95
12_A	15_H	0.687	0.95
46_A	71_I	0.687	0.95
283_P	286_T	0.686	0.95
331_V	342_A	0.686	0.95
81_F	100_H	0.678	0.94
325_W	345_L	0.678	0.94
86_D	89_T	0.677	0.94
221_E	336_E	0.676	0.94
43_L	71_I	0.673	0.94
112_S	117_V	0.669	0.94
232_Q	327_E	0.669	0.94
140_F	144_L	0.669	0.94
168_C	200_W	0.665	0.94
288_V	322_V	0.664	0.94
168_C	172_E	0.664	0.94
21_R	29_M	0.662	0.93
237_L	349_L	0.659	0.93
7_V	236_S	0.659	0.93
133_R	136_Q	0.658	0.93
42_L	275_G	0.656	0.93
91_S	112_S	0.655	0.93
243_A	269_V	0.655	0.93
295_V	316_D	0.654	0.93
11_R	14_R	0.653	0.93
49_L	55_F	0.652	0.93
9_N	327_E	0.649	0.93
266_R	312_P	0.648	0.93
102_E	139_A	0.646	0.93
12_A	231_C	0.645	0.93
237_L	325_W	0.644	0.92
65_R	351_S	0.643	0.92
60_L	63_A	0.640	0.92
139_A	143_R	0.639	0.92
28_K	207_W	0.639	0.92
253_V	298_V	0.639	0.92
125_T	174_Q	0.638	0.92
286_T	337_M	0.638	0.92
293_R	315_Q	0.637	0.92
100_H	243_A	0.636	0.92
133_R	245_R	0.632	0.92
155_N	188_Q	0.630	0.92
72_T	94_H	0.628	0.92
144_L	153_P	0.627	0.91
31_A	55_F	0.625	0.91
180_T	183_E	0.624	0.91
83_D	86_D	0.623	0.91
45_T	48_T	0.623	0.91
199_L	220_L	0.621	0.91
19_R	23_L	0.619	0.91
29_M	208_V	0.618	0.91
285_G	337_M	0.618	0.91
148_K	151_R	0.618	0.91
15_H	18_Q	0.618	0.91
291_N	313_Q	0.616	0.91
103_E	107_A	0.616	0.91
27_S	208_V	0.615	0.91
54_A	76_L	0.615	0.91
56_G	78_L	0.612	0.90
332_E	336_E	0.612	0.90
139_A	142_H	0.612	0.90
342_A	346_I	0.612	0.90
295_V	310_L	0.612	0.90
156_I	187_G	0.612	0.90
276_D	352_R	0.611	0.90
262_E	296_P	0.607	0.90
340_V	345_L	0.607	0.90
312_P	316_D	0.607	0.90
287_P	333_R	0.604	0.90
279_P	282_A	0.601	0.90
58_A	304_D	0.599	0.89
64_L	89_T	0.598	0.89
242_I	305_M	0.594	0.89
35_A	352_R	0.591	0.89
105_L	109_E	0.591	0.89
297_I	306_I	0.590	0.89
18_Q	21_R	0.588	0.89
282_A	286_T	0.588	0.89
91_S	113_L	0.587	0.89
37_A	42_L	0.586	0.88
266_R	310_L	0.583	0.88
244_V	266_R	0.583	0.88
246_E	265_T	0.582	0.88
65_R	69_G	0.581	0.88
253_V	261_S	0.581	0.88
30_V	76_L	0.580	0.88
323_I	326_G	0.578	0.88
297_I	308_V	0.578	0.88
297_I	301_V	0.576	0.88
196_G	200_W	0.575	0.88
334_I	345_L	0.574	0.87
75_V	95_F	0.573	0.87
33_V	215_Y	0.571	0.87
18_Q	22_E	0.569	0.87
138_E	141_Y	0.568	0.87
46_A	55_F	0.568	0.87
50_P	53_D	0.567	0.87
180_T	184_G	0.562	0.86
325_W	349_L	0.561	0.86
212_I	346_I	0.558	0.86
259_W	298_V	0.557	0.86
323_I	329_L	0.557	0.86
164_D	300_R	0.556	0.86
164_D	280_R	0.556	0.86
210_P	214_L	0.555	0.86
19_R	229_F	0.555	0.86
12_A	234_V	0.553	0.85
81_F	90_I	0.553	0.85
11_R	15_H	0.553	0.85
52_A	55_F	0.552	0.85
137_A	140_F	0.549	0.85
104_Q	108_L	0.547	0.85
105_L	147_C	0.547	0.85
121_M	141_Y	0.546	0.85
71_I	74_P	0.545	0.85
37_A	47_R	0.545	0.85
9_N	232_Q	0.542	0.84
175_L	200_W	0.542	0.84
253_V	259_W	0.540	0.84
76_L	98_A	0.540	0.84
176_A	179_N	0.538	0.84
218_S	332_E	0.536	0.84
294_E	329_L	0.536	0.84
20_L	197_I	0.535	0.84
276_D	304_D	0.535	0.84
4_A	237_L	0.534	0.83
81_F	97_T	0.534	0.83
120_W	154_V	0.534	0.83
53_D	74_P	0.533	0.83
60_L	64_L	0.531	0.83
24_A	208_V	0.531	0.83
333_R	337_M	0.531	0.83
290_V	310_L	0.531	0.83
158_S	171_T	0.528	0.83
108_L	117_V	0.528	0.83
112_S	115_E	0.527	0.83
325_W	334_I	0.525	0.82
125_T	161_A	0.525	0.82
249_A	263_R	0.523	0.82
35_A	304_D	0.521	0.82
191_I	196_G	0.521	0.82
286_T	334_I	0.521	0.82
10_R	14_R	0.519	0.82
112_S	150_V	0.519	0.82
134_P	181_F	0.518	0.82
275_G	350_T	0.517	0.81
160_F	203_S	0.517	0.81
13_L	214_L	0.516	0.81
197_I	213_I	0.516	0.81
25_P	204_H	0.514	0.81
168_C	171_T	0.514	0.81
133_R	248_K	0.514	0.81
19_R	232_Q	0.512	0.81
343_Y	347_T	0.511	0.81
143_R	146_Q	0.510	0.81
92_A	115_E	0.510	0.81
244_V	268_G	0.509	0.80
292_G	328_G	0.509	0.80
5_T	321_P	0.509	0.80
125_T	177_I	0.506	0.80
265_T	312_P	0.506	0.80
218_S	230_G	0.506	0.80
43_L	46_A	0.505	0.80
274_Y	303_M	0.504	0.80
54_A	188_Q	0.504	0.80
336_E	339_K	0.504	0.80
269_V	305_M	0.504	0.80
218_S	223_R	0.503	0.80
181_F	184_G	0.503	0.80
54_A	73_K	0.502	0.80
275_G	352_R	0.502	0.80
282_A	334_I	0.501	0.79
290_V	313_Q	0.500	0.79
160_F	192_A	0.500	0.79
200_W	203_S	0.500	0.79

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1bd0A	2	0.9861	100	0.236	Contact Map
3hurA	4	0.9777	100	0.245	Contact Map
3e5pA	2	0.9805	100	0.249	Contact Map
4bhyA	2	0.9387	100	0.252	Contact Map
2rjgA	2	0.9972	100	0.252	Contact Map
1rcqA	2	0.9889	100	0.258	Contact Map
2vd8A	2	0.9415	100	0.259	Contact Map
3co8A	2	0.9777	100	0.264	Contact Map
4a3qA	2	0.9164	100	0.266	Contact Map
3s46A	2	0.9777	100	0.268	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0113 seconds.