GREMLIN Database
ACP - Acyl carrier protein
UniProt: P0A6A8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG50003
Length: 78 (68)
Sequences: 23732 (18688)
Seq/√Len: 2266.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_R50_E2.3261.00
26_N67_Q2.3051.00
56_P59_E2.0351.00
65_T68_A1.9881.00
63_I72_Y1.9831.00
59_E72_Y1.9391.00
5_E25_N1.8581.00
36_D39_D1.7841.00
14_E46_A1.7801.00
28_S31_E1.7211.00
29_F35_A1.6601.00
28_S64_T1.6501.00
12_I35_A1.6471.00
24_T27_A1.5361.00
11_I14_E1.4991.00
9_K25_N1.4641.00
7_R10_K1.4621.00
11_I46_A1.4281.00
63_I68_A1.4251.00
48_E54_E1.4161.00
9_K66_V1.3531.00
25_N67_Q1.3521.00
28_S32_D1.3041.00
9_K13_G1.3001.00
19_K22_E1.2221.00
12_I66_V1.2111.00
4_I74_N1.2021.00
7_R11_I1.1891.00
13_G22_E1.1761.00
44_V48_E1.1671.00
46_A50_E1.1571.00
11_I50_E1.1531.00
43_L60_A1.1331.00
8_V70_I1.1221.00
15_Q46_A1.1181.00
10_K50_E1.1081.00
39_D42_E1.0721.00
8_V66_V1.0561.00
8_V47_L1.0471.00
12_I43_L1.0421.00
25_N66_V1.0361.00
58_E62_K1.0271.00
40_T60_A1.0181.00
4_I7_R1.0001.00
5_E67_Q0.9711.00
5_E70_I0.9641.00
37_S41_V0.9531.00
12_I69_A0.9501.00
40_T44_V0.9461.00
11_I43_L0.9351.00
7_R51_F0.9261.00
42_E46_A0.9101.00
9_K23_V0.8861.00
6_E10_K0.8771.00
15_Q43_L0.8761.00
59_E63_I0.8401.00
18_V22_E0.8271.00
15_Q42_E0.8261.00
59_E62_K0.8061.00
16_L35_A0.8011.00
46_A49_E0.7641.00
10_K13_G0.7431.00
47_L55_I0.7351.00
48_E53_T0.7181.00
41_V45_M0.7171.00
40_T57_D0.6931.00
10_K14_E0.6761.00
45_M49_E0.6711.00
55_I69_A0.6591.00
14_E50_E0.6571.00
43_L69_A0.6561.00
6_E9_K0.6561.00
68_A71_D0.6551.00
31_E35_A0.6471.00
11_I47_L0.6411.00
27_A33_L0.6381.00
28_S65_T0.6211.00
44_V57_D0.6151.00
13_G23_V0.6141.00
18_V33_L0.6061.00
4_I73_I0.6061.00
35_A39_D0.5991.00
13_G19_K0.5921.00
60_A69_A0.5651.00
5_E66_V0.5581.00
23_V33_L0.5541.00
15_Q39_D0.5521.00
66_V70_I0.5441.00
27_A32_D0.5421.00
35_A43_L0.5421.00
35_A40_T0.5371.00
64_T68_A0.5291.00
62_K72_Y0.5211.00
53_T73_I0.5191.00
47_L53_T0.5181.00
31_E61_E0.5171.00
5_E9_K0.5161.00
13_G18_V0.5141.00
41_V57_D0.5121.00
12_I16_L0.5091.00
18_V23_V0.5061.00
71_D74_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r0mB 1 0.9103 99.6 0.095 Contact Map
2jgpA 1 0.9615 99.5 0.104 Contact Map
2vsqA 1 0.9615 99.5 0.109 Contact Map
4oqjA 2 0 99.5 0.13 Contact Map
4dg8A 1 0 99.5 0.151 Contact Map
4pxhB 1 0.9231 99.4 0.171 Contact Map
1dnyA 1 0.9231 99.4 0.172 Contact Map
3tejA 1 0.9487 99.4 0.177 Contact Map
2cq8A 1 0.9744 99.4 0.177 Contact Map
2l22A 1 0.9872 99.4 0.184 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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