GREMLIN Database
LEUC - 3-isopropylmalate dehydratase large subunit
UniProt: P0A6A6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11576
Length: 466 (417)
Sequences: 6544 (2236)
Seq/√Len: 109.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_E278_T5.0111.00
285_S301_N4.8621.00
280_Q283_E4.1451.00
356_R389_E4.0561.00
456_T460_A4.0031.00
237_E241_N3.5911.00
167_K204_C3.4301.00
3_K11_D3.3231.00
171_Q278_T3.1671.00
45_R92_E3.0291.00
342_V450_A2.9971.00
373_A400_F2.7541.00
180_A215_G2.7481.00
352_I385_Q2.7171.00
167_K276_V2.6201.00
189_G297_V2.5931.00
171_Q206_E2.5711.00
238_T241_N2.5101.00
425_A445_V2.5091.00
169_E276_V2.5071.00
355_L386_A2.4691.00
204_C276_V2.3991.00
363_K394_I2.3921.00
186_A190_K2.3811.00
393_K397_E2.3791.00
207_A281_A2.3781.00
190_K279_L2.3281.00
344_I373_A2.2211.00
427_T450_A2.2121.00
186_A287_Q2.2001.00
449_M453_A2.1871.00
285_S299_S2.1591.00
27_I123_T2.1321.00
173_K210_D2.0791.00
360_E363_K2.0711.00
6_Y163_A2.0581.00
170_V281_A2.0391.00
170_V187_I2.0381.00
261_Y264_T2.0241.00
344_I358_A2.0031.00
174_A183_I1.9761.00
357_A448_A1.9451.00
184_V219_L1.9161.00
199_H275_T1.9141.00
392_D396_I1.9051.00
342_V425_A1.8461.00
169_E204_C1.8421.00
173_K206_E1.8301.00
203_F223_A1.8251.00
352_I389_E1.8151.00
7_E165_T1.7991.00
164_K274_D1.7751.00
168_I187_I1.7731.00
352_I356_R1.7711.00
299_S302_D1.7661.00
287_Q297_V1.7351.00
175_A178_I1.7341.00
80_R84_Q1.7331.00
391_L395_F1.7301.00
365_R455_V1.7201.00
212_S353_E1.7101.00
186_A189_G1.7061.00
170_V183_I1.6821.00
356_R391_L1.6691.00
219_L233_V1.6551.00
339_I453_A1.6511.00
200_V230_A1.6501.00
355_L375_V1.6431.00
392_D402_W1.6221.00
418_L424_C1.6061.00
186_A284_I1.6061.00
376_V408_S1.5951.00
186_A279_L1.5811.00
341_K422_E1.5791.00
235_P260_A1.5781.00
168_I201_V1.5751.00
338_A458_H1.5711.00
201_V226_M1.5691.00
209_R237_E1.5661.00
385_Q389_E1.5601.00
183_I211_L1.5571.00
166_M275_T1.5381.00
9_L232_L1.5231.00
255_F259_V1.5221.00
45_R93_F1.5011.00
213_M238_T1.4981.00
164_K199_H1.4951.00
383_K387_E1.4941.00
51_V95_V1.4931.00
362_A373_A1.4901.00
215_G353_E1.4761.00
26_Y157_T1.4741.00
257_D261_Y1.4741.00
179_T357_A1.4691.00
254_D257_D1.4671.00
445_V459_F1.4671.00
438_R441_R1.4661.00
179_T448_A1.4661.00
8_K268_D1.4611.00
339_I371_V1.4371.00
58_F117_V1.4371.00
387_E392_D1.4251.00
235_P240_F1.4191.00
184_V222_M1.4161.00
180_A211_L1.4111.00
338_A370_G1.4051.00
57_T153_L1.4051.00
194_A275_T1.3941.00
140_L230_A1.3931.00
137_F213_M1.3881.00
339_I342_V1.3721.00
367_V373_A1.3701.00
170_V208_I1.3651.00
376_V403_R1.3621.00
445_V450_A1.3581.00
223_A231_G1.3541.00
290_W298_I1.3471.00
358_A395_F1.3451.00
90_C97_L1.3371.00
88_K92_E1.3361.00
183_I207_A1.3361.00
175_A284_I1.3170.99
383_K405_P1.3080.99
138_G235_P1.3030.99
394_I397_E1.3010.99
300_V449_M1.2990.99
144_I149_V1.2950.99
6_Y200_V1.2910.99
412_A417_R1.2880.99
84_Q88_K1.2830.99
110_V378_G1.2800.99
110_V379_S1.2780.99
125_V144_I1.2690.99
119_L122_M1.2660.99
16_Y21_E1.2640.99
220_C233_V1.2580.99
190_K277_V1.2570.99
288_V303_N1.2560.99
287_Q299_S1.2550.99
175_A285_S1.2540.99
421_G439_G1.2530.99
213_M239_T1.2400.99
187_I201_V1.2270.99
110_V350_S1.2260.99
420_P439_G1.2260.99
81_I85_E1.2250.99
6_Y165_T1.2230.99
289_T297_V1.2140.99
118_T134_H1.2080.99
237_E263_K1.2030.99
253_K257_D1.2010.99
6_Y230_A1.2010.99
208_I219_L1.1980.99
384_A397_E1.1960.99
340_D422_E1.1880.99
388_A393_K1.1830.99
241_N244_K1.1830.99
174_A178_I1.1770.99
170_V207_A1.1730.99
29_R117_V1.1560.99
137_F217_M1.1520.99
136_A213_M1.1520.99
43_G150_E1.1450.99
393_K396_I1.1420.98
343_F428_S1.1360.98
36_T411_L1.1360.98
132_A223_A1.1220.98
418_L440_G1.1210.98
113_P217_M1.1040.98
281_A284_I1.1030.98
36_T127_G1.1010.98
61_M97_L1.0930.98
118_T137_F1.0880.98
372_Q401_E1.0830.98
31_L108_V1.0830.98
339_I425_A1.0810.98
166_M199_H1.0790.98
445_V449_M1.0750.98
208_I211_L1.0710.98
446_S449_M1.0700.98
191_T195_G1.0660.98
240_F263_K1.0630.98
355_L395_F1.0610.98
363_K397_E1.0590.98
453_A460_A1.0480.97
190_K283_E1.0460.97
337_V458_H1.0450.97
190_K275_T1.0430.97
240_F259_V1.0410.97
384_A388_A1.0400.97
425_A459_F1.0390.97
174_A210_D1.0390.97
7_E162_R1.0380.97
207_A211_L1.0350.97
342_V427_T1.0340.97
125_V152_V1.0340.97
214_E353_E1.0330.97
59_A86_L1.0310.97
305_P337_V1.0310.97
288_V445_V1.0280.97
304_I337_V1.0280.97
342_V454_A1.0240.97
32_V108_V1.0220.97
357_A360_E1.0210.97
396_I401_E1.0210.97
293_N296_Q1.0190.97
134_H141_A1.0180.97
4_T165_T1.0160.97
27_I152_V1.0130.97
343_F408_S1.0120.97
212_S215_G1.0090.97
174_A281_A1.0010.97
140_L200_V1.0010.97
341_K440_G0.9970.96
199_H274_D0.9960.96
212_S238_T0.9920.96
191_T226_M0.9920.96
171_Q280_Q0.9910.96
59_A90_C0.9880.96
425_A453_A0.9870.96
118_T124_I0.9870.96
361_I451_A0.9840.96
35_V38_P0.9820.96
191_T201_V0.9790.96
341_K372_Q0.9740.96
209_R266_Q0.9700.96
234_A266_Q0.9690.96
253_K256_D0.9590.96
118_T139_A0.9550.95
208_I233_V0.9540.95
298_I302_D0.9540.95
240_F244_K0.9490.95
348_T429_N0.9470.95
206_E209_R0.9450.95
244_K249_A0.9440.95
425_A450_A0.9420.95
362_A455_V0.9410.95
337_V459_F0.9410.95
356_R385_Q0.9400.95
206_E210_D0.9360.95
387_E396_I0.9350.95
12_A263_K0.9350.95
339_I423_R0.9350.95
12_A261_Y0.9340.95
49_R154_A0.9310.95
228_A231_G0.9280.95
356_R360_E0.9270.95
259_V263_K0.9230.95
29_R122_M0.9220.95
241_N245_G0.9210.94
423_R441_R0.9180.94
5_L9_L0.9170.94
183_I284_I0.9170.94
183_I219_L0.9160.94
169_E206_E0.9070.94
7_E11_D0.9070.94
244_K250_P0.9060.94
18_A21_E0.9020.94
33_H108_V0.9020.94
362_A400_F0.8980.94
42_D46_A0.8960.94
290_W303_N0.8960.94
364_G397_E0.8950.94
256_D259_V0.8930.94
384_A387_E0.8900.93
403_R408_S0.8900.93
168_I277_V0.8890.93
171_Q281_A0.8890.93
223_A228_A0.8880.93
203_F231_G0.8880.93
385_Q388_A0.8880.93
189_G287_Q0.8850.93
372_Q422_E0.8800.93
267_T273_F0.8730.93
30_H149_V0.8720.93
246_R381_P0.8660.92
32_V57_T0.8660.92
51_V57_T0.8650.92
6_Y232_L0.8630.92
144_I152_V0.8610.92
50_P92_E0.8600.92
175_A282_E0.8560.92
14_V23_P0.8550.92
51_V153_L0.8540.92
216_R236_D0.8540.92
367_V454_A0.8510.92
423_R443_H0.8500.92
104_Y381_P0.8500.92
53_Q56_K0.8490.92
355_L391_L0.8480.92
267_T270_G0.8460.92
188_I226_M0.8460.92
268_D271_A0.8450.92
247_L381_P0.8430.91
183_I281_A0.8430.91
166_M274_D0.8400.91
233_V281_A0.8400.91
210_D238_T0.8380.91
32_V37_S0.8340.91
305_P458_H0.8330.91
244_K255_F0.8310.91
54_P94_G0.8300.91
104_Y247_L0.8300.91
173_K282_E0.8290.91
391_L394_I0.8290.91
132_A224_I0.8230.90
136_A217_M0.8220.90
183_I208_I0.8200.90
125_V158_L0.8120.90
29_R58_F0.8120.90
290_W443_H0.8100.90
55_G96_E0.8100.90
346_S428_S0.8090.90
358_A375_V0.8080.90
254_D258_A0.8050.89
352_I391_L0.8020.89
209_R238_T0.8010.89
376_V409_M0.8000.89
30_H152_V0.7980.89
5_L232_L0.7950.89
10_F23_P0.7940.89
107_I350_S0.7940.89
27_I30_H0.7940.89
5_L265_L0.7920.89
204_C273_F0.7910.89
64_N79_A0.7880.88
300_V459_F0.7880.88
4_T271_A0.7840.88
112_G118_T0.7830.88
366_K397_E0.7810.88
68_Q415_N0.7780.88
25_L160_Q0.7770.88
198_G229_K0.7760.88
17_E23_P0.7740.88
65_V105_Q0.7710.87
358_A448_A0.7680.87
285_S302_D0.7660.87
383_K392_D0.7630.87
27_I158_L0.7630.87
340_D440_G0.7580.86
375_V400_F0.7580.86
452_A456_T0.7580.86
24_L159_K0.7570.86
176_P360_E0.7550.86
96_E248_H0.7530.86
384_A393_K0.7500.86
117_V248_H0.7490.86
32_V127_G0.7450.85
54_P57_T0.7440.85
424_C440_G0.7440.85
420_P438_R0.7430.85
240_F243_V0.7420.85
206_E281_A0.7410.85
43_G46_A0.7410.85
356_R386_A0.7400.85
85_E88_K0.7360.85
186_A283_E0.7360.85
302_D305_P0.7350.85
422_E440_G0.7330.85
11_D14_V0.7310.84
105_Q380_G0.7200.83
148_E160_Q0.7190.83
11_D18_A0.7180.83
119_L247_L0.7160.83
367_V370_G0.7150.83
10_F162_R0.7150.83
37_S86_L0.7130.83
166_M201_V0.7090.83
362_A365_R0.7080.82
174_A215_G0.7050.82
449_M460_A0.7040.82
103_P384_A0.7030.82
419_N422_E0.7030.82
342_V371_V0.7020.82
107_I378_G0.6980.82
60_T108_V0.6980.82
454_A457_G0.6960.81
396_I402_W0.6930.81
3_K7_E0.6930.81
387_E402_W0.6930.81
14_V17_E0.6910.81
207_A215_G0.6900.81
352_I386_A0.6900.81
207_A282_E0.6900.81
52_R57_T0.6890.81
269_E272_T0.6840.80
30_H57_T0.6830.80
163_A200_V0.6830.80
87_I91_K0.6830.80
117_V122_M0.6820.80
138_G265_L0.6820.80
164_K275_T0.6810.80
34_E37_S0.6810.80
70_K101_N0.6800.80
9_L200_V0.6800.80
98_Y248_H0.6770.80
445_V453_A0.6770.80
337_V423_R0.6750.79
220_C230_A0.6740.79
380_G405_P0.6740.79
168_I279_L0.6710.79
29_R112_G0.6690.79
266_Q269_E0.6660.78
88_K91_K0.6650.78
33_H36_T0.6620.78
385_Q391_L0.6620.78
81_I420_P0.6620.78
133_T217_M0.6610.78
187_I277_V0.6600.78
113_P137_F0.6600.78
175_A283_E0.6600.78
32_V153_L0.6570.78
187_I279_L0.6570.78
79_A411_L0.6570.78
342_V453_A0.6550.77
341_K419_N0.6550.77
214_E382_V0.6550.77
183_I206_E0.6540.77
178_I286_P0.6510.77
362_A398_A0.6500.77
181_K348_T0.6500.77
453_A458_H0.6500.77
170_V174_A0.6490.77
226_M231_G0.6470.76
30_H125_V0.6470.76
189_G193_S0.6470.76
57_T95_V0.6450.76
341_K374_L0.6450.76
300_V303_N0.6440.76
418_L422_E0.6430.76
403_R406_G0.6430.76
14_V25_L0.6430.76
26_Y53_Q0.6430.76
382_V385_Q0.6420.76
359_A394_I0.6420.76
383_K402_W0.6410.76
222_M348_T0.6400.76
352_I382_V0.6390.76
184_V187_I0.6380.75
250_P262_W0.6380.75
29_R119_L0.6370.75
165_T273_F0.6370.75
13_H28_D0.6360.75
453_A459_F0.6350.75
243_V249_A0.6340.75
125_V160_Q0.6340.75
343_F409_M0.6330.75
113_P134_H0.6330.75
61_M101_N0.6320.75
425_A449_M0.6320.75
170_V206_E0.6290.74
15_V26_Y0.6270.74
193_S295_G0.6240.74
258_A262_W0.6230.74
87_I102_H0.6220.74
341_K424_C0.6220.74
124_I139_A0.6210.73
144_I158_L0.6200.73
191_T196_G0.6180.73
279_L283_E0.6180.73
244_K259_V0.6170.73
218_T447_P0.6170.73
110_V382_V0.6160.73
338_A368_A0.6150.73
133_T221_N0.6150.73
150_E433_E0.6130.73
359_A391_L0.6120.72
136_A220_C0.6120.72
237_E240_F0.6120.72
412_A415_N0.6110.72
350_S355_L0.6110.72
35_V411_L0.6100.72
180_A219_L0.6090.72
284_I287_Q0.6090.72
367_V398_A0.6080.72
132_A141_A0.6080.72
165_T200_V0.6060.72
35_V82_Q0.6040.71
303_N453_A0.6020.71
288_V425_A0.6020.71
419_N440_G0.6020.71
162_R165_T0.6020.71
166_M277_V0.6010.71
152_V158_L0.6000.71
167_K273_F0.5990.71
17_E20_N0.5980.71
191_T277_V0.5970.71
49_R150_E0.5970.71
43_G47_H0.5960.70
61_M83_M0.5940.70
371_V453_A0.5940.70
13_H26_Y0.5930.70
22_T159_K0.5920.70
257_D260_A0.5910.70
166_M191_T0.5910.70
50_P93_F0.5900.70
220_C232_L0.5900.70
58_F248_H0.5900.70
367_V371_V0.5890.70
196_G228_A0.5890.70
25_L123_T0.5880.69
372_Q419_N0.5870.69
232_L235_P0.5870.69
4_T7_E0.5860.69
208_I238_T0.5850.69
373_A451_A0.5850.69
213_M217_M0.5850.69
60_T98_Y0.5830.69
173_K207_A0.5820.69
417_R421_G0.5820.69
207_A278_T0.5800.68
64_N82_Q0.5790.68
211_L219_L0.5760.68
208_I234_A0.5750.68
403_R409_M0.5740.68
443_H459_F0.5740.68
6_Y123_T0.5740.68
362_A375_V0.5730.67
426_S459_F0.5720.67
55_G122_M0.5720.67
267_T271_A0.5720.67
300_V460_A0.5720.67
20_N161_G0.5710.67
245_G250_P0.5710.67
131_T141_A0.5710.67
204_C267_T0.5690.67
192_G295_G0.5680.67
60_T111_M0.5670.67
211_L215_G0.5670.67
111_M379_S0.5660.66
90_C95_V0.5660.66
168_I190_K0.5660.66
189_G299_S0.5650.66
337_V443_H0.5640.66
24_L157_T0.5640.66
42_D45_R0.5640.66
44_L154_A0.5630.66
362_A395_F0.5620.66
253_K259_V0.5620.66
135_G220_C0.5610.66
209_R234_A0.5610.66
174_A207_A0.5610.66
171_Q174_A0.5590.66
376_V395_F0.5580.65
429_N447_P0.5570.65
196_G226_M0.5570.65
172_G282_E0.5570.65
37_S59_A0.5570.65
123_T230_A0.5550.65
51_V93_F0.5540.65
84_Q419_N0.5520.65
387_E393_K0.5510.64
383_K404_L0.5500.64
64_N415_N0.5500.64
37_S40_A0.5490.64
292_T433_E0.5490.64
36_T40_A0.5450.64
375_V395_F0.5420.63
124_I134_H0.5420.63
344_I350_S0.5410.63
68_Q372_Q0.5410.63
353_E357_A0.5410.63
10_F14_V0.5400.63
122_M139_A0.5380.63
357_A361_I0.5360.62
34_E39_Q0.5350.62
129_S145_G0.5350.62
175_A301_N0.5340.62
174_A211_L0.5330.62
298_I337_V0.5320.62
181_K222_M0.5320.62
137_F243_V0.5320.62
145_G185_L0.5320.62
249_A258_A0.5320.62
209_R281_A0.5310.62
43_G146_T0.5310.62
140_L434_G0.5300.61
144_I148_E0.5290.61
133_T348_T0.5290.61
240_F264_T0.5290.61
341_K418_L0.5280.61
424_C436_Q0.5280.61
419_N439_G0.5280.61
207_A210_D0.5270.61
187_I281_A0.5270.61
207_A219_L0.5270.61
400_F454_A0.5270.61
452_A460_A0.5260.61
218_T348_T0.5260.61
187_I191_T0.5260.61
10_F160_Q0.5260.61
342_V367_V0.5260.61
361_I448_A0.5220.60
407_C410_C0.5210.60
389_E392_D0.5200.60
386_A392_D0.5190.60
56_K122_M0.5190.60
379_S382_V0.5150.59
64_N411_L0.5150.59
411_L415_N0.5140.59
38_P41_F0.5140.59
303_N459_F0.5140.59
180_A218_T0.5140.59
401_E404_L0.5130.59
374_L403_R0.5130.59
171_Q209_R0.5130.59
41_F89_N0.5130.59
304_I458_H0.5120.59
67_T374_L0.5120.59
176_P361_I0.5110.59
129_S430_R0.5100.59
339_I458_H0.5100.59
256_D260_A0.5090.58
180_A183_I0.5090.58
210_D244_K0.5080.58
36_T64_N0.5080.58
171_Q279_L0.5070.58
87_I97_L0.5060.58
79_A82_Q0.5060.58
406_G415_N0.5020.57
206_E278_T0.5020.57
85_E91_K0.5010.57
31_L134_H0.5010.57
33_H411_L0.5000.57
241_N269_E0.5000.57
221_N429_N0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kp1A 1 0.8884 100 0.116 Contact Map
4kp2A 2 0.8884 100 0.127 Contact Map
1c96A 1 0.9313 100 0.177 Contact Map
2b3yA 1 0.9893 100 0.201 Contact Map
1l5jA 1 0.8927 100 0.228 Contact Map
1p3y1 6 0.3348 44.7 0.978 Contact Map
1mvlA 3 0.3326 30.5 0.98 Contact Map
1qzuA 3 0.3004 27.2 0.981 Contact Map
1vk9A 3 0.1824 17 0.982 Contact Map
3qjgA 5 0.324 14.5 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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