LEUC - ECOLI - GREMLIN Contacts

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LEUC - 3-isopropylmalate dehydratase large subunit

UniProt:	P0A6A6	Sequences: MAKTLYEKLFDAHVVYEAENETPLLYIDRHLVHEVTSPQAFDGLRAHGRPVRQPGKTFATMDHNVSTQTKDINACGEMARIQMQELIKNCKEFGVELYDLNHPYQGIVHVMGPEQGVTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVQGKAAPGITAKDIVLAIIGKTGSAGGTGHVVEFCGEAIRDLSMEGRMTLCNMAIEMGAKAGLVAPDETTFNYVKGRLHAPKGKDFDDAVAYWKTLQTDEGATFDTVVTLQAEEISPQVTWGTNPGQVISVNDNIPDPASFADPVERASAEKALAYMGLKPGIPLTEVAIDKVFIGSCTNSRIEDLRAAAEIAKGRKVAPGVQALVVPGSGPVKAQAEAEGLDKIFIEAGFEWRLPGCSMCLAMNNDRLNPGERCASTSNRNFEGRQGRGGRTHLVSPAMAAAAAVTGHFADIRNIK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11576
Length:	466 (417)
Sequences:	6544 (2236)
Seq/√Len:	109.5

ECOLI - LEUC YBHJ ACON1 ACON2
BACSU - LEUC ACON
HALSA - Q9HMF1
SULSO - LEUC Q97Z42

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
169_E	278_T	5.011	1.00
285_S	301_N	4.862	1.00
280_Q	283_E	4.145	1.00
356_R	389_E	4.056	1.00
456_T	460_A	4.003	1.00
237_E	241_N	3.591	1.00
167_K	204_C	3.430	1.00
3_K	11_D	3.323	1.00
171_Q	278_T	3.167	1.00
45_R	92_E	3.029	1.00
342_V	450_A	2.997	1.00
373_A	400_F	2.754	1.00
180_A	215_G	2.748	1.00
352_I	385_Q	2.717	1.00
167_K	276_V	2.620	1.00
189_G	297_V	2.593	1.00
171_Q	206_E	2.571	1.00
238_T	241_N	2.510	1.00
425_A	445_V	2.509	1.00
169_E	276_V	2.507	1.00
355_L	386_A	2.469	1.00
204_C	276_V	2.399	1.00
363_K	394_I	2.392	1.00
186_A	190_K	2.381	1.00
393_K	397_E	2.379	1.00
207_A	281_A	2.378	1.00
190_K	279_L	2.328	1.00
344_I	373_A	2.221	1.00
427_T	450_A	2.212	1.00
186_A	287_Q	2.200	1.00
449_M	453_A	2.187	1.00
285_S	299_S	2.159	1.00
27_I	123_T	2.132	1.00
173_K	210_D	2.079	1.00
360_E	363_K	2.071	1.00
6_Y	163_A	2.058	1.00
170_V	281_A	2.039	1.00
170_V	187_I	2.038	1.00
261_Y	264_T	2.024	1.00
344_I	358_A	2.003	1.00
174_A	183_I	1.976	1.00
357_A	448_A	1.945	1.00
184_V	219_L	1.916	1.00
199_H	275_T	1.914	1.00
392_D	396_I	1.905	1.00
342_V	425_A	1.846	1.00
169_E	204_C	1.842	1.00
173_K	206_E	1.830	1.00
203_F	223_A	1.825	1.00
352_I	389_E	1.815	1.00
7_E	165_T	1.799	1.00
164_K	274_D	1.775	1.00
168_I	187_I	1.773	1.00
352_I	356_R	1.771	1.00
299_S	302_D	1.766	1.00
287_Q	297_V	1.735	1.00
175_A	178_I	1.734	1.00
80_R	84_Q	1.733	1.00
391_L	395_F	1.730	1.00
365_R	455_V	1.720	1.00
212_S	353_E	1.710	1.00
186_A	189_G	1.706	1.00
170_V	183_I	1.682	1.00
356_R	391_L	1.669	1.00
219_L	233_V	1.655	1.00
339_I	453_A	1.651	1.00
200_V	230_A	1.650	1.00
355_L	375_V	1.643	1.00
392_D	402_W	1.622	1.00
418_L	424_C	1.606	1.00
186_A	284_I	1.606	1.00
376_V	408_S	1.595	1.00
186_A	279_L	1.581	1.00
341_K	422_E	1.579	1.00
235_P	260_A	1.578	1.00
168_I	201_V	1.575	1.00
338_A	458_H	1.571	1.00
201_V	226_M	1.569	1.00
209_R	237_E	1.566	1.00
385_Q	389_E	1.560	1.00
183_I	211_L	1.557	1.00
166_M	275_T	1.538	1.00
9_L	232_L	1.523	1.00
255_F	259_V	1.522	1.00
45_R	93_F	1.501	1.00
213_M	238_T	1.498	1.00
164_K	199_H	1.495	1.00
383_K	387_E	1.494	1.00
51_V	95_V	1.493	1.00
362_A	373_A	1.490	1.00
215_G	353_E	1.476	1.00
26_Y	157_T	1.474	1.00
257_D	261_Y	1.474	1.00
179_T	357_A	1.469	1.00
254_D	257_D	1.467	1.00
445_V	459_F	1.467	1.00
438_R	441_R	1.466	1.00
179_T	448_A	1.466	1.00
8_K	268_D	1.461	1.00
339_I	371_V	1.437	1.00
58_F	117_V	1.437	1.00
387_E	392_D	1.425	1.00
235_P	240_F	1.419	1.00
184_V	222_M	1.416	1.00
180_A	211_L	1.411	1.00
338_A	370_G	1.405	1.00
57_T	153_L	1.405	1.00
194_A	275_T	1.394	1.00
140_L	230_A	1.393	1.00
137_F	213_M	1.388	1.00
339_I	342_V	1.372	1.00
367_V	373_A	1.370	1.00
170_V	208_I	1.365	1.00
376_V	403_R	1.362	1.00
445_V	450_A	1.358	1.00
223_A	231_G	1.354	1.00
290_W	298_I	1.347	1.00
358_A	395_F	1.345	1.00
90_C	97_L	1.337	1.00
88_K	92_E	1.336	1.00
183_I	207_A	1.336	1.00
175_A	284_I	1.317	0.99
383_K	405_P	1.308	0.99
138_G	235_P	1.303	0.99
394_I	397_E	1.301	0.99
300_V	449_M	1.299	0.99
144_I	149_V	1.295	0.99
6_Y	200_V	1.291	0.99
412_A	417_R	1.288	0.99
84_Q	88_K	1.283	0.99
110_V	378_G	1.280	0.99
110_V	379_S	1.278	0.99
125_V	144_I	1.269	0.99
119_L	122_M	1.266	0.99
16_Y	21_E	1.264	0.99
220_C	233_V	1.258	0.99
190_K	277_V	1.257	0.99
288_V	303_N	1.256	0.99
287_Q	299_S	1.255	0.99
175_A	285_S	1.254	0.99
421_G	439_G	1.253	0.99
213_M	239_T	1.240	0.99
187_I	201_V	1.227	0.99
110_V	350_S	1.226	0.99
420_P	439_G	1.226	0.99
81_I	85_E	1.225	0.99
6_Y	165_T	1.223	0.99
289_T	297_V	1.214	0.99
118_T	134_H	1.208	0.99
237_E	263_K	1.203	0.99
253_K	257_D	1.201	0.99
6_Y	230_A	1.201	0.99
208_I	219_L	1.198	0.99
384_A	397_E	1.196	0.99
340_D	422_E	1.188	0.99
388_A	393_K	1.183	0.99
241_N	244_K	1.183	0.99
174_A	178_I	1.177	0.99
170_V	207_A	1.173	0.99
29_R	117_V	1.156	0.99
137_F	217_M	1.152	0.99
136_A	213_M	1.152	0.99
43_G	150_E	1.145	0.99
393_K	396_I	1.142	0.98
343_F	428_S	1.136	0.98
36_T	411_L	1.136	0.98
132_A	223_A	1.122	0.98
418_L	440_G	1.121	0.98
113_P	217_M	1.104	0.98
281_A	284_I	1.103	0.98
36_T	127_G	1.101	0.98
61_M	97_L	1.093	0.98
118_T	137_F	1.088	0.98
372_Q	401_E	1.083	0.98
31_L	108_V	1.083	0.98
339_I	425_A	1.081	0.98
166_M	199_H	1.079	0.98
445_V	449_M	1.075	0.98
208_I	211_L	1.071	0.98
446_S	449_M	1.070	0.98
191_T	195_G	1.066	0.98
240_F	263_K	1.063	0.98
355_L	395_F	1.061	0.98
363_K	397_E	1.059	0.98
453_A	460_A	1.048	0.97
190_K	283_E	1.046	0.97
337_V	458_H	1.045	0.97
190_K	275_T	1.043	0.97
240_F	259_V	1.041	0.97
384_A	388_A	1.040	0.97
425_A	459_F	1.039	0.97
174_A	210_D	1.039	0.97
7_E	162_R	1.038	0.97
207_A	211_L	1.035	0.97
342_V	427_T	1.034	0.97
125_V	152_V	1.034	0.97
214_E	353_E	1.033	0.97
59_A	86_L	1.031	0.97
305_P	337_V	1.031	0.97
288_V	445_V	1.028	0.97
304_I	337_V	1.028	0.97
342_V	454_A	1.024	0.97
32_V	108_V	1.022	0.97
357_A	360_E	1.021	0.97
396_I	401_E	1.021	0.97
293_N	296_Q	1.019	0.97
134_H	141_A	1.018	0.97
4_T	165_T	1.016	0.97
27_I	152_V	1.013	0.97
343_F	408_S	1.012	0.97
212_S	215_G	1.009	0.97
174_A	281_A	1.001	0.97
140_L	200_V	1.001	0.97
341_K	440_G	0.997	0.96
199_H	274_D	0.996	0.96
212_S	238_T	0.992	0.96
191_T	226_M	0.992	0.96
171_Q	280_Q	0.991	0.96
59_A	90_C	0.988	0.96
425_A	453_A	0.987	0.96
118_T	124_I	0.987	0.96
361_I	451_A	0.984	0.96
35_V	38_P	0.982	0.96
191_T	201_V	0.979	0.96
341_K	372_Q	0.974	0.96
209_R	266_Q	0.970	0.96
234_A	266_Q	0.969	0.96
253_K	256_D	0.959	0.96
118_T	139_A	0.955	0.95
208_I	233_V	0.954	0.95
298_I	302_D	0.954	0.95
240_F	244_K	0.949	0.95
348_T	429_N	0.947	0.95
206_E	209_R	0.945	0.95
244_K	249_A	0.944	0.95
425_A	450_A	0.942	0.95
362_A	455_V	0.941	0.95
337_V	459_F	0.941	0.95
356_R	385_Q	0.940	0.95
206_E	210_D	0.936	0.95
387_E	396_I	0.935	0.95
12_A	263_K	0.935	0.95
339_I	423_R	0.935	0.95
12_A	261_Y	0.934	0.95
49_R	154_A	0.931	0.95
228_A	231_G	0.928	0.95
356_R	360_E	0.927	0.95
259_V	263_K	0.923	0.95
29_R	122_M	0.922	0.95
241_N	245_G	0.921	0.94
423_R	441_R	0.918	0.94
5_L	9_L	0.917	0.94
183_I	284_I	0.917	0.94
183_I	219_L	0.916	0.94
169_E	206_E	0.907	0.94
7_E	11_D	0.907	0.94
244_K	250_P	0.906	0.94
18_A	21_E	0.902	0.94
33_H	108_V	0.902	0.94
362_A	400_F	0.898	0.94
42_D	46_A	0.896	0.94
290_W	303_N	0.896	0.94
364_G	397_E	0.895	0.94
256_D	259_V	0.893	0.94
384_A	387_E	0.890	0.93
403_R	408_S	0.890	0.93
168_I	277_V	0.889	0.93
171_Q	281_A	0.889	0.93
223_A	228_A	0.888	0.93
203_F	231_G	0.888	0.93
385_Q	388_A	0.888	0.93
189_G	287_Q	0.885	0.93
372_Q	422_E	0.880	0.93
267_T	273_F	0.873	0.93
30_H	149_V	0.872	0.93
246_R	381_P	0.866	0.92
32_V	57_T	0.866	0.92
51_V	57_T	0.865	0.92
6_Y	232_L	0.863	0.92
144_I	152_V	0.861	0.92
50_P	92_E	0.860	0.92
175_A	282_E	0.856	0.92
14_V	23_P	0.855	0.92
51_V	153_L	0.854	0.92
216_R	236_D	0.854	0.92
367_V	454_A	0.851	0.92
423_R	443_H	0.850	0.92
104_Y	381_P	0.850	0.92
53_Q	56_K	0.849	0.92
355_L	391_L	0.848	0.92
267_T	270_G	0.846	0.92
188_I	226_M	0.846	0.92
268_D	271_A	0.845	0.92
247_L	381_P	0.843	0.91
183_I	281_A	0.843	0.91
166_M	274_D	0.840	0.91
233_V	281_A	0.840	0.91
210_D	238_T	0.838	0.91
32_V	37_S	0.834	0.91
305_P	458_H	0.833	0.91
244_K	255_F	0.831	0.91
54_P	94_G	0.830	0.91
104_Y	247_L	0.830	0.91
173_K	282_E	0.829	0.91
391_L	394_I	0.829	0.91
132_A	224_I	0.823	0.90
136_A	217_M	0.822	0.90
183_I	208_I	0.820	0.90
125_V	158_L	0.812	0.90
29_R	58_F	0.812	0.90
290_W	443_H	0.810	0.90
55_G	96_E	0.810	0.90
346_S	428_S	0.809	0.90
358_A	375_V	0.808	0.90
254_D	258_A	0.805	0.89
352_I	391_L	0.802	0.89
209_R	238_T	0.801	0.89
376_V	409_M	0.800	0.89
30_H	152_V	0.798	0.89
5_L	232_L	0.795	0.89
10_F	23_P	0.794	0.89
107_I	350_S	0.794	0.89
27_I	30_H	0.794	0.89
5_L	265_L	0.792	0.89
204_C	273_F	0.791	0.89
64_N	79_A	0.788	0.88
300_V	459_F	0.788	0.88
4_T	271_A	0.784	0.88
112_G	118_T	0.783	0.88
366_K	397_E	0.781	0.88
68_Q	415_N	0.778	0.88
25_L	160_Q	0.777	0.88
198_G	229_K	0.776	0.88
17_E	23_P	0.774	0.88
65_V	105_Q	0.771	0.87
358_A	448_A	0.768	0.87
285_S	302_D	0.766	0.87
383_K	392_D	0.763	0.87
27_I	158_L	0.763	0.87
340_D	440_G	0.758	0.86
375_V	400_F	0.758	0.86
452_A	456_T	0.758	0.86
24_L	159_K	0.757	0.86
176_P	360_E	0.755	0.86
96_E	248_H	0.753	0.86
384_A	393_K	0.750	0.86
117_V	248_H	0.749	0.86
32_V	127_G	0.745	0.85
54_P	57_T	0.744	0.85
424_C	440_G	0.744	0.85
420_P	438_R	0.743	0.85
240_F	243_V	0.742	0.85
206_E	281_A	0.741	0.85
43_G	46_A	0.741	0.85
356_R	386_A	0.740	0.85
85_E	88_K	0.736	0.85
186_A	283_E	0.736	0.85
302_D	305_P	0.735	0.85
422_E	440_G	0.733	0.85
11_D	14_V	0.731	0.84
105_Q	380_G	0.720	0.83
148_E	160_Q	0.719	0.83
11_D	18_A	0.718	0.83
119_L	247_L	0.716	0.83
367_V	370_G	0.715	0.83
10_F	162_R	0.715	0.83
37_S	86_L	0.713	0.83
166_M	201_V	0.709	0.83
362_A	365_R	0.708	0.82
174_A	215_G	0.705	0.82
449_M	460_A	0.704	0.82
103_P	384_A	0.703	0.82
419_N	422_E	0.703	0.82
342_V	371_V	0.702	0.82
107_I	378_G	0.698	0.82
60_T	108_V	0.698	0.82
454_A	457_G	0.696	0.81
396_I	402_W	0.693	0.81
3_K	7_E	0.693	0.81
387_E	402_W	0.693	0.81
14_V	17_E	0.691	0.81
207_A	215_G	0.690	0.81
352_I	386_A	0.690	0.81
207_A	282_E	0.690	0.81
52_R	57_T	0.689	0.81
269_E	272_T	0.684	0.80
30_H	57_T	0.683	0.80
163_A	200_V	0.683	0.80
87_I	91_K	0.683	0.80
117_V	122_M	0.682	0.80
138_G	265_L	0.682	0.80
164_K	275_T	0.681	0.80
34_E	37_S	0.681	0.80
70_K	101_N	0.680	0.80
9_L	200_V	0.680	0.80
98_Y	248_H	0.677	0.80
445_V	453_A	0.677	0.80
337_V	423_R	0.675	0.79
220_C	230_A	0.674	0.79
380_G	405_P	0.674	0.79
168_I	279_L	0.671	0.79
29_R	112_G	0.669	0.79
266_Q	269_E	0.666	0.78
88_K	91_K	0.665	0.78
33_H	36_T	0.662	0.78
385_Q	391_L	0.662	0.78
81_I	420_P	0.662	0.78
133_T	217_M	0.661	0.78
187_I	277_V	0.660	0.78
113_P	137_F	0.660	0.78
175_A	283_E	0.660	0.78
32_V	153_L	0.657	0.78
187_I	279_L	0.657	0.78
79_A	411_L	0.657	0.78
342_V	453_A	0.655	0.77
341_K	419_N	0.655	0.77
214_E	382_V	0.655	0.77
183_I	206_E	0.654	0.77
178_I	286_P	0.651	0.77
362_A	398_A	0.650	0.77
181_K	348_T	0.650	0.77
453_A	458_H	0.650	0.77
170_V	174_A	0.649	0.77
226_M	231_G	0.647	0.76
30_H	125_V	0.647	0.76
189_G	193_S	0.647	0.76
57_T	95_V	0.645	0.76
341_K	374_L	0.645	0.76
300_V	303_N	0.644	0.76
418_L	422_E	0.643	0.76
403_R	406_G	0.643	0.76
14_V	25_L	0.643	0.76
26_Y	53_Q	0.643	0.76
382_V	385_Q	0.642	0.76
359_A	394_I	0.642	0.76
383_K	402_W	0.641	0.76
222_M	348_T	0.640	0.76
352_I	382_V	0.639	0.76
184_V	187_I	0.638	0.75
250_P	262_W	0.638	0.75
29_R	119_L	0.637	0.75
165_T	273_F	0.637	0.75
13_H	28_D	0.636	0.75
453_A	459_F	0.635	0.75
243_V	249_A	0.634	0.75
125_V	160_Q	0.634	0.75
343_F	409_M	0.633	0.75
113_P	134_H	0.633	0.75
61_M	101_N	0.632	0.75
425_A	449_M	0.632	0.75
170_V	206_E	0.629	0.74
15_V	26_Y	0.627	0.74
193_S	295_G	0.624	0.74
258_A	262_W	0.623	0.74
87_I	102_H	0.622	0.74
341_K	424_C	0.622	0.74
124_I	139_A	0.621	0.73
144_I	158_L	0.620	0.73
191_T	196_G	0.618	0.73
279_L	283_E	0.618	0.73
244_K	259_V	0.617	0.73
218_T	447_P	0.617	0.73
110_V	382_V	0.616	0.73
338_A	368_A	0.615	0.73
133_T	221_N	0.615	0.73
150_E	433_E	0.613	0.73
359_A	391_L	0.612	0.72
136_A	220_C	0.612	0.72
237_E	240_F	0.612	0.72
412_A	415_N	0.611	0.72
350_S	355_L	0.611	0.72
35_V	411_L	0.610	0.72
180_A	219_L	0.609	0.72
284_I	287_Q	0.609	0.72
367_V	398_A	0.608	0.72
132_A	141_A	0.608	0.72
165_T	200_V	0.606	0.72
35_V	82_Q	0.604	0.71
303_N	453_A	0.602	0.71
288_V	425_A	0.602	0.71
419_N	440_G	0.602	0.71
162_R	165_T	0.602	0.71
166_M	277_V	0.601	0.71
152_V	158_L	0.600	0.71
167_K	273_F	0.599	0.71
17_E	20_N	0.598	0.71
191_T	277_V	0.597	0.71
49_R	150_E	0.597	0.71
43_G	47_H	0.596	0.70
61_M	83_M	0.594	0.70
371_V	453_A	0.594	0.70
13_H	26_Y	0.593	0.70
22_T	159_K	0.592	0.70
257_D	260_A	0.591	0.70
166_M	191_T	0.591	0.70
50_P	93_F	0.590	0.70
220_C	232_L	0.590	0.70
58_F	248_H	0.590	0.70
367_V	371_V	0.589	0.70
196_G	228_A	0.589	0.70
25_L	123_T	0.588	0.69
372_Q	419_N	0.587	0.69
232_L	235_P	0.587	0.69
4_T	7_E	0.586	0.69
208_I	238_T	0.585	0.69
373_A	451_A	0.585	0.69
213_M	217_M	0.585	0.69
60_T	98_Y	0.583	0.69
173_K	207_A	0.582	0.69
417_R	421_G	0.582	0.69
207_A	278_T	0.580	0.68
64_N	82_Q	0.579	0.68
211_L	219_L	0.576	0.68
208_I	234_A	0.575	0.68
403_R	409_M	0.574	0.68
443_H	459_F	0.574	0.68
6_Y	123_T	0.574	0.68
362_A	375_V	0.573	0.67
426_S	459_F	0.572	0.67
55_G	122_M	0.572	0.67
267_T	271_A	0.572	0.67
300_V	460_A	0.572	0.67
20_N	161_G	0.571	0.67
245_G	250_P	0.571	0.67
131_T	141_A	0.571	0.67
204_C	267_T	0.569	0.67
192_G	295_G	0.568	0.67
60_T	111_M	0.567	0.67
211_L	215_G	0.567	0.67
111_M	379_S	0.566	0.66
90_C	95_V	0.566	0.66
168_I	190_K	0.566	0.66
189_G	299_S	0.565	0.66
337_V	443_H	0.564	0.66
24_L	157_T	0.564	0.66
42_D	45_R	0.564	0.66
44_L	154_A	0.563	0.66
362_A	395_F	0.562	0.66
253_K	259_V	0.562	0.66
135_G	220_C	0.561	0.66
209_R	234_A	0.561	0.66
174_A	207_A	0.561	0.66
171_Q	174_A	0.559	0.66
376_V	395_F	0.558	0.65
429_N	447_P	0.557	0.65
196_G	226_M	0.557	0.65
172_G	282_E	0.557	0.65
37_S	59_A	0.557	0.65
123_T	230_A	0.555	0.65
51_V	93_F	0.554	0.65
84_Q	419_N	0.552	0.65
387_E	393_K	0.551	0.64
383_K	404_L	0.550	0.64
64_N	415_N	0.550	0.64
37_S	40_A	0.549	0.64
292_T	433_E	0.549	0.64
36_T	40_A	0.545	0.64
375_V	395_F	0.542	0.63
124_I	134_H	0.542	0.63
344_I	350_S	0.541	0.63
68_Q	372_Q	0.541	0.63
353_E	357_A	0.541	0.63
10_F	14_V	0.540	0.63
122_M	139_A	0.538	0.63
357_A	361_I	0.536	0.62
34_E	39_Q	0.535	0.62
129_S	145_G	0.535	0.62
175_A	301_N	0.534	0.62
174_A	211_L	0.533	0.62
298_I	337_V	0.532	0.62
181_K	222_M	0.532	0.62
137_F	243_V	0.532	0.62
145_G	185_L	0.532	0.62
249_A	258_A	0.532	0.62
209_R	281_A	0.531	0.62
43_G	146_T	0.531	0.62
140_L	434_G	0.530	0.61
144_I	148_E	0.529	0.61
133_T	348_T	0.529	0.61
240_F	264_T	0.529	0.61
341_K	418_L	0.528	0.61
424_C	436_Q	0.528	0.61
419_N	439_G	0.528	0.61
207_A	210_D	0.527	0.61
187_I	281_A	0.527	0.61
207_A	219_L	0.527	0.61
400_F	454_A	0.527	0.61
452_A	460_A	0.526	0.61
218_T	348_T	0.526	0.61
187_I	191_T	0.526	0.61
10_F	160_Q	0.526	0.61
342_V	367_V	0.526	0.61
361_I	448_A	0.522	0.60
407_C	410_C	0.521	0.60
389_E	392_D	0.520	0.60
386_A	392_D	0.519	0.60
56_K	122_M	0.519	0.60
379_S	382_V	0.515	0.59
64_N	411_L	0.515	0.59
411_L	415_N	0.514	0.59
38_P	41_F	0.514	0.59
303_N	459_F	0.514	0.59
180_A	218_T	0.514	0.59
401_E	404_L	0.513	0.59
374_L	403_R	0.513	0.59
171_Q	209_R	0.513	0.59
41_F	89_N	0.513	0.59
304_I	458_H	0.512	0.59
67_T	374_L	0.512	0.59
176_P	361_I	0.511	0.59
129_S	430_R	0.510	0.59
339_I	458_H	0.510	0.59
256_D	260_A	0.509	0.58
180_A	183_I	0.509	0.58
210_D	244_K	0.508	0.58
36_T	64_N	0.508	0.58
171_Q	279_L	0.507	0.58
87_I	97_L	0.506	0.58
79_A	82_Q	0.506	0.58
406_G	415_N	0.502	0.57
206_E	278_T	0.502	0.57
85_E	91_K	0.501	0.57
31_L	134_H	0.501	0.57
33_H	411_L	0.500	0.57
241_N	269_E	0.500	0.57
221_N	429_N	0.500	0.57

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4kp1A	1	0.8884	100	0.116	Contact Map
4kp2A	2	0.8884	100	0.127	Contact Map
1c96A	1	0.9313	100	0.177	Contact Map
2b3yA	1	0.9893	100	0.201	Contact Map
1l5jA	1	0.8927	100	0.228	Contact Map
1p3y1	6	0.3348	44.7	0.978	Contact Map
1mvlA	3	0.3326	30.5	0.98	Contact Map
1qzuA	3	0.3004	27.2	0.981	Contact Map
1vk9A	3	0.1824	17	0.982	Contact Map
3qjgA	5	0.324	14.5	0.983	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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