GREMLIN Database
ACKA - Acetate kinase
UniProt: P0A6A3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10027
Length: 400 (384)
Sequences: 4316 (2933)
Seq/√Len: 149.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_K132_E3.9321.00
343_E358_H3.3841.00
262_S265_A3.3661.00
290_E338_A3.2791.00
355_E375_E3.2621.00
192_E195_K3.1281.00
105_I147_A2.8421.00
370_G379_P2.7611.00
311_A348_K2.7551.00
279_L305_V2.6401.00
239_V305_V2.5751.00
310_L345_S2.5701.00
218_S225_C2.5291.00
268_K273_E2.5191.00
308_H320_L2.4701.00
168_Y298_D2.4161.00
165_A239_V2.3931.00
236_E246_D2.3881.00
360_R374_K2.3761.00
187_F394_D2.2881.00
192_E368_K2.2821.00
16_L66_A2.2771.00
110_I135_L2.2161.00
257_D264_D2.1831.00
306_Y334_I2.1821.00
92_I131_I2.1761.00
354_F380_A2.1721.00
98_K112_G2.1651.00
205_N323_G2.1561.00
160_E304_D2.1401.00
292_N296_K2.1311.00
300_K304_D2.1191.00
307_C341_V2.1171.00
154_H225_C2.0581.00
370_G381_V2.0451.00
291_D295_T2.0371.00
62_A65_E2.0121.00
355_E373_N1.9871.00
68_N72_N1.9731.00
107_E135_L1.9621.00
244_S270_L1.9591.00
161_S308_H1.9481.00
293_Y303_M1.9361.00
102_S394_D1.9221.00
18_F46_W1.9091.00
110_I128_L1.8931.00
213_N241_G1.8771.00
186_H208_T1.8711.00
174_H259_L1.8691.00
343_E347_G1.8681.00
170_L269_L1.8161.00
292_N299_A1.7991.00
112_G115_D1.7961.00
39_L284_S1.7831.00
199_K204_L1.7741.00
104_V142_K1.7561.00
318_T351_V1.7431.00
193_A381_V1.7401.00
104_V398_L1.7281.00
169_N173_E1.7161.00
169_N273_E1.7131.00
252_I266_I1.7131.00
26_G393_Q1.7031.00
373_N376_G1.6831.00
93_V120_A1.6771.00
110_I132_E1.6681.00
290_E340_M1.6641.00
167_P278_G1.6601.00
64_S136_K1.6581.00
293_Y300_K1.6491.00
89_G391_I1.6391.00
208_T329_V1.6291.00
386_N389_L1.6261.00
159_E297_E1.6251.00
268_K272_K1.6171.00
307_C344_L1.6081.00
193_A329_V1.5901.00
390_V394_D1.5841.00
5_L84_Q1.5751.00
101_S397_R1.5681.00
207_I325_L1.5591.00
113_I147_A1.5581.00
303_M344_L1.5581.00
257_D267_N1.5551.00
256_H266_I1.5531.00
189_V331_T1.5421.00
111_Q114_K1.5401.00
94_H181_A1.5251.00
346_L380_A1.5211.00
286_C303_M1.5131.00
48_M51_N1.5031.00
203_E222_N1.4951.00
344_L347_G1.4791.00
196_M381_V1.4721.00
372_I380_A1.4591.00
92_I147_A1.4571.00
111_Q115_D1.4431.00
273_E277_L1.4341.00
200_P203_E1.4281.00
328_V354_F1.4211.00
235_L270_L1.4151.00
209_C217_V1.4121.00
323_G351_V1.4021.00
239_V279_L1.3901.00
206_I327_A1.3881.00
87_A395_A1.3871.00
166_L170_L1.3861.00
280_T283_T1.3851.00
205_N221_R1.3781.00
103_V109_V1.3751.00
18_F32_G1.3731.00
208_T220_I1.3671.00
318_T325_L1.3541.00
229_S317_Y1.3521.00
14_S213_N1.3481.00
194_A204_L1.3471.00
98_K115_D1.3381.00
197_L381_V1.3371.00
255_L259_L1.3321.00
168_Y301_R1.3181.00
163_L171_Y1.3171.00
256_H263_V1.3141.00
325_L328_V1.3051.00
207_I314_I1.3001.00
217_V229_S1.2941.00
261_M269_L1.2911.00
186_H218_S1.2851.00
199_K203_E1.2851.00
187_F390_V1.2791.00
72_N76_A1.2761.00
162_Y177_R1.2711.00
359_E362_L1.2681.00
315_G319_A1.2661.00
163_L305_V1.2621.00
163_L168_Y1.2611.00
215_G306_Y1.2591.00
193_A197_L1.2591.00
288_Y291_D1.2571.00
160_E308_H1.2571.00
311_A319_A1.2531.00
322_D348_K1.2501.00
118_S258_T1.2411.00
113_I128_L1.2291.00
346_L354_F1.2241.00
346_L356_V1.2151.00
92_I127_H1.2081.00
241_G284_S1.2061.00
166_L244_S1.1981.00
105_I109_V1.1971.00
312_K320_L1.1941.00
389_L393_Q1.1811.00
61_A65_E1.1721.00
216_S231_G1.1721.00
227_D312_K1.1711.00
297_E300_K1.1641.00
107_E111_Q1.1631.00
281_E298_D1.1581.00
355_E377_T1.1541.00
138_F141_L1.1531.00
208_T218_S1.1521.00
34_A70_I1.1461.00
163_L301_R1.1411.00
340_M344_L1.1381.00
215_G238_L1.1371.00
176_I251_I1.1260.99
192_E196_M1.1230.99
161_S226_V1.1190.99
197_L327_A1.1170.99
372_I376_G1.1080.99
265_A273_E1.1060.99
105_I131_I1.1050.99
187_F191_Q1.1030.99
327_A381_V1.1010.99
276_L286_C1.1010.99
292_N295_T1.0990.99
279_L301_R1.0940.99
300_K344_L1.0930.99
22_D27_E1.0870.99
247_I251_I1.0860.99
114_K117_A1.0850.99
19_A31_S1.0820.99
229_S313_Y1.0660.99
64_S68_N1.0660.99
376_G380_A1.0610.99
217_V314_I1.0610.99
159_E163_L1.0600.99
28_E31_S1.0580.99
190_T208_T1.0570.99
31_S47_K1.0540.99
307_C311_A1.0520.99
246_D313_Y1.0470.99
88_I145_N1.0450.99
211_L334_I1.0430.99
164_Y236_E1.0410.99
253_F267_N1.0390.99
34_A60_G1.0380.99
188_Y192_E1.0290.99
190_T220_I1.0250.99
134_A138_F1.0150.99
108_S112_G1.0130.99
191_Q393_Q1.0080.99
221_R321_M1.0060.99
146_V395_A0.9990.99
168_Y278_G0.9940.99
173_E259_L0.9930.99
339_A362_L0.9910.99
290_E341_V0.9880.99
16_L70_I0.9870.99
161_S320_L0.9860.99
22_D25_N0.9850.99
193_A383_I0.9830.99
5_L22_D0.9780.99
360_R370_G0.9740.99
280_T289_V0.9720.98
211_L310_L0.9660.98
99_Y112_G0.9630.98
253_F256_H0.9620.98
286_C334_I0.9600.98
213_N284_S0.9570.98
127_H130_G0.9560.98
166_L269_L0.9540.98
148_V184_T0.9510.98
191_Q390_V0.9490.98
194_A201_V0.9490.98
36_C288_Y0.9470.98
206_I329_V0.9470.98
318_T352_L0.9430.98
170_L255_L0.9410.98
157_M162_Y0.9400.98
219_A321_M0.9400.98
227_D320_L0.9390.98
135_L145_N0.9380.98
134_A145_N0.9330.98
43_R55_A0.9320.98
309_R313_Y0.9260.98
69_F72_N0.9230.98
304_D344_L0.9220.98
283_T288_Y0.9210.98
194_A199_K0.9180.98
312_K316_A0.9160.98
209_C314_I0.9140.98
19_A28_E0.9120.98
261_M265_A0.9080.98
303_M307_C0.9070.98
311_A350_G0.9060.98
244_S247_I0.9020.98
294_A340_M0.9010.98
92_I113_I0.8990.97
303_M341_V0.8980.97
364_A369_S0.8970.97
354_F378_R0.8940.97
217_V317_Y0.8930.97
131_I147_A0.8920.97
343_E362_L0.8870.97
217_V238_L0.8860.97
159_E162_Y0.8820.97
311_A349_L0.8770.97
45_K53_Q0.8760.97
164_Y279_L0.8710.97
128_L132_E0.8670.97
185_S385_T0.8660.97
234_P271_T0.8660.97
181_A225_C0.8650.97
193_A206_I0.8630.97
230_M233_T0.8630.97
155_Q162_Y0.8630.97
19_A386_N0.8600.97
97_E171_Y0.8590.97
35_E287_R0.8570.97
322_D347_G0.8550.97
313_Y317_Y0.8430.96
100_T155_Q0.8420.96
6_V396_S0.8380.96
162_Y171_Y0.8380.96
204_L222_N0.8370.96
131_I135_L0.8320.96
359_E363_A0.8310.96
341_V344_L0.8240.96
368_K384_P0.8210.96
117_A128_L0.8210.96
236_E309_R0.8180.96
40_P59_A0.8170.96
221_R226_V0.8140.95
293_Y344_L0.8140.95
296_K299_A0.8120.95
88_I141_L0.8080.95
28_E386_N0.8080.95
261_M266_I0.8080.95
196_M368_K0.8010.95
289_V293_Y0.8010.95
188_Y385_T0.7990.95
132_E135_L0.7950.95
209_C328_V0.7940.95
170_L259_L0.7940.95
286_C306_Y0.7910.95
288_Y292_N0.7890.95
88_I134_A0.7880.95
283_T292_N0.7860.95
313_Y316_A0.7840.94
347_G358_H0.7780.94
371_F382_V0.7780.94
306_Y341_V0.7780.94
322_D350_G0.7760.94
253_F270_L0.7750.94
325_L378_R0.7750.94
290_E303_M0.7740.94
205_N351_V0.7740.94
106_D109_V0.7710.94
157_M227_D0.7690.94
44_I73_T0.7690.94
328_V346_L0.7650.94
319_A351_V0.7610.94
327_A379_P0.7610.94
189_V208_T0.7610.94
290_E294_A0.7610.94
153_F180_G0.7610.94
159_E301_R0.7600.94
11_C16_L0.7600.94
58_G61_A0.7570.93
41_E57_L0.7570.93
33_L43_R0.7560.93
167_P171_Y0.7550.93
341_V345_S0.7530.93
89_G395_A0.7530.93
322_D351_V0.7500.93
9_L134_A0.7490.93
23_A396_S0.7470.93
166_L176_I0.7450.93
370_G376_G0.7440.93
178_R236_E0.7440.93
253_F263_V0.7430.93
60_G66_A0.7400.93
205_N222_N0.7400.93
97_E175_G0.7380.92
356_V373_N0.7350.92
211_L215_G0.7310.92
238_L309_R0.7300.92
363_A369_S0.7280.92
204_L327_A0.7260.92
100_T152_A0.7250.92
255_L269_L0.7250.92
85_L141_L0.7240.92
42_A60_G0.7180.91
21_I386_N0.7170.91
357_D361_N0.7170.91
58_G69_F0.7130.91
280_T292_N0.7130.91
277_L284_S0.7110.91
113_I131_I0.7080.91
230_M234_P0.7080.91
99_Y109_V0.7070.91
358_H362_L0.7050.91
88_I133_E0.7010.90
88_I138_F0.7010.90
252_I270_L0.6980.90
71_V138_F0.6980.90
217_V310_L0.6970.90
85_L138_F0.6960.90
90_H145_N0.6950.90
169_N281_E0.6950.90
108_S111_Q0.6920.90
77_Q80_E0.6910.90
360_R363_A0.6900.90
157_M228_T0.6890.90
301_R305_V0.6890.90
160_E348_K0.6880.90
170_L174_H0.6860.90
190_T206_I0.6860.90
307_C345_S0.6800.89
269_L274_S0.6770.89
256_H259_L0.6740.89
5_L86_T0.6740.89
372_I379_P0.6730.89
194_A203_E0.6720.89
45_K55_A0.6710.88
36_C39_L0.6700.88
342_R361_N0.6680.88
176_I254_H0.6680.88
211_L306_Y0.6650.88
298_D301_R0.6640.88
43_R57_L0.6640.88
373_N380_A0.6600.88
156_T224_K0.6580.87
71_V75_L0.6560.87
306_Y310_L0.6560.87
166_L270_L0.6520.87
318_T378_R0.6500.87
337_N364_A0.6490.87
12_G17_K0.6480.87
307_C310_L0.6480.87
103_V106_D0.6470.87
20_I85_L0.6470.87
263_V266_I0.6460.87
132_E136_K0.6420.86
83_A140_Q0.6390.86
308_H312_K0.6380.86
161_S227_D0.6380.86
232_L254_H0.6380.86
239_V306_Y0.6380.86
244_S249_P0.6380.86
81_L84_Q0.6360.86
97_E162_Y0.6360.86
205_N322_D0.6340.85
73_T76_A0.6340.85
193_A196_M0.6330.85
158_P221_R0.6270.85
156_T225_C0.6260.85
170_L261_M0.6250.85
226_V320_L0.6250.85
334_I341_V0.6240.85
200_P204_L0.6230.85
319_A322_D0.6230.85
253_F257_D0.6230.85
44_I69_F0.6220.84
170_L176_I0.6200.84
165_A305_V0.6200.84
309_R312_K0.6190.84
204_L381_V0.6190.84
332_G371_F0.6180.84
207_I321_M0.6180.84
133_E136_K0.6170.84
24_V396_S0.6170.84
184_T187_F0.6170.84
102_S187_F0.6160.84
371_F376_G0.6150.84
36_C41_E0.6130.84
304_D307_C0.6130.84
227_D308_H0.6120.83
23_A26_G0.6100.83
230_M235_L0.6100.83
168_Y171_Y0.6080.83
207_I318_T0.6070.83
286_C338_A0.6060.83
265_A268_K0.6060.83
63_H66_A0.6050.83
370_G380_A0.6010.82
158_P161_S0.6000.82
325_L352_L0.5990.82
199_K326_D0.5960.82
321_M325_L0.5960.82
126_A130_G0.5940.82
15_S213_N0.5940.82
226_V321_M0.5940.82
339_A343_E0.5930.82
318_T321_M0.5900.81
102_S149_F0.5900.81
330_F345_S0.5890.81
89_G149_F0.5890.81
258_T261_M0.5860.81
6_V395_A0.5850.81
201_V220_I0.5840.81
114_K128_L0.5840.81
253_F264_D0.5840.81
67_L134_A0.5840.81
193_A357_D0.5820.80
8_V134_A0.5810.80
303_M340_M0.5800.80
135_L140_Q0.5790.80
19_A363_A0.5790.80
280_T302_A0.5770.80
47_K51_N0.5760.80
196_M370_G0.5740.79
80_E84_Q0.5740.79
141_L145_N0.5720.79
257_D263_V0.5720.79
32_G77_Q0.5710.79
171_Y279_L0.5700.79
186_H190_T0.5700.79
167_P170_L0.5690.79
63_H213_N0.5690.79
269_L273_E0.5670.79
357_D360_R0.5640.78
301_R304_D0.5630.78
8_V391_I0.5620.78
157_M161_S0.5610.78
72_N75_L0.5600.78
340_M343_E0.5600.78
311_A320_L0.5590.78
32_G76_A0.5550.77
276_L289_V0.5550.77
98_K108_S0.5550.77
233_T250_A0.5540.77
53_Q56_A0.5530.77
69_F73_T0.5530.77
154_H157_M0.5520.77
267_N271_T0.5520.77
205_N321_M0.5510.77
206_I220_I0.5510.77
73_T77_Q0.5510.77
127_H250_A0.5500.76
68_N136_K0.5490.76
90_H130_G0.5490.76
189_V193_A0.5490.76
185_S331_T0.5490.76
289_V303_M0.5490.76
39_L42_A0.5480.76
279_L302_A0.5470.76
154_H218_S0.5470.76
290_E293_Y0.5450.76
112_G116_A0.5450.76
318_T323_G0.5440.76
370_G374_K0.5440.76
34_A66_A0.5430.76
325_L351_V0.5410.75
289_V292_N0.5410.75
16_L34_A0.5410.75
349_L354_F0.5400.75
190_T194_A0.5400.75
372_I378_R0.5400.75
315_G320_L0.5390.75
110_I131_I0.5380.75
319_A348_K0.5370.75
99_Y116_A0.5360.75
155_Q177_R0.5360.75
176_I232_L0.5360.75
164_Y231_G0.5350.74
255_L261_M0.5340.74
291_D294_A0.5330.74
21_I28_E0.5320.74
47_K53_Q0.5310.74
394_D397_R0.5310.74
338_A341_V0.5300.74
266_I269_L0.5300.74
123_H152_A0.5260.73
153_F220_I0.5250.73
157_M177_R0.5250.73
93_V152_A0.5240.73
113_I148_V0.5240.73
393_Q396_S0.5240.73
104_V146_V0.5230.73
276_L303_M0.5230.73
169_N174_H0.5230.73
193_A327_A0.5230.73
127_H181_A0.5230.73
236_E312_K0.5220.73
134_A141_L0.5210.73
314_I328_V0.5200.72
116_A128_L0.5200.72
56_A69_F0.5190.72
110_I113_I0.5190.72
91_R150_D0.5190.72
26_G389_L0.5180.72
235_L250_A0.5180.72
332_G384_P0.5180.72
293_Y340_M0.5170.72
278_G289_V0.5150.72
17_K333_G0.5150.72
360_R369_S0.5140.72
56_A76_A0.5130.71
373_N377_T0.5130.71
37_F60_G0.5120.71
211_L330_F0.5120.71
239_V309_R0.5120.71
314_I345_S0.5110.71
371_F380_A0.5110.71
347_G350_G0.5100.71
165_A236_E0.5100.71
261_M273_E0.5100.71
189_V383_I0.5080.71
202_E222_N0.5070.71
356_V371_F0.5070.71
335_G342_R0.5070.71
13_S17_K0.5060.70
244_S274_S0.5060.70
297_E301_R0.5060.70
97_E116_A0.5050.70
289_V306_Y0.5050.70
87_A142_K0.5040.70
190_T331_T0.5040.70
369_S372_I0.5030.70
9_L70_I0.5020.70
119_F181_A0.5020.70
311_A354_F0.5010.70
21_I26_G0.5010.70
253_F266_I0.5010.70
201_V206_I0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sk3A 2 0.98 100 0.037 Contact Map
4h0pA 2 0.98 100 0.051 Contact Map
4h0oA 6 0.9525 100 0.077 Contact Map
2iirA 2 0.9825 100 0.146 Contact Map
1g99A 2 0.9825 100 0.15 Contact Map
2e1zA 2 0.9725 100 0.153 Contact Map
3khyA 2 0.9575 100 0.208 Contact Map
3r9pA 2 0.945 100 0.341 Contact Map
4ijnA 2 0.9325 100 0.494 Contact Map
1sazA 3 0.855 100 0.524 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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