GREMLIN Database
UBIB - Probable protein kinase UbiB
UniProt: P0A6A0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11476
Length: 546 (447)
Sequences: 4633 (2904)
Seq/√Len: 137.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_D142_R5.2151.00
112_A239_G4.8821.00
214_I233_P4.3011.00
140_T149_E4.0231.00
258_E264_M3.7351.00
219_N282_D3.6431.00
125_F152_I3.5981.00
136_A206_L3.5581.00
140_T245_R3.4401.00
215_Q316_S3.3481.00
266_L270_R3.1331.00
148_K232_Y3.1131.00
110_E117_P3.1071.00
295_F309_I3.0691.00
149_E247_Y3.0221.00
106_K119_E2.9381.00
112_A237_S2.9351.00
100_F105_A2.9321.00
125_F141_A2.8911.00
106_K110_E2.8851.00
246_I307_I2.8601.00
148_K230_E2.8561.00
54_G86_I2.8441.00
123_D144_K2.8251.00
142_R149_E2.8101.00
210_S233_P2.7931.00
297_S305_K2.7771.00
297_S307_I2.7391.00
171_Y197_E2.6011.00
106_K127_I2.5221.00
84_P88_D2.5161.00
265_K420_Y2.4871.00
164_K201_I2.4841.00
213_A231_V2.4701.00
116_L120_A2.4561.00
151_V245_R2.4551.00
253_D256_A2.4551.00
123_D142_R2.4261.00
227_Y244_E2.4071.00
58_R89_Q2.3491.00
160_L238_E2.3351.00
110_E118_V2.2381.00
101_D104_L2.2191.00
130_L151_V2.2161.00
249_I260_N2.2071.00
126_E140_T2.1351.00
152_I240_M2.1171.00
277_T281_R2.1131.00
336_D339_K2.1011.00
231_V243_M2.0951.00
277_T282_D2.0941.00
225_M270_R2.0531.00
55_E89_Q2.0511.00
109_I154_V2.0391.00
331_A339_K2.0341.00
155_I239_G2.0181.00
150_V242_V2.0161.00
233_P236_C1.9501.00
217_R230_E1.9391.00
111_A239_G1.9261.00
141_A152_I1.9021.00
424_D427_K1.8991.00
116_L121_W1.8861.00
232_Y244_E1.8671.00
143_L146_N1.8571.00
107_Q111_A1.8471.00
327_E339_K1.8321.00
338_R360_E1.8291.00
95_D250_P1.8191.00
171_Y194_R1.8161.00
155_I206_L1.8051.00
210_S236_C1.7781.00
105_A139_H1.7671.00
318_N321_D1.7591.00
297_S303_N1.7551.00
102_G105_A1.7371.00
76_S94_Q1.7261.00
227_Y305_K1.7211.00
117_P120_A1.7151.00
109_I113_M1.7091.00
79_R82_F1.7081.00
122_F242_V1.7081.00
102_G127_I1.7071.00
109_I121_W1.7031.00
232_Y235_Y1.6851.00
181_L184_G1.6811.00
213_A243_M1.6621.00
102_G106_K1.6391.00
218_R221_E1.6391.00
223_S277_T1.6351.00
294_I308_G1.6241.00
113_M242_V1.6211.00
355_N358_E1.6101.00
210_S231_V1.5871.00
236_C242_V1.5581.00
143_L150_V1.5471.00
141_A150_V1.5461.00
214_I217_R1.5441.00
254_V258_E1.5231.00
331_A340_V1.5161.00
256_A260_N1.5021.00
188_R191_E1.4931.00
100_F156_R1.4861.00
109_I118_V1.4741.00
273_Q428_T1.4621.00
283_S322_K1.4581.00
287_A313_I1.4491.00
217_R227_Y1.4341.00
274_V308_G1.4261.00
72_G93_L1.4241.00
207_L238_E1.4161.00
227_Y297_S1.4041.00
57_L90_L1.4021.00
205_N238_E1.3971.00
210_S241_M1.3971.00
121_W235_Y1.3921.00
89_Q92_L1.3901.00
178_P188_R1.3841.00
104_L107_Q1.3691.00
120_A144_K1.3651.00
160_L164_K1.3631.00
178_P190_T1.3571.00
271_G416_G1.3561.00
130_L245_R1.3501.00
202_D208_R1.3471.00
152_I242_V1.3431.00
247_Y302_E1.3371.00
58_R62_Q1.3361.00
143_L232_Y1.3341.00
109_I125_F1.3031.00
123_D146_N1.2961.00
284_F314_V1.2961.00
256_A259_K1.2941.00
257_L261_G1.2931.00
285_F315_G1.2891.00
257_L264_M1.2891.00
254_V264_M1.2851.00
118_V125_F1.2821.00
106_K125_F1.2811.00
167_L197_E1.2651.00
197_E201_I1.2601.00
227_Y246_I1.2591.00
215_Q284_F1.2531.00
122_F141_A1.2521.00
106_K118_V1.2451.00
246_I297_S1.2391.00
270_R306_Y1.2371.00
265_K422_Q1.2361.00
122_F125_F1.2361.00
102_G125_F1.2281.00
132_S156_R1.2271.00
376_A422_Q1.2241.00
324_Y346_D1.2231.00
174_A190_T1.2221.00
423_L428_T1.2181.00
225_M273_Q1.2161.00
230_E244_E1.2161.00
257_L262_T1.1981.00
251_V296_V1.1921.00
51_K55_E1.1891.00
228_I314_V1.1881.00
158_D162_V1.1790.99
109_I240_M1.1780.99
155_I160_L1.1750.99
216_L311_C1.1700.99
192_V403_V1.1670.99
88_D91_A1.1660.99
257_L263_N1.1570.99
174_A193_V1.1480.99
51_K88_D1.1480.99
255_A258_E1.1450.99
102_G118_V1.1330.99
175_R190_T1.1320.99
105_A154_V1.1300.99
328_N340_V1.1240.99
227_Y307_I1.1230.99
430_K434_E1.1190.99
362_A394_F1.1190.99
22_D56_R1.1140.99
55_E58_R1.0980.99
324_Y343_L1.0970.99
255_A259_K1.0960.99
108_Q112_A1.0880.99
113_M122_F1.0800.99
327_E346_D1.0750.99
151_V243_M1.0740.99
262_T267_L1.0660.99
82_F87_A1.0580.99
268_A419_L1.0560.99
121_W242_V1.0520.99
143_L235_Y1.0460.99
225_M305_K1.0460.99
435_S439_D1.0400.99
207_L236_C1.0390.99
120_A123_D1.0390.99
15_T60_A1.0380.99
331_A343_L1.0370.99
119_E127_I1.0370.99
274_V278_Q1.0360.99
138_V151_V1.0340.99
249_I253_D1.0330.99
207_L211_A1.0260.99
61_L72_G1.0240.99
163_I200_L1.0230.99
117_P121_W1.0180.99
143_L148_K1.0140.98
211_A233_P1.0130.98
57_L86_I1.0120.98
339_K343_L1.0110.98
94_Q250_P1.0100.98
246_I295_F1.0080.98
53_L86_I1.0030.98
95_D295_F0.9960.98
267_L296_V0.9960.98
279_V405_L0.9930.98
453_K466_E0.9930.98
126_E130_L0.9920.98
62_Q92_L0.9820.98
113_M240_M0.9790.98
55_E92_L0.9760.98
160_L239_G0.9750.98
374_P377_E0.9730.98
220_F308_G0.9700.98
281_R435_S0.9620.98
269_E273_Q0.9590.98
249_I256_A0.9560.98
59_L62_Q0.9550.98
82_F90_L0.9430.98
266_L269_E0.9430.98
148_K244_E0.9420.98
92_L96_K0.9390.97
330_I334_N0.9380.97
243_M309_I0.9380.97
457_W461_M0.9340.97
100_F157_P0.9330.97
123_D147_G0.9310.97
66_P413_E0.9280.97
213_A311_C0.9260.97
268_A420_Y0.9260.97
83_P86_I0.9220.97
65_G68_W0.9210.97
100_F108_Q0.9150.97
442_G445_A0.9090.97
94_Q292_G0.9090.97
210_S214_I0.9080.97
219_N284_F0.9060.97
212_N314_V0.9060.97
338_R342_E0.9040.97
460_K465_P0.9030.97
215_Q219_N0.9000.97
151_V309_I0.8950.97
113_M116_L0.8900.97
47_R85_H0.8890.96
457_W460_K0.8870.96
359_F362_A0.8860.96
260_N263_N0.8860.96
149_E245_R0.8850.96
235_Y242_V0.8780.96
342_E356_V0.8760.96
212_N284_F0.8750.96
317_L405_L0.8740.96
231_V236_C0.8740.96
339_K342_E0.8670.96
274_V306_Y0.8650.96
340_V363_I0.8650.96
55_E59_L0.8650.96
271_G306_Y0.8640.96
265_K269_E0.8560.96
194_R197_E0.8490.95
287_A404_L0.8480.95
167_L201_I0.8480.95
458_V462_P0.8470.95
323_R327_E0.8420.95
118_V121_W0.8390.95
140_T151_V0.8340.95
281_R432_F0.8330.95
263_N266_L0.8330.95
320_E346_D0.8320.95
25_I29_R0.8280.95
228_I311_C0.8270.95
52_L56_R0.8250.95
211_A214_I0.8250.95
311_C314_V0.8150.94
308_G314_V0.8140.94
214_I218_R0.8140.94
343_L347_S0.8140.94
287_A315_G0.8130.94
53_L85_H0.8120.94
58_R92_L0.8090.94
216_L278_Q0.8080.94
345_V356_V0.8040.94
113_M121_W0.8020.94
216_L220_F0.7990.94
133_A203_E0.7990.94
220_F278_Q0.7930.93
379_S382_H0.7900.93
342_E346_D0.7890.93
104_L108_Q0.7860.93
388_F391_A0.7840.93
226_L308_G0.7820.93
334_N430_K0.7810.93
264_M267_L0.7800.93
321_D401_Q0.7770.93
75_L82_F0.7730.93
447_V451_K0.7720.93
216_L314_V0.7710.92
190_T194_R0.7680.92
425_L428_T0.7660.92
94_Q291_P0.7650.92
462_P465_P0.7650.92
57_L61_L0.7650.92
355_N363_I0.7640.92
407_K411_Y0.7640.92
40_S43_W0.7600.92
341_A363_I0.7590.92
319_K322_K0.7570.92
50_D85_H0.7570.92
143_L147_G0.7560.92
260_N264_M0.7550.92
111_A422_Q0.7550.92
130_L139_H0.7540.92
122_F152_I0.7520.92
370_I386_N0.7490.91
220_F274_V0.7470.91
103_K127_I0.7450.91
454_A458_V0.7450.91
219_N277_T0.7440.91
78_R413_E0.7420.91
22_D52_L0.7420.91
214_I230_E0.7410.91
83_P87_A0.7400.91
121_W143_L0.7380.91
12_I68_W0.7370.91
9_L169_L0.7370.91
155_I238_E0.7370.91
275_F412_V0.7360.91
69_I97_V0.7350.91
254_V418_Q0.7310.90
171_Y190_T0.7240.90
143_L242_V0.7240.90
52_L55_E0.7240.90
348_G396_M0.7230.90
450_F454_A0.7220.90
381_G384_L0.7220.90
434_E438_K0.7210.90
457_W465_P0.7190.90
374_P422_Q0.7190.90
159_I162_V0.7180.90
51_K89_Q0.7170.89
341_A360_E0.7160.89
226_L274_V0.7150.89
456_F465_P0.7140.89
121_W240_M0.7110.89
62_Q65_G0.7110.89
168_K171_Y0.7090.89
76_S250_P0.7070.89
322_K432_F0.7070.89
124_D149_E0.7050.89
102_G139_H0.7050.89
70_K73_Q0.7050.89
69_I98_A0.7030.89
366_V390_T0.7010.88
110_E119_E0.7010.88
283_S319_K0.7010.88
258_E261_G0.7000.88
19_Y23_E0.6960.88
243_M311_C0.6950.88
146_N149_E0.6950.88
208_R212_N0.6940.88
338_R341_A0.6910.88
205_N208_R0.6910.88
100_F104_L0.6900.88
59_L89_Q0.6880.87
254_V257_L0.6880.87
268_A416_G0.6880.87
456_F466_E0.6880.87
103_K107_Q0.6860.87
196_Y403_V0.6830.87
215_Q218_R0.6830.87
451_K454_A0.6820.87
341_A345_V0.6820.87
295_F307_I0.6810.87
279_V408_T0.6800.87
321_D347_S0.6800.87
446_L451_K0.6790.87
454_A465_P0.6790.87
386_N389_N0.6770.87
266_L304_P0.6750.86
211_A215_Q0.6740.86
220_F223_S0.6730.86
105_A108_Q0.6720.86
108_Q239_G0.6710.86
249_I261_G0.6680.86
12_I64_L0.6670.86
390_T394_F0.6670.86
253_D257_L0.6650.86
405_L408_T0.6650.86
54_G129_P0.6620.85
132_S135_I0.6610.85
440_Q443_I0.6610.85
84_P87_A0.6600.85
199_T404_L0.6600.85
22_D26_P0.6590.85
355_N362_A0.6560.85
355_N359_F0.6550.85
112_A238_E0.6540.85
451_K455_P0.6520.85
445_A449_A0.6510.84
449_A453_K0.6500.84
78_R156_R0.6490.84
173_L177_V0.6460.84
344_H363_I0.6450.84
217_R221_E0.6450.84
449_A454_A0.6450.84
249_I262_T0.6450.84
13_I16_F0.6450.84
51_K59_L0.6450.84
59_L63_E0.6430.84
210_S213_A0.6420.84
342_E345_V0.6410.84
260_N302_E0.6390.83
269_E428_T0.6380.83
213_A217_R0.6350.83
429_A433_L0.6330.83
267_L270_R0.6330.83
163_I204_L0.6300.83
119_E123_D0.6290.82
453_K461_M0.6290.82
100_F139_H0.6290.82
42_F45_P0.6280.82
249_I263_N0.6260.82
456_F460_K0.6250.82
286_H290_H0.6240.82
323_R445_A0.6240.82
39_Y42_F0.6240.82
308_G311_C0.6220.82
97_V132_S0.6210.82
94_Q252_S0.6210.82
286_H404_L0.6200.81
132_S208_R0.6200.81
91_A94_Q0.6190.81
19_Y22_D0.6190.81
54_G85_H0.6190.81
134_S203_E0.6170.81
10_Y14_R0.6170.81
273_Q431_P0.6170.81
80_D413_E0.6170.81
57_L60_A0.6170.81
21_L25_I0.6170.81
258_E263_N0.6170.81
427_K430_K0.6150.81
296_V308_G0.6150.81
79_R87_A0.6140.81
453_K460_K0.6130.81
107_Q110_E0.6130.81
449_A463_E0.6110.81
113_M237_S0.6090.80
170_I174_A0.6090.80
446_L449_A0.6090.80
104_L158_D0.6090.80
460_K464_L0.6080.80
118_V127_I0.6080.80
446_L450_F0.6070.80
453_K462_P0.6070.80
369_P386_N0.6060.80
195_E198_K0.6050.80
203_E407_K0.6050.80
15_T18_S0.6030.80
313_I407_K0.6020.80
113_M154_V0.6020.80
15_T20_G0.6010.79
107_Q116_L0.6010.79
355_N361_F0.6010.79
407_K436_W0.6010.79
19_Y60_A0.6010.79
335_R368_E0.6000.79
248_G307_I0.6000.79
87_A91_A0.6000.79
148_K234_D0.5990.79
416_G425_L0.5990.79
251_V291_P0.5980.79
233_P242_V0.5970.79
404_L407_K0.5950.79
363_I366_V0.5940.79
362_A366_V0.5940.79
100_F132_S0.5920.78
335_R371_F0.5920.78
460_K466_E0.5910.78
10_Y17_L0.5910.78
203_E289_M0.5900.78
460_K463_E0.5900.78
458_V461_M0.5890.78
208_R211_A0.5860.78
68_W169_L0.5860.78
130_L140_T0.5850.78
58_R143_L0.5840.78
236_C241_M0.5830.77
444_P454_A0.5830.77
320_E324_Y0.5820.77
87_A90_L0.5810.77
415_V418_Q0.5800.77
69_I93_L0.5790.77
275_F424_D0.5790.77
114_G117_P0.5780.77
276_F280_F0.5750.76
121_W144_K0.5750.76
71_F196_Y0.5750.76
111_A161_P0.5740.76
7_R10_Y0.5720.76
214_I236_C0.5720.76
213_A233_P0.5710.76
11_F14_R0.5700.76
65_G156_R0.5690.76
122_F137_Q0.5680.76
162_V177_V0.5670.75
271_G294_I0.5670.75
7_R11_F0.5660.75
321_D324_Y0.5660.75
334_N339_K0.5660.75
88_D107_Q0.5650.75
155_I399_Q0.5650.75
250_P253_D0.5650.75
444_P461_M0.5640.75
21_L24_L0.5630.75
378_I381_G0.5620.75
251_V306_Y0.5620.75
68_W165_A0.5620.75
444_P448_R0.5610.75
450_F457_W0.5600.75
65_G286_H0.5600.75
158_D161_P0.5600.75
278_Q314_V0.5600.75
45_P48_H0.5590.74
257_L260_N0.5590.74
170_I193_V0.5580.74
6_V10_Y0.5580.74
344_H396_M0.5580.74
319_K452_E0.5580.74
337_Y341_A0.5580.74
296_V303_N0.5570.74
259_K262_T0.5570.74
96_K128_K0.5570.74
324_Y347_S0.5570.74
461_M465_P0.5550.74
15_T19_Y0.5540.74
191_E410_L0.5540.74
176_W180_L0.5540.74
128_K256_A0.5540.74
27_K30_I0.5540.74
51_K85_H0.5510.73
95_D252_S0.5500.73
341_A356_V0.5500.73
25_I30_I0.5490.73
196_Y416_G0.5490.73
77_T414_G0.5490.73
253_D262_T0.5480.73
194_R198_K0.5470.73
14_R18_S0.5470.73
12_I19_Y0.5470.73
131_A136_A0.5460.73
217_R228_I0.5460.73
248_G295_F0.5440.72
107_Q125_F0.5430.72
318_N401_Q0.5430.72
445_A452_E0.5420.72
445_A458_V0.5420.72
9_L13_I0.5410.72
453_K457_W0.5400.72
289_M340_V0.5400.72
39_Y44_M0.5390.72
141_A242_V0.5390.72
207_L214_I0.5380.72
341_A350_V0.5380.72
205_N211_A0.5380.72
99_P128_K0.5370.71
323_R440_Q0.5370.71
347_S412_V0.5370.71
333_F433_L0.5350.71
326_A437_I0.5350.71
449_A466_E0.5340.71
253_D259_K0.5340.71
271_G412_V0.5340.71
220_F225_M0.5330.71
74_M196_Y0.5330.71
135_I395_N0.5320.71
445_A448_R0.5320.71
452_E456_F0.5320.71
13_I198_K0.5320.71
276_F432_F0.5310.71
337_Y364_R0.5310.71
278_Q411_Y0.5310.71
454_A462_P0.5310.71
199_T202_D0.5300.70
110_E116_L0.5300.70
311_C407_K0.5290.70
25_I40_S0.5290.70
446_L452_E0.5290.70
333_F430_K0.5280.70
26_P29_R0.5280.70
220_F228_I0.5270.70
18_S22_D0.5270.70
172_R176_W0.5270.70
375_L416_G0.5260.70
16_F60_A0.5250.70
6_V107_Q0.5240.70
450_F460_K0.5240.70
136_A417_R0.5240.70
62_Q98_A0.5240.70
426_W430_K0.5230.69
141_A151_V0.5220.69
388_F392_R0.5220.69
24_L27_K0.5210.69
288_D293_N0.5210.69
199_T313_I0.5200.69
445_A451_K0.5200.69
18_S43_W0.5200.69
259_K263_N0.5190.69
8_R12_I0.5190.69
369_P382_H0.5180.69
357_E360_E0.5180.69
66_P326_A0.5180.69
204_L317_L0.5170.69
449_A462_P0.5170.69
274_V280_F0.5170.69
16_F19_Y0.5170.69
61_L68_W0.5170.69
283_S304_P0.5160.68
272_V416_G0.5160.68
77_T291_P0.5150.68
17_L25_I0.5140.68
322_K391_A0.5140.68
171_Y175_R0.5140.68
331_A336_D0.5130.68
417_R424_D0.5130.68
66_P156_R0.5120.68
456_F461_M0.5120.68
146_N232_Y0.5120.68
454_A461_M0.5120.68
136_A423_L0.5110.68
40_S44_M0.5100.68
98_A101_D0.5100.68
70_K290_H0.5090.67
452_E463_E0.5090.67
251_V385_L0.5090.67
135_I313_I0.5090.67
18_S56_R0.5090.67
463_E466_E0.5080.67
359_F370_I0.5080.67
155_I159_I0.5070.67
245_R295_F0.5070.67
76_S278_Q0.5070.67
278_Q308_G0.5070.67
196_Y419_L0.5060.67
433_L437_I0.5060.67
195_E312_G0.5050.67
226_L316_S0.5050.67
230_E382_H0.5040.67
90_L93_L0.5040.67
109_I119_E0.5030.67
272_V425_L0.5030.67
74_M313_I0.5030.67
77_T94_Q0.5030.67
313_I408_T0.5020.66
91_A291_P0.5020.66
164_K168_K0.5020.66
366_V369_P0.5010.66
41_L46_N0.5010.66
18_S21_L0.5000.66
126_E149_E0.5000.66
327_E356_V0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pedA 1 0.6923 100 0.461 Contact Map
2y7jA 3 0.4524 100 0.737 Contact Map
3byvA 1 0.5989 100 0.738 Contact Map
4yhjA 2 0.7875 100 0.754 Contact Map
3v5wA 1 0.7289 100 0.801 Contact Map
1u5qA 2 0.5366 99.9 0.824 Contact Map
1zarA 1 0.4524 99.9 0.83 Contact Map
4otpA 1 0.4158 99.9 0.849 Contact Map
3dzoA 1 0.5879 99.8 0.859 Contact Map
3fegA 2 0.5366 99.8 0.862 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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