GREMLIN Database
YIDB - Uncharacterized protein YidB
UniProt: P09996 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11196
Length: 132 (112)
Sequences: 435 (322)
Seq/√Len: 30.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_L105_S6.7411.00
2_G5_D3.8491.00
36_L48_L3.6641.00
39_L69_A3.5221.00
99_K102_D3.1721.00
37_E40_Q3.0021.00
39_L47_I2.6451.00
90_S94_A2.0880.98
70_L75_V1.9850.97
75_V84_V1.9320.97
22_I26_V1.9020.96
46_A59_Q1.7820.94
61_V69_A1.7810.94
59_Q69_A1.7770.94
54_N102_D1.7070.93
102_D105_S1.6970.93
21_A105_S1.6700.92
66_L90_S1.5840.90
88_T92_L1.5280.88
8_V12_L1.5070.88
36_L110_V1.5030.88
47_I69_A1.5030.88
32_I52_L1.4700.86
6_E10_A1.3960.83
52_L111_S1.3510.81
66_L93_L1.3280.80
77_D81_K1.3270.80
4_F15_D1.2840.78
99_K103_A1.2800.77
22_I28_E1.2580.76
22_I25_W1.2360.75
88_T91_S1.2160.74
47_I65_Q1.2110.73
7_V11_F1.1970.72
85_D88_T1.1840.72
77_D80_Q1.1800.71
96_Q99_K1.1620.70
46_A68_S1.1530.70
27_E30_G1.1070.66
39_L91_S1.0950.66
15_D75_V1.0930.65
33_Q48_L1.0840.65
42_G89_A1.0680.64
33_Q94_A1.0650.63
42_G46_A1.0440.62
9_G36_L1.0420.62
48_L89_A1.0420.62
25_W44_L1.0410.62
86_T110_V1.0360.61
23_L113_Q1.0350.61
7_V70_L1.0290.61
73_N77_D1.0130.59
29_Q38_K1.0110.59
67_E85_D1.0070.59
100_I104_L1.0050.59
17_G22_I0.9780.57
16_A113_Q0.9710.56
107_Q111_S0.9590.55
22_I29_Q0.9540.55
44_L65_Q0.9480.54
6_E75_V0.9460.54
2_G6_E0.9350.53
111_S114_A0.8990.50
62_S94_A0.8940.50
49_S102_D0.8900.50
7_V15_D0.8850.49
64_E75_V0.8810.49
84_V89_A0.8760.49
13_K66_L0.8700.48
65_Q101_I0.8670.48
6_E69_A0.8650.48
6_E12_L0.8620.47
8_V11_F0.8510.47
54_N110_V0.8490.46
41_S45_G0.8330.45
7_V16_A0.8310.45
52_L78_L0.8240.44
11_F29_Q0.8110.43
4_F7_V0.8080.43
58_N97_L0.7940.42
80_Q110_V0.7790.41
7_V71_G0.7740.41
99_K107_Q0.7690.40
21_A28_E0.7690.40
2_G7_V0.7680.40
32_I77_D0.7630.40
44_L61_V0.7520.39
39_L53_S0.7500.39
2_G15_D0.7500.39
26_V99_K0.7320.37
22_I100_I0.7310.37
18_K24_S0.7300.37
7_V61_V0.7280.37
34_V62_S0.7270.37
92_L96_Q0.7260.37
8_V78_L0.7240.37
37_E41_S0.7210.37
55_Q66_L0.7180.36
79_G104_L0.7150.36
89_A92_L0.7150.36
22_I102_D0.7130.36
19_Y23_L0.7090.36
39_L42_G0.7090.36
64_E87_S0.7080.36
37_E49_S0.7080.36
52_L94_A0.7020.35
75_V95_E0.7000.35
82_L90_S0.6890.34
45_G112_P0.6840.34
4_F84_V0.6820.34
49_S52_L0.6780.33
99_K105_S0.6710.33
10_A14_G0.6700.33
50_T59_Q0.6670.33
86_T89_A0.6610.32
34_V80_Q0.6580.32
3_L100_I0.6530.32
19_Y37_E0.6500.31
19_Y52_L0.6470.31
34_V104_L0.6430.31
5_D10_A0.6420.31
82_L105_S0.6140.29
67_E94_A0.6100.29
66_L94_A0.6090.29
9_G14_G0.6040.28
73_N110_V0.6000.28
75_V88_T0.5990.28
42_G85_D0.5970.28
23_L32_I0.5970.28
23_L26_V0.5940.28
34_V43_G0.5930.28
87_S110_V0.5910.28
30_G108_G0.5890.27
45_G94_A0.5890.27
61_V66_L0.5890.27
23_L73_N0.5880.27
82_L89_A0.5850.27
39_L78_L0.5830.27
70_L81_K0.5830.27
85_D103_A0.5790.27
29_Q39_L0.5730.26
79_G86_T0.5730.26
16_A19_Y0.5620.26
2_G49_S0.5550.25
81_K95_E0.5510.25
24_S29_Q0.5510.25
13_K61_V0.5480.25
82_L86_T0.5470.25
91_S95_E0.5450.25
51_W98_P0.5440.25
49_S78_L0.5430.25
78_L109_E0.5420.24
85_D92_L0.5410.24
71_G106_P0.5400.24
63_G94_A0.5370.24
92_L104_L0.5350.24
54_N63_G0.5250.24
28_E32_I0.5220.23
91_S96_Q0.5200.23
70_L93_L0.5200.23
19_Y24_S0.5190.23
36_L69_A0.5170.23
66_L89_A0.5140.23
39_L61_V0.5120.23
25_W29_Q0.5060.22
74_A112_P0.5030.22
34_V65_Q0.5020.22
21_A27_E0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z67A 1 0.9545 100 0.11 Contact Map
3do6A 3 0.4697 18.8 0.93 Contact Map
1tuzA 1 0.5303 17.8 0.931 Contact Map
2gloA 1 0.3864 11.7 0.936 Contact Map
1qpzA 2 0.4394 11.6 0.936 Contact Map
3dbiA 2 0.1061 9.7 0.938 Contact Map
1neqA 1 0.4924 9.6 0.938 Contact Map
4fhrB 1 0.5152 9 0.939 Contact Map
1rzsA 1 0.3939 8.8 0.94 Contact Map
1jkoC 1 0.3182 8.3 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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