GREMLIN Database
REP - ATP-dependent DNA helicase Rep
UniProt: P09980 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10837
Length: 673 (615)
Sequences: 10981 (8114)
Seq/√Len: 327.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_H209_R5.0781.00
557_L599_G4.2681.00
367_I552_V3.9781.00
8_Q12_E3.9581.00
330_E333_A3.9141.00
195_Q225_E3.7871.00
327_V571_V3.5631.00
566_P605_K3.5161.00
573_M609_F3.4021.00
330_E569_Y3.3391.00
9_Q269_K3.2911.00
4_N277_Y3.2701.00
567_Y606_E3.2041.00
566_P604_Q3.1321.00
344_D566_P3.1291.00
340_T567_Y3.0371.00
575_E628_R2.9351.00
170_L173_A2.9241.00
335_H342_Y2.9011.00
343_K550_D2.8671.00
189_L192_L2.7601.00
570_M599_G2.7291.00
341_Q550_D2.7261.00
281_G285_K2.6891.00
555_M565_F2.5831.00
224_Y264_D2.5611.00
174_H177_A2.5501.00
6_G9_Q2.5491.00
332_I365_N2.5351.00
350_R592_E2.5211.00
462_E481_G2.4391.00
192_L196_R2.4221.00
80_M208_I2.4201.00
13_F18_C2.3721.00
228_K264_D2.3611.00
398_D401_A2.2781.00
46_Q49_H2.2761.00
569_Y608_T2.2611.00
342_Y368_P2.2471.00
331_L345_Y2.2471.00
349_Y554_L2.2431.00
382_E504_N2.2301.00
564_E604_Q2.1951.00
567_Y608_T2.1801.00
328_T365_N2.1671.00
330_E608_T2.1561.00
88_G190_P2.1141.00
477_D481_G2.1081.00
329_G365_N2.0891.00
187_I222_S2.0331.00
123_G170_L2.0301.00
62_E66_R2.0171.00
483_D486_S2.0141.00
475_V512_M2.0051.00
325_E361_F1.9771.00
173_A177_A1.9641.00
30_R34_N1.9591.00
174_H178_C1.9561.00
34_N70_T1.9441.00
195_Q229_L1.9441.00
325_E365_N1.9411.00
256_Q260_L1.9231.00
170_L174_H1.9141.00
600_I607_L1.9091.00
334_H567_Y1.9091.00
18_C271_I1.9001.00
466_L477_D1.8981.00
402_F406_V1.8941.00
306_L605_K1.8811.00
349_Y355_S1.8681.00
332_I336_F1.8631.00
340_T345_Y1.8611.00
95_E203_R1.8511.00
361_F364_Q1.8491.00
201_R205_Q1.8371.00
123_G174_H1.8331.00
82_S87_L1.8321.00
140_S184_D1.8261.00
108_F180_V1.8201.00
120_L174_H1.8011.00
358_F571_V1.7901.00
221_T254_R1.7871.00
36_I52_A1.7711.00
323_E610_T1.7661.00
335_H345_Y1.7651.00
191_T225_E1.7541.00
334_H569_Y1.7491.00
340_T605_K1.7461.00
198_E201_R1.7341.00
39_L210_Y1.7311.00
314_V611_L1.7251.00
361_F365_N1.7241.00
181_L189_L1.7241.00
317_A326_R1.7201.00
326_R610_T1.7161.00
91_I190_P1.7131.00
98_A200_V1.6841.00
85_H186_L1.6611.00
403_L422_G1.6541.00
20_V238_T1.6481.00
225_E228_K1.6481.00
65_E69_Q1.6401.00
334_H345_Y1.6331.00
276_N279_S1.6271.00
38_H42_G1.6271.00
334_H340_T1.6261.00
414_G417_T1.6261.00
485_E502_M1.6091.00
102_K179_N1.6021.00
169_G173_A1.6021.00
194_L201_R1.5791.00
175_L185_D1.5761.00
213_V227_V1.5681.00
341_Q344_D1.5661.00
244_D297_V1.5581.00
12_E38_H1.5511.00
530_V534_F1.5461.00
437_F461_A1.5401.00
202_K206_N1.5091.00
172_D175_L1.5081.00
327_V569_Y1.4991.00
382_E501_R1.4991.00
120_L124_L1.4871.00
290_L600_I1.4861.00
181_L186_L1.4731.00
96_Y181_L1.4661.00
486_S489_Y1.4641.00
346_A565_F1.4621.00
470_E473_A1.4611.00
310_A606_E1.4551.00
216_Y224_Y1.4491.00
211_L231_V1.4451.00
6_G275_Q1.4441.00
330_E334_H1.4401.00
419_K423_E1.4391.00
16_G269_K1.4371.00
235_A267_A1.4361.00
120_L170_L1.4321.00
392_V405_I1.4311.00
515_M529_Q1.4251.00
40_I71_L1.4231.00
202_K205_Q1.4221.00
484_Y488_L1.4161.00
275_Q305_E1.4131.00
91_I194_L1.4121.00
313_K330_E1.4121.00
347_I362_L1.4081.00
334_H608_T1.4041.00
286_A312_L1.4011.00
153_A169_G1.3981.00
18_C238_T1.3961.00
316_S611_L1.3951.00
91_I204_W1.3941.00
95_E204_W1.3881.00
51_A211_L1.3871.00
275_Q303_F1.3831.00
434_T438_D1.3831.00
119_E174_H1.3821.00
260_L263_Q1.3791.00
526_T529_Q1.3781.00
116_L174_H1.3781.00
485_E506_N1.3761.00
261_L268_L1.3761.00
313_K606_E1.3731.00
573_M596_A1.3721.00
350_R595_L1.3711.00
557_L578_L1.3631.00
33_T67_V1.3621.00
172_D176_K1.3581.00
335_H341_Q1.3571.00
286_A600_I1.3561.00
570_M609_F1.3551.00
386_L505_V1.3541.00
362_L554_L1.3531.00
37_A70_T1.3421.00
476_R509_F1.3411.00
117_L167_C1.3411.00
87_L91_I1.3381.00
148_T151_Q1.3361.00
354_Q572_G1.3321.00
454_T458_H1.3311.00
340_T566_P1.3311.00
355_S554_L1.3271.00
201_R229_L1.3231.00
260_L264_D1.3221.00
205_Q233_S1.3201.00
262_S270_V1.3201.00
36_I67_V1.3171.00
191_T226_L1.3171.00
197_N200_V1.3151.00
194_L229_L1.3141.00
327_V358_F1.3131.00
51_A208_I1.3091.00
88_G226_L1.3071.00
527_L530_V1.3031.00
331_L552_V1.2981.00
124_L170_L1.2961.00
349_Y571_V1.2871.00
193_L200_V1.2811.00
101_M189_L1.2801.00
6_G274_E1.2771.00
596_A600_I1.2751.00
281_G307_G1.2721.00
334_H606_E1.2701.00
416_A420_K1.2691.00
300_K304_S1.2691.00
448_R452_A1.2651.00
328_T361_F1.2631.00
5_P9_Q1.2611.00
626_P630_L1.2611.00
96_Y99_L1.2521.00
5_P8_Q1.2521.00
456_F460_L1.2491.00
171_Y182_D1.2421.00
391_R535_T1.2411.00
370_K551_Q1.2401.00
386_L475_V1.2401.00
80_M90_D1.2391.00
340_T344_D1.2391.00
24_A288_N1.2331.00
191_T229_L1.2331.00
446_S449_G1.2291.00
331_L569_Y1.2281.00
221_T225_E1.2271.00
35_K238_T1.2221.00
485_E489_Y1.2221.00
283_I287_A1.2201.00
388_A404_R1.2161.00
347_I358_F1.2121.00
342_Y345_Y1.2041.00
92_I190_P1.2021.00
163_I166_H1.2011.00
332_I342_Y1.2001.00
61_R65_E1.1971.00
567_Y605_K1.1971.00
166_H169_G1.1951.00
246_S249_S1.1941.00
390_L475_V1.1921.00
472_I516_L1.1851.00
9_Q12_E1.1841.00
99_L193_L1.1821.00
198_E202_K1.1751.00
76_A79_L1.1741.00
16_G236_R1.1731.00
385_D404_R1.1611.00
191_T195_Q1.1601.00
210_Y236_R1.1551.00
21_L243_D1.1521.00
120_L167_C1.1471.00
463_I481_G1.1431.00
204_W208_I1.1421.00
150_S169_G1.1411.00
67_V81_I1.1401.00
345_Y567_Y1.1371.00
89_L93_K1.1371.00
310_A313_K1.1361.00
39_L45_Y1.1351.00
389_Y478_L1.1331.00
248_Y251_R1.1291.00
61_R64_K1.1281.00
447_G450_Y1.1261.00
331_L342_Y1.1231.00
19_L239_V1.1191.00
38_H43_C1.1191.00
391_R401_A1.1171.00
424_W428_R1.1121.00
82_S86_T1.1021.00
98_A197_N1.0981.00
138_T142_W1.0981.00
402_F436_S1.0971.00
32_I212_L1.0941.00
36_I50_I1.0921.00
158_G161_D1.0891.00
121_T126_E1.0871.00
85_H187_I1.0861.00
508_L512_M1.0851.00
113_Q171_Y1.0851.00
317_A610_T1.0841.00
310_A314_V1.0791.00
119_E123_G1.0761.00
101_M181_L1.0741.00
351_G354_Q1.0731.00
90_D94_R1.0721.00
395_N398_D1.0721.00
555_M560_S1.0711.00
569_Y610_T1.0701.00
397_D431_S1.0681.00
94_R207_K1.0661.00
190_P226_L1.0651.00
430_K438_D1.0611.00
14_V39_L1.0611.00
324_A328_T1.0611.00
394_T528_T1.0581.00
362_L369_Y1.0541.00
13_F269_K1.0531.00
287_A601_T1.0511.00
386_L508_L1.0511.00
459_W463_I1.0461.00
58_K62_E1.0451.00
396_P464_Q1.0431.00
512_M530_V1.0401.00
407_N411_R1.0391.00
323_E572_G1.0381.00
523_E526_T1.0351.00
282_R285_K1.0351.00
457_T461_A1.0341.00
117_L136_I1.0331.00
146_L222_S1.0311.00
360_K364_Q1.0291.00
48_R78_G1.0271.00
345_Y569_Y1.0251.00
106_S112_D1.0241.00
295_P304_S1.0221.00
137_S141_N1.0221.00
316_S613_K1.0191.00
356_R360_K1.0181.00
333_A337_V1.0161.00
85_H184_D1.0121.00
530_V533_R1.0081.00
151_Q154_A1.0081.00
389_Y405_I0.9991.00
507_Q510_S0.9981.00
491_T498_A0.9981.00
325_E329_G0.9901.00
342_Y367_I0.9891.00
526_T530_V0.9881.00
392_V402_F0.9871.00
326_R330_E0.9841.00
13_F16_G0.9841.00
370_K553_Q0.9821.00
397_D434_T0.9771.00
246_S253_A0.9761.00
166_H170_L0.9731.00
455_R458_H0.9701.00
45_Y49_H0.9681.00
450_Y454_T0.9681.00
600_I609_F0.9641.00
318_N613_K0.9611.00
153_A165_A0.9581.00
318_N322_H0.9581.00
142_W147_K0.9581.00
393_L474_A0.9541.00
216_Y239_V0.9511.00
280_S605_K0.9451.00
176_K189_L0.9451.00
462_E477_D0.9421.00
301_R304_S0.9361.00
294_N304_S0.9321.00
142_W152_A0.9321.00
505_V509_F0.9321.00
19_L270_V0.9311.00
328_T332_I0.9311.00
10_A20_V0.9251.00
54_T59_A0.9241.00
141_N145_D0.9221.00
383_I508_L0.9211.00
53_V227_V0.9201.00
329_G333_A0.9171.00
14_V43_C0.9171.00
315_L326_R0.9151.00
472_I513_T0.9151.00
523_E530_V0.9141.00
352_N355_S0.9131.00
140_S144_N0.9121.00
110_D113_Q0.9111.00
405_I456_F0.9101.00
335_H340_T0.9091.00
393_L463_I0.9061.00
91_I193_L0.9051.00
332_I335_H0.9051.00
114_L132_L0.9031.00
190_P194_L0.9011.00
476_R480_H0.9001.00
95_E98_A0.8971.00
462_E466_L0.8961.00
421_L432_M0.8941.00
579_P592_E0.8931.00
359_E363_M0.8911.00
310_A315_L0.8901.00
168_Y172_D0.8891.00
571_V610_T0.8881.00
359_E369_Y0.8881.00
216_Y219_T0.8861.00
24_A597_Y0.8861.00
285_K289_I0.8831.00
294_N297_V0.8831.00
522_D525_M0.8831.00
294_N300_K0.8831.00
282_R312_L0.8791.00
433_F437_F0.8791.00
359_E554_L0.8791.00
448_R451_E0.8781.00
87_L204_W0.8771.00
437_F457_T0.8741.00
510_S514_E0.8741.00
415_P419_K0.8731.00
330_E606_E0.8711.00
97_A103_A0.8711.00
215_E561_K0.8711.00
53_V87_L0.8701.00
328_T362_L0.8691.00
580_H583_S0.8671.00
147_K152_A0.8671.00
144_N184_D0.8671.00
430_K435_A0.8651.00
428_R438_D0.8651.00
557_L570_M0.8631.00
262_S298_F0.8631.00
261_L265_F0.8621.00
17_P235_A0.8621.00
384_K388_A0.8551.00
143_K185_D0.8551.00
114_L133_Q0.8531.00
227_V237_F0.8521.00
372_S559_A0.8521.00
336_F339_K0.8461.00
35_K236_R0.8441.00
574_E612_C0.8431.00
449_G452_A0.8421.00
585_D588_N0.8421.00
461_A464_Q0.8361.00
458_H462_E0.8361.00
188_L222_S0.8331.00
289_I292_A0.8321.00
343_K551_Q0.8261.00
533_R537_R0.8251.00
295_P300_K0.8241.00
376_S379_S0.8231.00
452_A455_R0.8221.00
474_A478_L0.8221.00
124_L166_H0.8221.00
219_T257_N0.8211.00
291_I294_N0.8211.00
553_Q565_F0.8201.00
89_L186_L0.8191.00
334_H338_N0.8191.00
417_T452_A0.8191.00
187_I226_L0.8181.00
162_R166_H0.8181.00
463_I467_A0.8171.00
459_W462_E0.8131.00
324_A358_F0.8131.00
325_E364_Q0.8121.00
322_H325_E0.8121.00
525_M529_Q0.8111.00
287_A600_I0.8101.00
150_S154_A0.8091.00
297_V300_K0.8091.00
147_K151_Q0.8081.00
333_A338_N0.8081.00
331_L362_L0.8081.00
319_N322_H0.8071.00
40_I79_L0.8061.00
228_K265_F0.8051.00
534_F537_R0.8021.00
244_D291_I0.7991.00
573_M578_L0.7971.00
302_L305_E0.7961.00
357_V361_F0.7941.00
255_P258_L0.7941.00
477_D480_H0.7921.00
358_F554_L0.7921.00
489_Y502_M0.7901.00
98_A199_E0.7891.00
187_I191_T0.7891.00
299_E302_L0.7851.00
524_P530_V0.7851.00
546_E549_L0.7841.00
570_M573_M0.7841.00
486_S490_E0.7821.00
287_A290_L0.7821.00
246_S250_W0.7821.00
386_L479_I0.7811.00
459_W481_G0.7811.00
369_Y554_L0.7801.00
475_V509_F0.7801.00
165_A169_G0.7801.00
502_M506_N0.7791.00
117_L121_T0.7761.00
413_I417_T0.7751.00
327_V610_T0.7731.00
284_L287_A0.7721.00
385_D484_Y0.7721.00
472_I476_R0.7711.00
320_E357_V0.7711.00
243_D300_K0.7701.00
417_T420_K0.7691.00
99_L197_N0.7691.00
85_H220_N0.7671.00
514_E517_E0.7671.00
512_M515_M0.7661.00
380_R383_I0.7661.00
14_V38_H0.7651.00
522_D530_V0.7621.00
342_Y550_D0.7621.00
387_L391_R0.7601.00
299_E304_S0.7580.99
530_V535_T0.7570.99
113_Q136_I0.7560.99
135_L164_F0.7560.99
6_G303_F0.7540.99
85_H92_I0.7530.99
142_W164_F0.7520.99
560_S565_F0.7520.99
580_H584_I0.7510.99
68_G77_R0.7510.99
480_H485_E0.7510.99
191_T222_S0.7500.99
231_V237_F0.7490.99
461_A465_R0.7490.99
15_T210_Y0.7480.99
590_D593_R0.7470.99
64_K68_G0.7460.99
393_L478_L0.7460.99
328_T367_I0.7460.99
35_K210_Y0.7440.99
332_I367_I0.7440.99
475_V508_L0.7410.99
431_S434_T0.7400.99
455_R459_W0.7400.99
528_T532_T0.7390.99
139_I143_K0.7380.99
326_R608_T0.7380.99
463_I474_A0.7380.99
314_V630_L0.7370.99
465_R469_R0.7360.99
324_A361_F0.7340.99
17_P236_R0.7340.99
94_R203_R0.7330.99
284_L302_L0.7320.99
37_A41_R0.7320.99
479_I509_F0.7320.99
96_Y101_M0.7310.99
451_E455_R0.7310.99
117_L132_L0.7300.99
570_M596_A0.7290.99
132_L136_I0.7290.99
225_E229_L0.7240.99
531_V534_F0.7220.99
280_S283_I0.7210.99
279_S283_I0.7210.99
172_D189_L0.7190.99
433_F461_A0.7190.99
212_L238_T0.7190.99
152_A156_A0.7180.99
524_P528_T0.7180.99
14_V210_Y0.7180.99
523_E529_Q0.7180.99
405_I408_T0.7170.99
20_V271_I0.7170.99
529_Q533_R0.7160.99
60_A63_M0.7140.99
589_I628_R0.7130.99
598_V602_R0.7130.99
209_R234_R0.7110.99
424_W438_D0.7100.99
30_R33_T0.7100.99
52_A63_M0.7080.99
203_R206_N0.7070.99
626_P631_L0.7060.99
218_D561_K0.7060.99
141_N144_N0.7060.99
529_Q532_T0.7040.99
119_E178_C0.7040.99
194_L204_W0.7030.99
377_F383_I0.7030.99
513_T516_L0.7020.99
324_A357_V0.7010.99
282_R308_Y0.7010.99
391_R398_D0.6980.99
511_W530_V0.6970.99
53_V57_N0.6970.99
202_K233_S0.6950.99
49_H207_K0.6940.99
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105_F181_L0.5370.95
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175_L180_V0.5300.95
558_H561_K0.5300.95
456_F459_W0.5290.95
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205_Q234_R0.5290.95
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378_F382_E0.5280.95
95_E200_V0.5280.95
442_S445_L0.5270.95
50_I210_Y0.5270.95
59_A63_M0.5270.95
112_D180_V0.5260.95
55_F561_K0.5260.95
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433_F457_T0.5250.95
6_G271_I0.5250.95
522_D526_T0.5250.95
385_D408_T0.5250.95
592_E595_L0.5240.94
454_T457_T0.5240.94
465_R468_E0.5240.94
321_E357_V0.5240.94
463_I477_D0.5240.94
132_L135_L0.5240.94
218_D602_R0.5240.94
446_S450_Y0.5230.94
87_L208_I0.5230.94
92_I99_L0.5230.94
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473_A476_R0.5230.94
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377_F380_R0.5220.94
242_D561_K0.5220.94
67_V79_L0.5200.94
505_V512_M0.5200.94
171_Y592_E0.5200.94
98_A203_R0.5200.94
237_F261_L0.5190.94
216_Y258_L0.5190.94
346_A555_M0.5190.94
422_G425_A0.5190.94
449_G463_I0.5180.94
175_L182_D0.5170.94
20_V212_L0.5170.94
114_L136_I0.5160.94
30_R604_Q0.5150.94
391_R532_T0.5130.94
138_T146_L0.5130.94
239_V261_L0.5130.94
281_G306_L0.5130.94
224_Y228_K0.5120.94
513_T517_E0.5110.94
399_D431_S0.5110.94
204_W207_K0.5100.94
523_E528_T0.5100.94
215_E598_V0.5100.94
51_A230_L0.5100.94
324_A572_G0.5100.94
354_Q571_V0.5090.94
58_K66_R0.5090.94
55_F251_R0.5080.94
420_K423_E0.5080.94
51_A87_L0.5080.94
453_L456_F0.5080.94
217_Q245_Q0.5080.94
484_Y487_W0.5070.93
379_S384_K0.5060.93
533_R536_L0.5060.93
215_E562_G0.5060.93
85_H182_D0.5060.93
294_N593_R0.5050.93
115_A119_E0.5040.93
13_F236_R0.5040.93
121_T125_I0.5030.93
389_Y411_R0.5020.93
134_Q137_S0.5020.93
446_S452_A0.5000.93
30_R277_Y0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pjrA 1 0.9079 100 0.145 Contact Map
4c2tA 1 0.9435 100 0.146 Contact Map
1uaaA 2 0.948 100 0.152 Contact Map
3lfuA 1 0.9287 100 0.22 Contact Map
4c2uA 1 0.9495 100 0.224 Contact Map
3u4qA 1 0.9629 100 0.224 Contact Map
1w36B 1 0.9435 100 0.292 Contact Map
3u4qB 1 0.9316 100 0.352 Contact Map
4pj3A 1 0.7043 100 0.548 Contact Map
2xzlA 1 0.5988 100 0.623 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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