REP - ECOLI - GREMLIN Contacts

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REP - ATP-dependent DNA helicase Rep

UniProt:	P09980	Sequences: MRLNPGQQQAVEFVTGPCLVLAGAGSGKTRVITNKIAHLIRGCGYQARHIAAVTFTNKAAREMKERVGQTLGRKEARGLMISTFHTLGLDIIKREYAALGMKANFSLFDDTDQLALLKELTEGLIEDDKVLLQQLISTISNWKNDLKTPSQAAASAIGERDRIFAHCYGLYDAHLKACNVLDFDDLILLPTLLLQRNEEVRKRWQNKIRYLLVDEYQDTNTSQYELVKLLVGSRARFTVVGDDDQSIYSWRGARPQNLVLLSQDFPALKVIKLEQNYRSSGRILKAANILIANNPHVFEKRLFSELGYGAELKVLSANNEEHEAERVTGELIAHHFVNKTQYKDYAILYRGNHQSRVFEKFLMQNRIPYKISGGTSFFSRPEIKDLLAYLRVLTNPDDDSAFLRIVNTPKREIGPATLKKLGEWAMTRNKSMFTASFDMGLSQTLSGRGYEALTRFTHWLAEIQRLAEREPIAAVRDLIHGMDYESWLYETSPSPKAAEMRMKNVNQLFSWMTEMLEGSELDEPMTLTQVVTRFTLRDMMERGESEEELDQVQLMTLHASKGLEFPYVYMVGMEEGFLPHQSSIDEDNIDEERRLAYVGITRAQKELTFTLCKERRQYGELVRPEPSRFLLELPQDDLIWEQERKVVSAEERMQKGQSHLANLKAMMAAKRGK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10837
Length:	673 (615)
Sequences:	10981 (8114)
Seq/√Len:	327.2

ECOLI - REP UVRD RECB
BACSU - YJCD PCRA ADDA ADDB
HALSA - Q9HMB4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
49_H	209_R	5.078	1.00
557_L	599_G	4.268	1.00
367_I	552_V	3.978	1.00
8_Q	12_E	3.958	1.00
330_E	333_A	3.914	1.00
195_Q	225_E	3.787	1.00
327_V	571_V	3.563	1.00
566_P	605_K	3.516	1.00
573_M	609_F	3.402	1.00
330_E	569_Y	3.339	1.00
9_Q	269_K	3.291	1.00
4_N	277_Y	3.270	1.00
567_Y	606_E	3.204	1.00
566_P	604_Q	3.132	1.00
344_D	566_P	3.129	1.00
340_T	567_Y	3.037	1.00
575_E	628_R	2.935	1.00
170_L	173_A	2.924	1.00
335_H	342_Y	2.901	1.00
343_K	550_D	2.867	1.00
189_L	192_L	2.760	1.00
570_M	599_G	2.729	1.00
341_Q	550_D	2.726	1.00
281_G	285_K	2.689	1.00
555_M	565_F	2.583	1.00
224_Y	264_D	2.561	1.00
174_H	177_A	2.550	1.00
6_G	9_Q	2.549	1.00
332_I	365_N	2.535	1.00
350_R	592_E	2.521	1.00
462_E	481_G	2.439	1.00
192_L	196_R	2.422	1.00
80_M	208_I	2.420	1.00
13_F	18_C	2.372	1.00
228_K	264_D	2.361	1.00
398_D	401_A	2.278	1.00
46_Q	49_H	2.276	1.00
569_Y	608_T	2.261	1.00
342_Y	368_P	2.247	1.00
331_L	345_Y	2.247	1.00
349_Y	554_L	2.243	1.00
382_E	504_N	2.230	1.00
564_E	604_Q	2.195	1.00
567_Y	608_T	2.180	1.00
328_T	365_N	2.167	1.00
330_E	608_T	2.156	1.00
88_G	190_P	2.114	1.00
477_D	481_G	2.108	1.00
329_G	365_N	2.089	1.00
187_I	222_S	2.033	1.00
123_G	170_L	2.030	1.00
62_E	66_R	2.017	1.00
483_D	486_S	2.014	1.00
475_V	512_M	2.005	1.00
325_E	361_F	1.977	1.00
173_A	177_A	1.964	1.00
30_R	34_N	1.959	1.00
174_H	178_C	1.956	1.00
34_N	70_T	1.944	1.00
195_Q	229_L	1.944	1.00
325_E	365_N	1.941	1.00
256_Q	260_L	1.923	1.00
170_L	174_H	1.914	1.00
600_I	607_L	1.909	1.00
334_H	567_Y	1.909	1.00
18_C	271_I	1.900	1.00
466_L	477_D	1.898	1.00
402_F	406_V	1.894	1.00
306_L	605_K	1.881	1.00
349_Y	355_S	1.868	1.00
332_I	336_F	1.863	1.00
340_T	345_Y	1.861	1.00
95_E	203_R	1.851	1.00
361_F	364_Q	1.849	1.00
201_R	205_Q	1.837	1.00
123_G	174_H	1.833	1.00
82_S	87_L	1.832	1.00
140_S	184_D	1.826	1.00
108_F	180_V	1.820	1.00
120_L	174_H	1.801	1.00
358_F	571_V	1.790	1.00
221_T	254_R	1.787	1.00
36_I	52_A	1.771	1.00
323_E	610_T	1.766	1.00
335_H	345_Y	1.765	1.00
191_T	225_E	1.754	1.00
334_H	569_Y	1.749	1.00
340_T	605_K	1.746	1.00
198_E	201_R	1.734	1.00
39_L	210_Y	1.731	1.00
314_V	611_L	1.725	1.00
361_F	365_N	1.724	1.00
181_L	189_L	1.724	1.00
317_A	326_R	1.720	1.00
326_R	610_T	1.716	1.00
91_I	190_P	1.713	1.00
98_A	200_V	1.684	1.00
85_H	186_L	1.661	1.00
403_L	422_G	1.654	1.00
20_V	238_T	1.648	1.00
225_E	228_K	1.648	1.00
65_E	69_Q	1.640	1.00
334_H	345_Y	1.633	1.00
276_N	279_S	1.627	1.00
38_H	42_G	1.627	1.00
334_H	340_T	1.626	1.00
414_G	417_T	1.626	1.00
485_E	502_M	1.609	1.00
102_K	179_N	1.602	1.00
169_G	173_A	1.602	1.00
194_L	201_R	1.579	1.00
175_L	185_D	1.576	1.00
213_V	227_V	1.568	1.00
341_Q	344_D	1.566	1.00
244_D	297_V	1.558	1.00
12_E	38_H	1.551	1.00
530_V	534_F	1.546	1.00
437_F	461_A	1.540	1.00
202_K	206_N	1.509	1.00
172_D	175_L	1.508	1.00
327_V	569_Y	1.499	1.00
382_E	501_R	1.499	1.00
120_L	124_L	1.487	1.00
290_L	600_I	1.486	1.00
181_L	186_L	1.473	1.00
96_Y	181_L	1.466	1.00
486_S	489_Y	1.464	1.00
346_A	565_F	1.462	1.00
470_E	473_A	1.461	1.00
310_A	606_E	1.455	1.00
216_Y	224_Y	1.449	1.00
211_L	231_V	1.445	1.00
6_G	275_Q	1.444	1.00
330_E	334_H	1.440	1.00
419_K	423_E	1.439	1.00
16_G	269_K	1.437	1.00
235_A	267_A	1.436	1.00
120_L	170_L	1.432	1.00
392_V	405_I	1.431	1.00
515_M	529_Q	1.425	1.00
40_I	71_L	1.423	1.00
202_K	205_Q	1.422	1.00
484_Y	488_L	1.416	1.00
275_Q	305_E	1.413	1.00
91_I	194_L	1.412	1.00
313_K	330_E	1.412	1.00
347_I	362_L	1.408	1.00
334_H	608_T	1.404	1.00
286_A	312_L	1.401	1.00
153_A	169_G	1.398	1.00
18_C	238_T	1.396	1.00
316_S	611_L	1.395	1.00
91_I	204_W	1.394	1.00
95_E	204_W	1.388	1.00
51_A	211_L	1.387	1.00
275_Q	303_F	1.383	1.00
434_T	438_D	1.383	1.00
119_E	174_H	1.382	1.00
260_L	263_Q	1.379	1.00
526_T	529_Q	1.378	1.00
116_L	174_H	1.378	1.00
485_E	506_N	1.376	1.00
261_L	268_L	1.376	1.00
313_K	606_E	1.373	1.00
573_M	596_A	1.372	1.00
350_R	595_L	1.371	1.00
557_L	578_L	1.363	1.00
33_T	67_V	1.362	1.00
172_D	176_K	1.358	1.00
335_H	341_Q	1.357	1.00
286_A	600_I	1.356	1.00
570_M	609_F	1.355	1.00
386_L	505_V	1.354	1.00
362_L	554_L	1.353	1.00
37_A	70_T	1.342	1.00
476_R	509_F	1.341	1.00
117_L	167_C	1.341	1.00
87_L	91_I	1.338	1.00
148_T	151_Q	1.336	1.00
354_Q	572_G	1.332	1.00
454_T	458_H	1.331	1.00
340_T	566_P	1.331	1.00
355_S	554_L	1.327	1.00
201_R	229_L	1.323	1.00
260_L	264_D	1.322	1.00
205_Q	233_S	1.320	1.00
262_S	270_V	1.320	1.00
36_I	67_V	1.317	1.00
191_T	226_L	1.317	1.00
197_N	200_V	1.315	1.00
194_L	229_L	1.314	1.00
327_V	358_F	1.313	1.00
51_A	208_I	1.309	1.00
88_G	226_L	1.307	1.00
527_L	530_V	1.303	1.00
331_L	552_V	1.298	1.00
124_L	170_L	1.296	1.00
349_Y	571_V	1.287	1.00
193_L	200_V	1.281	1.00
101_M	189_L	1.280	1.00
6_G	274_E	1.277	1.00
596_A	600_I	1.275	1.00
281_G	307_G	1.272	1.00
334_H	606_E	1.270	1.00
416_A	420_K	1.269	1.00
300_K	304_S	1.269	1.00
448_R	452_A	1.265	1.00
328_T	361_F	1.263	1.00
5_P	9_Q	1.261	1.00
626_P	630_L	1.261	1.00
96_Y	99_L	1.252	1.00
5_P	8_Q	1.252	1.00
456_F	460_L	1.249	1.00
171_Y	182_D	1.242	1.00
391_R	535_T	1.241	1.00
370_K	551_Q	1.240	1.00
386_L	475_V	1.240	1.00
80_M	90_D	1.239	1.00
340_T	344_D	1.239	1.00
24_A	288_N	1.233	1.00
191_T	229_L	1.233	1.00
446_S	449_G	1.229	1.00
331_L	569_Y	1.228	1.00
221_T	225_E	1.227	1.00
35_K	238_T	1.222	1.00
485_E	489_Y	1.222	1.00
283_I	287_A	1.220	1.00
388_A	404_R	1.216	1.00
347_I	358_F	1.212	1.00
342_Y	345_Y	1.204	1.00
92_I	190_P	1.202	1.00
163_I	166_H	1.201	1.00
332_I	342_Y	1.200	1.00
61_R	65_E	1.197	1.00
567_Y	605_K	1.197	1.00
166_H	169_G	1.195	1.00
246_S	249_S	1.194	1.00
390_L	475_V	1.192	1.00
472_I	516_L	1.185	1.00
9_Q	12_E	1.184	1.00
99_L	193_L	1.182	1.00
198_E	202_K	1.175	1.00
76_A	79_L	1.174	1.00
16_G	236_R	1.173	1.00
385_D	404_R	1.161	1.00
191_T	195_Q	1.160	1.00
210_Y	236_R	1.155	1.00
21_L	243_D	1.152	1.00
120_L	167_C	1.147	1.00
463_I	481_G	1.143	1.00
204_W	208_I	1.142	1.00
150_S	169_G	1.141	1.00
67_V	81_I	1.140	1.00
345_Y	567_Y	1.137	1.00
89_L	93_K	1.137	1.00
310_A	313_K	1.136	1.00
39_L	45_Y	1.135	1.00
389_Y	478_L	1.133	1.00
248_Y	251_R	1.129	1.00
61_R	64_K	1.128	1.00
447_G	450_Y	1.126	1.00
331_L	342_Y	1.123	1.00
19_L	239_V	1.119	1.00
38_H	43_C	1.119	1.00
391_R	401_A	1.117	1.00
424_W	428_R	1.112	1.00
82_S	86_T	1.102	1.00
98_A	197_N	1.098	1.00
138_T	142_W	1.098	1.00
402_F	436_S	1.097	1.00
32_I	212_L	1.094	1.00
36_I	50_I	1.092	1.00
158_G	161_D	1.089	1.00
121_T	126_E	1.087	1.00
85_H	187_I	1.086	1.00
508_L	512_M	1.085	1.00
113_Q	171_Y	1.085	1.00
317_A	610_T	1.084	1.00
310_A	314_V	1.079	1.00
119_E	123_G	1.076	1.00
101_M	181_L	1.074	1.00
351_G	354_Q	1.073	1.00
90_D	94_R	1.072	1.00
395_N	398_D	1.072	1.00
555_M	560_S	1.071	1.00
569_Y	610_T	1.070	1.00
397_D	431_S	1.068	1.00
94_R	207_K	1.066	1.00
190_P	226_L	1.065	1.00
430_K	438_D	1.061	1.00
14_V	39_L	1.061	1.00
324_A	328_T	1.061	1.00
394_T	528_T	1.058	1.00
362_L	369_Y	1.054	1.00
13_F	269_K	1.053	1.00
287_A	601_T	1.051	1.00
386_L	508_L	1.051	1.00
459_W	463_I	1.046	1.00
58_K	62_E	1.045	1.00
396_P	464_Q	1.043	1.00
512_M	530_V	1.040	1.00
407_N	411_R	1.039	1.00
323_E	572_G	1.038	1.00
523_E	526_T	1.035	1.00
282_R	285_K	1.035	1.00
457_T	461_A	1.034	1.00
117_L	136_I	1.033	1.00
146_L	222_S	1.031	1.00
360_K	364_Q	1.029	1.00
48_R	78_G	1.027	1.00
345_Y	569_Y	1.025	1.00
106_S	112_D	1.024	1.00
295_P	304_S	1.022	1.00
137_S	141_N	1.022	1.00
316_S	613_K	1.019	1.00
356_R	360_K	1.018	1.00
333_A	337_V	1.016	1.00
85_H	184_D	1.012	1.00
530_V	533_R	1.008	1.00
151_Q	154_A	1.008	1.00
389_Y	405_I	0.999	1.00
507_Q	510_S	0.998	1.00
491_T	498_A	0.998	1.00
325_E	329_G	0.990	1.00
342_Y	367_I	0.989	1.00
526_T	530_V	0.988	1.00
392_V	402_F	0.987	1.00
326_R	330_E	0.984	1.00
13_F	16_G	0.984	1.00
370_K	553_Q	0.982	1.00
397_D	434_T	0.977	1.00
246_S	253_A	0.976	1.00
166_H	170_L	0.973	1.00
455_R	458_H	0.970	1.00
45_Y	49_H	0.968	1.00
450_Y	454_T	0.968	1.00
600_I	609_F	0.964	1.00
318_N	613_K	0.961	1.00
153_A	165_A	0.958	1.00
318_N	322_H	0.958	1.00
142_W	147_K	0.958	1.00
393_L	474_A	0.954	1.00
216_Y	239_V	0.951	1.00
280_S	605_K	0.945	1.00
176_K	189_L	0.945	1.00
462_E	477_D	0.942	1.00
301_R	304_S	0.936	1.00
294_N	304_S	0.932	1.00
142_W	152_A	0.932	1.00
505_V	509_F	0.932	1.00
19_L	270_V	0.931	1.00
328_T	332_I	0.931	1.00
10_A	20_V	0.925	1.00
54_T	59_A	0.924	1.00
141_N	145_D	0.922	1.00
383_I	508_L	0.921	1.00
53_V	227_V	0.920	1.00
329_G	333_A	0.917	1.00
14_V	43_C	0.917	1.00
315_L	326_R	0.915	1.00
472_I	513_T	0.915	1.00
523_E	530_V	0.914	1.00
352_N	355_S	0.913	1.00
140_S	144_N	0.912	1.00
110_D	113_Q	0.911	1.00
405_I	456_F	0.910	1.00
335_H	340_T	0.909	1.00
393_L	463_I	0.906	1.00
91_I	193_L	0.905	1.00
332_I	335_H	0.905	1.00
114_L	132_L	0.903	1.00
190_P	194_L	0.901	1.00
476_R	480_H	0.900	1.00
95_E	98_A	0.897	1.00
462_E	466_L	0.896	1.00
421_L	432_M	0.894	1.00
579_P	592_E	0.893	1.00
359_E	363_M	0.891	1.00
310_A	315_L	0.890	1.00
168_Y	172_D	0.889	1.00
571_V	610_T	0.888	1.00
359_E	369_Y	0.888	1.00
216_Y	219_T	0.886	1.00
24_A	597_Y	0.886	1.00
285_K	289_I	0.883	1.00
294_N	297_V	0.883	1.00
522_D	525_M	0.883	1.00
294_N	300_K	0.883	1.00
282_R	312_L	0.879	1.00
433_F	437_F	0.879	1.00
359_E	554_L	0.879	1.00
448_R	451_E	0.878	1.00
87_L	204_W	0.877	1.00
437_F	457_T	0.874	1.00
510_S	514_E	0.874	1.00
415_P	419_K	0.873	1.00
330_E	606_E	0.871	1.00
97_A	103_A	0.871	1.00
215_E	561_K	0.871	1.00
53_V	87_L	0.870	1.00
328_T	362_L	0.869	1.00
580_H	583_S	0.867	1.00
147_K	152_A	0.867	1.00
144_N	184_D	0.867	1.00
430_K	435_A	0.865	1.00
428_R	438_D	0.865	1.00
557_L	570_M	0.863	1.00
262_S	298_F	0.863	1.00
261_L	265_F	0.862	1.00
17_P	235_A	0.862	1.00
384_K	388_A	0.855	1.00
143_K	185_D	0.855	1.00
114_L	133_Q	0.853	1.00
227_V	237_F	0.852	1.00
372_S	559_A	0.852	1.00
336_F	339_K	0.846	1.00
35_K	236_R	0.844	1.00
574_E	612_C	0.843	1.00
449_G	452_A	0.842	1.00
585_D	588_N	0.842	1.00
461_A	464_Q	0.836	1.00
458_H	462_E	0.836	1.00
188_L	222_S	0.833	1.00
289_I	292_A	0.832	1.00
343_K	551_Q	0.826	1.00
533_R	537_R	0.825	1.00
295_P	300_K	0.824	1.00
376_S	379_S	0.823	1.00
452_A	455_R	0.822	1.00
474_A	478_L	0.822	1.00
124_L	166_H	0.822	1.00
219_T	257_N	0.821	1.00
291_I	294_N	0.821	1.00
553_Q	565_F	0.820	1.00
89_L	186_L	0.819	1.00
334_H	338_N	0.819	1.00
417_T	452_A	0.819	1.00
187_I	226_L	0.818	1.00
162_R	166_H	0.818	1.00
463_I	467_A	0.817	1.00
459_W	462_E	0.813	1.00
324_A	358_F	0.813	1.00
325_E	364_Q	0.812	1.00
322_H	325_E	0.812	1.00
525_M	529_Q	0.811	1.00
287_A	600_I	0.810	1.00
150_S	154_A	0.809	1.00
297_V	300_K	0.809	1.00
147_K	151_Q	0.808	1.00
333_A	338_N	0.808	1.00
331_L	362_L	0.808	1.00
319_N	322_H	0.807	1.00
40_I	79_L	0.806	1.00
228_K	265_F	0.805	1.00
534_F	537_R	0.802	1.00
244_D	291_I	0.799	1.00
573_M	578_L	0.797	1.00
302_L	305_E	0.796	1.00
357_V	361_F	0.794	1.00
255_P	258_L	0.794	1.00
477_D	480_H	0.792	1.00
358_F	554_L	0.792	1.00
489_Y	502_M	0.790	1.00
98_A	199_E	0.789	1.00
187_I	191_T	0.789	1.00
299_E	302_L	0.785	1.00
524_P	530_V	0.785	1.00
546_E	549_L	0.784	1.00
570_M	573_M	0.784	1.00
486_S	490_E	0.782	1.00
287_A	290_L	0.782	1.00
246_S	250_W	0.782	1.00
386_L	479_I	0.781	1.00
459_W	481_G	0.781	1.00
369_Y	554_L	0.780	1.00
475_V	509_F	0.780	1.00
165_A	169_G	0.780	1.00
502_M	506_N	0.779	1.00
117_L	121_T	0.776	1.00
413_I	417_T	0.775	1.00
327_V	610_T	0.773	1.00
284_L	287_A	0.772	1.00
385_D	484_Y	0.772	1.00
472_I	476_R	0.771	1.00
320_E	357_V	0.771	1.00
243_D	300_K	0.770	1.00
417_T	420_K	0.769	1.00
99_L	197_N	0.769	1.00
85_H	220_N	0.767	1.00
514_E	517_E	0.767	1.00
512_M	515_M	0.766	1.00
380_R	383_I	0.766	1.00
14_V	38_H	0.765	1.00
522_D	530_V	0.762	1.00
342_Y	550_D	0.762	1.00
387_L	391_R	0.760	1.00
299_E	304_S	0.758	0.99
530_V	535_T	0.757	0.99
113_Q	136_I	0.756	0.99
135_L	164_F	0.756	0.99
6_G	303_F	0.754	0.99
85_H	92_I	0.753	0.99
142_W	164_F	0.752	0.99
560_S	565_F	0.752	0.99
580_H	584_I	0.751	0.99
68_G	77_R	0.751	0.99
480_H	485_E	0.751	0.99
191_T	222_S	0.750	0.99
231_V	237_F	0.749	0.99
461_A	465_R	0.749	0.99
15_T	210_Y	0.748	0.99
590_D	593_R	0.747	0.99
64_K	68_G	0.746	0.99
393_L	478_L	0.746	0.99
328_T	367_I	0.746	0.99
35_K	210_Y	0.744	0.99
332_I	367_I	0.744	0.99
475_V	508_L	0.741	0.99
431_S	434_T	0.740	0.99
455_R	459_W	0.740	0.99
528_T	532_T	0.739	0.99
139_I	143_K	0.738	0.99
326_R	608_T	0.738	0.99
463_I	474_A	0.738	0.99
314_V	630_L	0.737	0.99
465_R	469_R	0.736	0.99
324_A	361_F	0.734	0.99
17_P	236_R	0.734	0.99
94_R	203_R	0.733	0.99
284_L	302_L	0.732	0.99
37_A	41_R	0.732	0.99
479_I	509_F	0.732	0.99
96_Y	101_M	0.731	0.99
451_E	455_R	0.731	0.99
117_L	132_L	0.730	0.99
570_M	596_A	0.729	0.99
132_L	136_I	0.729	0.99
225_E	229_L	0.724	0.99
531_V	534_F	0.722	0.99
280_S	283_I	0.721	0.99
279_S	283_I	0.721	0.99
172_D	189_L	0.719	0.99
433_F	461_A	0.719	0.99
212_L	238_T	0.719	0.99
152_A	156_A	0.718	0.99
524_P	528_T	0.718	0.99
14_V	210_Y	0.718	0.99
523_E	529_Q	0.718	0.99
405_I	408_T	0.717	0.99
20_V	271_I	0.717	0.99
529_Q	533_R	0.716	0.99
60_A	63_M	0.714	0.99
589_I	628_R	0.713	0.99
598_V	602_R	0.713	0.99
209_R	234_R	0.711	0.99
424_W	438_D	0.710	0.99
30_R	33_T	0.710	0.99
52_A	63_M	0.708	0.99
203_R	206_N	0.707	0.99
626_P	631_L	0.706	0.99
218_D	561_K	0.706	0.99
141_N	144_N	0.706	0.99
529_Q	532_T	0.704	0.99
119_E	178_C	0.704	0.99
194_L	204_W	0.703	0.99
377_F	383_I	0.703	0.99
513_T	516_L	0.702	0.99
324_A	357_V	0.701	0.99
282_R	308_Y	0.701	0.99
391_R	398_D	0.698	0.99
511_W	530_V	0.697	0.99
53_V	57_N	0.697	0.99
202_K	233_S	0.695	0.99
49_H	207_K	0.694	0.99
385_D	388_A	0.694	0.99
84_F	219_T	0.693	0.99
80_M	207_K	0.692	0.99
228_K	232_G	0.691	0.99
89_L	107_L	0.691	0.99
416_A	419_K	0.689	0.99
424_W	435_A	0.689	0.99
285_K	308_Y	0.687	0.99
538_D	542_R	0.687	0.99
524_P	534_F	0.687	0.99
38_H	41_R	0.687	0.99
503_K	506_N	0.687	0.99
338_N	344_D	0.686	0.99
85_H	181_L	0.686	0.99
20_V	31_V	0.685	0.99
388_A	401_A	0.685	0.99
290_L	596_A	0.684	0.99
501_R	504_N	0.684	0.99
213_V	239_V	0.680	0.99
292_A	299_E	0.679	0.99
156_A	165_A	0.679	0.99
23_G	26_S	0.679	0.99
438_D	442_S	0.676	0.99
245_Q	598_V	0.676	0.99
33_T	63_M	0.675	0.99
342_Y	552_V	0.675	0.99
206_N	233_S	0.674	0.99
34_N	38_H	0.673	0.99
110_D	136_I	0.672	0.99
408_T	487_W	0.668	0.99
492_S	496_K	0.668	0.99
108_F	175_L	0.667	0.99
59_A	62_E	0.667	0.99
24_A	244_D	0.666	0.99
173_A	176_K	0.664	0.99
106_S	180_V	0.664	0.99
385_D	409_P	0.663	0.99
466_L	469_R	0.663	0.99
149_P	168_Y	0.663	0.99
470_E	516_L	0.663	0.99
208_I	211_L	0.662	0.99
185_D	189_L	0.662	0.99
423_E	427_T	0.661	0.99
75_E	78_G	0.661	0.99
447_G	451_E	0.661	0.99
120_L	123_G	0.659	0.99
570_M	600_I	0.659	0.99
70_T	73_R	0.659	0.99
515_M	530_V	0.655	0.99
117_L	120_L	0.654	0.99
471_P	474_A	0.654	0.99
422_G	426_M	0.653	0.99
472_I	509_F	0.653	0.99
359_E	371_I	0.650	0.98
39_L	50_I	0.650	0.98
133_Q	137_S	0.650	0.98
171_Y	175_L	0.650	0.98
279_S	284_L	0.650	0.98
82_S	90_D	0.649	0.98
57_N	61_R	0.648	0.98
326_R	329_G	0.645	0.98
561_K	598_V	0.644	0.98
390_L	394_T	0.644	0.98
597_Y	601_T	0.644	0.98
362_L	552_V	0.642	0.98
342_Y	566_P	0.641	0.98
257_N	261_L	0.641	0.98
521_L	524_P	0.641	0.98
229_L	232_G	0.639	0.98
221_T	260_L	0.639	0.98
297_V	302_L	0.639	0.98
381_P	408_T	0.639	0.98
211_L	230_L	0.638	0.98
443_Q	446_S	0.638	0.98
500_M	503_K	0.638	0.98
574_E	615_R	0.638	0.98
455_R	481_G	0.638	0.98
121_T	167_C	0.638	0.98
241_G	245_Q	0.637	0.98
138_T	141_N	0.636	0.98
135_L	139_I	0.636	0.98
160_R	164_F	0.636	0.98
19_L	258_L	0.635	0.98
531_V	535_T	0.635	0.98
524_P	533_R	0.634	0.98
258_L	262_S	0.631	0.98
509_F	512_M	0.630	0.98
9_Q	271_I	0.630	0.98
255_P	259_V	0.629	0.98
432_M	435_A	0.629	0.98
424_W	427_T	0.626	0.98
34_N	37_A	0.626	0.98
450_Y	457_T	0.626	0.98
381_P	385_D	0.626	0.98
259_V	263_Q	0.625	0.98
57_N	60_A	0.624	0.98
479_I	485_E	0.623	0.98
408_T	484_Y	0.622	0.98
282_R	311_E	0.622	0.98
387_L	534_F	0.622	0.98
349_Y	358_F	0.620	0.98
506_N	510_S	0.619	0.98
417_T	453_L	0.618	0.98
284_L	288_N	0.617	0.98
218_D	598_V	0.616	0.98
21_L	258_L	0.616	0.98
540_M	543_G	0.615	0.98
598_V	601_T	0.614	0.98
386_L	484_Y	0.614	0.98
274_E	301_R	0.614	0.98
335_H	550_D	0.614	0.98
63_M	66_R	0.613	0.98
476_R	506_N	0.613	0.98
362_L	367_I	0.612	0.98
434_T	437_F	0.612	0.98
35_K	212_L	0.611	0.98
215_E	218_D	0.611	0.98
328_T	552_V	0.611	0.98
417_T	449_G	0.610	0.98
110_D	114_L	0.609	0.98
57_N	85_H	0.608	0.98
206_N	234_R	0.608	0.98
579_P	582_S	0.607	0.98
151_Q	155_S	0.607	0.98
576_G	581_Q	0.606	0.98
510_S	513_T	0.606	0.98
241_G	258_L	0.606	0.98
219_T	253_A	0.605	0.98
453_L	457_T	0.605	0.98
203_R	207_K	0.603	0.98
55_F	215_E	0.602	0.97
36_I	79_L	0.602	0.97
92_I	193_L	0.601	0.97
451_E	454_T	0.601	0.97
36_I	212_L	0.601	0.97
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300_K	303_F	0.600	0.97
390_L	474_A	0.600	0.97
99_L	189_L	0.600	0.97
313_K	608_T	0.600	0.97
286_A	290_L	0.599	0.97
377_F	504_N	0.598	0.97
9_Q	13_F	0.598	0.97
107_L	186_L	0.597	0.97
68_G	76_A	0.596	0.97
243_D	272_K	0.595	0.97
219_T	223_Q	0.594	0.97
330_E	610_T	0.593	0.97
54_T	63_M	0.593	0.97
15_T	43_C	0.593	0.97
528_T	534_F	0.592	0.97
593_R	629_F	0.591	0.97
258_L	261_L	0.589	0.97
287_A	291_I	0.589	0.97
487_W	491_T	0.588	0.97
108_F	112_D	0.588	0.97
492_S	497_A	0.587	0.97
146_L	188_L	0.586	0.97
146_L	225_E	0.585	0.97
348_L	557_L	0.584	0.97
85_H	558_H	0.584	0.97
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407_N	415_P	0.583	0.97
143_K	146_L	0.583	0.97
244_D	300_K	0.583	0.97
281_G	308_Y	0.582	0.97
72_G	76_A	0.582	0.97
322_H	326_R	0.582	0.97
40_I	47_A	0.582	0.97
309_G	312_L	0.580	0.97
59_A	66_R	0.579	0.97
84_F	227_V	0.579	0.97
215_E	278_R	0.579	0.97
280_S	309_G	0.578	0.97
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357_V	360_K	0.576	0.97
279_S	287_A	0.575	0.97
463_I	478_L	0.574	0.97
312_L	315_L	0.573	0.97
387_L	531_V	0.572	0.97
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131_L	135_L	0.570	0.97
254_R	257_N	0.570	0.97
116_L	120_L	0.567	0.96
127_D	130_V	0.566	0.96
40_I	45_Y	0.566	0.96
88_G	187_I	0.566	0.96
245_Q	558_H	0.565	0.96
522_D	529_Q	0.565	0.96
111_T	114_L	0.565	0.96
589_I	592_E	0.565	0.96
445_L	449_G	0.564	0.96
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12_E	42_G	0.563	0.96
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218_D	562_G	0.561	0.96
372_S	553_Q	0.560	0.96
511_W	514_E	0.559	0.96
427_T	444_T	0.559	0.96
298_F	302_L	0.559	0.96
63_M	81_I	0.558	0.96
478_L	481_G	0.557	0.96
283_I	312_L	0.557	0.96
30_R	66_R	0.557	0.96
56_T	59_A	0.556	0.96
442_S	450_Y	0.556	0.96
263_Q	297_V	0.556	0.96
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136_I	139_I	0.555	0.96
117_L	139_I	0.555	0.96
116_L	178_C	0.555	0.96
57_N	89_L	0.554	0.96
297_V	304_S	0.554	0.96
323_E	327_V	0.554	0.96
13_F	17_P	0.553	0.96
382_E	505_V	0.553	0.96
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33_T	70_T	0.552	0.96
52_A	212_L	0.552	0.96
242_D	245_Q	0.552	0.96
487_W	490_E	0.551	0.96
188_L	191_T	0.551	0.96
311_E	315_L	0.550	0.96
545_S	551_Q	0.550	0.96
348_L	555_M	0.550	0.96
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253_A	257_N	0.548	0.96
526_T	534_F	0.548	0.96
426_M	429_N	0.547	0.96
338_N	606_E	0.546	0.96
157_I	160_R	0.546	0.96
422_G	432_M	0.546	0.96
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292_A	301_R	0.545	0.96
188_L	192_L	0.545	0.96
464_Q	467_A	0.543	0.95
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591_E	594_R	0.541	0.95
192_L	195_Q	0.540	0.95
476_R	513_T	0.540	0.95
406_V	413_I	0.540	0.95
449_G	459_W	0.539	0.95
109_D	112_D	0.539	0.95
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281_G	304_S	0.537	0.95
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168_Y	175_L	0.534	0.95
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274_E	303_F	0.533	0.95
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102_K	397_D	0.532	0.95
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215_E	242_D	0.531	0.95
175_L	180_V	0.530	0.95
558_H	561_K	0.530	0.95
456_F	459_W	0.529	0.95
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190_P	193_L	0.528	0.95
378_F	382_E	0.528	0.95
95_E	200_V	0.528	0.95
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112_D	180_V	0.526	0.95
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522_D	526_T	0.525	0.95
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592_E	595_L	0.524	0.94
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153_A	166_H	0.522	0.94
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449_G	463_I	0.518	0.94
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114_L	136_I	0.516	0.94
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239_V	261_L	0.513	0.94
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224_Y	228_K	0.512	0.94
513_T	517_E	0.511	0.94
399_D	431_S	0.511	0.94
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523_E	528_T	0.510	0.94
215_E	598_V	0.510	0.94
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324_A	572_G	0.510	0.94
354_Q	571_V	0.509	0.94
58_K	66_R	0.509	0.94
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420_K	423_E	0.508	0.94
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217_Q	245_Q	0.508	0.94
484_Y	487_W	0.507	0.93
379_S	384_K	0.506	0.93
533_R	536_L	0.506	0.93
215_E	562_G	0.506	0.93
85_H	182_D	0.506	0.93
294_N	593_R	0.505	0.93
115_A	119_E	0.504	0.93
13_F	236_R	0.504	0.93
121_T	125_I	0.503	0.93
389_Y	411_R	0.502	0.93
134_Q	137_S	0.502	0.93
446_S	452_A	0.500	0.93
30_R	277_Y	0.500	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1pjrA	1	0.9079	100	0.145	Contact Map
4c2tA	1	0.9435	100	0.146	Contact Map
1uaaA	2	0.948	100	0.152	Contact Map
3lfuA	1	0.9287	100	0.22	Contact Map
4c2uA	1	0.9495	100	0.224	Contact Map
3u4qA	1	0.9629	100	0.224	Contact Map
1w36B	1	0.9435	100	0.292	Contact Map
3u4qB	1	0.9316	100	0.352	Contact Map
4pj3A	1	0.7043	100	0.548	Contact Map
2xzlA	1	0.5988	100	0.623	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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