GREMLIN Database
UHPB - Sensor protein UhpB
UniProt: P09835 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11052
Length: 500 (412)
Sequences: 5836 (5360)
Seq/√Len: 264.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
327_A347_I5.0861.00
276_L279_L4.0371.00
294_A297_L3.7451.00
471_R475_T3.7111.00
450_E490_R3.6531.00
429_A452_D3.6521.00
482_H492_S3.5401.00
444_R494_S3.4951.00
483_I491_V3.4041.00
474_V479_G3.2061.00
451_D455_G3.1531.00
276_L280_N3.1241.00
417_V474_V3.0721.00
448_V492_S3.0641.00
374_T377_Q3.0641.00
470_M481_L3.0601.00
437_Q448_V3.0591.00
417_V473_R3.0211.00
474_V493_V2.9631.00
448_V490_R2.8331.00
446_M494_S2.8021.00
283_L287_L2.7841.00
279_L283_L2.6901.00
396_H433_A2.6571.00
398_E437_Q2.6511.00
331_Q348_E2.6431.00
485_C489_T2.6131.00
447_L493_V2.5561.00
446_M492_S2.5401.00
324_R351_S2.5171.00
287_L290_N2.4161.00
441_Q446_M2.3681.00
451_D488_G2.3271.00
373_L409_N2.3241.00
280_N283_L2.3231.00
425_I434_V2.2681.00
439_W446_M2.2421.00
409_N477_L2.2251.00
330_V344_G2.2161.00
437_Q450_E2.2131.00
293_L297_L2.1561.00
433_A452_D2.1311.00
283_L286_E2.1241.00
323_I351_S2.0961.00
439_W448_V2.0851.00
413_T416_R2.0691.00
396_H435_T2.0501.00
323_I347_I2.0461.00
336_D340_V2.0251.00
484_S490_R2.0181.00
480_T494_S2.0041.00
435_T450_E1.9831.00
315_D416_R1.9771.00
398_E435_T1.9761.00
417_V470_M1.9731.00
331_Q345_Q1.9061.00
429_A432_S1.8921.00
290_N293_L1.8881.00
473_R477_L1.8811.00
418_C447_L1.8291.00
333_L340_V1.8211.00
302_E306_R1.7891.00
280_N284_Q1.7341.00
429_A434_V1.7111.00
286_E290_N1.7011.00
316_I354_V1.6911.00
381_S415_F1.6731.00
371_D411_R1.6391.00
423_N427_K1.6201.00
416_R419_Q1.6191.00
315_D318_Q1.6001.00
315_D319_T1.5861.00
303_S307_D1.5841.00
291_Q295_E1.5511.00
422_L436_L1.5391.00
330_V340_V1.5371.00
96_P102_R1.5321.00
302_E305_R1.5141.00
337_N340_V1.5141.00
432_S452_D1.5131.00
475_T480_T1.5011.00
445_L497_Q1.4971.00
407_S410_Q1.4961.00
394_V433_A1.4921.00
98_A102_R1.4801.00
290_N294_A1.4491.00
280_N287_L1.4351.00
456_L489_T1.4341.00
324_R352_L1.4321.00
305_R309_A1.4301.00
325_T329_I1.4251.00
484_S492_S1.4071.00
360_R413_T1.4011.00
99_L102_R1.3981.00
327_A344_G1.3941.00
315_D357_A1.3891.00
421_G491_V1.3881.00
327_A351_S1.3791.00
421_G470_M1.3781.00
326_Q343_S1.3681.00
388_L426_V1.3601.00
317_G359_R1.3561.00
328_G348_E1.3491.00
413_T473_R1.3451.00
465_F469_G1.3441.00
287_L291_Q1.3261.00
455_G489_T1.3241.00
301_E305_R1.3191.00
97_V102_R1.3161.00
291_Q294_A1.2961.00
481_L491_V1.2901.00
97_V101_S1.2861.00
421_G493_V1.2721.00
451_D489_T1.2701.00
322_A326_Q1.2681.00
474_V481_L1.2521.00
313_H319_T1.2511.00
166_T169_P1.2491.00
254_D258_S1.2431.00
379_I418_C1.2421.00
94_L100_I1.2361.00
164_N169_P1.2331.00
372_D408_E1.2321.00
258_S262_Q1.2231.00
376_E438_G1.2031.00
202_G206_E1.1961.00
289_R292_H1.1911.00
418_C422_L1.1861.00
374_T405_A1.1821.00
436_L449_I1.1811.00
417_V493_V1.1791.00
338_A341_K1.1761.00
165_N169_P1.1711.00
259_L262_Q1.1681.00
269_L273_I1.1651.00
456_L485_C1.1591.00
383_M397_L1.1571.00
376_E380_R1.1551.00
386_M426_V1.1531.00
322_A350_L1.1491.00
416_R469_G1.1431.00
94_L102_R1.1391.00
299_E302_E1.1371.00
355_Y359_R1.1151.00
282_S285_K1.1151.00
94_L98_A1.1131.00
93_T97_V1.1121.00
309_A318_Q1.1071.00
317_G362_L1.1051.00
324_R328_G1.1041.00
276_L283_L1.1011.00
422_L434_V1.0991.00
416_R473_R1.0991.00
294_A299_E1.0911.00
386_M419_Q1.0901.00
453_G488_G1.0891.00
85_L88_I1.0881.00
86_L93_T1.0841.00
404_S407_S1.0811.00
364_R468_T1.0801.00
438_G447_L1.0621.00
281_Q285_K1.0611.00
316_I357_A1.0601.00
97_V100_I1.0511.00
310_R315_D1.0461.00
91_L102_R1.0441.00
482_H494_S1.0441.00
280_N286_E1.0391.00
317_G354_V1.0341.00
329_I343_S1.0331.00
342_Q346_L1.0281.00
93_T100_I1.0271.00
266_G272_G1.0241.00
428_H460_S1.0231.00
326_Q346_L1.0211.00
259_L270_G1.0211.00
483_I489_T1.0181.00
95_L100_I1.0151.00
327_A348_E1.0101.00
405_A409_N1.0081.00
262_Q269_L1.0071.00
93_T102_R1.0051.00
318_Q322_A1.0031.00
456_L483_I1.0021.00
391_R426_V1.0001.00
479_G495_L0.9991.00
349_Q381_S0.9981.00
331_Q341_K0.9931.00
312_L361_L0.9881.00
472_E475_T0.9861.00
440_Q497_Q0.9861.00
366_R463_Q0.9861.00
286_E289_R0.9781.00
279_L287_L0.9691.00
96_P100_I0.9671.00
315_D321_T0.9641.00
382_L386_M0.9611.00
305_R318_Q0.9611.00
288_A291_Q0.9611.00
388_L395_S0.9601.00
89_G97_V0.9571.00
314_D420_E0.9531.00
308_V313_H0.9511.00
309_A313_H0.9511.00
393_I426_V0.9501.00
270_G273_I0.9501.00
423_N428_H0.9501.00
94_L97_V0.9501.00
93_T96_P0.9481.00
289_R293_L0.9481.00
96_P101_S0.9481.00
368_R413_T0.9471.00
261_V265_T0.9461.00
266_G269_L0.9461.00
318_Q354_V0.9421.00
293_L296_R0.9411.00
455_G485_C0.9411.00
383_M395_S0.9401.00
313_H317_G0.9391.00
395_S436_L0.9391.00
354_V359_R0.9321.00
314_D317_G0.9311.00
270_G274_Q0.9301.00
351_S355_Y0.9281.00
375_L445_L0.9231.00
276_L282_S0.9221.00
279_L282_S0.9211.00
393_I397_L0.9181.00
380_R384_R0.9161.00
420_E470_M0.9141.00
362_L366_R0.9131.00
454_S489_T0.9131.00
300_T303_S0.9121.00
85_L89_G0.9101.00
382_L422_L0.9101.00
393_I429_A0.9081.00
379_I438_G0.9081.00
265_T268_L0.9071.00
320_I358_V0.9041.00
215_L218_P0.9001.00
202_G205_D0.8981.00
305_R308_V0.8961.00
267_L271_A0.8961.00
345_Q349_Q0.8951.00
302_E416_R0.8951.00
455_G488_G0.8931.00
399_W438_G0.8911.00
89_G98_A0.8871.00
86_L89_G0.8851.00
324_R348_E0.8811.00
271_A274_Q0.8811.00
318_Q325_T0.8801.00
327_A331_Q0.8801.00
279_L286_E0.8761.00
89_G102_R0.8761.00
425_I429_A0.8751.00
245_S248_W0.8741.00
321_T350_L0.8741.00
406_L409_N0.8741.00
305_R321_T0.8731.00
388_L391_R0.8721.00
233_I237_M0.8591.00
262_Q270_G0.8591.00
316_I361_L0.8591.00
313_H318_Q0.8581.00
309_A428_H0.8571.00
279_L284_Q0.8561.00
203_L206_E0.8551.00
296_R300_T0.8521.00
422_L426_V0.8521.00
388_L434_V0.8511.00
441_Q494_S0.8501.00
281_Q284_Q0.8491.00
378_A381_S0.8461.00
288_A292_H0.8461.00
305_R427_K0.8461.00
305_R313_H0.8390.99
95_L102_R0.8380.99
234_A238_N0.8370.99
253_V258_S0.8370.99
269_L272_G0.8320.99
96_P99_L0.8300.99
313_H420_E0.8290.99
325_T350_L0.8270.99
311_E317_G0.8260.99
315_D420_E0.8260.99
93_T98_A0.8240.99
479_G496_P0.8240.99
261_V270_G0.8190.99
470_M473_R0.8180.99
111_T114_L0.8140.99
382_L419_Q0.8140.99
319_T469_G0.8130.99
267_L270_G0.8120.99
95_L99_L0.8090.99
98_A101_S0.8080.99
383_M422_L0.8020.99
167_W171_G0.8010.99
90_S93_T0.8000.99
262_Q266_G0.7980.99
417_V477_L0.7950.99
469_G473_R0.7950.99
278_E281_Q0.7940.99
326_Q350_L0.7930.99
197_L200_Q0.7900.99
350_L353_G0.7890.99
406_L410_Q0.7870.99
89_G101_S0.7850.99
258_S271_A0.7820.99
324_R355_Y0.7820.99
368_R477_L0.7820.99
108_D111_T0.7800.99
474_V495_L0.7790.99
446_M482_H0.7790.99
305_R428_H0.7750.99
266_G270_G0.7740.99
282_S287_L0.7730.99
413_T469_G0.7730.99
185_H188_W0.7720.99
91_L94_L0.7700.99
375_L447_L0.7690.99
308_V312_L0.7680.99
409_N479_G0.7670.99
156_L160_H0.7660.99
83_F86_L0.7660.99
379_I436_L0.7650.99
265_T269_L0.7640.99
410_Q413_T0.7640.99
168_L172_P0.7590.99
316_I358_V0.7580.99
368_R410_Q0.7560.99
415_F419_Q0.7470.99
454_S485_C0.7470.99
163_A166_T0.7420.99
421_G449_I0.7420.99
258_S270_G0.7410.99
315_D469_G0.7390.99
303_S306_R0.7390.99
315_D419_Q0.7390.99
311_E315_D0.7380.99
382_L385_E0.7380.99
356_D412_V0.7380.99
231_A234_A0.7360.99
230_G234_A0.7360.99
315_D470_M0.7350.99
232_L236_L0.7320.99
265_T273_I0.7310.99
234_A237_M0.7250.98
361_L365_L0.7250.98
284_Q288_A0.7240.98
420_E469_G0.7240.98
383_M387_E0.7230.98
292_H296_R0.7220.98
438_G445_L0.7200.98
152_A160_H0.7190.98
310_R316_I0.7180.98
282_S286_E0.7180.98
300_T304_V0.7170.98
89_G92_L0.7160.98
167_W170_L0.7160.98
286_E291_Q0.7150.98
400_R404_S0.7140.98
341_K345_Q0.7140.98
436_L447_L0.7140.98
378_A415_F0.7140.98
117_A120_T0.7130.98
253_V257_L0.7080.98
155_C159_W0.7080.98
94_L101_S0.7040.98
268_L271_A0.7040.98
358_V416_R0.7030.98
362_L463_Q0.7020.98
116_G124_L0.7020.98
482_H493_V0.7010.98
169_P172_P0.7010.98
308_V311_E0.7010.98
360_R416_R0.7000.98
385_E419_Q0.6980.98
444_R480_T0.6950.98
376_E399_W0.6950.98
311_E318_Q0.6950.98
257_L269_L0.6920.98
88_I93_T0.6900.98
89_G96_P0.6890.98
263_S267_L0.6840.98
162_L166_T0.6840.98
260_L264_L0.6820.98
84_P88_I0.6820.98
458_P486_L0.6810.98
405_A408_E0.6800.98
456_L467_L0.6800.98
309_A473_R0.6800.98
317_G321_T0.6790.98
420_E465_F0.6780.98
304_V307_D0.6780.98
327_A330_V0.6760.98
362_L365_L0.6740.98
315_D350_L0.6740.98
370_L408_E0.6730.98
354_V357_A0.6710.97
416_R477_L0.6700.97
318_Q463_Q0.6700.97
86_L90_S0.6690.97
380_R383_M0.6680.97
179_I182_R0.6680.97
348_E352_L0.6670.97
315_D353_G0.6670.97
435_T452_D0.6660.97
314_D318_Q0.6660.97
353_G357_A0.6650.97
312_L324_R0.6640.97
292_H295_E0.6630.97
154_I160_H0.6620.97
184_R187_V0.6610.97
277_R281_Q0.6600.97
377_Q411_R0.6580.97
270_G275_R0.6570.97
485_C492_S0.6570.97
204_P208_S0.6560.97
191_L194_V0.6560.97
91_L101_S0.6560.97
301_E427_K0.6560.97
311_E360_R0.6530.97
340_V344_G0.6510.97
315_D361_L0.6490.97
299_E303_S0.6480.97
261_V266_G0.6480.97
346_L350_L0.6470.97
321_T324_R0.6460.97
278_E282_S0.6450.97
374_T378_A0.6450.97
413_T477_L0.6440.97
205_D208_S0.6440.97
311_E416_R0.6420.97
317_G355_Y0.6410.97
305_R429_A0.6370.97
323_I327_A0.6350.96
89_G93_T0.6350.96
84_P101_S0.6340.96
163_A169_P0.6340.96
420_E463_Q0.6320.96
88_I91_L0.6310.96
373_L411_R0.6300.96
301_E306_R0.6290.96
384_R387_E0.6290.96
301_E318_Q0.6290.96
272_G275_R0.6280.96
137_S140_A0.6280.96
84_P97_V0.6260.96
342_Q345_Q0.6240.96
321_T326_Q0.6230.96
393_I452_D0.6230.96
92_L96_P0.6220.96
91_L96_P0.6220.96
95_L101_S0.6220.96
251_H254_D0.6210.96
271_A275_R0.6200.96
382_L415_F0.6190.96
276_L287_L0.6190.96
364_R472_E0.6190.96
256_L265_T0.6180.96
95_L98_A0.6170.96
418_C449_I0.6150.96
277_R280_N0.6120.96
88_I92_L0.6100.96
239_A243_I0.6100.96
318_Q419_Q0.6090.96
263_S270_G0.6080.95
314_D473_R0.6080.95
420_E423_N0.6050.95
321_T325_T0.6050.95
91_L97_V0.6050.95
318_Q355_Y0.6050.95
138_W141_L0.6040.95
287_L294_A0.6030.95
414_L418_C0.6030.95
258_S275_R0.6020.95
317_G427_K0.6020.95
370_L409_N0.6000.95
307_D472_E0.6000.95
305_R311_E0.6000.95
319_T360_R0.5960.95
317_G360_R0.5930.95
254_D257_L0.5910.95
305_R315_D0.5900.95
237_M241_A0.5900.95
90_S95_L0.5900.95
118_A121_A0.5870.95
414_L495_L0.5860.95
470_M493_V0.5860.95
424_N466_G0.5830.94
308_V427_K0.5830.94
139_N142_L0.5830.94
357_A365_L0.5820.94
318_Q423_N0.5820.94
200_Q204_P0.5810.94
305_R317_G0.5810.94
336_D339_S0.5800.94
266_G275_R0.5800.94
85_L93_T0.5800.94
311_E428_H0.5790.94
88_I96_P0.5780.94
307_D311_E0.5780.94
112_L115_Q0.5780.94
424_N451_D0.5760.94
109_W113_L0.5760.94
322_A346_L0.5760.94
254_D266_G0.5760.94
94_L99_L0.5740.94
213_F221_A0.5740.94
318_Q362_L0.5730.94
266_G273_I0.5730.94
286_E294_A0.5720.94
166_T172_P0.5710.94
84_P95_L0.5700.94
367_P370_L0.5700.94
90_S98_A0.5690.94
138_W157_V0.5680.94
163_A168_L0.5670.93
409_N414_L0.5660.93
286_E293_L0.5640.93
314_D421_G0.5640.93
354_V362_L0.5640.93
169_P174_L0.5630.93
358_V364_R0.5620.93
367_P415_F0.5620.93
347_I351_S0.5620.93
213_F220_I0.5610.93
114_L118_A0.5610.93
204_P207_L0.5570.93
84_P94_L0.5570.93
163_A167_W0.5570.93
309_A427_K0.5570.93
424_N464_G0.5560.93
451_D485_C0.5560.93
350_L354_V0.5550.93
129_P133_H0.5530.93
92_L98_A0.5510.93
331_Q344_G0.5510.93
301_E304_V0.5510.93
379_I397_L0.5500.92
88_I98_A0.5490.92
269_L275_R0.5490.92
404_S440_Q0.5480.92
195_I199_L0.5480.92
91_L98_A0.5480.92
171_G175_V0.5480.92
385_E415_F0.5470.92
141_L147_G0.5460.92
334_A341_K0.5450.92
268_L272_G0.5440.92
430_D454_S0.5430.92
431_A452_D0.5430.92
109_W112_L0.5430.92
140_A144_T0.5420.92
354_V365_L0.5420.92
356_D360_R0.5420.92
173_S178_P0.5410.92
127_S130_W0.5400.92
164_N168_L0.5400.92
411_R415_F0.5400.92
320_I354_V0.5390.92
92_L95_L0.5380.92
312_L362_L0.5380.92
230_G233_I0.5370.92
103_Y106_Q0.5370.92
168_L175_V0.5360.91
202_G208_S0.5350.91
254_D270_G0.5350.91
108_D112_L0.5350.91
379_I382_L0.5340.91
359_R362_L0.5330.91
141_L146_T0.5330.91
315_D413_T0.5330.91
234_A242_L0.5320.91
374_T402_D0.5320.91
203_L208_S0.5300.91
234_A240_I0.5290.91
263_S269_L0.5280.91
268_L274_Q0.5270.91
122_A125_L0.5270.91
90_S102_R0.5260.91
141_L144_T0.5260.91
255_L259_L0.5250.91
357_A362_L0.5250.91
92_L100_I0.5230.90
128_L132_W0.5200.90
85_L100_I0.5200.90
169_P173_S0.5200.90
314_D462_Q0.5200.90
165_N168_L0.5190.90
313_H365_L0.5150.90
256_L260_L0.5140.90
357_A364_R0.5130.90
311_E468_T0.5130.90
308_V362_L0.5120.90
380_R397_L0.5120.90
456_L491_V0.5100.89
186_L191_L0.5100.89
453_G489_T0.5100.89
87_M91_L0.5090.89
311_E322_A0.5080.89
319_T358_V0.5080.89
309_A321_T0.5080.89
330_V347_I0.5070.89
167_W172_P0.5070.89
223_A226_Y0.5070.89
362_L427_K0.5070.89
146_T157_V0.5070.89
393_I431_A0.5060.89
468_T472_E0.5060.89
102_R106_Q0.5060.89
306_R326_Q0.5040.89
227_G232_L0.5040.89
453_G485_C0.5030.89
264_L272_G0.5010.89
321_T429_A0.5000.88
267_L275_R0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.526 100 0.555 Contact Map
4r39A 1 0.394 100 0.56 Contact Map
3ehhA 2 0.386 100 0.564 Contact Map
4q20A 2 0.414 100 0.568 Contact Map
3d36A 2 0.404 100 0.579 Contact Map
4bixA 2 0.416 100 0.579 Contact Map
2c2aA 2 0.424 100 0.584 Contact Map
4ctiA 2 0.448 100 0.59 Contact Map
2q8gA 2 0.498 100 0.591 Contact Map
3jz3A 2 0.302 100 0.591 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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