GREMLIN Database
MODC - Molybdenum import ATP-binding protein ModC
UniProt: P09833 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10152
Length: 352 (280)
Sequences: 13422 (10586)
Seq/√Len: 632.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_G198_R4.7121.00
211_G215_E4.1941.00
12_N15_L4.1641.00
28_A196_A4.1231.00
193_L214_E4.0111.00
114_A119_E3.8011.00
94_R98_R3.1031.00
41_I185_V3.0131.00
27_T200_M2.9911.00
15_L206_Q2.7801.00
212_A215_E2.7541.00
41_I151_L2.6601.00
22_P25_G2.6061.00
121_L124_R2.4391.00
43_A50_P2.2891.00
91_Y99_Y2.2641.00
106_V110_D2.2421.00
42_N48_T2.2121.00
6_F51_Q2.1161.00
107_D111_K2.0831.00
14_C43_A2.0501.00
21_L27_T1.9761.00
172_Q194_H1.9521.00
28_A192_I1.9361.00
43_A55_I1.9281.00
77_R148_E1.9241.00
90_H127_G1.9201.00
88_F91_Y1.9041.00
174_L180_I1.8931.00
94_R123_D1.8541.00
108_Q146_A1.8421.00
112_L144_L1.7911.00
42_N47_L1.7751.00
292_I295_V1.7741.00
19_E200_M1.7521.00
7_S12_N1.7521.00
108_Q111_K1.7501.00
6_F43_A1.7311.00
186_S192_I1.7231.00
94_R109_F1.6231.00
44_I183_L1.6041.00
58_N148_E1.5521.00
117_G166_E1.4951.00
261_N265_E1.4711.00
79_G147_P1.4591.00
116_L140_G1.4441.00
118_I121_L1.4121.00
45_S151_L1.4051.00
260_V264_D1.4041.00
208_K222_M1.4031.00
104_S108_Q1.3961.00
198_R210_F1.3961.00
94_R110_D1.3881.00
299_K302_N1.3841.00
266_P269_A1.3831.00
94_R106_V1.3831.00
14_C17_I1.3821.00
96_N141_R1.3741.00
105_M108_Q1.3711.00
276_Q280_V1.3641.00
215_E219_S1.3611.00
152_L182_M1.3601.00
92_K95_G1.3481.00
257_H260_V1.3431.00
125_L128_S1.3391.00
184_Y196_A1.3201.00
200_M207_V1.3171.00
268_Q272_R1.3171.00
258_L261_N1.3091.00
265_E268_Q1.3081.00
279_D283_V1.3061.00
95_G98_R1.3011.00
203_E208_K1.3001.00
256_Q259_W1.2971.00
124_R128_S1.2791.00
251_L255_D1.2741.00
110_D114_A1.2731.00
35_A202_L1.2731.00
50_P55_I1.2621.00
272_R278_S1.2621.00
290_T293_R1.2581.00
255_D258_L1.2461.00
214_E218_G1.2411.00
248_M251_L1.2391.00
284_L287_P1.2371.00
171_L182_M1.2181.00
254_G257_H1.2151.00
200_M210_F1.2131.00
201_V216_V1.2081.00
113_V118_I1.2011.00
292_I300_V1.1971.00
7_S10_L1.1801.00
251_L254_G1.1791.00
273_I276_Q1.1771.00
295_V299_K1.1751.00
223_N227_P1.1751.00
257_H261_N1.1731.00
27_T198_R1.1711.00
293_R299_K1.1701.00
296_L300_V1.1681.00
91_Y95_G1.1591.00
43_A51_Q1.1591.00
296_L299_K1.1501.00
279_D285_Q1.1491.00
253_L257_H1.1471.00
113_V122_L1.1461.00
79_G142_A1.1191.00
265_E269_A1.1181.00
256_Q260_V1.1171.00
255_D260_V1.1091.00
263_L267_L1.1061.00
98_R102_S1.1041.00
32_V35_A1.1031.00
201_V220_S1.1011.00
298_A302_N1.1011.00
259_W262_K1.0971.00
123_D126_P1.0961.00
246_Y249_T1.0951.00
278_S282_L1.0911.00
87_L96_N1.0901.00
98_R109_F1.0851.00
111_K115_L1.0811.00
126_P137_V1.0801.00
262_K265_E1.0661.00
292_I296_L1.0641.00
7_S51_Q1.0611.00
249_T253_L1.0521.00
213_L217_W1.0471.00
203_E206_Q1.0441.00
14_C40_L1.0421.00
21_L181_P1.0421.00
225_W229_E1.0371.00
297_R301_V1.0371.00
164_K188_S1.0361.00
285_Q288_Q1.0341.00
112_L140_G1.0331.00
283_V286_P1.0321.00
6_F48_T1.0261.00
91_Y96_N1.0251.00
217_W220_S1.0231.00
97_L113_V1.0201.00
272_R286_P1.0171.00
146_A180_I1.0131.00
89_P127_G1.0101.00
117_G121_L1.0091.00
258_L262_K1.0081.00
112_L116_L1.0021.00
24_N181_P1.0011.00
302_N305_D0.9881.00
293_R296_L0.9881.00
30_F201_V0.9771.00
255_D261_N0.9731.00
151_L183_L0.9671.00
168_L194_H0.9671.00
27_T183_L0.9671.00
100_G141_R0.9661.00
110_D122_L0.9641.00
94_R122_L0.9641.00
277_A280_V0.9621.00
40_L202_L0.9611.00
269_A272_R0.9601.00
275_I279_D0.9561.00
216_V220_S0.9561.00
293_R297_R0.9531.00
271_L275_I0.9521.00
236_K239_V0.9501.00
111_K114_A0.9501.00
268_Q271_L0.9501.00
96_N126_P0.9461.00
25_G197_D0.9421.00
268_Q275_I0.9381.00
274_R277_A0.9331.00
17_I40_L0.9311.00
93_V129_L0.9301.00
250_A254_G0.9301.00
301_V305_D0.9291.00
262_K267_L0.9261.00
278_S286_P0.9241.00
300_V304_Y0.9241.00
278_S285_Q0.9201.00
101_M144_L0.9201.00
215_E218_G0.9191.00
161_I165_R0.9141.00
270_A275_I0.9011.00
282_L286_P0.8991.00
277_A281_S0.8961.00
258_L263_L0.8911.00
92_K125_L0.8901.00
103_K107_D0.8871.00
283_V287_P0.8861.00
112_L115_L0.8851.00
294_N297_R0.8841.00
292_I299_K0.8831.00
280_V283_V0.8831.00
272_R275_I0.8801.00
81_V135_Q0.8781.00
60_R148_E0.8751.00
104_S107_D0.8751.00
81_V142_A0.8711.00
117_G120_P0.8701.00
299_K303_S0.8701.00
298_A301_V0.8681.00
139_I152_L0.8641.00
232_S235_L0.8631.00
275_I278_S0.8621.00
6_F9_T0.8621.00
233_S237_V0.8611.00
279_D286_P0.8561.00
192_I196_A0.8541.00
248_M252_A0.8521.00
288_Q291_S0.8511.00
6_F12_N0.8431.00
247_A251_L0.8421.00
190_D194_H0.8381.00
269_A273_I0.8381.00
226_L230_Q0.8351.00
264_D267_L0.8341.00
109_F112_L0.8331.00
256_Q261_N0.8331.00
297_R300_V0.8311.00
264_D268_Q0.8281.00
265_E271_L0.8221.00
45_S80_Y0.8151.00
247_A250_A0.8141.00
266_P270_A0.8121.00
254_G258_L0.8121.00
270_A274_R0.8051.00
225_W228_K0.7981.00
294_N298_A0.7961.00
255_D259_W0.7951.00
26_I182_M0.7941.00
105_M109_F0.7941.00
271_L278_S0.7931.00
92_K96_N0.7931.00
272_R276_Q0.7911.00
280_V284_L0.7911.00
224_P227_P0.7851.00
291_S295_V0.7841.00
172_Q195_L0.7821.00
274_R278_S0.7801.00
275_I282_L0.7791.00
293_R300_V0.7751.00
267_L270_A0.7701.00
281_S284_L0.7701.00
288_Q292_I0.7641.00
169_P173_R0.7611.00
259_W263_L0.7581.00
252_A256_Q0.7541.00
198_R209_A0.7461.00
196_A199_V0.7401.00
38_T42_N0.7391.00
80_Y83_Q0.7391.00
230_Q234_I0.7381.00
291_S294_N0.7361.00
22_P198_R0.7341.00
88_F96_N0.7331.00
253_L256_Q0.7311.00
252_A258_L0.7281.00
100_G145_T0.7261.00
260_V263_L0.7261.00
253_L258_L0.7261.00
290_T294_N0.7241.00
273_I280_V0.7221.00
263_L266_P0.7221.00
275_I286_P0.7221.00
21_L183_L0.7221.00
268_Q276_Q0.7191.00
301_V304_Y0.7181.00
296_L303_S0.7151.00
286_P290_T0.7141.00
24_N179_N0.7121.00
279_D282_L0.7111.00
47_L82_F0.7111.00
292_I297_R0.7101.00
296_L304_Y0.7091.00
261_N264_D0.7091.00
90_H125_L0.7091.00
224_P228_K0.7071.00
295_V298_A0.7061.00
227_P230_Q0.7021.00
267_L271_L0.7001.00
258_L265_E0.6981.00
115_L173_R0.6961.00
293_R303_S0.6951.00
291_S296_L0.6951.00
300_V303_S0.6941.00
250_A256_Q0.6931.00
251_L256_Q0.6921.00
43_A48_T0.6901.00
278_S281_S0.6901.00
262_K268_Q0.6891.00
259_W266_P0.6881.00
217_W221_V0.6881.00
9_T12_N0.6851.00
276_Q279_D0.6831.00
250_A253_L0.6821.00
249_T255_D0.6811.00
244_P247_A0.6781.00
278_S283_V0.6771.00
120_P133_E0.6761.00
7_S52_K0.6761.00
251_L257_H0.6681.00
223_N226_L0.6571.00
257_H263_L0.6561.00
214_E217_W0.6551.00
271_L274_R0.6501.00
147_P150_L0.6491.00
227_P234_I0.6471.00
260_V265_E0.6391.00
244_P248_M0.6381.00
270_A273_I0.6371.00
203_E207_V0.6321.00
270_A284_L0.6301.00
154_E187_H0.6291.00
262_K266_P0.6291.00
261_N268_Q0.6291.00
258_L264_D0.6271.00
15_L204_N0.6251.00
213_L216_V0.6201.00
254_G259_W0.6191.00
92_K123_D0.6181.00
226_L229_E0.6171.00
109_F113_V0.6171.00
79_G182_M0.6131.00
174_L182_M0.6071.00
42_N80_Y0.6071.00
149_L181_P0.6061.00
199_V213_L0.6061.00
231_Q234_I0.6051.00
247_A252_A0.6031.00
171_L195_L0.6031.00
184_Y195_L0.6021.00
165_R169_P0.6001.00
218_G221_V0.5991.00
238_T270_A0.5971.00
184_Y192_I0.5961.00
273_I278_S0.5931.00
254_G261_N0.5931.00
209_A216_V0.5911.00
282_L285_Q0.5911.00
257_H267_L0.5911.00
112_L143_L0.5901.00
156_L184_Y0.5901.00
98_R105_M0.5861.00
263_L268_Q0.5861.00
113_V116_L0.5841.00
242_H246_Y0.5821.00
248_M256_Q0.5821.00
97_L144_L0.5821.00
237_V241_E0.5791.00
290_T297_R0.5791.00
299_K304_Y0.5771.00
77_R145_T0.5741.00
150_L180_I0.5741.00
295_V300_V0.5731.00
15_L205_G0.5731.00
273_I277_A0.5691.00
268_Q278_S0.5691.00
260_V267_L0.5691.00
265_E272_R0.5681.00
242_H245_H0.5661.00
228_K231_Q0.5661.00
284_L288_Q0.5651.00
29_I40_L0.5631.00
227_P231_Q0.5621.00
161_I168_L0.5591.00
242_H248_M0.5581.00
260_V266_P0.5561.00
79_G83_Q0.5561.00
253_L259_W0.5551.00
16_T52_K0.5551.00
111_K146_A0.5541.00
255_D262_K0.5541.00
268_Q282_L0.5541.00
252_A255_D0.5521.00
243_H246_Y0.5511.00
229_E233_S0.5511.00
47_L86_R0.5491.00
232_S274_R0.5461.00
23_A148_E0.5451.00
48_T51_Q0.5451.00
249_T254_G0.5441.00
121_L133_E0.5441.00
82_F85_A0.5421.00
87_L126_P0.5410.99
250_A257_H0.5400.99
79_G145_T0.5390.99
170_Y173_R0.5390.99
257_H262_K0.5370.99
259_W267_L0.5350.99
282_L287_P0.5320.99
281_S285_Q0.5300.99
149_L183_L0.5280.99
93_V137_V0.5250.99
26_I195_L0.5210.99
292_I304_Y0.5210.99
8_Q13_H0.5210.99
255_D263_L0.5190.99
258_L266_P0.5170.99
297_R304_Y0.5170.99
56_V59_G0.5160.99
247_A255_D0.5140.99
264_D272_R0.5140.99
7_S13_H0.5110.99
241_E244_P0.5110.99
81_V139_I0.5090.99
44_I151_L0.5080.99
26_I184_Y0.5080.99
252_A260_V0.5080.99
253_L261_N0.5070.99
288_Q293_R0.5070.99
95_G102_S0.5060.99
46_G57_L0.5050.99
233_S236_K0.5020.99
259_W264_D0.5020.99
263_L270_A0.5010.99
29_I200_M0.5000.99
265_E278_S0.5000.99
186_S191_E0.5000.99
257_H265_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d31A 2 0.9659 100 0.262 Contact Map
1g291 4 0.9801 100 0.265 Contact Map
1v43A 2 0.9318 100 0.266 Contact Map
2yyzA 1 0.9517 100 0.269 Contact Map
1oxxK 1 0.9545 100 0.27 Contact Map
3fvqA 2 0.9517 100 0.271 Contact Map
2it1A 1 0.9403 100 0.271 Contact Map
3rlfA 2 0.9602 100 0.274 Contact Map
4ry2A 2 0.6364 100 0.277 Contact Map
1z47A 2 0.9375 100 0.28 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0131 seconds.