MODC - ECOLI - GREMLIN Contacts

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MODC - Molybdenum import ATP-binding protein ModC

UniProt:	P09833	Sequences: MLELNFSQTLGNHCLTINETLPANGITAIFGVSGAGKTSLINAISGLTRPQKGRIVLNGRVLNDAEKGICLTPEKRRVGYVFQDARLFPHYKVRGNLRYGMSKSMVDQFDKLVALLGIEPLLDRLPGSLSGGEKQRVAIGRALLTAPELLLLDEPLASLDIPRKRELLPYLQRLTREINIPMLYVSHSLDEILHLADRVMVLENGQVKAFGALEEVWGSSVMNPWLPKEQQSSILKVTVLEHHPHYAMTALALGDQHLWVNKLDEPLQAALRIRIQASDVSLVLQPPQQTSIRNVLRAKVVNSYDDNGQVEVELEVGGKTLWARISPWARDELAIKPGLWLYAQIKSVSITA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10152
Length:	352 (280)
Sequences:	13422 (10586)
Seq/√Len:	632.6

ECOLI - MODC POTG MALK CYSA YCJV UGPC FBPC PROV POTA METN YDCT DPPF YHES OPPD OPPF GSIA SAPD DPPD UUP RBSA YEHX DDPD YADG DDPF ARAG MDLA MACB CYDC MDLB MSBA NIKE LSRA FEPC CYDD YOJI SSUB ETTA SAPF MLAF TAUB HISP FECE YTFR FHUC YECC BTUD ZNUC GLNQ PHNC LPTB YHDZ LIVG LIVF GLTL MODF YPHE XYLG SUFC PHNK ARTP ALSA LOLD THIQ NIKD PSTB FTSE FETA YBHF YDDA CCMA YBBA YEJF MGLA PHNL YNJD YBIT
BACSU - MSMX YURJ YVRA OPUCA OPUBA OPUAA OPPD METN APPF DPPD YKFD TAGH YHCH YCBN YDIF YDBJ APPD YFIL YXLF YVFR YHEH YKPA SUNT OPPF YFMR YHAQ YFMM RBSA YGAD YFIB YTRB YFIC YHEI YKNU BMRA YUSV ECFA1 YKNV YFMF FHUC ECFA2 YWJA CYDC CYDD YCLP YKOD TCYN YTLC SSUB YLMA ECSA SUFC YXDL SKFE BCEA YVCR YJKB ALBC NATA MNTB EXPZ YXEO GLNQ FTSE TCYC PSTB1 ARTM YVRO YTHP PSTB2 YKNY YCLH YTRE YYBJ YHCG ZNUC YYDI YUFO
HALSA - Q9HHQ5 Q9HNZ9 BTUDA Q9HR06 Q9HMX3 Q9HMW0 Q9HMT3 Q9HMX2 Q9HMU8 Q9HRJ6 Q9HMG1 Q9HSQ7 PSTB2 PHNC Q9HRH8 Q9HHM2 Q9HMG6 Q9HNY3 Q9HRV7 Y1631 PSTB1 Q9HRZ9 Y2317 Q9HS04 Q9HHR7 Q9HR96 Q9HT03 Q9HQA8 Q9HMC1 Q9HR21 Q9HMW1
SULSO - Q97UF2 Q97UY8 Q97YY4 Q97UJ9 Q97ZC0 Q7LX64 Q97VK9 Q97VF5 Q97VC1 Q97UH3 Q97VF4 Q97VK8 Q97YP3 Q97YP7 Q97VH6 Q97YK2 Q97X18 Q980W0 Q97UD4 Q97YP8 Q97YQ7 Q97Z03 Q97U54 Q97UH4 Q7LY07 Y2030 Q97VY4 Q97V01 PSTB Y1893 Q97V00 Q97VM2 Q7LXM4 Q97W42 Q7LX80 Q97UG5 Q97Z56 Q97UC2 Q97YP4 Q97Z96 Q980K5 Q97ZU0 Q980E6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
25_G	198_R	4.712	1.00
211_G	215_E	4.194	1.00
12_N	15_L	4.164	1.00
28_A	196_A	4.123	1.00
193_L	214_E	4.011	1.00
114_A	119_E	3.801	1.00
94_R	98_R	3.103	1.00
41_I	185_V	3.013	1.00
27_T	200_M	2.991	1.00
15_L	206_Q	2.780	1.00
212_A	215_E	2.754	1.00
41_I	151_L	2.660	1.00
22_P	25_G	2.606	1.00
121_L	124_R	2.439	1.00
43_A	50_P	2.289	1.00
91_Y	99_Y	2.264	1.00
106_V	110_D	2.242	1.00
42_N	48_T	2.212	1.00
6_F	51_Q	2.116	1.00
107_D	111_K	2.083	1.00
14_C	43_A	2.050	1.00
21_L	27_T	1.976	1.00
172_Q	194_H	1.952	1.00
28_A	192_I	1.936	1.00
43_A	55_I	1.928	1.00
77_R	148_E	1.924	1.00
90_H	127_G	1.920	1.00
88_F	91_Y	1.904	1.00
174_L	180_I	1.893	1.00
94_R	123_D	1.854	1.00
108_Q	146_A	1.842	1.00
112_L	144_L	1.791	1.00
42_N	47_L	1.775	1.00
292_I	295_V	1.774	1.00
19_E	200_M	1.752	1.00
7_S	12_N	1.752	1.00
108_Q	111_K	1.750	1.00
6_F	43_A	1.731	1.00
186_S	192_I	1.723	1.00
94_R	109_F	1.623	1.00
44_I	183_L	1.604	1.00
58_N	148_E	1.552	1.00
117_G	166_E	1.495	1.00
261_N	265_E	1.471	1.00
79_G	147_P	1.459	1.00
116_L	140_G	1.444	1.00
118_I	121_L	1.412	1.00
45_S	151_L	1.405	1.00
260_V	264_D	1.404	1.00
208_K	222_M	1.403	1.00
104_S	108_Q	1.396	1.00
198_R	210_F	1.396	1.00
94_R	110_D	1.388	1.00
299_K	302_N	1.384	1.00
266_P	269_A	1.383	1.00
94_R	106_V	1.383	1.00
14_C	17_I	1.382	1.00
96_N	141_R	1.374	1.00
105_M	108_Q	1.371	1.00
276_Q	280_V	1.364	1.00
215_E	219_S	1.361	1.00
152_L	182_M	1.360	1.00
92_K	95_G	1.348	1.00
257_H	260_V	1.343	1.00
125_L	128_S	1.339	1.00
184_Y	196_A	1.320	1.00
200_M	207_V	1.317	1.00
268_Q	272_R	1.317	1.00
258_L	261_N	1.309	1.00
265_E	268_Q	1.308	1.00
279_D	283_V	1.306	1.00
95_G	98_R	1.301	1.00
203_E	208_K	1.300	1.00
256_Q	259_W	1.297	1.00
124_R	128_S	1.279	1.00
251_L	255_D	1.274	1.00
110_D	114_A	1.273	1.00
35_A	202_L	1.273	1.00
50_P	55_I	1.262	1.00
272_R	278_S	1.262	1.00
290_T	293_R	1.258	1.00
255_D	258_L	1.246	1.00
214_E	218_G	1.241	1.00
248_M	251_L	1.239	1.00
284_L	287_P	1.237	1.00
171_L	182_M	1.218	1.00
254_G	257_H	1.215	1.00
200_M	210_F	1.213	1.00
201_V	216_V	1.208	1.00
113_V	118_I	1.201	1.00
292_I	300_V	1.197	1.00
7_S	10_L	1.180	1.00
251_L	254_G	1.179	1.00
273_I	276_Q	1.177	1.00
295_V	299_K	1.175	1.00
223_N	227_P	1.175	1.00
257_H	261_N	1.173	1.00
27_T	198_R	1.171	1.00
293_R	299_K	1.170	1.00
296_L	300_V	1.168	1.00
91_Y	95_G	1.159	1.00
43_A	51_Q	1.159	1.00
296_L	299_K	1.150	1.00
279_D	285_Q	1.149	1.00
253_L	257_H	1.147	1.00
113_V	122_L	1.146	1.00
79_G	142_A	1.119	1.00
265_E	269_A	1.118	1.00
256_Q	260_V	1.117	1.00
255_D	260_V	1.109	1.00
263_L	267_L	1.106	1.00
98_R	102_S	1.104	1.00
32_V	35_A	1.103	1.00
201_V	220_S	1.101	1.00
298_A	302_N	1.101	1.00
259_W	262_K	1.097	1.00
123_D	126_P	1.096	1.00
246_Y	249_T	1.095	1.00
278_S	282_L	1.091	1.00
87_L	96_N	1.090	1.00
98_R	109_F	1.085	1.00
111_K	115_L	1.081	1.00
126_P	137_V	1.080	1.00
262_K	265_E	1.066	1.00
292_I	296_L	1.064	1.00
7_S	51_Q	1.061	1.00
249_T	253_L	1.052	1.00
213_L	217_W	1.047	1.00
203_E	206_Q	1.044	1.00
14_C	40_L	1.042	1.00
21_L	181_P	1.042	1.00
225_W	229_E	1.037	1.00
297_R	301_V	1.037	1.00
164_K	188_S	1.036	1.00
285_Q	288_Q	1.034	1.00
112_L	140_G	1.033	1.00
283_V	286_P	1.032	1.00
6_F	48_T	1.026	1.00
91_Y	96_N	1.025	1.00
217_W	220_S	1.023	1.00
97_L	113_V	1.020	1.00
272_R	286_P	1.017	1.00
146_A	180_I	1.013	1.00
89_P	127_G	1.010	1.00
117_G	121_L	1.009	1.00
258_L	262_K	1.008	1.00
112_L	116_L	1.002	1.00
24_N	181_P	1.001	1.00
302_N	305_D	0.988	1.00
293_R	296_L	0.988	1.00
30_F	201_V	0.977	1.00
255_D	261_N	0.973	1.00
151_L	183_L	0.967	1.00
168_L	194_H	0.967	1.00
27_T	183_L	0.967	1.00
100_G	141_R	0.966	1.00
110_D	122_L	0.964	1.00
94_R	122_L	0.964	1.00
277_A	280_V	0.962	1.00
40_L	202_L	0.961	1.00
269_A	272_R	0.960	1.00
275_I	279_D	0.956	1.00
216_V	220_S	0.956	1.00
293_R	297_R	0.953	1.00
271_L	275_I	0.952	1.00
236_K	239_V	0.950	1.00
111_K	114_A	0.950	1.00
268_Q	271_L	0.950	1.00
96_N	126_P	0.946	1.00
25_G	197_D	0.942	1.00
268_Q	275_I	0.938	1.00
274_R	277_A	0.933	1.00
17_I	40_L	0.931	1.00
93_V	129_L	0.930	1.00
250_A	254_G	0.930	1.00
301_V	305_D	0.929	1.00
262_K	267_L	0.926	1.00
278_S	286_P	0.924	1.00
300_V	304_Y	0.924	1.00
278_S	285_Q	0.920	1.00
101_M	144_L	0.920	1.00
215_E	218_G	0.919	1.00
161_I	165_R	0.914	1.00
270_A	275_I	0.901	1.00
282_L	286_P	0.899	1.00
277_A	281_S	0.896	1.00
258_L	263_L	0.891	1.00
92_K	125_L	0.890	1.00
103_K	107_D	0.887	1.00
283_V	287_P	0.886	1.00
112_L	115_L	0.885	1.00
294_N	297_R	0.884	1.00
292_I	299_K	0.883	1.00
280_V	283_V	0.883	1.00
272_R	275_I	0.880	1.00
81_V	135_Q	0.878	1.00
60_R	148_E	0.875	1.00
104_S	107_D	0.875	1.00
81_V	142_A	0.871	1.00
117_G	120_P	0.870	1.00
299_K	303_S	0.870	1.00
298_A	301_V	0.868	1.00
139_I	152_L	0.864	1.00
232_S	235_L	0.863	1.00
275_I	278_S	0.862	1.00
6_F	9_T	0.862	1.00
233_S	237_V	0.861	1.00
279_D	286_P	0.856	1.00
192_I	196_A	0.854	1.00
248_M	252_A	0.852	1.00
288_Q	291_S	0.851	1.00
6_F	12_N	0.843	1.00
247_A	251_L	0.842	1.00
190_D	194_H	0.838	1.00
269_A	273_I	0.838	1.00
226_L	230_Q	0.835	1.00
264_D	267_L	0.834	1.00
109_F	112_L	0.833	1.00
256_Q	261_N	0.833	1.00
297_R	300_V	0.831	1.00
264_D	268_Q	0.828	1.00
265_E	271_L	0.822	1.00
45_S	80_Y	0.815	1.00
247_A	250_A	0.814	1.00
266_P	270_A	0.812	1.00
254_G	258_L	0.812	1.00
270_A	274_R	0.805	1.00
225_W	228_K	0.798	1.00
294_N	298_A	0.796	1.00
255_D	259_W	0.795	1.00
26_I	182_M	0.794	1.00
105_M	109_F	0.794	1.00
271_L	278_S	0.793	1.00
92_K	96_N	0.793	1.00
272_R	276_Q	0.791	1.00
280_V	284_L	0.791	1.00
224_P	227_P	0.785	1.00
291_S	295_V	0.784	1.00
172_Q	195_L	0.782	1.00
274_R	278_S	0.780	1.00
275_I	282_L	0.779	1.00
293_R	300_V	0.775	1.00
267_L	270_A	0.770	1.00
281_S	284_L	0.770	1.00
288_Q	292_I	0.764	1.00
169_P	173_R	0.761	1.00
259_W	263_L	0.758	1.00
252_A	256_Q	0.754	1.00
198_R	209_A	0.746	1.00
196_A	199_V	0.740	1.00
38_T	42_N	0.739	1.00
80_Y	83_Q	0.739	1.00
230_Q	234_I	0.738	1.00
291_S	294_N	0.736	1.00
22_P	198_R	0.734	1.00
88_F	96_N	0.733	1.00
253_L	256_Q	0.731	1.00
252_A	258_L	0.728	1.00
100_G	145_T	0.726	1.00
260_V	263_L	0.726	1.00
253_L	258_L	0.726	1.00
290_T	294_N	0.724	1.00
273_I	280_V	0.722	1.00
263_L	266_P	0.722	1.00
275_I	286_P	0.722	1.00
21_L	183_L	0.722	1.00
268_Q	276_Q	0.719	1.00
301_V	304_Y	0.718	1.00
296_L	303_S	0.715	1.00
286_P	290_T	0.714	1.00
24_N	179_N	0.712	1.00
279_D	282_L	0.711	1.00
47_L	82_F	0.711	1.00
292_I	297_R	0.710	1.00
296_L	304_Y	0.709	1.00
261_N	264_D	0.709	1.00
90_H	125_L	0.709	1.00
224_P	228_K	0.707	1.00
295_V	298_A	0.706	1.00
227_P	230_Q	0.702	1.00
267_L	271_L	0.700	1.00
258_L	265_E	0.698	1.00
115_L	173_R	0.696	1.00
293_R	303_S	0.695	1.00
291_S	296_L	0.695	1.00
300_V	303_S	0.694	1.00
250_A	256_Q	0.693	1.00
251_L	256_Q	0.692	1.00
43_A	48_T	0.690	1.00
278_S	281_S	0.690	1.00
262_K	268_Q	0.689	1.00
259_W	266_P	0.688	1.00
217_W	221_V	0.688	1.00
9_T	12_N	0.685	1.00
276_Q	279_D	0.683	1.00
250_A	253_L	0.682	1.00
249_T	255_D	0.681	1.00
244_P	247_A	0.678	1.00
278_S	283_V	0.677	1.00
120_P	133_E	0.676	1.00
7_S	52_K	0.676	1.00
251_L	257_H	0.668	1.00
223_N	226_L	0.657	1.00
257_H	263_L	0.656	1.00
214_E	217_W	0.655	1.00
271_L	274_R	0.650	1.00
147_P	150_L	0.649	1.00
227_P	234_I	0.647	1.00
260_V	265_E	0.639	1.00
244_P	248_M	0.638	1.00
270_A	273_I	0.637	1.00
203_E	207_V	0.632	1.00
270_A	284_L	0.630	1.00
154_E	187_H	0.629	1.00
262_K	266_P	0.629	1.00
261_N	268_Q	0.629	1.00
258_L	264_D	0.627	1.00
15_L	204_N	0.625	1.00
213_L	216_V	0.620	1.00
254_G	259_W	0.619	1.00
92_K	123_D	0.618	1.00
226_L	229_E	0.617	1.00
109_F	113_V	0.617	1.00
79_G	182_M	0.613	1.00
174_L	182_M	0.607	1.00
42_N	80_Y	0.607	1.00
149_L	181_P	0.606	1.00
199_V	213_L	0.606	1.00
231_Q	234_I	0.605	1.00
247_A	252_A	0.603	1.00
171_L	195_L	0.603	1.00
184_Y	195_L	0.602	1.00
165_R	169_P	0.600	1.00
218_G	221_V	0.599	1.00
238_T	270_A	0.597	1.00
184_Y	192_I	0.596	1.00
273_I	278_S	0.593	1.00
254_G	261_N	0.593	1.00
209_A	216_V	0.591	1.00
282_L	285_Q	0.591	1.00
257_H	267_L	0.591	1.00
112_L	143_L	0.590	1.00
156_L	184_Y	0.590	1.00
98_R	105_M	0.586	1.00
263_L	268_Q	0.586	1.00
113_V	116_L	0.584	1.00
242_H	246_Y	0.582	1.00
248_M	256_Q	0.582	1.00
97_L	144_L	0.582	1.00
237_V	241_E	0.579	1.00
290_T	297_R	0.579	1.00
299_K	304_Y	0.577	1.00
77_R	145_T	0.574	1.00
150_L	180_I	0.574	1.00
295_V	300_V	0.573	1.00
15_L	205_G	0.573	1.00
273_I	277_A	0.569	1.00
268_Q	278_S	0.569	1.00
260_V	267_L	0.569	1.00
265_E	272_R	0.568	1.00
242_H	245_H	0.566	1.00
228_K	231_Q	0.566	1.00
284_L	288_Q	0.565	1.00
29_I	40_L	0.563	1.00
227_P	231_Q	0.562	1.00
161_I	168_L	0.559	1.00
242_H	248_M	0.558	1.00
260_V	266_P	0.556	1.00
79_G	83_Q	0.556	1.00
253_L	259_W	0.555	1.00
16_T	52_K	0.555	1.00
111_K	146_A	0.554	1.00
255_D	262_K	0.554	1.00
268_Q	282_L	0.554	1.00
252_A	255_D	0.552	1.00
243_H	246_Y	0.551	1.00
229_E	233_S	0.551	1.00
47_L	86_R	0.549	1.00
232_S	274_R	0.546	1.00
23_A	148_E	0.545	1.00
48_T	51_Q	0.545	1.00
249_T	254_G	0.544	1.00
121_L	133_E	0.544	1.00
82_F	85_A	0.542	1.00
87_L	126_P	0.541	0.99
250_A	257_H	0.540	0.99
79_G	145_T	0.539	0.99
170_Y	173_R	0.539	0.99
257_H	262_K	0.537	0.99
259_W	267_L	0.535	0.99
282_L	287_P	0.532	0.99
281_S	285_Q	0.530	0.99
149_L	183_L	0.528	0.99
93_V	137_V	0.525	0.99
26_I	195_L	0.521	0.99
292_I	304_Y	0.521	0.99
8_Q	13_H	0.521	0.99
255_D	263_L	0.519	0.99
258_L	266_P	0.517	0.99
297_R	304_Y	0.517	0.99
56_V	59_G	0.516	0.99
247_A	255_D	0.514	0.99
264_D	272_R	0.514	0.99
7_S	13_H	0.511	0.99
241_E	244_P	0.511	0.99
81_V	139_I	0.509	0.99
44_I	151_L	0.508	0.99
26_I	184_Y	0.508	0.99
252_A	260_V	0.508	0.99
253_L	261_N	0.507	0.99
288_Q	293_R	0.507	0.99
95_G	102_S	0.506	0.99
46_G	57_L	0.505	0.99
233_S	236_K	0.502	0.99
259_W	264_D	0.502	0.99
263_L	270_A	0.501	0.99
29_I	200_M	0.500	0.99
265_E	278_S	0.500	0.99
186_S	191_E	0.500	0.99
257_H	265_E	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3d31A	2	0.9659	100	0.262	Contact Map
1g291	4	0.9801	100	0.265	Contact Map
1v43A	2	0.9318	100	0.266	Contact Map
2yyzA	1	0.9517	100	0.269	Contact Map
1oxxK	1	0.9545	100	0.27	Contact Map
3fvqA	2	0.9517	100	0.271	Contact Map
2it1A	1	0.9403	100	0.271	Contact Map
3rlfA	2	0.9602	100	0.274	Contact Map
4ry2A	2	0.6364	100	0.277	Contact Map
1z47A	2	0.9375	100	0.28	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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