GREMLIN Database
GLTD - Glutamate synthase [NADPH] small chain
UniProt: P09832 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10404
Length: 472 (416)
Sequences: 5595 (3236)
Seq/√Len: 158.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
350_G363_K4.9151.00
76_R79_E3.8791.00
173_V214_K3.7551.00
145_T170_V3.7431.00
204_E207_T3.1411.00
289_R313_H2.9481.00
250_E350_G2.8901.00
440_F469_W2.8801.00
181_I215_L2.8611.00
322_E336_R2.7981.00
361_G389_I2.7731.00
354_N358_K2.7711.00
236_F466_I2.7581.00
291_V392_A2.7461.00
289_R393_D2.7431.00
415_E423_I2.7331.00
236_F442_G2.7331.00
175_F232_Y2.7221.00
352_E363_K2.7041.00
289_R391_P2.6421.00
363_K389_I2.6361.00
171_K212_E2.5701.00
417_D421_R2.4941.00
186_T200_T2.4861.00
161_C236_F2.4501.00
364_M388_H2.4341.00
352_E361_G2.4311.00
170_V467_M2.4181.00
174_V213_F2.4151.00
200_T204_E2.4121.00
218_E221_R2.4091.00
289_R312_K2.4021.00
255_D358_K2.4021.00
71_L83_L2.3921.00
229_L438_K2.3651.00
177_R218_E2.3621.00
81_A130_A2.3321.00
313_H341_E2.2871.00
263_F306_S2.2701.00
129_K133_M2.2111.00
204_E208_G2.1911.00
147_K233_D2.1781.00
288_K312_K2.1731.00
438_K469_W2.0591.00
78_F82_E2.0311.00
72_A122_I2.0081.00
359_V395_V1.9381.00
352_E389_I1.9171.00
351_I359_V1.8931.00
447_R458_E1.8841.00
214_K217_T1.8691.00
246_R252_E1.8681.00
366_R388_H1.8531.00
227_D231_D1.8511.00
349_L382_I1.8491.00
144_Q166_T1.8421.00
157_A236_F1.8351.00
363_K387_E1.8311.00
239_V445_I1.7911.00
226_D230_S1.7911.00
257_V351_I1.7841.00
166_T211_I1.7821.00
180_E200_T1.7611.00
354_N360_S1.7601.00
383_V386_S1.7491.00
315_T343_K1.7421.00
346_V388_H1.7361.00
331_E334_N1.7321.00
291_V362_V1.7201.00
291_V390_V1.7181.00
71_L76_R1.7171.00
229_L436_N1.7081.00
168_N467_M1.7031.00
154_A181_I1.6861.00
254_A354_N1.6841.00
315_T341_E1.6651.00
248_G252_E1.6551.00
144_Q171_K1.6421.00
355_G360_S1.6281.00
317_A390_V1.6191.00
152_I237_L1.6171.00
361_G391_P1.5991.00
173_V212_E1.5961.00
224_Q227_D1.5861.00
97_V452_V1.5861.00
245_M402_R1.5801.00
392_A395_V1.5751.00
217_T223_V1.5581.00
77_I125_Y1.5331.00
173_V232_Y1.5281.00
181_I203_R1.5261.00
81_A85_H1.5241.00
433_Q438_K1.5141.00
321_D324_N1.4911.00
181_I213_F1.4721.00
217_T222_D1.4721.00
150_A175_F1.4611.00
154_A176_D1.4451.00
70_K74_E1.4451.00
64_Y67_N1.4361.00
219_V223_V1.4351.00
267_N305_T1.4301.00
317_A364_M1.4231.00
71_L79_E1.4131.00
36_S39_Q1.3941.00
148_K231_D1.3841.00
351_I395_V1.3821.00
148_K171_K1.3731.00
151_I172_A1.3671.00
459_G463_A1.3631.00
339_G342_F1.3411.00
433_Q440_F1.3331.00
384_A387_E1.3311.00
365_V382_I1.3221.00
152_I228_L1.3201.00
349_L363_K1.3191.00
151_I158_G1.3181.00
381_E384_A1.3161.00
90_L174_V1.3141.00
111_N116_A1.3141.00
124_R128_D1.3121.00
129_K132_E1.3071.00
307_V340_V1.3051.00
244_S259_A1.2991.00
37_E41_K1.2961.00
89_T163_D1.2961.00
317_A346_V1.2831.00
127_N136_R1.2811.00
150_A232_Y1.2791.00
96_R128_D1.2751.00
360_S389_I1.2731.00
365_V383_V1.2701.00
422_I445_I1.2651.00
303_V316_C1.2641.00
236_F462_A1.2621.00
146_G171_K1.2621.00
292_V303_V1.2591.00
175_F214_K1.2571.00
67_N83_L1.2521.00
263_F396_I1.2471.00
365_V386_S1.2471.00
179_P216_N1.2451.00
147_K170_V1.2441.00
220_G223_V1.2421.00
291_V317_A1.2411.00
72_A126_I1.2401.00
176_D215_L1.2331.00
364_M390_V1.2301.00
366_R383_V1.2301.00
331_E335_A1.2271.00
366_R386_S1.2271.00
441_A446_V1.2271.00
238_G442_G1.2231.00
180_E187_F1.2201.00
457_A461_K1.2161.00
365_V387_E1.2071.00
131_F201_R1.2051.00
352_E360_S1.2051.00
424_A446_V1.2011.00
346_V364_M1.1961.00
335_A339_G1.1911.00
335_A338_E1.1881.00
285_M394_A1.1751.00
349_L365_V1.1601.00
207_T213_F1.1601.00
290_V311_A1.1501.00
343_K388_H1.1491.00
343_K366_R1.1451.00
321_D345_N1.1381.00
69_L122_I1.1351.00
178_H265_I1.1251.00
199_M203_R1.1251.00
290_V306_S1.1191.00
266_A282_F1.1141.00
433_Q437_P1.1101.00
251_N254_A1.1091.00
168_N464_D1.1091.00
436_N439_I1.1051.00
146_G170_V1.0960.99
415_E435_S1.0950.99
372_P375_K1.0930.99
336_R342_F1.0890.99
380_A384_A1.0780.99
465_G468_N1.0770.99
39_Q42_A1.0690.99
178_H242_Y1.0650.99
429_D433_Q1.0630.99
434_T441_A1.0620.99
89_T164_V1.0580.99
234_A466_I1.0560.99
78_F133_M1.0470.99
154_A215_L1.0430.99
373_D377_R1.0400.99
323_E326_P1.0360.99
118_T121_N1.0360.99
147_K470_L1.0330.99
450_D454_T1.0330.99
225_L229_L1.0310.99
88_N94_C1.0290.99
154_A213_F1.0250.99
365_V384_A1.0250.99
330_R333_K1.0180.99
417_D423_I1.0160.99
83_L86_Q1.0160.99
338_E342_F1.0140.99
186_T199_M1.0110.99
226_D436_N1.0110.99
263_F309_Q1.0100.99
241_T403_P1.0100.99
447_R454_T1.0080.99
237_L445_I1.0040.99
336_R339_G1.0040.99
63_N87_T0.9990.99
87_T460_R0.9940.99
159_L203_R0.9920.99
289_R315_T0.9880.99
175_F231_D0.9850.99
191_A197_E0.9840.99
141_G144_Q0.9830.99
227_D230_S0.9830.99
165_L466_I0.9790.99
286_E394_A0.9780.99
424_A441_A0.9770.99
37_E129_K0.9730.99
179_P187_F0.9690.99
326_P329_R0.9650.99
78_F135_W0.9540.99
431_A465_G0.9510.99
223_V227_D0.9490.99
246_R259_A0.9440.98
433_Q469_W0.9430.98
166_T209_M0.9420.98
303_V314_V0.9380.98
300_M316_C0.9370.98
85_H130_A0.9340.98
252_E397_M0.9310.98
64_Y86_Q0.9290.98
414_V422_I0.9170.98
122_I126_I0.9160.98
373_D376_G0.9150.98
148_K232_Y0.9100.98
161_C462_A0.9090.98
372_P376_G0.9090.98
330_R335_A0.9080.98
37_E75_G0.9060.98
61_V457_A0.9050.98
64_Y83_L0.9050.98
176_D213_F0.8980.98
319_R326_P0.8970.98
41_K75_G0.8920.98
422_I441_A0.8910.98
72_A77_I0.8910.98
70_K73_N0.8870.98
343_K346_V0.8850.98
163_D167_R0.8840.98
404_H407_E0.8840.98
335_A342_F0.8810.98
220_G224_Q0.8770.98
150_A235_V0.8730.97
142_V168_N0.8730.97
330_R334_N0.8700.97
442_G462_A0.8700.97
464_D468_N0.8690.97
335_A340_V0.8680.97
157_A442_G0.8610.97
345_N348_P0.8600.97
161_C442_G0.8600.97
267_N309_Q0.8590.97
331_E339_G0.8590.97
138_D208_G0.8550.97
81_A136_R0.8540.97
40_A122_I0.8530.97
35_F39_Q0.8500.97
383_V387_E0.8480.97
185_L194_L0.8480.97
288_K393_D0.8460.97
58_K107_S0.8450.97
177_R242_Y0.8430.97
424_A432_F0.8430.97
322_E325_M0.8360.97
333_K337_E0.8310.97
161_C238_G0.8300.97
446_V458_E0.8290.97
84_S88_N0.8290.97
68_W123_E0.8260.96
380_A383_V0.8230.96
37_E77_I0.8230.96
180_E186_T0.8210.96
45_D73_N0.8210.96
206_F211_I0.8210.96
418_S423_I0.8200.96
97_V194_L0.8200.96
259_A262_P0.8190.96
323_E327_G0.8190.96
409_L416_L0.8120.96
252_E351_I0.8090.96
332_V342_F0.8090.96
300_M304_R0.8080.96
362_V395_V0.8040.96
249_L348_P0.8010.96
349_L352_E0.7980.96
185_L452_V0.7980.96
315_T392_A0.7930.96
218_E222_D0.7930.96
319_R325_M0.7900.95
377_R380_A0.7890.95
79_E82_E0.7870.95
347_Q367_T0.7850.95
61_V456_I0.7810.95
225_L412_H0.7760.95
319_R348_P0.7730.95
373_D379_R0.7730.95
234_A469_W0.7720.95
329_R333_K0.7710.95
300_M335_A0.7690.95
440_F465_G0.7680.95
203_R207_T0.7670.95
266_A281_P0.7670.95
407_E410_A0.7660.95
466_I470_L0.7610.94
409_L414_V0.7590.94
257_V359_V0.7580.94
349_L387_E0.7570.94
287_G394_A0.7560.94
93_V199_M0.7540.94
258_Y283_V0.7530.94
346_V366_R0.7530.94
63_N88_N0.7520.94
150_A228_L0.7490.94
293_L395_V0.7480.94
159_L174_V0.7470.94
322_E344_F0.7460.94
258_Y266_A0.7440.94
424_A429_D0.7430.94
103_L119_I0.7420.94
170_V233_D0.7410.94
177_R405_N0.7360.93
200_T207_T0.7360.93
52_N109_T0.7350.93
332_V335_A0.7340.93
38_G42_A0.7340.93
139_M167_R0.7330.93
382_I386_S0.7330.93
191_A268_T0.7300.93
250_E363_K0.7290.93
149_V466_I0.7290.93
424_A433_Q0.7290.93
226_D411_K0.7270.93
369_M372_P0.7240.93
54_Y109_T0.7210.93
254_A355_G0.7200.93
197_E200_T0.7180.93
319_R323_E0.7130.92
91_P95_G0.7100.92
410_A416_L0.7090.92
228_L235_V0.7090.92
322_E329_R0.7080.92
226_D229_L0.7080.92
110_L114_F0.7070.92
315_T390_V0.7060.92
325_M329_R0.7060.92
61_V453_V0.7050.92
229_L235_V0.7030.92
338_E341_E0.7010.92
241_T445_I0.6980.92
345_N367_T0.6980.92
178_H187_F0.6960.91
35_F121_N0.6960.91
128_D198_V0.6940.91
432_F461_K0.6930.91
191_A196_K0.6920.91
120_G123_E0.6910.91
217_T224_Q0.6900.91
371_E375_K0.6900.91
258_Y394_A0.6890.91
64_Y87_T0.6870.91
318_Y399_F0.6860.91
149_V165_L0.6860.91
245_M419_Q0.6860.91
234_A470_L0.6860.91
141_G166_T0.6850.91
432_F446_V0.6840.91
162_A174_V0.6840.91
249_L351_I0.6810.91
95_G127_N0.6810.91
164_V460_R0.6800.90
229_L437_P0.6790.90
319_R345_N0.6780.90
224_Q229_L0.6770.90
252_E257_V0.6770.90
380_A386_S0.6750.90
150_A231_D0.6730.90
181_I200_T0.6720.90
350_G389_I0.6710.90
247_G397_M0.6700.90
451_L454_T0.6680.90
77_I129_K0.6670.90
371_E374_A0.6660.90
336_R340_V0.6660.90
332_V339_G0.6620.89
110_L113_E0.6610.89
243_Q402_R0.6600.89
149_V170_V0.6600.89
318_Y321_D0.6600.89
149_V470_L0.6580.89
207_T212_E0.6580.89
371_E381_E0.6560.89
90_L456_I0.6530.89
432_F458_E0.6530.89
62_H457_A0.6500.88
292_V314_V0.6490.88
148_K173_V0.6490.88
362_V392_A0.6490.88
92_E127_N0.6460.88
99_P451_L0.6430.88
164_V167_R0.6430.88
260_A302_C0.6420.88
365_V380_A0.6420.88
151_I238_G0.6420.88
63_N84_S0.6410.88
291_V315_T0.6390.88
100_Q120_G0.6380.87
125_Y129_K0.6370.87
302_C396_I0.6360.87
40_A121_N0.6360.87
71_L74_E0.6350.87
41_K45_D0.6350.87
174_V211_I0.6340.87
413_S436_N0.6330.87
254_A351_I0.6330.87
331_E340_V0.6330.87
442_G466_I0.6330.87
151_I236_F0.6310.87
82_E86_Q0.6310.87
243_Q404_H0.6300.87
88_N456_I0.6300.87
78_F137_P0.6280.87
54_Y110_L0.6270.87
312_K393_D0.6260.86
130_A136_R0.6250.86
121_N128_D0.6230.86
249_L257_V0.6230.86
442_G458_E0.6230.86
85_H136_R0.6210.86
85_H127_N0.6210.86
365_V385_G0.6190.86
286_E310_G0.6160.86
288_K394_A0.6150.85
109_T112_D0.6130.85
320_R367_T0.6130.85
146_G149_V0.6120.85
433_Q465_G0.6120.85
187_F242_Y0.6090.85
369_M373_D0.6070.85
331_E338_E0.6060.85
117_V123_E0.6050.85
67_N70_K0.6050.85
332_V336_R0.6040.84
84_S123_E0.6020.84
130_A134_G0.6020.84
320_R380_A0.6010.84
261_L265_I0.6010.84
324_N327_G0.6000.84
85_H205_I0.5980.84
46_R50_C0.5980.84
35_F40_A0.5970.84
441_A445_I0.5950.84
92_E202_R0.5940.83
49_S70_K0.5930.83
320_R323_E0.5930.83
34_P40_A0.5920.83
225_L228_L0.5900.83
148_K212_E0.5900.83
331_E336_R0.5900.83
123_E126_I0.5900.83
159_L206_F0.5890.83
337_E340_V0.5880.83
295_G325_M0.5880.83
350_G387_E0.5870.83
123_E127_N0.5860.83
331_E337_E0.5860.83
251_N395_V0.5850.83
65_I69_L0.5850.83
89_T160_A0.5850.83
239_V403_P0.5850.83
81_A126_I0.5840.82
34_P132_E0.5830.82
258_Y396_I0.5830.82
348_P351_I0.5820.82
131_F205_I0.5820.82
442_G459_G0.5810.82
245_M399_F0.5790.82
372_P379_R0.5790.82
319_R347_Q0.5780.82
103_L451_L0.5770.82
433_Q436_N0.5770.82
212_E232_Y0.5760.82
372_P377_R0.5760.82
332_V344_F0.5750.81
131_F134_G0.5750.81
129_K135_W0.5740.81
359_V393_D0.5740.81
40_A125_Y0.5730.81
112_D115_G0.5730.81
318_Y367_T0.5720.81
454_T458_E0.5710.81
462_A466_I0.5710.81
158_G238_G0.5700.81
167_R209_M0.5690.81
56_E64_Y0.5690.81
242_Y265_I0.5680.81
281_P284_S0.5670.81
334_N338_E0.5660.80
146_G233_D0.5650.80
359_V396_I0.5650.80
284_S396_I0.5630.80
287_G312_K0.5630.80
450_D453_V0.5620.80
207_T215_L0.5610.80
250_E253_D0.5610.80
42_A45_D0.5600.80
292_V395_V0.5570.79
196_K199_M0.5570.79
125_Y128_D0.5570.79
320_R345_N0.5570.79
58_K65_I0.5570.79
188_G261_L0.5560.79
260_A264_L0.5550.79
320_R347_Q0.5550.79
418_S421_R0.5550.79
255_D354_N0.5540.79
318_Y345_N0.5530.79
317_A343_K0.5520.79
320_R348_P0.5520.79
263_F286_E0.5510.79
137_P208_G0.5500.79
96_R198_V0.5500.79
206_F209_M0.5500.79
226_D413_S0.5500.79
308_R338_E0.5490.78
422_I435_S0.5490.78
235_V439_I0.5490.78
47_C50_C0.5460.78
365_V388_H0.5450.78
68_W84_S0.5450.78
345_N369_M0.5440.78
369_M379_R0.5430.78
263_F267_N0.5420.78
121_N125_Y0.5420.78
298_T458_E0.5410.77
224_Q411_K0.5400.77
56_E67_N0.5400.77
360_S391_P0.5390.77
455_A458_E0.5390.77
367_T371_E0.5390.77
461_K464_D0.5380.77
237_L439_I0.5370.77
409_L422_I0.5360.77
258_Y262_P0.5360.77
318_Y326_P0.5360.77
100_Q103_L0.5340.77
336_R341_E0.5340.77
247_G399_F0.5330.76
130_A135_W0.5330.76
143_K146_G0.5320.76
99_P298_T0.5310.76
228_L232_Y0.5310.76
205_I208_G0.5310.76
230_S356_N0.5310.76
414_V436_N0.5300.76
375_K379_R0.5290.76
320_R325_M0.5280.76
160_A164_V0.5270.76
160_A456_I0.5270.76
147_K171_K0.5260.75
324_N369_M0.5250.75
332_V340_V0.5240.75
319_R367_T0.5240.75
156_P452_V0.5240.75
119_I126_I0.5220.75
151_I174_V0.5210.75
191_A300_M0.5210.75
334_N339_G0.5200.75
399_F402_R0.5200.75
43_Q46_R0.5200.75
127_N130_A0.5180.74
367_T372_P0.5170.74
68_W119_I0.5160.74
85_H88_N0.5150.74
131_F136_R0.5150.74
99_P103_L0.5150.74
343_K390_V0.5140.74
192_F304_R0.5140.74
247_G252_E0.5140.74
63_N68_W0.5130.74
36_S40_A0.5120.74
185_L196_K0.5120.74
189_I194_L0.5110.73
318_Y402_R0.5110.73
334_N337_E0.5110.73
33_E37_E0.5110.73
72_A125_Y0.5100.73
40_A44_A0.5100.73
95_G124_R0.5100.73
330_R340_V0.5100.73
140_S143_K0.5090.73
127_N131_F0.5090.73
121_N124_R0.5090.73
138_D142_V0.5090.73
312_K315_T0.5090.73
255_D360_S0.5080.73
280_E284_S0.5070.73
191_A195_E0.5060.73
369_M380_A0.5060.73
40_A124_R0.5050.72
457_A460_R0.5040.72
251_N350_G0.5040.72
68_W453_V0.5040.72
291_V395_V0.5030.72
450_D456_I0.5020.72
123_E128_D0.5010.72
371_E377_R0.5010.72
139_M142_V0.5000.72
345_N371_E0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ylfB 1 0.9703 100 0.24 Contact Map
1gteA 4 0.9767 100 0.257 Contact Map
2vdcG 1 0.9364 100 0.273 Contact Map
1cjcA 1 0.6589 100 0.622 Contact Map
1lqtA 1 0.6568 100 0.634 Contact Map
1mo9A 2 0.6907 100 0.643 Contact Map
1hyuA 2 0.911 100 0.662 Contact Map
1vdcA 2 0.6314 100 0.67 Contact Map
3ctyA 2 0.6059 100 0.672 Contact Map
1o94A 2 0.8898 100 0.672 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0133 seconds.