GREMLIN Database
ARGT - Lysine/arginine/ornithine-binding periplasmic protein
UniProt: P09551 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10072
Length: 260 (235)
Sequences: 22994 (16728)
Seq/√Len: 1091.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_G86_I3.8211.00
137_G177_L3.6071.00
27_T68_T3.5541.00
62_R238_E2.8581.00
162_Y171_D2.4591.00
145_E161_A2.4581.00
80_S86_I2.2871.00
107_D237_G2.2831.00
95_I100_Q2.2611.00
43_D49_V2.2321.00
29_R68_T2.2191.00
164_N167_L2.1941.00
27_T66_K2.1431.00
95_I218_G2.1201.00
97_D100_Q2.0891.00
145_E149_N2.0831.00
29_R70_V2.0831.00
246_D250_K2.0491.00
244_T247_K2.0131.00
60_C67_C2.0031.00
82_K102_E2.0031.00
58_E61_K2.0001.00
221_L229_T1.9521.00
135_H160_V1.9401.00
237_G241_Q1.9331.00
229_T233_N1.9261.00
62_R235_A1.9171.00
104_A229_T1.9071.00
103_I220_G1.8911.00
182_Q187_A1.8691.00
168_V180_A1.8221.00
127_T130_S1.8041.00
107_D233_N1.7731.00
58_E244_T1.7641.00
221_L232_F1.7621.00
30_I56_G1.7111.00
135_H158_D1.6761.00
117_I187_A1.6731.00
171_D176_R1.6561.00
80_S85_K1.6411.00
90_I219_V1.5811.00
106_S233_N1.5791.00
58_E62_R1.5781.00
58_E239_L1.5691.00
140_Q163_A1.5681.00
119_A175_G1.5481.00
72_S80_S1.5131.00
222_R225_D1.5081.00
230_A234_K1.4601.00
119_A122_S1.4251.00
111_A216_G1.4231.00
62_R242_D1.4181.00
77_L89_I1.4181.00
54_D251_K1.3901.00
226_A230_A1.3781.00
78_I103_I1.3661.00
43_D47_D1.3651.00
184_E188_S1.3471.00
120_K199_D1.3461.00
146_A150_E1.3381.00
59_M235_A1.3351.00
104_A224_D1.3271.00
53_I57_N1.3191.00
42_K71_A1.3181.00
231_A234_K1.3161.00
63_M235_A1.3131.00
134_K178_D1.3121.00
121_G201_A1.3071.00
20_S24_L1.3061.00
135_H178_D1.3011.00
147_Y151_T1.2981.00
57_N69_W1.2961.00
93_L220_G1.2931.00
41_S49_V1.2821.00
149_N161_A1.2791.00
171_D177_L1.2751.00
173_A199_D1.2721.00
115_R184_E1.2711.00
30_I88_A1.2651.00
118_A179_A1.2581.00
170_S174_A1.2261.00
52_D109_L1.2231.00
34_T71_A1.2021.00
172_L200_F1.1931.00
56_G90_I1.1911.00
114_S144_Q1.1891.00
137_G162_Y1.1841.00
235_A238_E1.1821.00
120_K201_A1.1781.00
163_A167_L1.1771.00
238_E242_D1.1761.00
84_K222_R1.1721.00
132_K156_G1.1671.00
79_P83_A1.1651.00
26_E65_V1.1631.00
116_L179_A1.1621.00
235_A239_L1.1571.00
89_I93_L1.1541.00
136_V179_A1.1451.00
79_P82_K1.1431.00
240_R245_Y1.1391.00
138_V145_E1.1361.00
51_F253_F1.1291.00
231_A235_A1.1121.00
98_K101_Q1.1101.00
51_F248_M1.1091.00
115_R202_F1.1021.00
65_V231_A1.0951.00
21_Y25_P1.0951.00
170_S173_A1.0861.00
73_D76_A1.0851.00
162_Y168_V1.0831.00
72_S86_I1.0821.00
172_L180_A1.0671.00
51_F249_A1.0421.00
139_L142_S1.0331.00
57_N61_K1.0331.00
30_I67_C1.0261.00
20_S23_A1.0181.00
118_A203_A1.0171.00
56_G69_W1.0161.00
172_L177_L1.0091.00
104_A223_K1.0051.00
49_V54_D1.0021.00
244_T248_M0.9991.00
62_R244_T0.9971.00
55_L239_L0.9951.00
54_D252_Y0.9921.00
234_K238_E0.9881.00
122_S125_Q0.9871.00
227_E231_A0.9831.00
56_G67_C0.9831.00
88_A232_F0.9791.00
55_L245_Y0.9751.00
25_P29_R0.9681.00
96_T99_R0.9661.00
173_A195_P0.9541.00
104_A226_A0.9491.00
22_A25_P0.9491.00
167_L170_S0.9461.00
48_F53_I0.9451.00
140_Q161_A0.9411.00
59_M232_F0.9371.00
137_G168_V0.9361.00
82_K103_I0.9351.00
54_D57_N0.9351.00
47_D57_N0.9321.00
78_I93_L0.9321.00
239_L244_T0.9271.00
146_A149_N0.9251.00
88_A221_L0.9231.00
233_N237_G0.9201.00
118_A122_S0.9081.00
42_K46_G0.9071.00
189_E194_Q0.9011.00
51_F245_Y0.8901.00
233_N236_L0.8861.00
247_K251_K0.8761.00
247_K250_K0.8751.00
10_L13_G0.8741.00
166_D170_S0.8651.00
245_Y249_A0.8631.00
100_Q223_K0.8631.00
226_A229_T0.8631.00
97_D101_Q0.8601.00
106_S232_F0.8571.00
249_A253_F0.8571.00
105_F220_G0.8571.00
76_A80_S0.8561.00
39_F110_Y0.8541.00
74_F77_L0.8531.00
107_D240_R0.8521.00
125_Q130_S0.8511.00
152_W155_K0.8511.00
118_A201_A0.8461.00
112_A185_V0.8441.00
37_A41_S0.8431.00
22_A65_V0.8411.00
42_K48_F0.8401.00
147_Y150_E0.8261.00
160_V171_D0.8231.00
22_A26_E0.8211.00
94_S215_D0.8171.00
95_I108_K0.8171.00
165_Q182_Q0.8131.00
28_V65_V0.8101.00
113_D184_E0.8101.00
56_G219_V0.8051.00
152_W157_V0.8051.00
32_T69_W0.8051.00
89_I220_G0.8031.00
238_E241_Q0.7991.00
13_G16_T0.7971.00
34_T48_F0.7971.00
227_E230_A0.7961.00
88_A219_V0.7961.00
58_E235_A0.7961.00
116_L181_L0.7901.00
99_R105_F0.7841.00
123_P201_A0.7821.00
63_M231_A0.7801.00
56_G88_A0.7791.00
239_L242_D0.7771.00
129_D132_K0.7731.00
28_V88_A0.7721.00
246_D249_A0.7711.00
17_A227_E0.7601.00
32_T91_S0.7591.00
29_R87_D0.7581.00
62_R239_L0.7541.00
32_T53_I0.7531.00
70_V85_K0.7511.00
81_L89_I0.7471.00
115_R204_G0.7451.00
41_S252_Y0.7441.00
57_N67_C0.7421.00
59_M63_M0.7411.00
27_T65_V0.7381.00
124_I134_K0.7281.00
119_A199_D0.7261.00
137_G171_D0.7221.00
125_Q201_A0.7221.00
112_A184_E0.7191.00
78_I82_K0.7171.00
148_A159_V0.7121.00
117_I200_F0.7101.00
72_S77_L0.7071.00
195_P198_K0.7061.00
28_V60_C0.7051.00
59_M90_I0.7041.00
234_K237_G0.7031.00
239_L243_G0.7021.00
239_L245_Y0.6991.00
81_L86_I0.6961.00
162_Y177_L0.6911.00
31_G77_L0.6911.00
169_Y200_F0.6861.00
169_Y173_A0.6841.00
33_D74_F0.6831.00
115_R187_A0.6821.00
131_L179_A0.6811.00
219_V232_F0.6811.00
84_K224_D0.6801.00
188_S193_K0.6791.00
81_L103_I0.6781.00
33_D40_S0.6771.00
36_Y92_S0.6751.00
17_A20_S0.6741.00
106_S221_L0.6711.00
117_I169_Y0.6701.00
34_T40_S0.6701.00
76_A79_P0.6701.00
167_L171_D0.6681.00
58_E248_M0.6681.00
95_I105_F0.6651.00
94_S99_R0.6641.00
30_I69_W0.6641.00
106_S219_V0.6571.00
38_P41_S0.6521.00
225_D228_L0.6481.00
23_A26_E0.6471.00
17_A21_Y0.6441.00
104_A225_D0.6421.00
192_L195_P0.6411.00
53_I69_W0.6411.00
55_L236_L0.6401.00
19_S22_A0.6401.00
135_H177_L0.6391.00
113_D214_G0.6391.00
111_A214_G0.6371.00
149_N159_V0.6361.00
70_V86_I0.6361.00
60_C64_Q0.6351.00
189_E193_K0.6351.00
237_G240_R0.6311.00
49_V252_Y0.6261.00
10_L14_L0.6241.00
188_S202_F0.6191.00
33_D91_S0.6191.00
32_T48_F0.6181.00
60_C63_M0.6171.00
105_F218_G0.6161.00
113_D208_K0.6141.00
74_F93_L0.6121.00
114_S181_L0.6091.00
36_Y74_F0.6081.00
143_T215_D0.6031.00
138_V161_A0.6001.00
230_A233_N0.5981.00
33_D139_L0.5951.00
60_C65_V0.5951.00
160_V177_L0.5931.00
106_S236_L0.5911.00
18_A21_Y0.5861.00
59_M219_V0.5861.00
52_D92_S0.5851.00
107_D236_L0.5811.00
81_L222_R0.5801.00
148_A181_L0.5791.00
9_S12_V0.5781.00
208_K214_G0.5751.00
110_Y217_T0.5741.00
12_V15_S0.5741.00
40_S91_S0.5721.00
34_T42_K0.5721.00
191_F194_Q0.5711.00
61_K244_T0.5711.00
100_Q104_A0.5701.00
56_G60_C0.5671.00
93_L103_I0.5671.00
36_Y39_F0.5651.00
243_G246_D0.5651.00
152_W156_G0.5591.00
82_K222_R0.5591.00
197_G200_F0.5551.00
106_S229_T0.5531.00
26_E231_A0.5531.00
31_G89_I0.5521.00
243_G247_K0.5521.00
177_L180_A0.5511.00
221_L225_D0.5511.00
108_K111_A0.5491.00
184_E206_S0.5491.00
139_L165_Q0.5471.00
94_S143_T0.5451.00
70_V80_S0.5431.00
121_G175_G0.5421.00
195_P199_D0.5421.00
116_L131_L0.5391.00
136_V148_A0.5391.00
63_M228_L0.5361.00
182_Q186_A0.5361.00
173_A200_F0.5311.00
239_L248_M0.5301.00
29_R84_K0.5281.00
200_F203_A0.5261.00
74_F99_R0.5251.00
54_D248_M0.5251.00
168_V171_D0.5241.00
240_R243_G0.5231.00
112_A217_T0.5221.00
85_K176_R0.5211.00
77_L93_L0.5181.00
140_Q145_E0.5171.00
25_P87_D0.5171.00
37_A189_E0.5131.00
28_V228_L0.5111.00
22_A231_A0.5091.00
56_G59_M0.5061.00
26_E66_K0.5051.00
104_A221_L0.5021.00
77_L80_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ylnA 1 0.8808 100 0.243 Contact Map
1xt8A 1 0.8846 100 0.246 Contact Map
3hv1A 2 0.9423 100 0.252 Contact Map
2yjpA 1 0.8846 100 0.252 Contact Map
4powA 1 0.8846 100 0.255 Contact Map
4ohnA 1 0.9231 100 0.26 Contact Map
3kbrA 4 0.8769 100 0.262 Contact Map
3k4uA 5 0.8846 100 0.263 Contact Map
1lstA 1 0.9154 100 0.263 Contact Map
2vhaA 2 0.9308 100 0.265 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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