GREMLIN Database
DEDD - Protein DedD
UniProt: P09549 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10218
Length: 220 (202)
Sequences: 1054 (983)
Seq/√Len: 69.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_V197_L4.2451.00
173_T184_T3.9931.00
178_P181_G3.9621.00
161_V165_R2.9561.00
191_D200_S2.8681.00
205_K211_S2.5551.00
201_L205_K2.4351.00
146_V201_L2.3771.00
150_A213_V2.2371.00
150_A156_K2.2151.00
191_D196_K2.1991.00
144_Y194_K2.1921.00
193_S196_K2.1201.00
98_E102_A2.0831.00
20_V27_L2.0691.00
162_G166_G2.0121.00
194_K198_K1.9921.00
151_L156_K1.9871.00
21_I24_P1.9311.00
16_V20_V1.9101.00
20_V24_P1.8631.00
145_V172_Y1.8411.00
24_P27_L1.8291.00
12_T23_L1.8121.00
201_L212_G1.7761.00
194_K197_L1.7681.00
12_T25_G1.7161.00
148_L164_L1.6831.00
157_V171_V1.6660.99
157_V173_T1.6640.99
198_K201_L1.6560.99
66_Q70_G1.6460.99
161_V214_V1.6310.99
16_V23_L1.6280.99
149_G162_G1.5670.99
90_I94_N1.5240.99
154_A158_N1.5070.99
154_A184_T1.5060.99
12_T197_L1.4890.99
13_I27_L1.4860.99
116_K120_E1.4790.99
180_Q203_E1.4700.99
19_G25_G1.4240.98
105_A112_V1.4220.98
148_L210_L1.4170.98
158_N162_G1.3910.98
102_A105_A1.3840.98
94_N106_P1.3790.98
105_A108_K1.3720.98
119_V123_P1.3670.98
65_T68_P1.3670.98
12_T15_L1.3640.98
28_D41_I1.3610.98
148_L169_Y1.3600.98
97_F101_P1.3570.98
96_E100_E1.3290.97
152_K183_I1.3290.97
118_K121_A1.3160.97
21_I26_L1.3080.97
43_L47_A1.2970.97
122_P126_K1.2720.97
71_A74_E1.2620.96
174_S185_R1.2580.96
177_T182_K1.2460.96
118_K122_P1.2440.96
174_S187_L1.2400.96
157_V184_T1.2350.96
25_G29_G1.2310.96
151_L159_E1.2290.96
100_E105_A1.2240.96
68_P76_R1.2060.95
92_A104_V1.2030.95
28_D31_K1.1920.95
174_S194_K1.1920.95
69_E75_V1.1860.95
16_V27_L1.1850.95
118_K123_P1.1780.95
100_E103_P1.1780.95
22_V26_L1.1760.95
19_G30_Q1.1740.95
54_D59_A1.1720.95
14_V22_V1.1720.95
119_V122_P1.1720.95
93_N98_E1.1710.95
147_Q185_R1.1700.95
94_N98_E1.1660.94
145_V215_M1.1620.94
156_K173_T1.1620.94
82_A104_V1.1420.94
15_L23_L1.1420.94
176_S183_I1.1410.94
24_P28_D1.1400.94
17_A21_I1.1300.93
91_A104_V1.1240.93
114_P118_K1.1140.93
160_I186_I1.1080.93
69_E73_E1.1080.93
22_V25_G1.1010.93
153_N184_T1.0730.92
199_G202_G1.0630.91
23_L28_D1.0620.91
23_L27_L1.0360.90
18_L22_V1.0330.90
74_E78_G1.0250.90
112_V122_P1.0240.90
157_V186_I1.0240.90
100_E104_V1.0210.89
83_P118_K1.0120.89
170_R204_L1.0010.88
16_V32_K1.0000.88
21_I29_G0.9950.88
124_A131_P0.9930.88
60_T65_T0.9830.88
125_P129_P0.9770.87
94_N97_F0.9740.87
16_V30_Q0.9740.87
70_G74_E0.9690.87
100_E106_P0.9650.87
93_N135_E0.9530.86
110_K118_K0.9470.86
77_A83_P0.9390.85
100_E111_P0.9310.85
161_V171_V0.9290.84
13_I146_V0.9280.84
10_V181_G0.9230.84
39_A42_P0.9210.84
89_T94_N0.9160.84
151_L160_I0.9130.83
169_Y204_L0.9120.83
167_A207_L0.9020.83
115_P119_V0.8940.82
76_R79_D0.8910.82
77_A81_A0.8900.82
156_K159_E0.8880.82
40_A43_L0.8710.80
109_P121_A0.8670.80
150_A173_T0.8660.80
23_L36_D0.8570.79
143_A169_Y0.8530.79
21_I25_G0.8440.78
105_A109_P0.8430.78
158_N161_V0.8420.78
108_K112_V0.8420.78
191_D197_L0.8390.78
98_E106_P0.8370.78
72_A82_A0.8370.78
148_L184_T0.8360.78
108_K118_K0.8360.78
108_K121_A0.8350.78
108_K116_K0.8340.77
138_A141_G0.8330.77
112_V133_V0.8250.77
62_A66_Q0.8240.77
22_V29_G0.8210.76
109_P113_E0.8200.76
103_P107_P0.8180.76
124_A132_V0.8180.76
154_A175_P0.8120.76
156_K184_T0.8060.75
181_G184_T0.8060.75
97_F105_A0.8010.75
147_Q168_G0.8010.75
12_T194_K0.7970.74
111_P115_P0.7940.74
165_R200_S0.7910.74
20_V25_G0.7890.73
166_G171_V0.7870.73
107_P127_P0.7860.73
157_V178_P0.7840.73
73_E77_A0.7820.73
47_A50_R0.7730.72
68_P72_A0.7730.72
127_P131_P0.7710.72
98_E105_A0.7710.72
102_A106_P0.7640.71
88_A116_K0.7610.71
153_N169_Y0.7560.70
106_P110_K0.7550.70
96_E99_P0.7550.70
148_L160_I0.7520.70
107_P125_P0.7440.69
165_R171_V0.7390.68
95_T98_E0.7370.68
151_L201_L0.7340.68
95_T99_P0.7310.68
169_Y187_L0.7300.68
32_K37_E0.7300.68
12_T28_D0.7270.67
61_Q64_P0.7240.67
117_P131_P0.7200.66
112_V116_K0.7190.66
22_V27_L0.7180.66
164_L171_V0.7120.66
30_Q37_E0.7090.65
151_L213_V0.7060.65
53_P56_M0.7030.65
95_T135_E0.6990.64
41_I45_P0.6950.64
61_Q69_E0.6930.63
106_P109_P0.6900.63
131_P134_E0.6900.63
90_I95_T0.6880.63
78_G81_A0.6860.63
160_I183_I0.6850.63
21_I28_D0.6850.63
115_P118_K0.6840.62
14_V144_Y0.6830.62
177_T180_Q0.6810.62
149_G190_P0.6770.62
144_Y156_K0.6750.61
29_G34_Y0.6690.61
14_V17_A0.6670.61
19_G193_S0.6660.60
144_Y150_A0.6650.60
29_G32_K0.6650.60
148_L158_N0.6590.60
88_A92_A0.6570.59
121_A131_P0.6540.59
55_M59_A0.6540.59
98_E104_V0.6530.59
41_I44_V0.6480.58
165_R170_R0.6460.58
160_I176_S0.6430.58
110_K113_E0.6420.58
162_G204_L0.6360.57
101_P122_P0.6330.57
99_P107_P0.6310.56
89_T93_N0.6310.56
157_V175_P0.6310.56
159_E163_K0.6300.56
106_P115_P0.6300.56
104_V110_K0.6200.55
67_P75_V0.6200.55
156_K187_L0.6190.55
95_T125_P0.6160.55
124_A128_E0.6140.54
76_R81_A0.6090.54
173_T182_K0.6070.53
14_V29_G0.6030.53
184_T201_L0.6000.53
23_L26_L0.5980.52
148_L168_G0.5960.52
123_P129_P0.5960.52
110_K114_P0.5930.52
42_P190_P0.5920.52
25_G201_L0.5910.52
146_V172_Y0.5890.51
106_P127_P0.5870.51
196_K199_G0.5860.51
102_A116_K0.5830.51
28_D156_K0.5830.51
10_V148_L0.5820.50
69_E81_A0.5820.50
95_T102_A0.5720.49
17_A24_P0.5720.49
92_A96_E0.5710.49
158_N166_G0.5690.49
152_K170_R0.5670.49
188_V204_L0.5660.49
19_G43_L0.5640.48
100_E115_P0.5640.48
41_I50_R0.5590.48
105_A116_K0.5580.48
14_V167_A0.5560.47
191_D207_L0.5550.47
123_P126_K0.5550.47
92_A95_T0.5550.47
62_A73_E0.5520.47
72_A77_A0.5490.46
149_G160_I0.5480.46
20_V26_L0.5460.46
195_D199_G0.5460.46
21_I165_R0.5460.46
33_H36_D0.5440.46
16_V193_S0.5430.46
44_V49_D0.5430.46
98_E127_P0.5400.45
94_N99_P0.5380.45
10_V157_V0.5370.45
93_N111_P0.5360.45
64_P112_V0.5340.45
145_V187_L0.5320.44
10_V13_I0.5310.44
30_Q33_H0.5310.44
97_F131_P0.5300.44
98_E108_K0.5280.44
121_A124_A0.5270.44
64_P107_P0.5250.44
119_V124_A0.5240.44
92_A121_A0.5220.43
111_P121_A0.5220.43
149_G213_V0.5210.43
70_G75_V0.5190.43
16_V35_Q0.5190.43
24_P41_I0.5160.43
61_Q65_T0.5150.42
49_D53_P0.5130.42
53_P58_A0.5090.42
101_P104_V0.5070.41
10_V37_E0.5020.41
13_I157_V0.5020.41
98_E117_P0.5010.41
156_K166_G0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1x60A 1 0.3591 99.7 0.621 Contact Map
1utaA 1 0.35 99.7 0.623 Contact Map
2lfvA 1 0.4545 98.9 0.761 Contact Map
4zpjA 1 0.3364 78.7 0.909 Contact Map
2lepA 1 0.2727 43.6 0.928 Contact Map
4s1aA 2 0.3409 31.1 0.934 Contact Map
4hddA 6 0.3 28.5 0.935 Contact Map
2hfvA 1 0.4136 26.3 0.936 Contact Map
5bmqA 3 0.2955 19.8 0.939 Contact Map
4hnoA 1 0.3182 19.5 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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