GREMLIN Database
PUTA - Bifunctional protein PutA
UniProt: P09546 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10801
Length: 1320 (1084)
Sequences: 1086 (642)
Seq/√Len: 19.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
711_H758_R11.7891.00
713_A818_L6.5311.00
1039_E1066_S6.4251.00
694_N827_V6.4181.00
1035_P1066_S5.0931.00
813_Q816_A4.9861.00
941_M1006_L4.7241.00
750_L790_A4.5951.00
1050_L1067_A4.5251.00
717_M786_T4.4161.00
718_E747_V4.3651.00
263_E267_E4.2201.00
350_Y386_K4.1361.00
709_I823_V4.1161.00
1050_L1069_V4.0921.00
927_D1030_N4.0831.00
358_L392_E4.0791.00
924_C1037_L4.0441.00
354_K392_E3.9311.00
680_T683_E3.8701.00
806_Q961_D3.8201.00
858_E1017_K3.7831.00
929_I933_T3.7521.00
688_L845_D3.6761.00
453_Y606_P3.6471.00
729_V739_A3.5681.00
92_R382_D3.5511.00
415_D472_K3.4371.00
723_Q813_Q3.4211.00
294_A298_Q3.3971.00
965_K969_E3.3811.00
1035_P1062_Q3.3661.00
357_T367_I3.3171.00
344_R943_E3.3091.00
934_L1026_V3.2571.00
344_R348_E3.2431.00
902_V937_L3.2341.00
892_V901_V3.1840.99
350_Y383_L3.1450.99
354_K358_L3.1210.99
452_G601_P3.1120.99
1062_Q1066_S3.0900.99
100_R623_D3.0730.99
456_Y465_S3.0490.99
669_P1000_T3.0370.99
1033_Q1036_E3.0230.99
688_L848_V3.0110.99
311_I326_I3.0010.99
309_H359_L2.9950.99
670_K998_S2.9820.99
368_N402_V2.9770.99
969_E1002_V2.9390.99
467_L494_A2.9210.99
298_Q352_R2.9200.99
1191_E1215_S2.8730.99
123_Q497_Q2.8680.99
720_Q723_Q2.8660.99
129_Y578_D2.8600.99
354_K390_E2.8400.99
419_D423_R2.8340.99
688_L847_R2.8200.99
786_T790_A2.7970.99
342_Y382_D2.7660.99
761_F764_E2.7360.98
967_N1017_K2.7360.98
155_F210_T2.7360.98
389_F424_S2.7000.98
901_V905_V2.6980.98
645_W649_P2.6750.98
1008_E1028_R2.6600.98
284_Y324_P2.6440.98
800_L831_L2.6400.98
294_A352_R2.6350.98
969_E973_Q2.5550.97
771_P798_S2.5070.97
350_Y387_L2.4810.97
925_L933_T2.4800.97
649_P832_P2.4750.97
924_C1012_F2.4740.97
1029_Y1038_I2.4240.96
309_H363_Y2.4200.96
714_A751_H2.4200.96
703_P794_A2.4140.96
348_E943_E2.4100.96
99_Y625_A2.4080.96
292_L903_V2.4000.96
615_G755_G2.3980.96
982_V1007_I2.3870.96
773_V848_V2.3730.96
388_C428_L2.3560.96
887_M922_V2.3380.96
922_V1012_F2.3360.96
962_S966_A2.3110.95
1035_P1038_I2.3050.95
350_Y390_E2.2980.95
175_I895_S2.2630.95
704_A758_R2.2630.95
1052_V1063_V2.2600.95
679_A687_A2.2570.95
1030_N1033_Q2.2530.95
732_A807_T2.2380.94
691_A829_Q2.2320.94
716_L821_A2.2290.94
1010_D1014_E2.2210.94
302_V306_Q2.1930.94
152_L255_M2.1800.94
411_P456_Y2.1800.94
942_A984_Q2.1760.94
328_I353_L2.1480.93
272_A284_Y2.1380.93
1050_L1072_L2.1370.93
909_A1024_L2.1300.93
725_I736_F2.1260.93
1193_V1255_A2.1010.92
702_P705_E2.1000.92
720_Q813_Q2.0960.92
325_G366_G2.0800.92
403_I414_I2.0700.92
962_S965_K2.0650.92
193_N196_S2.0470.91
685_E841_Q2.0430.91
905_V923_L2.0380.91
96_T378_E2.0350.91
756_Q759_D2.0270.91
651_L654_P2.0230.91
727_I809_L2.0130.91
325_G429_M2.0030.90
1054_T1060_I1.9970.90
772_V1109_L1.9930.90
738_N911_D1.9930.90
101_R105_E1.9880.90
713_A750_L1.9730.90
1009_L1027_V1.9660.89
422_T479_L1.9570.89
712_R716_L1.9510.89
461_Y588_V1.9380.89
819_L828_V1.9330.89
385_E416_Y1.9320.89
353_L369_I1.9260.88
739_A743_V1.9250.88
852_M1109_L1.9220.88
709_I828_V1.9220.88
1038_I1066_S1.9080.88
312_G363_Y1.9070.88
887_M1044_S1.9000.88
695_A699_F1.8960.88
819_L825_P1.8870.87
388_C424_S1.8830.87
695_A798_S1.8790.87
115_R589_E1.8780.87
276_E284_Y1.8720.87
812_A816_A1.8660.87
387_L399_I1.8640.87
946_M956_I1.8610.87
975_M1007_I1.8540.86
111_L588_V1.8390.86
129_Y581_V1.8280.86
120_V123_Q1.8280.86
805_E835_G1.8260.86
1036_E1040_Q1.8150.85
931_D1028_R1.8030.85
716_L719_S1.7730.84
295_A935_K1.7710.84
629_R632_S1.7690.84
687_A831_L1.7690.84
678_E808_P1.7670.84
214_L217_G1.7640.83
569_R579_E1.7590.83
715_V751_H1.7570.83
1038_I1062_Q1.7570.83
127_L497_Q1.7540.83
384_L399_I1.7470.83
147_M150_G1.7380.83
266_A306_Q1.7350.82
766_H1110_L1.7310.82
750_L818_L1.7310.82
705_E708_A1.7300.82
584_P588_V1.7270.82
688_L831_L1.6930.81
905_V933_T1.6930.81
388_C399_I1.6900.81
1121_T1124_R1.6700.80
151_L214_L1.6680.80
965_K1002_V1.6630.80
684_V831_L1.6630.80
167_C217_G1.6630.80
708_A712_R1.6590.79
721_M743_V1.6580.79
771_P800_L1.6570.79
308_I365_I1.6560.79
298_Q302_V1.6330.78
129_Y577_L1.6300.78
772_V797_N1.6300.78
685_E689_E1.6250.78
661_S678_E1.6250.78
806_Q1179_T1.6240.78
319_G323_G1.6210.78
280_F522_E1.6150.78
272_A276_E1.6040.77
858_E862_L1.5990.77
133_D578_D1.5980.77
386_K390_E1.5970.77
1011_D1040_Q1.5930.77
151_L156_S1.5890.76
819_L823_V1.5800.76
290_A903_V1.5690.75
818_L823_V1.5690.75
640_S726_G1.5660.75
345_V348_E1.5550.75
772_V850_G1.5540.75
134_K523_Q1.5420.74
1069_V1072_L1.5400.74
934_L937_L1.5340.74
1118_L1121_T1.5340.74
648_L651_L1.5300.74
1210_V1215_S1.5270.73
294_A943_E1.5250.73
941_M984_Q1.5250.73
1210_V1217_V1.5210.73
305_Q359_L1.5160.73
418_I476_V1.5120.73
422_T478_N1.5090.72
713_A828_V1.5090.72
815_I828_V1.5050.72
930_A1028_R1.5050.72
681_P841_Q1.5030.72
707_A754_A1.5020.72
1038_I1042_N1.5020.72
201_S206_V1.4980.72
679_A831_L1.4950.72
343_D945_R1.4950.72
687_A832_P1.4920.72
665_N671_D1.4880.71
138_Q523_Q1.4750.71
646_Q649_P1.4710.70
984_Q1006_L1.4670.70
292_L328_I1.4650.70
375_D444_R1.4640.70
684_V838_V1.4630.70
925_L934_L1.4630.70
757_V794_A1.4610.70
124_A497_Q1.4590.70
302_V305_Q1.4560.70
972_I1002_V1.4540.70
1012_F1027_V1.4520.69
1011_D1027_V1.4520.69
650_M819_L1.4520.69
616_R621_G1.4500.69
1120_V1123_A1.4490.69
985_A988_E1.4440.69
898_T933_T1.4390.69
467_L498_L1.4350.69
716_L820_E1.4350.69
301_M355_S1.4350.69
422_T476_V1.4330.68
439_D560_N1.4230.68
101_R106_A1.4110.67
1119_A1125_Q1.4060.67
281_R407_Q1.4050.67
490_H494_A1.4040.67
663_V808_P1.4000.67
701_T705_E1.3890.66
716_L720_Q1.3890.66
982_V1005_T1.3850.66
805_E963_E1.3820.66
924_C1027_V1.3820.66
1041_I1050_L1.3810.65
645_W651_L1.3810.65
972_I1007_I1.3800.65
664_I669_P1.3800.65
104_T108_S1.3750.65
1121_T1125_Q1.3700.65
819_L826_G1.3680.65
243_L255_M1.3640.64
961_D1179_T1.3620.64
117_P120_V1.3580.64
713_A823_V1.3570.64
720_Q820_E1.3560.64
133_D137_N1.3560.64
944_C956_I1.3550.64
95_I413_V1.3540.64
467_L491_T1.3520.64
135_L571_A1.3430.63
341_Q344_R1.3300.62
102_P105_E1.3250.62
133_D573_T1.3240.62
130_Q133_D1.3230.62
139_K149_Q1.3200.62
947_G954_T1.3130.61
432_L482_P1.3130.61
703_P757_V1.3090.61
1209_A1294_L1.3040.61
1050_L1063_V1.3040.61
699_F827_V1.3000.61
969_E1054_T1.2980.61
728_L782_L1.2980.61
1067_A1072_L1.2960.60
649_P653_Q1.2950.60
278_K522_E1.2910.60
793_L828_V1.2890.60
453_Y607_L1.2890.60
132_A577_L1.2870.60
905_V925_L1.2810.59
974_T979_G1.2810.59
741_A1063_V1.2730.59
239_S243_L1.2670.59
534_N925_L1.2670.59
692_V847_R1.2670.59
383_L387_L1.2660.59
649_P831_L1.2640.58
1184_T1305_V1.2630.58
1211_L1215_S1.2630.58
892_V905_V1.2610.58
985_A1003_A1.2600.58
688_L773_V1.2570.58
615_G756_Q1.2530.58
645_W648_L1.2500.58
402_V1078_M1.2470.57
804_A960_I1.2430.57
715_V719_S1.2410.57
407_Q1052_V1.2400.57
208_A211_W1.2400.57
315_S323_G1.2380.57
464_V468_A1.2370.57
135_L968_I1.2370.57
623_D629_R1.2350.57
713_A786_T1.2340.57
429_M623_D1.2340.57
907_A1079_V1.2330.56
699_F768_P1.2320.56
771_P849_R1.2300.56
673_V730_R1.2290.56
512_C852_M1.2270.56
154_E197_H1.2220.56
645_W1052_V1.2210.56
710_L790_A1.2150.55
1112_N1121_T1.2140.55
1029_Y1034_L1.2100.55
713_A720_Q1.2090.55
826_G829_Q1.2000.54
963_E967_N1.1980.54
1191_E1210_V1.1970.54
1119_A1124_R1.1880.54
202_P224_N1.1860.54
834_R837_T1.1850.53
414_I702_P1.1840.53
929_I932_H1.1820.53
720_Q817_I1.1820.53
325_G398_G1.1740.53
1195_C1301_R1.1730.53
761_F1110_L1.1720.53
203_S210_T1.1720.53
551_A936_M1.1700.52
324_P537_C1.1670.52
119_P123_Q1.1650.52
389_F420_L1.1580.52
313_K865_R1.1580.52
626_N629_R1.1560.52
664_I672_I1.1560.52
898_T929_I1.1560.52
1203_A1215_S1.1530.51
384_L401_F1.1480.51
922_V1044_S1.1470.51
688_L844_G1.1470.51
218_K253_R1.1470.51
414_I417_L1.1460.51
816_A823_V1.1450.51
678_E834_R1.1440.51
686_Q690_S1.1430.51
1119_A1123_A1.1420.51
750_L786_T1.1400.51
972_I1005_T1.1390.51
702_P708_A1.1380.50
905_V1026_V1.1380.50
417_L428_L1.1360.50
186_R1058_E1.1340.50
339_R630_L1.1300.50
713_A790_A1.1300.50
477_P507_Q1.1290.50
985_A1005_T1.1290.50
446_Q1180_G1.1250.50
359_L363_Y1.1140.49
662_P672_I1.1120.49
1118_L1123_A1.1040.48
622_L629_R1.1030.48
129_Y133_D1.1030.48
724_L743_V1.1020.48
704_A711_H1.1010.48
512_C1109_L1.1010.48
862_L865_R1.1000.48
98_A412_L1.0990.48
745_E780_F1.0970.48
235_I239_S1.0970.48
358_L390_E1.0960.48
328_I1185_W1.0940.48
160_Q315_S1.0890.47
198_I210_T1.0880.47
824_P827_V1.0860.47
412_L415_D1.0860.47
927_D1028_R1.0850.47
823_V827_V1.0840.47
107_V464_V1.0840.47
790_A818_L1.0830.47
735_T741_A1.0810.47
971_H975_M1.0810.47
683_E686_Q1.0800.47
246_K249_D1.0800.47
269_L310_A1.0790.47
347_E351_P1.0790.47
924_C1041_I1.0740.46
315_S365_I1.0740.46
782_L810_I1.0740.46
411_P472_K1.0730.46
649_P652_E1.0680.46
836_E840_A1.0680.46
147_M153_Q1.0670.46
96_T626_N1.0660.46
301_M352_R1.0630.46
1112_N1118_L1.0620.46
789_I1039_E1.0610.46
282_Y324_P1.0600.45
779_N784_I1.0580.45
481_Y961_D1.0570.45
211_W217_G1.0550.45
698_W706_R1.0520.45
308_I326_I1.0520.45
96_T627_E1.0510.45
965_K973_Q1.0510.45
151_L210_T1.0480.45
418_I422_T1.0470.45
121_A214_L1.0440.44
696_P700_A1.0420.44
192_G222_T1.0400.44
1091_E1301_R1.0380.44
668_E671_D1.0360.44
187_D889_A1.0340.44
368_N429_M1.0340.44
209_A214_L1.0330.44
389_F423_R1.0300.44
416_Y1078_M1.0290.44
281_R322_E1.0240.43
214_L292_L1.0230.43
1035_P1039_E1.0210.43
859_V862_L1.0170.43
257_E519_P1.0160.43
101_R109_M1.0140.43
384_L428_L1.0120.42
114_A585_V1.0110.42
91_S94_A1.0100.42
279_G539_I1.0050.42
759_D764_E1.0040.42
214_L573_T1.0030.42
716_L817_I0.9990.42
139_K588_V0.9990.42
212_G476_V0.9970.41
794_A1110_L0.9970.41
152_L183_A0.9960.41
608_P612_Y0.9950.41
934_L938_R0.9940.41
328_I1057_D0.9930.41
98_A106_A0.9890.41
983_F1006_L0.9880.41
129_Y153_Q0.9870.41
93_A97_A0.9850.41
780_F784_I0.9850.41
774_C852_M0.9840.41
745_E779_N0.9820.41
968_I1019_V0.9790.40
368_N401_F0.9790.40
862_L963_E0.9780.40
522_E925_L0.9780.40
159_S239_S0.9780.40
232_L979_G0.9780.40
494_A498_L0.9760.40
768_P795_A0.9750.40
335_P439_D0.9750.40
105_E108_S0.9730.40
154_E200_R0.9710.40
139_K147_M0.9700.40
767_R1113_R0.9700.40
481_Y1179_T0.9690.40
481_Y806_Q0.9690.40
113_Q320_I0.9660.40
138_Q153_Q0.9650.40
348_E351_P0.9650.40
1195_C1217_V0.9640.39
977_S980_R0.9620.39
353_L367_I0.9620.39
384_L417_L0.9610.39
838_V1305_V0.9610.39
106_A411_P0.9600.39
320_I366_G0.9590.39
968_I1023_V0.9580.39
1168_Q1173_R0.9570.39
132_A352_R0.9560.39
988_E996_W0.9560.39
647_A650_M0.9510.39
894_S926_Q0.9500.39
107_V658_G0.9500.39
391_P414_I0.9490.39
710_L794_A0.9480.38
196_S205_F0.9460.38
167_C205_F0.9440.38
711_H751_H0.9410.38
148_V151_L0.9400.38
928_E1029_Y0.9390.38
124_A127_L0.9390.38
772_V852_M0.9380.38
887_M1009_L0.9380.38
229_S233_N0.9370.38
100_R626_N0.9370.38
368_N551_A0.9370.38
650_M812_A0.9360.38
784_I883_E0.9350.38
114_A464_V0.9330.38
773_V851_V0.9330.38
114_A468_A0.9310.37
694_N826_G0.9300.37
729_V736_F0.9290.37
202_P239_S0.9280.37
325_G368_N0.9260.37
236_I244_I0.9250.37
209_A548_T0.9240.37
779_N1020_F0.9230.37
335_P560_N0.9190.37
768_P1109_L0.9180.37
281_R324_P0.9150.37
347_E386_K0.9130.36
745_E1020_F0.9110.36
125_H129_Y0.9100.36
209_A726_G0.9090.36
711_H755_G0.9070.36
602_H605_I0.9070.36
341_Q945_R0.9050.36
966_A970_R0.9030.36
1009_L1012_F0.9020.36
1010_D1032_N0.9020.36
1194_L1206_Q0.8990.36
192_G220_V0.8970.35
181_R212_G0.8970.35
198_I214_L0.8970.35
1052_V1072_L0.8960.35
145_A153_Q0.8950.35
214_L490_H0.8950.35
643_Q649_P0.8950.35
167_C207_N0.8940.35
621_G629_R0.8940.35
795_A1110_L0.8940.35
255_M588_V0.8940.35
345_V943_E0.8940.35
1191_E1211_L0.8910.35
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315_S410_C0.5080.17
320_I368_N0.5080.17
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175_I272_A0.5070.17
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315_S717_M0.5060.17
475_A498_L0.5060.17
410_C497_Q0.5050.17
202_P225_E0.5040.17
120_V129_Y0.5040.17
601_P739_A0.5040.17
235_I662_P0.5040.17
116_L272_A0.5040.17
130_Q705_E0.5040.17
603_P607_L0.5040.17
231_S255_M0.5040.17
1073_Y1080_G0.5030.17
209_A1058_E0.5030.17
265_I337_Y0.5030.17
210_T1006_L0.5030.17
418_I480_I0.5030.17
943_E1052_V0.5030.17
210_T263_E0.5020.17
1112_N1119_A0.5020.17
1176_P1210_V0.5020.17
1196_I1213_V0.5020.17
779_N1071_N0.5020.17
578_D820_E0.5010.17
205_F319_G0.5010.17
155_F219_L0.5000.17
850_G1109_L0.5000.17
108_S318_R0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hazA 3 0.7348 100 0.444 Contact Map
4nm9A 2 0.7205 100 0.507 Contact Map
4o8aA 2 0.35 100 0.62 Contact Map
3e2qA 2 0.3545 100 0.674 Contact Map
4jdcA 5 0.3864 100 0.781 Contact Map
4oe6A 5 0.3455 100 0.782 Contact Map
4e3xA 2 0.3955 100 0.788 Contact Map
1uzbA 5 0.378 100 0.793 Contact Map
3qanA 2 0.3795 100 0.797 Contact Map
4pz2A 4 0.3538 100 0.805 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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