GREMLIN Database
MTLD - Mannitol-1-phosphate 5-dehydrogenase
UniProt: P09424 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10616
Length: 382 (346)
Sequences: 2956 (1967)
Seq/√Len: 105.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
232_H241_D3.7541.00
30_A73_V3.6941.00
21_A58_D3.3471.00
249_K275_Q3.1841.00
128_T154_D3.1061.00
245_R282_E3.0351.00
22_D58_D2.9061.00
131_K135_M2.8441.00
20_L196_I2.7441.00
78_A105_K2.6481.00
245_R249_K2.5691.00
28_T76_L2.5651.00
222_I327_G2.5241.00
65_A76_L2.4801.00
71_D105_K2.4601.00
184_V199_M2.4411.00
238_A244_I2.3621.00
3_A20_L2.3621.00
236_R240_L2.3081.00
314_T319_L2.1951.00
49_H57_V2.1611.00
288_D292_R2.1521.00
138_L146_V2.0961.00
253_E274_I2.0901.00
115_L150_V2.0741.00
101_K105_K2.0641.00
107_K141_D2.0511.00
144_A148_E2.0501.00
38_D42_A2.0381.00
4_L80_V2.0371.00
105_K109_Q2.0251.00
26_Q64_N2.0211.00
71_D75_D2.0091.00
135_M147_E1.9881.00
226_L330_A1.9471.00
125_R128_T1.9441.00
134_V152_F1.9171.00
225_Y297_P1.9091.00
222_I251_A1.9021.00
250_G254_E1.8951.00
250_G323_N1.8901.00
151_G190_K1.8701.00
19_L180_S1.8691.00
196_I199_M1.8661.00
233_Q237_D1.8321.00
12_G16_I1.8231.00
65_A72_D1.8171.00
101_K104_V1.8141.00
104_V108_E1.7741.00
72_D75_D1.7721.00
75_D109_Q1.7471.00
104_V142_A1.7341.00
346_A350_A1.7181.00
28_T65_A1.6971.00
100_A137_A1.6921.00
104_V139_P1.6891.00
255_S258_V1.6871.00
133_H136_N1.6671.00
29_F63_V1.6611.00
219_G248_V1.6591.00
34_Q38_D1.6541.00
235_I293_V1.6121.00
41_N45_S1.6111.00
227_G238_A1.6071.00
47_Q59_T1.6051.00
77_I102_G1.5901.00
94_R133_H1.5881.00
83_V115_L1.5621.00
74_V105_K1.5611.00
4_L30_A1.5611.00
340_P345_L1.5501.00
116_N190_K1.5451.00
117_I130_L1.5441.00
224_A294_G1.5301.00
118_I184_V1.5201.00
47_Q57_V1.5171.00
340_P344_E1.4811.00
311_L328_I1.4761.00
233_Q289_D1.4611.00
75_D79_Q1.4591.00
151_G188_Q1.4551.00
226_L326_E1.4551.00
267_A271_A1.4511.00
75_D78_A1.4311.00
28_T80_V1.4291.00
246_A250_G1.4291.00
341_Q344_E1.4241.00
81_D193_L1.4231.00
18_K48_V1.4211.00
146_V152_F1.4181.00
347_A351_D1.4121.00
50_V176_V1.4091.00
313_G316_E1.4031.00
23_A197_P1.4001.00
230_A243_K1.3961.00
20_L27_L1.3951.00
48_V60_V1.3871.00
145_W149_H1.3811.00
105_K108_E1.3781.00
4_L102_G1.3711.00
100_A134_V1.3651.00
278_L282_E1.3651.00
339_D342_A1.3601.00
132_G136_N1.3561.00
228_K334_F1.3531.00
107_K139_P1.3511.00
202_T207_A1.3390.99
75_D105_K1.3380.99
344_E347_A1.3320.99
189_F194_P1.3090.99
99_I117_I1.3030.99
215_T274_I1.3000.99
342_A345_L1.2960.99
219_G252_M1.2940.99
239_I245_R1.2920.99
43_R170_D1.2910.99
333_H337_E1.2890.99
257_A274_I1.2880.99
186_K203_D1.2860.99
87_V95_I1.2840.99
114_P150_V1.2820.99
97_P137_A1.2750.99
16_I84_T1.2690.99
118_I155_S1.2690.99
230_A244_I1.2680.99
77_I115_L1.2650.99
100_A138_L1.2630.99
308_I328_I1.2620.99
228_K290_V1.2580.99
18_K60_V1.2450.99
215_T252_M1.2380.99
223_T248_V1.2360.99
125_R206_M1.2350.99
342_A346_A1.2340.99
345_L349_I1.2310.99
204_N207_A1.2290.99
236_R287_K1.2260.99
85_T95_I1.2260.99
103_Q150_V1.2230.99
77_I83_V1.2140.99
154_D185_D1.2130.99
214_F313_G1.2130.99
99_I134_V1.2100.99
291_E334_F1.1880.99
8_A29_F1.1850.99
74_V101_K1.1680.99
344_E348_L1.1660.99
230_A241_D1.1620.98
67_S73_V1.1600.98
234_T237_D1.1590.98
135_M143_K1.1590.98
140_E144_A1.1510.98
269_K272_A1.1460.98
37_L41_N1.1450.98
51_V168_T1.1420.98
235_I238_A1.1330.98
135_M146_V1.1250.98
28_T64_N1.1190.98
222_I247_V1.1130.98
6_F95_I1.1080.98
252_M278_L1.1010.98
311_L325_I1.0930.98
103_Q145_W1.0900.98
276_K279_G1.0880.98
249_K253_E1.0780.98
313_G317_Y1.0780.98
17_G27_L1.0750.97
37_L65_A1.0700.97
100_A146_V1.0700.97
270_H274_I1.0680.97
112_E149_H1.0610.97
141_D144_A1.0600.97
237_D240_L1.0570.97
8_A63_V1.0530.97
139_P142_A1.0520.97
235_I290_V1.0460.97
247_V323_N1.0420.97
228_K291_E1.0400.97
242_E246_A1.0390.97
251_A324_L1.0380.97
234_T287_K1.0250.97
255_S259_L1.0240.97
107_K142_A1.0230.97
3_A27_L1.0210.97
129_Q132_G1.0010.96
271_A275_Q0.9980.96
239_I278_L0.9960.96
215_T277_I0.9890.96
4_L77_I0.9860.96
83_V117_I0.9850.96
289_D292_R0.9790.96
35_V39_A0.9680.95
272_A276_K0.9660.95
4_L83_V0.9600.95
117_I150_V0.9600.95
51_V55_E0.9570.95
41_N65_A0.9550.95
255_S260_I0.9540.95
275_Q278_L0.9510.95
113_S191_G0.9430.95
39_A171_P0.9390.95
223_T244_I0.9340.94
83_V99_I0.9340.94
301_L307_L0.9290.94
39_A42_A0.9280.94
340_P343_Q0.9280.94
253_E275_Q0.9270.94
40_L170_D0.9230.94
321_H325_I0.9190.94
164_S173_E0.9160.94
340_P346_A0.9100.94
76_L79_Q0.9090.94
128_T131_K0.9070.93
229_L330_A0.9050.93
117_I152_F0.9020.93
74_V98_A0.9000.93
298_L331_A0.8960.93
140_E143_K0.8950.93
18_K22_D0.8940.93
252_M274_I0.8930.93
346_A349_I0.8910.93
343_Q346_A0.8850.93
249_K278_L0.8840.93
18_K58_D0.8840.93
189_F193_L0.8790.92
78_A109_Q0.8770.92
253_E271_A0.8750.92
131_K147_E0.8700.92
221_A300_K0.8660.92
116_N151_G0.8630.92
35_V38_D0.8570.91
320_P325_I0.8560.91
50_V56_Q0.8520.91
159_R176_V0.8520.91
210_E261_K0.8510.91
102_G115_L0.8500.91
144_A147_E0.8490.91
5_H84_T0.8450.91
162_P273_Y0.8420.91
314_T321_H0.8380.90
210_E313_G0.8380.90
78_A102_G0.8300.90
307_L327_G0.8250.90
226_L247_V0.8220.90
352_K355_Q0.8210.89
310_P324_L0.8210.89
138_L143_K0.8160.89
215_T256_G0.8150.89
143_K146_V0.8140.89
340_P347_A0.8140.89
342_A349_I0.8110.89
31_D36_V0.8100.89
85_T119_A0.8050.89
215_T257_A0.8050.89
124_V209_V0.8050.89
196_I201_L0.8020.88
343_Q347_A0.8020.88
33_N36_V0.8010.88
252_M277_I0.8000.88
123_M126_G0.8000.88
107_K145_W0.7970.88
21_A62_G0.7930.88
55_E285_Y0.7910.88
266_D269_K0.7890.88
22_D180_S0.7890.88
228_K335_R0.7850.87
164_S174_V0.7840.87
72_D76_L0.7820.87
301_L327_G0.7750.87
223_T290_V0.7750.87
228_K233_Q0.7730.86
115_L190_K0.7730.86
31_D68_S0.7720.86
308_I311_L0.7710.86
253_E257_A0.7710.86
333_H338_D0.7700.86
81_D192_A0.7690.86
225_Y334_F0.7680.86
215_T219_G0.7680.86
84_T182_W0.7610.86
249_K274_I0.7600.86
219_G281_F0.7560.85
19_L197_P0.7530.85
96_A133_H0.7500.85
138_L142_A0.7500.85
64_N76_L0.7460.84
247_V250_G0.7460.84
158_D280_R0.7430.84
235_I248_V0.7410.84
348_L352_K0.7370.84
31_D37_L0.7370.84
16_I120_C0.7360.84
11_I16_I0.7360.84
40_L172_L0.7330.83
139_P143_K0.7320.83
341_Q345_L0.7320.83
89_P123_M0.7320.83
8_A31_D0.7310.83
165_A168_T0.7300.83
312_L316_E0.7250.83
347_A350_A0.7240.83
21_A61_S0.7240.83
158_D216_L0.7220.83
336_S349_I0.7160.82
108_E139_P0.7160.82
37_L66_V0.7130.82
84_T118_I0.7110.82
211_R268_D0.7110.82
294_G334_F0.7100.81
345_L348_L0.7090.81
256_G310_P0.7090.81
272_A275_Q0.7090.81
39_A172_L0.7080.81
90_V299_R0.7040.81
45_S66_V0.6980.80
142_A146_V0.6970.80
179_F182_W0.6970.80
309_K312_L0.6920.80
160_I216_L0.6920.80
6_F102_G0.6920.80
300_K306_R0.6910.80
142_A145_W0.6890.80
227_G232_H0.6880.79
311_L324_L0.6880.79
44_H59_T0.6870.79
5_H158_D0.6870.79
211_R270_H0.6850.79
127_T153_V0.6850.79
251_A323_N0.6840.79
215_T270_H0.6830.79
235_I300_K0.6820.79
129_Q133_H0.6820.79
256_G260_I0.6810.79
232_H237_D0.6800.79
243_K246_A0.6800.79
335_R346_A0.6800.79
90_V306_R0.6800.79
188_Q203_D0.6790.79
168_T175_T0.6790.79
12_G17_G0.6770.78
6_F73_V0.6760.78
177_E283_N0.6760.78
99_I130_L0.6750.78
288_D293_V0.6750.78
231_G241_D0.6750.78
103_Q146_V0.6750.78
11_I120_C0.6750.78
79_Q112_E0.6720.78
257_A267_A0.6720.78
181_E211_R0.6720.78
311_L321_H0.6690.77
120_C273_Y0.6680.77
221_A225_Y0.6660.77
153_V184_V0.6660.77
237_D290_V0.6660.77
11_I15_F0.6650.77
160_I177_E0.6590.76
109_Q112_E0.6580.76
228_K336_S0.6570.76
6_F30_A0.6540.76
113_S149_H0.6530.76
84_T120_C0.6530.76
84_T155_S0.6520.76
164_S172_L0.6500.75
181_E273_Y0.6470.75
74_V78_A0.6460.75
31_D66_V0.6450.75
223_T238_A0.6440.75
349_I354_P0.6440.75
275_Q279_G0.6400.74
232_H244_I0.6400.74
299_R306_R0.6390.74
247_V326_E0.6390.74
110_G149_H0.6380.74
290_V294_G0.6360.74
258_V313_G0.6350.74
34_Q70_G0.6310.73
307_L328_I0.6300.73
259_L310_P0.6290.73
15_F120_C0.6270.73
256_G270_H0.6230.72
18_K311_L0.6220.72
325_I329_A0.6210.72
257_A270_H0.6180.72
178_T279_G0.6170.72
22_D197_P0.6160.72
65_A75_D0.6160.72
86_A121_E0.6140.71
20_L199_M0.6140.71
214_F310_P0.6110.71
45_S65_A0.6100.71
348_L351_D0.6100.71
42_A171_P0.6100.71
218_T255_S0.6090.71
334_F338_D0.6060.70
116_N189_F0.6060.70
239_I248_V0.6040.70
89_P126_G0.6040.70
125_R154_D0.6030.70
20_L23_A0.6000.70
45_S59_T0.5990.69
71_D140_E0.5980.69
218_T307_L0.5980.69
218_T310_P0.5970.69
103_Q115_L0.5970.69
81_D113_S0.5960.69
107_K110_G0.5960.69
190_K194_P0.5950.69
164_S168_T0.5940.69
67_S72_D0.5930.69
156_A183_I0.5910.68
155_S182_W0.5910.68
128_T134_V0.5860.68
161_V286_L0.5850.68
186_K193_L0.5840.67
143_K147_E0.5840.67
94_R136_N0.5830.67
191_G194_P0.5810.67
326_E330_A0.5810.67
226_L244_I0.5810.67
51_V175_T0.5800.67
200_E269_K0.5790.67
46_Y60_V0.5780.67
20_L201_L0.5780.67
52_G178_T0.5770.67
120_C179_F0.5770.67
168_T173_E0.5760.66
20_L24_G0.5760.66
122_N292_R0.5740.66
225_Y238_A0.5710.66
38_D41_N0.5700.66
213_L225_Y0.5690.65
94_R129_Q0.5690.65
160_I182_W0.5690.65
167_A287_K0.5680.65
340_P349_I0.5660.65
254_E320_P0.5620.65
6_F77_I0.5610.64
177_E280_R0.5610.64
182_W216_L0.5600.64
49_H173_E0.5600.64
255_S323_N0.5580.64
125_R129_Q0.5560.64
162_P182_W0.5540.63
74_V77_I0.5520.63
290_V293_V0.5500.63
92_L209_V0.5500.63
341_Q346_A0.5500.63
241_D244_I0.5490.63
296_Q341_Q0.5490.63
51_V286_L0.5470.62
221_A297_P0.5460.62
147_E242_E0.5440.62
93_E96_A0.5440.62
288_D306_R0.5420.62
108_E112_E0.5420.62
151_G191_G0.5410.62
226_L327_G0.5410.62
48_V286_L0.5400.61
45_S48_V0.5400.61
223_T239_I0.5390.61
162_P174_V0.5380.61
52_G285_Y0.5380.61
55_E178_T0.5380.61
115_L138_L0.5370.61
161_V293_V0.5330.60
103_Q117_I0.5320.60
22_D242_E0.5320.60
256_G324_L0.5310.60
215_T218_T0.5300.60
299_R303_A0.5300.60
32_V36_V0.5300.60
108_E148_E0.5290.60
319_L322_K0.5280.60
59_T195_N0.5280.60
64_N80_V0.5250.59
308_I312_L0.5240.59
90_V296_Q0.5240.59
160_I283_N0.5240.59
256_G274_I0.5210.59
9_G13_R0.5200.59
314_T317_Y0.5190.58
50_V180_S0.5190.58
37_L164_S0.5180.58
116_N193_L0.5170.58
211_R290_V0.5170.58
194_P201_L0.5160.58
153_V201_L0.5150.58
234_T286_L0.5150.58
160_I280_R0.5150.58
294_G299_R0.5150.58
85_T99_I0.5140.58
34_Q37_L0.5130.58
24_G62_G0.5130.58
37_L68_S0.5120.57
272_A344_E0.5120.57
233_Q291_E0.5110.57
159_R180_S0.5110.57
81_D115_L0.5100.57
211_R334_F0.5090.57
206_M210_E0.5090.57
205_L209_V0.5090.57
309_K313_G0.5080.57
12_G29_F0.5070.57
219_G274_I0.5070.57
161_V324_L0.5060.57
311_L315_L0.5040.56
110_G113_S0.5040.56
307_L310_P0.5040.56
273_Y277_I0.5040.56
89_P221_A0.5040.56
17_G29_F0.5030.56
119_A130_L0.5030.56
135_M138_L0.5020.56
11_I176_V0.5020.56
260_I270_H0.5010.56
30_A67_S0.5010.56
10_N224_A0.5010.56
224_A227_G0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h2zA 2 0.9869 100 0.086 Contact Map
4im7A 1 0.9817 100 0.144 Contact Map
1lj8A 1 0.9843 100 0.147 Contact Map
2ew2A 2 0.788 99 0.889 Contact Map
3hn2A 2 0.767 99 0.892 Contact Map
3wfiA 2 0.7801 98.9 0.892 Contact Map
3i83A 2 0.7906 98.9 0.894 Contact Map
2qytA 1 0.712 98.8 0.896 Contact Map
3egoA 2 0.7435 98.5 0.907 Contact Map
4ol9A 2 0.7592 98.3 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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