GREMLIN Database
GLPQ - Glycerophosphoryl diester phosphodiesterase
UniProt: P09394 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10399
Length: 358 (286)
Sequences: 2765 (1796)
Seq/√Len: 106.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_K150_E3.7591.00
87_D91_R3.5831.00
304_Q341_N3.1821.00
42_Y349_D3.0271.00
41_G347_F2.9991.00
35_A50_A2.9731.00
76_V151_E2.8611.00
281_Y330_L2.8071.00
109_L147_T2.7661.00
298_G302_D2.7081.00
75_V112_I2.6881.00
48_L146_H2.5561.00
149_E192_V2.5381.00
331_Y343_L2.5081.00
153_E196_Y2.4001.00
95_R111_E2.3611.00
315_V334_L2.3471.00
279_P312_P2.3211.00
61_Y167_G2.3071.00
47_T117_F2.2661.00
149_E196_Y2.2241.00
192_V196_Y2.2141.00
52_A56_A2.2061.00
40_S50_A2.1851.00
66_L148_F2.1841.00
149_E195_K2.1791.00
88_V107_F2.1691.00
187_A221_E2.1311.00
270_V274_A2.1241.00
152_I168_I2.0771.00
108_T111_E2.0081.00
172_I189_T2.0011.00
317_S350_K1.9811.00
312_P340_V1.9431.00
37_R45_E1.9401.00
234_Q273_Y1.9391.00
109_L113_K1.9281.00
68_M188_K1.9231.00
345_T351_A1.9201.00
343_L351_A1.9051.00
149_E153_E1.8751.00
68_M185_I1.8651.00
73_N109_L1.7981.00
95_R98_K1.7791.00
191_E195_K1.7701.00
148_F170_P1.7601.00
93_P96_A1.7421.00
92_F95_R1.7391.00
331_Y351_A1.7201.00
333_A338_A1.6971.00
169_Y311_H1.6791.00
116_K142_D1.6551.00
347_F350_K1.6441.00
304_Q310_V1.6331.00
130_Q133_P1.6271.00
62_L155_V1.6261.00
147_T150_E1.6191.00
63_E78_H1.5991.00
332_D337_K1.5191.00
75_V104_A1.5171.00
69_T75_V1.5141.00
87_D90_D1.5071.00
129_V133_P1.4991.00
151_E155_V1.4961.00
187_A191_E1.4821.00
316_R346_D1.4681.00
64_Q76_V1.4291.00
69_T112_I1.4181.00
49_P143_F1.4101.00
317_S347_F1.3951.00
52_A157_G1.3861.00
256_Y261_M1.3741.00
187_A217_R1.3591.00
188_K191_E1.3571.00
300_V340_V1.3471.00
43_L53_M1.3380.99
53_M56_A1.3280.99
217_R221_E1.3270.99
113_K144_R1.2980.99
42_Y53_M1.2890.99
36_H78_H1.2890.99
72_D188_K1.2720.99
112_I145_V1.2660.99
174_A211_D1.2650.99
172_I185_I1.2580.99
48_L52_A1.2560.99
303_A310_V1.2380.99
48_L154_F1.2320.99
268_K306_N1.2130.99
312_P343_L1.2110.99
55_Y62_L1.2110.99
65_D78_H1.2100.99
35_A40_S1.2090.99
77_L104_A1.1980.99
209_C214_E1.1920.99
152_I192_V1.1910.99
46_H146_H1.1780.99
233_V276_G1.1760.99
92_F98_K1.1720.99
327_V331_Y1.1670.99
256_Y260_W1.1660.99
107_F112_I1.1660.99
51_K64_Q1.1590.98
257_N260_W1.1560.98
46_H51_K1.1490.98
278_G311_H1.1480.98
109_L150_E1.1470.98
92_F96_A1.1460.98
84_R120_G1.1350.98
53_M57_Q1.1330.98
93_P97_R1.1290.98
300_V304_Q1.1130.98
240_D244_T1.1090.98
311_H342_G1.1090.98
258_Y261_M1.1070.98
315_V331_Y1.1070.98
277_I299_M1.1060.98
285_I330_L1.1040.98
215_L232_L1.1030.98
42_Y57_Q1.0960.98
80_H103_Y1.0960.98
169_Y344_F1.0940.98
301_Q305_Q1.0930.98
172_I214_E1.0910.98
169_Y278_G1.0890.98
224_P230_L1.0820.98
156_Q196_Y1.0670.97
216_K269_Q1.0620.97
35_A39_A1.0590.97
70_K108_T1.0580.97
169_Y172_I1.0490.97
64_Q151_E1.0480.97
152_I196_Y1.0480.97
302_D305_Q1.0460.97
107_F111_E1.0420.97
171_E210_F1.0400.97
152_I193_L1.0350.97
276_G311_H1.0340.97
37_R78_H1.0300.97
190_L194_K1.0300.97
335_Y343_L1.0210.97
331_Y335_Y1.0160.97
277_I310_V1.0150.96
94_D98_K1.0060.96
194_K223_E1.0020.96
68_M74_L0.9960.96
266_A269_Q0.9930.96
66_L74_L0.9690.95
57_Q349_D0.9670.95
32_I60_D0.9630.95
103_Y106_D0.9620.95
190_L218_I0.9620.95
52_A154_F0.9590.95
169_Y206_Y0.9560.95
79_D103_Y0.9500.95
55_Y166_I0.9480.95
81_Y84_R0.9480.95
255_N258_Y0.9440.95
72_D184_D0.9350.94
155_V168_I0.9270.94
64_Q170_P0.9250.94
132_Y135_R0.9250.94
128_K133_P0.9250.94
212_A216_K0.9240.94
33_V352_V0.9230.94
276_G309_V0.9230.94
78_H173_K0.9220.94
79_D101_R0.9210.94
25_A28_S0.9170.94
263_K266_A0.9150.94
37_R63_E0.9110.94
266_A270_V0.9110.94
239_T244_T0.9100.94
184_D187_A0.9090.94
208_Q344_F0.9090.94
51_K76_V0.9060.93
194_K199_T0.9040.93
179_H184_D0.9020.93
148_F152_I0.8970.93
184_D188_K0.8920.93
262_F283_M0.8910.93
82_L104_A0.8890.93
146_H154_F0.8830.93
190_L221_E0.8800.92
173_K210_F0.8800.92
269_Q272_E0.8770.92
69_T109_L0.8760.92
131_T135_R0.8750.92
66_L189_T0.8710.92
169_Y208_Q0.8710.92
277_I308_L0.8690.92
212_A234_Q0.8690.92
267_M302_D0.8590.92
267_M270_V0.8550.91
315_V327_V0.8520.91
333_A337_K0.8510.91
284_L338_A0.8400.91
237_A243_E0.8380.91
92_F97_R0.8340.90
239_T242_N0.8320.90
332_D354_F0.8300.90
39_A42_Y0.8290.90
255_N261_M0.8270.90
165_N204_K0.8270.90
54_A62_L0.8260.90
255_N259_D0.8220.90
73_N149_E0.8210.90
312_P315_V0.8210.90
80_H105_I0.8200.90
56_A157_G0.8120.89
82_L85_V0.8100.89
37_R65_D0.8090.89
285_I334_L0.8030.89
231_N236_I0.8030.89
91_R114_S0.8030.89
279_P299_M0.8020.88
273_Y279_P0.7990.88
219_K275_D0.7980.88
210_F235_L0.7960.88
148_F192_V0.7950.88
156_Q204_K0.7940.88
78_H210_F0.7920.88
168_I198_Y0.7920.88
36_H63_E0.7820.87
241_W244_T0.7790.87
73_N147_T0.7750.87
186_A214_E0.7740.87
86_T117_F0.7710.86
93_P98_K0.7710.86
237_A313_Y0.7700.86
77_L145_V0.7680.86
207_L232_L0.7610.86
37_R173_K0.7600.86
72_D182_G0.7600.86
223_E230_L0.7600.86
45_E63_E0.7590.86
303_A308_L0.7570.85
238_Y244_T0.7570.85
166_I169_Y0.7560.85
127_K130_Q0.7550.85
102_Y107_F0.7520.85
200_G204_K0.7500.85
257_N262_F0.7490.85
34_I169_Y0.7470.85
47_T146_H0.7420.84
340_V343_L0.7410.84
34_I61_Y0.7400.84
236_I262_F0.7380.84
94_D97_R0.7380.84
286_E293_N0.7340.84
63_E173_K0.7340.84
74_L189_T0.7310.83
75_V109_L0.7300.83
74_L188_K0.7290.83
68_M183_K0.7280.83
116_K144_R0.7260.83
317_S327_V0.7250.83
223_E229_E0.7230.83
86_T115_L0.7230.83
234_Q261_M0.7170.82
78_H171_E0.7140.82
51_K151_E0.7140.82
210_F313_Y0.7130.82
104_A178_H0.7100.82
55_Y164_K0.7100.82
74_L148_F0.7100.82
316_R347_F0.7060.81
262_F266_A0.7010.81
110_D113_K0.6980.81
128_K131_T0.6970.80
61_Y169_Y0.6930.80
166_I171_E0.6930.80
214_E217_R0.6920.80
155_V165_N0.6910.80
81_Y101_R0.6910.80
129_V132_Y0.6880.80
58_G63_E0.6860.79
171_E314_T0.6810.79
77_L86_T0.6810.79
190_L207_L0.6810.79
113_K147_T0.6760.78
95_R107_F0.6740.78
280_D313_Y0.6740.78
327_V350_K0.6740.78
240_D243_E0.6720.78
42_Y347_F0.6710.78
70_K106_D0.6690.78
45_E78_H0.6680.78
298_G301_Q0.6670.77
189_T193_L0.6650.77
54_A59_A0.6650.77
119_E122_D0.6650.77
88_V115_L0.6640.77
63_E235_L0.6630.77
66_L170_P0.6630.77
177_F181_E0.6630.77
37_R346_D0.6610.77
309_V341_N0.6600.77
118_T121_F0.6520.76
77_L85_V0.6510.76
116_K119_E0.6500.76
206_Y311_H0.6490.76
214_E218_I0.6490.76
63_E79_D0.6480.75
173_K235_L0.6470.75
267_M306_N0.6420.75
51_K62_L0.6410.75
49_P52_A0.6360.74
277_I303_A0.6350.74
257_N261_M0.6330.74
232_L236_I0.6330.74
270_V273_Y0.6310.73
268_K272_E0.6310.73
210_F314_T0.6290.73
189_T207_L0.6290.73
177_F180_Q0.6280.73
258_Y262_F0.6280.73
96_A100_G0.6270.73
36_H313_Y0.6260.73
121_F127_K0.6230.73
313_Y344_F0.6210.72
46_H64_Q0.6200.72
109_L144_R0.6190.72
34_I342_G0.6180.72
278_G313_Y0.6140.71
255_N263_K0.6130.71
77_L117_F0.6130.71
268_K302_D0.6120.71
85_V120_G0.6120.71
83_D89_A0.6120.71
208_Q214_E0.6110.71
73_N188_K0.6110.71
38_G51_K0.6110.71
255_N260_W0.6100.71
172_I209_C0.6100.71
193_L207_L0.6100.71
284_L300_V0.6080.71
90_D133_P0.6080.71
183_K187_A0.6070.71
91_R107_F0.6070.71
48_L189_T0.6060.70
280_D283_M0.6050.70
332_D335_Y0.6010.70
68_M104_A0.6010.70
278_G344_F0.5990.70
271_A308_L0.5970.69
198_Y204_K0.5970.69
238_Y241_W0.5960.69
212_A270_V0.5950.69
283_M299_M0.5930.69
146_H151_E0.5930.69
172_I175_P0.5930.69
40_S178_H0.5920.69
237_A280_D0.5900.68
36_H173_K0.5900.68
173_K314_T0.5890.68
192_V195_K0.5840.68
57_Q352_V0.5820.67
268_K301_Q0.5810.67
27_D30_E0.5790.67
156_Q197_G0.5790.67
237_A244_T0.5780.67
317_S352_V0.5770.67
82_L88_V0.5750.66
331_Y345_T0.5740.66
78_H313_Y0.5730.66
236_I277_I0.5710.66
61_Y342_G0.5700.66
207_L218_I0.5660.65
117_F121_F0.5660.65
55_Y155_V0.5650.65
72_D133_P0.5650.65
93_P102_Y0.5630.65
205_V230_L0.5630.65
281_Y315_V0.5620.65
35_A54_A0.5610.65
300_V310_V0.5610.65
280_D284_L0.5610.65
206_Y231_N0.5600.64
300_V338_A0.5590.64
134_G141_S0.5570.64
80_H104_A0.5560.64
224_P229_E0.5550.64
33_V351_A0.5510.63
80_H181_E0.5500.63
50_A129_V0.5490.63
315_V340_V0.5470.63
34_I340_V0.5450.62
330_L334_L0.5450.62
36_H171_E0.5450.62
32_I61_Y0.5440.62
72_D183_K0.5440.62
39_A53_M0.5430.62
169_Y173_K0.5420.62
127_K131_T0.5420.62
284_L312_P0.5420.62
331_Y354_F0.5410.62
63_E210_F0.5410.62
350_K354_F0.5410.62
135_R143_F0.5410.62
87_D117_F0.5390.62
303_A307_K0.5390.62
111_E114_S0.5380.61
107_F115_L0.5370.61
65_D210_F0.5360.61
199_T229_E0.5310.60
274_A278_G0.5290.60
236_I283_M0.5270.60
236_I299_M0.5260.60
34_I276_G0.5250.60
80_H178_H0.5250.60
34_I311_H0.5240.59
148_F193_L0.5230.59
221_E224_P0.5200.59
38_G54_A0.5200.59
71_D75_V0.5190.59
78_H235_L0.5180.58
268_K305_Q0.5170.58
293_N296_L0.5150.58
302_D306_N0.5140.58
171_E235_L0.5140.58
86_T90_D0.5110.57
351_A354_F0.5100.57
105_I178_H0.5090.57
318_D353_K0.5080.57
41_G317_S0.5050.57
259_D262_F0.5050.57
67_V80_H0.5030.56
335_Y351_A0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ydyA 2 0.9134 100 0.206 Contact Map
4r7oA 4 0.7654 100 0.279 Contact Map
2oogA 4 0.7291 100 0.301 Contact Map
2pz0A 2 0.676 100 0.308 Contact Map
3ch0A 1 0.7402 100 0.315 Contact Map
3l12A 2 0.8017 100 0.32 Contact Map
1zccA 5 0.6536 100 0.324 Contact Map
3qvqA 4 0.6955 100 0.325 Contact Map
2otdA 1 0.6816 100 0.327 Contact Map
3ks6A 1 0.6816 100 0.329 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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