GLPG - ECOLI - GREMLIN Contacts

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GLPG - Rhomboid protease GlpG

UniProt:	P09391	Sequences: MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDVWLADESQAERVRAELARFLENPADPRYLAASWQAGHTGSGLHYRRYPFFAALRERAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAGWFDLFGMSMANGAHIAGLAVGLAMAFVDSLNARKRK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10397
Length:	276 (237)
Sequences:	724 (598)
Seq/√Len:	38.8

ECOLI - GLPG
BACSU - GLUP YDCA
HALSA - Q9HS82
SULSO - Q97ZW2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
142_A	182_A	5.117	1.00
181_S	206_A	4.513	1.00
189_Q	250_A	4.155	1.00
141_H	186_G	4.105	1.00
58_N	61_D	4.082	1.00
146_F	198_G	3.409	1.00
252_G	256_A	3.259	1.00
96_V	175_I	3.224	1.00
137_R	166_E	3.153	1.00
134_E	137_R	3.067	1.00
148_L	152_L	3.001	1.00
139_F	143_L	2.766	1.00
96_V	171_S	2.713	1.00
154_N	201_S	2.673	1.00
209_G	258_L	2.570	1.00
201_S	254_H	2.530	1.00
188_V	256_A	2.392	1.00
197_F	250_A	2.390	1.00
197_F	200_L	2.320	1.00
189_Q	197_F	2.274	1.00
155_L	158_W	2.126	0.99
109_I	113_I	1.985	0.99
213_L	262_L	1.949	0.99
41_D	44_Q	1.945	0.99
197_F	203_V	1.879	0.98
119_V	123_L	1.850	0.98
44_Q	53_A	1.801	0.98
213_L	265_A	1.770	0.97
101_M	158_W	1.730	0.97
208_M	233_A	1.726	0.97
175_I	182_A	1.724	0.97
145_H	150_H	1.719	0.97
256_A	260_V	1.714	0.97
186_G	253_A	1.691	0.96
178_T	200_L	1.651	0.96
55_F	59_P	1.648	0.96
154_N	254_H	1.633	0.96
200_L	203_V	1.628	0.95
137_R	144_M	1.608	0.95
64_Y	68_S	1.604	0.95
201_S	257_G	1.570	0.94
104_C	143_L	1.558	0.94
155_L	200_L	1.558	0.94
45_A	49_R	1.548	0.94
150_H	154_N	1.543	0.94
49_R	53_A	1.522	0.93
67_A	72_G	1.500	0.93
97_T	166_E	1.475	0.92
244_L	251_N	1.469	0.92
47_R	50_A	1.468	0.92
178_T	182_A	1.465	0.92
101_M	159_W	1.457	0.92
46_E	49_R	1.427	0.91
188_V	252_G	1.403	0.90
154_N	200_L	1.388	0.90
46_E	58_N	1.379	0.90
44_Q	50_A	1.377	0.89
40_A	50_A	1.361	0.89
59_P	64_Y	1.327	0.88
120_M	124_A	1.326	0.88
51_E	54_R	1.306	0.87
177_I	264_M	1.301	0.87
104_C	155_L	1.286	0.86
101_M	155_L	1.283	0.86
64_Y	69_W	1.273	0.85
40_A	44_Q	1.269	0.85
182_A	203_V	1.263	0.85
158_W	174_L	1.262	0.85
103_A	143_L	1.228	0.83
228_G	231_I	1.227	0.83
83_Y	88_A	1.223	0.83
134_E	166_E	1.217	0.83
64_Y	67_A	1.204	0.82
252_G	255_I	1.203	0.82
45_A	48_V	1.198	0.82
100_M	179_L	1.195	0.81
101_M	104_C	1.194	0.81
36_D	40_A	1.183	0.81
105_V	151_I	1.172	0.80
125_W	190_Q	1.168	0.80
37_V	41_D	1.162	0.80
141_H	203_V	1.161	0.80
200_L	204_V	1.147	0.79
151_I	252_G	1.145	0.79
51_E	55_F	1.142	0.78
159_W	163_G	1.142	0.78
154_N	162_G	1.133	0.78
232_F	236_W	1.127	0.77
41_D	52_L	1.127	0.77
130_T	133_F	1.125	0.77
192_F	208_M	1.125	0.77
240_G	251_N	1.115	0.77
63_R	71_A	1.112	0.77
177_I	265_A	1.109	0.76
61_D	65_L	1.106	0.76
72_G	75_G	1.106	0.76
42_E	46_E	1.100	0.76
237_I	240_G	1.098	0.76
154_N	257_G	1.092	0.75
212_W	251_N	1.091	0.75
100_M	158_W	1.089	0.75
202_G	253_A	1.078	0.74
70_Q	73_H	1.074	0.74
238_V	245_F	1.074	0.74
104_C	158_W	1.070	0.74
34_Q	185_S	1.070	0.74
185_S	264_M	1.069	0.74
150_H	201_S	1.067	0.73
69_W	155_L	1.066	0.73
138_Y	187_Y	1.062	0.73
47_R	53_A	1.055	0.73
68_S	72_G	1.053	0.72
111_M	144_M	1.044	0.72
236_W	250_A	1.036	0.71
65_L	75_G	1.032	0.71
203_V	250_A	1.022	0.70
46_E	57_E	1.005	0.69
202_G	254_H	0.997	0.68
181_S	260_V	0.985	0.67
235_I	263_A	0.981	0.67
139_F	183_L	0.981	0.67
42_E	45_A	0.970	0.66
70_Q	151_I	0.969	0.66
153_F	189_Q	0.967	0.66
158_W	178_T	0.963	0.66
192_F	252_G	0.958	0.65
105_V	155_L	0.950	0.64
230_I	262_L	0.946	0.64
195_P	225_L	0.938	0.63
105_V	111_M	0.935	0.63
177_I	210_Y	0.934	0.63
36_D	39_L	0.925	0.62
264_M	268_D	0.920	0.62
77_G	109_I	0.911	0.61
63_R	67_A	0.906	0.61
165_V	177_I	0.903	0.60
140_T	209_G	0.896	0.60
63_R	70_Q	0.885	0.59
192_F	263_A	0.885	0.59
130_T	140_T	0.883	0.59
254_H	257_G	0.879	0.58
50_A	60_A	0.879	0.58
118_E	121_L	0.870	0.58
199_G	261_G	0.867	0.57
230_I	241_W	0.867	0.57
151_I	160_Y	0.865	0.57
253_A	258_L	0.862	0.57
57_E	65_L	0.858	0.57
189_Q	236_W	0.858	0.57
202_G	205_Y	0.857	0.56
133_F	144_M	0.845	0.55
251_N	258_L	0.844	0.55
178_T	185_S	0.844	0.55
50_A	57_E	0.841	0.55
103_A	128_D	0.840	0.55
55_F	63_R	0.838	0.55
120_M	123_L	0.836	0.55
65_L	68_S	0.830	0.54
184_L	191_K	0.829	0.54
178_T	250_A	0.821	0.53
153_F	198_G	0.820	0.53
59_P	65_L	0.814	0.53
154_N	232_F	0.812	0.52
100_M	174_L	0.809	0.52
153_F	157_W	0.806	0.52
141_H	251_N	0.801	0.51
182_A	185_S	0.801	0.51
35_S	73_H	0.799	0.51
119_V	125_W	0.793	0.51
238_V	265_A	0.793	0.51
83_Y	87_A	0.792	0.51
137_R	251_N	0.789	0.50
80_Y	84_P	0.785	0.50
175_I	179_L	0.783	0.50
158_W	200_L	0.779	0.49
49_R	65_L	0.777	0.49
152_L	230_I	0.772	0.49
59_P	68_S	0.769	0.49
142_A	178_T	0.768	0.48
120_M	126_P	0.767	0.48
147_S	198_G	0.764	0.48
260_V	264_M	0.761	0.48
177_I	263_A	0.760	0.48
158_W	204_V	0.757	0.47
216_E	227_R	0.749	0.47
53_A	57_E	0.746	0.46
52_L	56_L	0.745	0.46
181_S	185_S	0.744	0.46
62_P	67_A	0.744	0.46
101_M	105_V	0.743	0.46
66_A	70_Q	0.742	0.46
60_A	65_L	0.737	0.46
137_R	147_S	0.736	0.46
158_W	182_A	0.734	0.45
51_E	64_Y	0.733	0.45
111_M	120_M	0.731	0.45
173_K	247_M	0.730	0.45
141_H	250_A	0.728	0.45
179_L	259_A	0.726	0.45
205_Y	258_L	0.720	0.44
35_S	54_R	0.717	0.44
104_C	142_A	0.717	0.44
163_G	167_K	0.715	0.44
109_I	267_V	0.713	0.44
102_I	159_W	0.709	0.43
241_W	244_L	0.708	0.43
55_F	64_Y	0.704	0.43
154_N	197_F	0.700	0.42
141_H	189_Q	0.700	0.42
64_Y	237_I	0.699	0.42
236_W	240_G	0.698	0.42
99_V	103_A	0.698	0.42
51_E	59_P	0.692	0.42
35_S	42_E	0.691	0.42
111_M	115_G	0.688	0.41
104_C	200_L	0.680	0.41
48_V	55_F	0.678	0.40
97_T	115_G	0.676	0.40
96_V	187_Y	0.675	0.40
93_A	149_M	0.674	0.40
80_Y	100_M	0.672	0.40
166_E	257_G	0.668	0.40
148_L	227_R	0.666	0.39
141_H	236_W	0.666	0.39
94_G	163_G	0.665	0.39
65_L	255_I	0.664	0.39
53_A	239_A	0.660	0.39
141_H	197_F	0.657	0.39
97_T	174_L	0.655	0.38
145_H	162_G	0.655	0.38
192_F	247_M	0.652	0.38
123_L	126_P	0.649	0.38
136_W	147_S	0.649	0.38
81_R	87_A	0.649	0.38
254_H	261_G	0.649	0.38
94_G	185_S	0.648	0.38
161_L	211_V	0.647	0.38
215_G	219_P	0.645	0.38
237_I	259_A	0.644	0.38
259_A	263_A	0.642	0.37
67_A	70_Q	0.636	0.37
219_P	252_G	0.633	0.37
185_S	202_G	0.632	0.36
229_L	240_G	0.632	0.36
153_F	250_A	0.632	0.36
74_T	81_R	0.631	0.36
151_I	238_V	0.631	0.36
35_S	43_S	0.630	0.36
64_Y	72_G	0.629	0.36
100_M	178_T	0.627	0.36
184_L	260_V	0.627	0.36
244_L	247_M	0.626	0.36
67_A	74_T	0.624	0.36
205_Y	240_G	0.623	0.36
138_Y	186_G	0.623	0.36
34_Q	38_W	0.622	0.36
184_L	225_L	0.621	0.36
219_P	230_I	0.620	0.35
105_V	109_I	0.620	0.35
136_W	212_W	0.619	0.35
77_G	87_A	0.619	0.35
162_G	209_G	0.619	0.35
205_Y	251_N	0.618	0.35
180_I	267_V	0.618	0.35
104_C	178_T	0.616	0.35
40_A	43_S	0.612	0.35
56_L	59_P	0.612	0.35
186_G	190_Q	0.611	0.35
36_D	49_R	0.610	0.35
253_A	257_G	0.609	0.35
159_W	177_I	0.609	0.35
197_F	251_N	0.609	0.35
208_M	227_R	0.606	0.34
186_G	197_F	0.602	0.34
106_V	110_A	0.602	0.34
189_Q	200_L	0.601	0.34
172_G	176_V	0.598	0.34
139_F	246_G	0.596	0.34
104_C	203_V	0.596	0.34
134_E	238_V	0.596	0.34
106_V	213_L	0.592	0.33
37_V	42_E	0.590	0.33
229_L	233_A	0.590	0.33
51_E	56_L	0.590	0.33
136_W	166_E	0.590	0.33
82_R	85_F	0.588	0.33
46_E	50_A	0.585	0.33
58_N	64_Y	0.585	0.33
82_R	139_F	0.584	0.33
173_K	262_L	0.584	0.33
202_G	251_N	0.583	0.32
117_Q	121_L	0.583	0.32
66_A	73_H	0.581	0.32
165_V	174_L	0.581	0.32
46_E	54_R	0.581	0.32
44_Q	56_L	0.579	0.32
208_M	230_I	0.579	0.32
157_W	236_W	0.579	0.32
79_H	86_F	0.578	0.32
243_D	247_M	0.577	0.32
153_F	232_F	0.572	0.32
241_W	255_I	0.569	0.31
229_L	236_W	0.566	0.31
146_F	185_S	0.565	0.31
150_H	170_G	0.563	0.31
162_G	260_V	0.563	0.31
54_R	57_E	0.562	0.31
67_A	73_H	0.560	0.31
69_W	72_G	0.559	0.31
152_L	209_G	0.558	0.31
61_D	67_A	0.557	0.30
109_I	151_I	0.553	0.30
178_T	203_V	0.552	0.30
40_A	46_E	0.552	0.30
54_R	75_G	0.552	0.30
38_W	41_D	0.551	0.30
150_H	254_H	0.550	0.30
189_Q	203_V	0.548	0.30
56_L	69_W	0.547	0.30
258_L	269_S	0.546	0.30
246_G	252_G	0.544	0.29
187_Y	193_S	0.544	0.29
143_L	178_T	0.541	0.29
210_Y	268_D	0.540	0.29
57_E	60_A	0.539	0.29
240_G	243_D	0.537	0.29
231_I	237_I	0.536	0.29
133_F	147_S	0.535	0.29
68_S	71_A	0.535	0.29
135_F	153_F	0.534	0.29
201_S	261_G	0.532	0.29
69_W	74_T	0.530	0.28
103_A	244_L	0.529	0.28
75_G	263_A	0.529	0.28
148_L	249_M	0.527	0.28
118_E	122_W	0.527	0.28
199_G	254_H	0.524	0.28
139_F	179_L	0.524	0.28
48_V	59_P	0.523	0.28
189_Q	198_G	0.522	0.28
97_T	149_M	0.521	0.28
146_F	250_A	0.521	0.28
146_F	236_W	0.520	0.28
104_C	197_F	0.518	0.28
73_H	84_P	0.518	0.28
206_A	240_G	0.518	0.28
83_Y	89_L	0.517	0.27
161_L	267_V	0.516	0.27
174_L	248_S	0.515	0.27
145_H	154_N	0.513	0.27
232_F	270_L	0.511	0.27
182_A	250_A	0.509	0.27
55_F	69_W	0.506	0.27
66_A	72_G	0.505	0.27
127_F	131_L	0.504	0.27
43_S	224_Y	0.500	0.26

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4njnA	4	0.6594	100	0.412	Contact Map
2nr9A	2	0.6775	100	0.431	Contact Map
2xovA	1	0.6558	100	0.452	Contact Map
2gqcA	1	0.2428	98.4	0.848	Contact Map
2lepA	1	0.2283	98.2	0.854	Contact Map
4hddA	6	0.2391	98.2	0.854	Contact Map
2hfvA	1	0.2319	83.6	0.927	Contact Map
4j05A	3	0.6014	51.9	0.942	Contact Map
2kluA	1	0.1087	34.5	0.948	Contact Map
1pw4A	1	0.6957	32.8	0.948	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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