GREMLIN Database
GRPE - Protein GrpE
UniProt: P09372 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10416
Length: 197 (174)
Sequences: 4769 (3748)
Seq/√Len: 284.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_Q58_E3.4681.00
47_L52_A2.9861.00
141_V176_K2.9831.00
94_E137_F2.5461.00
143_A147_V2.4701.00
140_E179_T2.4571.00
48_E51_L2.3931.00
60_D64_R2.2821.00
101_S104_R2.2501.00
101_S129_S2.1701.00
175_Q189_M2.1611.00
155_Q189_M2.1271.00
162_S165_V2.0911.00
51_L55_Q2.0831.00
135_R140_E2.0001.00
72_L76_T1.9901.00
132_D135_R1.9851.00
54_A59_R1.9391.00
94_E136_K1.9121.00
172_G191_T1.8791.00
158_A191_T1.8541.00
92_I139_V1.8471.00
69_M72_L1.8291.00
153_V179_T1.8111.00
50_Q54_A1.7971.00
160_V171_L1.7571.00
70_E73_R1.7081.00
132_D136_K1.7001.00
59_R63_L1.6951.00
52_A56_T1.6601.00
103_D176_K1.6591.00
144_E173_I1.6171.00
103_D127_L1.5721.00
104_R107_E1.5561.00
124_E128_K1.5551.00
78_L82_K1.5501.00
53_E57_R1.5491.00
166_A169_N1.5151.00
49_A52_A1.5081.00
171_L193_A1.4941.00
150_D153_V1.4921.00
74_R78_L1.4761.00
47_L50_Q1.4751.00
88_L91_F1.4741.00
48_E52_A1.4641.00
89_E183_R1.4591.00
44_V48_E1.4241.00
92_I185_I1.4121.00
70_E74_R1.3971.00
179_T182_G1.3711.00
161_E194_K1.3571.00
148_P169_N1.3431.00
67_A71_N1.3421.00
62_I65_V1.3421.00
160_V191_T1.3291.00
56_T60_D1.3291.00
118_A121_E1.3271.00
162_S193_A1.3091.00
121_E124_E1.2881.00
105_A123_I1.2821.00
114_P117_S1.2721.00
165_V193_A1.2471.00
140_E182_G1.2411.00
46_N50_Q1.2271.00
160_V172_G1.2251.00
165_V171_L1.2171.00
65_V69_M1.2151.00
77_E81_E1.2141.00
81_E85_K1.2061.00
142_I184_T1.2031.00
128_K132_D1.1971.00
46_N49_A1.1791.00
57_R61_G1.1691.00
80_I84_H1.1681.00
159_M194_K1.1561.00
174_M191_T1.1511.00
100_D186_R1.1491.00
42_E46_N1.1491.00
62_I66_K1.1431.00
91_F137_F1.1351.00
61_G66_K1.1331.00
145_T173_I1.1211.00
165_V169_N1.1101.00
41_D44_V1.1061.00
144_E147_V1.0981.00
55_Q59_R1.0941.00
159_M168_G1.0811.00
127_L131_L1.0771.00
76_T80_I1.0441.00
145_T172_G1.0401.00
117_S121_E1.0251.00
134_V139_V1.0181.00
86_F183_R1.0131.00
53_E56_T1.0041.00
44_V47_L0.9961.00
86_F181_N0.9941.00
80_I83_A0.9941.00
169_N193_A0.9931.00
102_L126_T0.9851.00
144_E188_A0.9841.00
98_V133_V0.9781.00
58_E62_I0.9741.00
64_R67_A0.9661.00
102_L127_L0.9601.00
85_K181_N0.9601.00
99_I134_V0.9541.00
99_I178_Y0.9511.00
141_V173_I0.9441.00
139_V180_L0.9351.00
66_K70_E0.9331.00
54_A57_R0.9231.00
157_I189_M0.9211.00
40_R45_A0.9211.00
173_I188_A0.9141.00
45_A49_A0.9021.00
131_L141_V0.8691.00
103_D107_E0.8641.00
184_T187_A0.8631.00
54_A58_E0.8581.00
109_A120_V0.8581.00
69_M76_T0.8571.00
34_A37_V0.8571.00
158_A174_M0.8561.00
58_E61_G0.8551.00
129_S132_D0.8531.00
149_L156_A0.8461.00
65_V72_L0.8461.00
104_R175_Q0.8401.00
155_Q175_Q0.8351.00
71_N74_R0.8171.00
167_P193_A0.8120.99
60_D68_E0.8080.99
171_L191_T0.7930.99
41_D45_A0.7910.99
49_A53_E0.7870.99
23_E26_E0.7820.99
42_E45_A0.7800.99
79_D82_K0.7670.99
56_T59_R0.7660.99
98_V130_M0.7630.99
131_L135_R0.7590.99
64_R71_N0.7560.99
37_V40_R0.7540.99
144_E170_V0.7520.99
38_D41_D0.7410.99
29_E32_A0.7390.99
24_E27_A0.7390.99
83_A87_A0.7390.99
40_R43_K0.7360.99
50_Q53_E0.7340.99
19_M22_H0.7340.99
158_A172_G0.7330.99
51_L54_A0.7310.99
117_S120_V0.7310.99
113_N116_M0.7230.99
147_V173_I0.7220.99
90_K93_N0.7210.99
174_M189_M0.7200.99
28_V31_E0.7170.99
39_P42_E0.7110.99
22_H25_I0.7100.99
87_A91_F0.6970.98
149_L170_V0.6930.98
81_E84_H0.6860.98
37_V41_D0.6840.98
147_V153_V0.6830.98
74_R77_E0.6790.98
20_D23_E0.6750.98
167_P194_K0.6690.98
97_P175_Q0.6690.98
52_A55_Q0.6670.98
85_K89_E0.6620.98
89_E180_L0.6610.98
154_H170_V0.6610.98
76_T79_D0.6600.98
68_E72_L0.6580.98
88_L137_F0.6580.98
99_I127_L0.6550.98
30_P34_A0.6520.98
121_E128_K0.6490.98
142_I179_T0.6450.97
99_I131_L0.6450.97
115_D118_A0.6450.97
130_M134_V0.6440.97
96_L186_R0.6380.97
43_K46_N0.6360.97
166_A193_A0.6350.97
69_M73_R0.6320.97
88_L92_I0.6310.97
161_E193_A0.6290.97
180_L185_I0.6280.97
31_E34_A0.6260.97
63_L70_E0.6230.97
60_D63_L0.6200.97
25_I28_V0.6190.97
20_D24_E0.6190.97
94_E97_P0.6140.97
55_Q62_I0.6130.97
106_L124_E0.6090.96
148_P168_G0.6080.96
79_D83_A0.6070.96
83_A86_F0.6070.96
88_L181_N0.6060.96
119_M123_I0.6040.96
97_P129_S0.6000.96
173_I176_K0.5970.96
86_F89_E0.5960.96
90_K94_E0.5900.96
82_K85_K0.5880.96
77_E80_I0.5880.96
157_I174_M0.5860.96
148_P166_A0.5860.96
109_A116_M0.5850.95
110_D116_M0.5820.95
32_A38_D0.5810.95
21_Q24_E0.5810.95
142_I188_A0.5740.95
89_E93_N0.5740.95
104_R108_V0.5730.95
102_L123_I0.5700.95
26_E29_E0.5670.95
160_V193_A0.5660.95
107_E172_G0.5650.95
19_M25_I0.5640.94
123_I126_T0.5630.94
30_P33_S0.5620.94
129_S133_V0.5620.94
89_E185_I0.5580.94
122_G125_L0.5570.94
45_A48_E0.5560.94
109_A119_M0.5510.94
19_M39_P0.5450.93
138_G181_N0.5450.93
23_E30_P0.5410.93
147_V170_V0.5410.93
88_L180_L0.5400.93
33_S37_V0.5400.93
35_E38_D0.5390.93
162_S166_A0.5370.93
38_D42_E0.5360.93
26_E30_P0.5350.93
85_K182_G0.5280.92
148_P170_V0.5280.92
125_L128_K0.5270.92
21_Q25_I0.5260.92
84_H90_K0.5250.92
67_A74_R0.5250.92
62_I69_M0.5230.92
110_D113_N0.5230.92
106_L120_V0.5210.92
58_E65_V0.5190.92
103_D131_L0.5170.92
141_V144_E0.5140.91
133_V137_F0.5140.91
61_G65_V0.5120.91
156_A192_V0.5110.91
106_L127_L0.5100.91
75_R79_D0.5080.91
20_D30_P0.5060.91
27_A30_P0.5050.91
92_I180_L0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dkgA 2 0.7817 100 0.094 Contact Map
4aniA 2 0.7919 100 0.111 Contact Map
3a6mA 2 0.8528 100 0.14 Contact Map
3swyA 3 0.2335 50.5 0.928 Contact Map
4etpB 1 0.6904 41.6 0.931 Contact Map
3swfA 3 0.2995 33.6 0.935 Contact Map
3vkgA 2 0.9086 32.6 0.935 Contact Map
3mkbB 1 0.665 30.4 0.936 Contact Map
1gcvB 1 0.665 28.5 0.937 Contact Map
3ojaB 1 0.3909 27.8 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0076 seconds.