GREMLIN Database
MOTA - Motility protein A
UniProt: P09348 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10601
Length: 295 (248)
Sequences: 2314 (1510)
Seq/√Len: 95.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_I242_K3.8571.00
169_G221_S3.8251.00
88_K100_D3.5001.00
88_K96_S3.3691.00
17_G36_I3.1271.00
62_P66_R3.0481.00
41_G168_V2.9961.00
9_V43_G2.8631.00
185_V207_V2.8321.00
165_L223_L2.7751.00
129_Y245_L2.7581.00
151_I235_S2.3891.00
166_A224_A2.3611.00
158_A234_T2.2601.00
154_H235_S2.2501.00
57_T165_L2.2361.00
24_S186_H2.2311.00
193_R197_E2.2231.00
46_I54_I2.2101.00
82_L257_A2.1981.00
215_L220_I2.1951.00
38_A215_L2.1651.00
193_R196_A2.1621.00
10_V218_G2.1371.00
128_D150_E2.1081.00
48_G225_T2.0361.00
41_G172_L2.0261.00
64_L223_L2.0181.00
27_A189_G1.9831.00
30_Q33_E1.9831.00
106_E238_M1.9401.00
74_M77_D1.9321.00
172_L215_L1.8911.00
50_N53_A1.8791.00
51_G55_K1.8781.00
126_I241_V1.8551.00
155_E235_S1.8531.00
244_T261_G1.8481.00
60_A161_P1.8121.00
158_A231_S1.7781.00
55_K59_K1.7581.00
154_H158_A1.7211.00
247_S252_Y1.7171.00
11_L15_F1.6981.00
8_L12_G1.6931.00
18_Y28_L1.6631.00
3_I226_V1.6571.00
34_L38_A1.6381.00
103_N106_E1.6271.00
80_A258_V1.5921.00
150_E270_R1.5611.00
187_A206_M1.5361.00
144_E243_V1.5301.00
144_E148_D1.5221.00
14_V40_A1.5181.00
243_V264_T1.5021.00
25_L29_Y1.4871.00
147_M245_L1.4571.00
172_L220_I1.4221.00
174_A206_M1.4201.00
10_V43_G1.4160.99
3_I47_V1.4120.99
59_K62_P1.4010.99
54_I57_T1.3920.99
45_F168_V1.3790.99
255_P258_V1.3790.99
258_V262_R1.3770.99
84_R87_A1.3770.99
166_A228_R1.3760.99
82_L244_T1.3470.99
53_A229_Q1.3470.99
3_I64_L1.3460.99
4_L8_L1.3320.99
181_V202_I1.3290.99
100_D103_N1.3220.99
5_L12_G1.3120.99
12_G16_G1.3050.99
16_G20_M1.2700.99
197_E200_A1.2530.99
88_K92_M1.2380.99
177_I208_G1.2260.99
89_S97_L1.2260.99
57_T61_L1.2210.98
78_L241_V1.2190.98
168_V220_I1.2090.98
14_V214_L1.1900.98
128_D259_E1.1890.98
177_I202_I1.1890.98
81_L104_P1.1860.98
45_F54_I1.1790.98
28_L186_H1.1790.98
142_E252_Y1.1780.98
33_E208_G1.1750.98
102_E131_R1.1720.98
162_A231_S1.1680.98
70_Y74_M1.1470.98
20_M35_V1.1430.98
202_I213_I1.1320.98
57_T164_S1.1180.97
149_E153_T1.0970.97
101_I131_R1.0940.97
214_L218_G1.0900.97
12_G15_F1.0890.97
158_A227_L1.0850.97
14_V218_G1.0770.97
186_H201_L1.0690.96
197_E201_L1.0560.96
202_I206_M1.0550.96
11_L219_F1.0550.96
13_T43_G1.0550.96
133_I143_I1.0490.96
202_I208_G1.0490.96
44_S171_S1.0470.96
18_Y23_G1.0470.96
53_A164_S1.0460.96
61_L165_L1.0460.96
129_Y147_M1.0330.96
180_A210_F1.0290.96
30_Q204_H1.0250.96
49_N163_N1.0140.95
237_M241_V1.0120.95
174_A202_I1.0050.95
139_N142_E0.9910.95
124_D127_V0.9900.95
29_Y34_L0.9880.95
55_K58_L0.9860.94
191_A199_G0.9850.94
154_H231_S0.9760.94
53_A160_V0.9700.94
60_A64_L0.9670.94
77_D81_L0.9640.94
143_I249_L0.9590.94
198_L202_I0.9570.94
64_L226_V0.9470.93
180_A187_A0.9450.93
19_L25_L0.9410.93
5_L9_V0.9370.93
132_L146_L0.9270.92
21_T186_H0.9270.92
131_R259_E0.9150.92
61_L223_L0.9140.92
180_A188_L0.9110.92
177_I213_I0.9030.91
247_S260_F0.8980.91
70_Y237_M0.8960.91
85_L130_L0.8930.91
178_V214_L0.8870.91
88_K97_L0.8860.91
199_G203_A0.8860.91
175_F201_L0.8850.91
171_S217_Y0.8830.90
148_D242_K0.8800.90
21_T208_G0.8740.90
266_Y269_E0.8720.90
200_A203_A0.8700.90
200_A204_H0.8700.90
37_I214_L0.8690.90
78_L237_M0.8670.90
67_R230_K0.8610.89
187_A202_I0.8560.89
90_R253_A0.8540.89
36_I182_M0.8530.89
162_A228_R0.8500.89
87_A91_Q0.8470.89
177_I187_A0.8470.89
21_T206_M0.8460.89
188_L210_F0.8390.88
81_L126_I0.8320.88
20_M32_A0.8320.88
136_G251_G0.8320.88
18_Y210_F0.8300.88
174_A208_G0.8270.87
226_V230_K0.8250.87
177_I181_V0.8220.87
56_G160_V0.8210.87
133_I249_L0.8190.87
145_A149_E0.8190.87
247_S257_A0.8180.87
48_G167_L0.8170.87
28_L187_A0.8150.87
165_L227_L0.8100.86
83_Y258_V0.8060.86
243_V260_F0.8060.86
231_S235_S0.8060.86
84_R100_D0.7950.85
33_E180_A0.7930.85
167_L170_D0.7830.84
31_P34_L0.7810.84
151_I238_M0.7780.84
38_A42_I0.7770.84
75_Y237_M0.7770.84
198_L201_L0.7710.83
18_Y177_I0.7690.83
193_R203_A0.7680.83
51_G54_I0.7610.83
49_N167_L0.7600.83
47_V64_L0.7550.82
22_G201_L0.7530.82
45_F57_T0.7520.82
167_L171_S0.7520.82
7_Y11_L0.7520.82
58_L61_L0.7490.82
140_T250_N0.7490.82
215_L219_F0.7480.82
181_V213_I0.7460.81
138_M146_L0.7450.81
24_S27_A0.7450.81
174_A187_A0.7440.81
174_A181_V0.7440.81
165_L220_I0.7420.81
151_I239_Q0.7360.81
46_I51_G0.7330.80
169_G206_M0.7320.80
35_V169_G0.7310.80
267_S270_R0.7280.80
86_M244_T0.7280.80
22_G186_H0.7260.80
33_E177_I0.7210.79
142_E145_A0.7210.79
9_V46_I0.7170.79
30_Q36_I0.7160.79
227_L234_T0.7120.78
37_I218_G0.7090.78
85_L97_L0.7070.78
152_E155_E0.7060.78
49_N164_S0.7040.78
252_Y260_F0.7040.78
181_V206_M0.7020.77
64_L165_L0.7010.77
175_F202_I0.7000.77
60_A227_L0.7000.77
157_E227_L0.6980.77
155_E231_S0.6940.76
180_A207_V0.6890.76
195_A200_A0.6880.76
196_A200_A0.6840.75
241_V245_L0.6830.75
44_S218_G0.6810.75
59_K163_N0.6790.75
85_L245_L0.6780.75
162_A166_A0.6760.75
83_Y254_P0.6730.74
175_F200_A0.6710.74
175_F178_V0.6700.74
197_E203_A0.6670.74
157_E234_T0.6630.73
7_Y47_V0.6610.73
23_G182_M0.6580.73
166_A170_D0.6570.73
177_I206_M0.6540.72
91_Q138_M0.6470.71
248_N257_A0.6440.71
187_A217_Y0.6430.71
94_M251_G0.6430.71
240_C264_T0.6430.71
81_L100_D0.6410.71
133_I245_L0.6400.71
61_L65_F0.6390.70
82_L138_M0.6390.70
180_A217_Y0.6380.70
145_A148_D0.6380.70
28_L202_I0.6370.70
134_I253_A0.6330.70
15_F25_L0.6330.70
52_K56_G0.6330.70
13_T39_G0.6320.70
124_D267_S0.6320.70
26_G29_Y0.6310.69
15_F24_S0.6250.69
186_H189_G0.6210.68
144_E250_N0.6210.68
87_A257_A0.6200.68
153_T156_S0.6170.68
246_L250_N0.6160.68
13_T35_V0.6160.68
132_L252_Y0.6150.68
180_A202_I0.6140.67
13_T28_L0.6140.67
187_A208_G0.6130.67
132_L263_K0.6110.67
180_A208_G0.6040.66
41_G220_I0.6030.66
149_E263_K0.6020.66
220_I223_L0.6000.66
13_T17_G0.5990.65
59_K268_S0.5980.65
53_A233_E0.5980.65
106_E241_V0.5950.65
16_G25_L0.5950.65
244_T260_F0.5920.65
27_A186_H0.5920.65
175_F189_G0.5910.64
24_S189_G0.5900.64
44_S175_F0.5880.64
225_T228_R0.5850.64
104_P129_Y0.5850.64
208_G214_L0.5850.64
18_Y182_M0.5830.63
211_L217_Y0.5830.63
21_T187_A0.5820.63
125_F147_M0.5810.63
174_A177_I0.5800.63
160_V163_N0.5760.62
233_E266_Y0.5760.62
180_A197_E0.5760.62
130_L134_I0.5750.62
181_V187_A0.5740.62
63_L231_S0.5740.62
171_S221_S0.5730.62
190_S193_R0.5720.62
33_E207_V0.5700.62
37_I41_G0.5670.61
50_N56_G0.5650.61
79_L240_C0.5630.61
179_A208_G0.5610.60
75_Y79_L0.5600.60
87_A255_P0.5590.60
174_A214_L0.5590.60
256_I259_E0.5570.60
170_D186_H0.5560.60
54_I58_L0.5560.60
181_V208_G0.5560.60
10_V44_S0.5510.59
89_S96_S0.5510.59
175_F186_H0.5480.59
204_H211_L0.5470.59
140_T246_L0.5460.58
246_L260_F0.5460.58
37_I195_A0.5450.58
68_S230_K0.5450.58
64_L227_L0.5450.58
105_R124_D0.5440.58
31_P35_V0.5440.58
18_Y30_Q0.5410.58
45_F164_S0.5410.58
30_Q177_I0.5400.58
252_Y257_A0.5380.57
158_A161_P0.5350.57
165_L168_V0.5350.57
101_I134_I0.5320.56
9_V13_T0.5310.56
216_A221_S0.5300.56
37_I168_V0.5260.56
92_M251_G0.5260.56
9_V12_G0.5250.55
86_M95_F0.5250.55
195_A198_L0.5210.55
19_L35_V0.5200.55
69_K268_S0.5190.55
28_L181_V0.5170.54
196_A199_G0.5170.54
81_L105_R0.5160.54
150_E263_K0.5160.54
175_F181_V0.5160.54
89_S95_F0.5150.54
13_T181_V0.5140.54
234_T238_M0.5140.54
63_L227_L0.5140.54
6_G43_G0.5130.54
208_G213_I0.5130.54
192_D198_L0.5120.54
175_F214_L0.5110.54
52_K233_E0.5110.54
95_F134_I0.5100.53
82_L261_G0.5090.53
37_I181_V0.5080.53
65_F246_L0.5080.53
47_V50_N0.5040.53
174_A210_F0.5040.53
129_Y143_I0.5020.52
150_E153_T0.5010.52
93_G97_L0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4il3A 1 0.8542 58.7 0.957 Contact Map
4aw6A 2 0.8576 51.6 0.959 Contact Map
1i5pA 1 0.522 41.6 0.961 Contact Map
2qk1A 1 0.7525 23.8 0.966 Contact Map
2f05A 1 0.261 14.2 0.969 Contact Map
4bgnA 3 0.4034 11.5 0.971 Contact Map
3wozA 1 0.6881 10.8 0.971 Contact Map
1h2vC 1 0.5356 8.6 0.972 Contact Map
4m70A 1 0.3356 8.5 0.972 Contact Map
1mhsA 2 0.3119 8.5 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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