GREMLIN Database
VSR - Very short patch repair protein
UniProt: P09184 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11068
Length: 156 (128)
Sequences: 1284 (1025)
Seq/√Len: 90.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_H90_I4.2781.00
5_H13_N3.7111.00
6_D9_T3.0631.00
13_N16_A2.9471.00
12_K16_A2.4171.00
32_L52_F2.2931.00
70_H94_V2.2901.00
5_H9_T2.2801.00
92_K99_R2.2331.00
11_S15_R2.1821.00
99_R103_R2.0111.00
33_T38_A1.9541.00
91_G95_E1.9261.00
26_K30_S1.8271.00
9_T13_N1.7691.00
101_I113_I1.7581.00
53_V109_W1.7151.00
44_A49_R1.7111.00
31_L35_Q1.6991.00
59_C110_R1.6791.00
9_T12_K1.6681.00
64_H113_I1.5801.00
43_D55_D1.5481.00
76_F90_I1.5441.00
71_H117_C1.5311.00
28_L63_T1.5311.00
64_H101_I1.5271.00
78_V87_L1.5231.00
102_S106_E1.4801.00
10_R13_N1.4440.99
30_S34_G1.4410.99
13_N17_I1.4170.99
54_V57_Y1.4070.99
42_Q49_R1.3910.99
66_C117_C1.3530.99
10_R17_I1.3360.99
8_A12_K1.3350.99
66_C71_H1.2960.99
29_A52_F1.2780.99
28_L31_L1.2750.99
101_I105_Q1.2610.99
5_H16_A1.2530.98
66_C79_P1.2400.98
78_V90_I1.2330.98
29_A41_V1.2220.98
88_E92_K1.2180.98
83_T87_L1.2050.98
59_C112_L1.1990.98
92_K95_E1.1710.98
47_P107_L1.1620.97
70_H76_F1.1530.97
100_D103_R1.1490.97
84_E88_E1.1460.97
87_L91_G1.1370.97
19_T42_Q1.1280.97
45_S48_G1.1260.97
23_A27_R1.1230.97
37_L54_V1.1160.97
26_K41_V1.1030.97
72_H76_F1.1030.97
43_D53_V1.0620.96
12_K15_R1.0580.96
102_S105_Q1.0380.95
28_L119_L1.0310.95
20_R42_Q1.0260.95
28_L127_D1.0250.95
72_H75_L1.0250.95
24_I65_G1.0110.94
73_C117_C1.0020.94
103_R106_E1.0000.94
32_L39_F0.9890.94
29_A38_A0.9870.94
33_T39_F0.9860.94
24_I63_T0.9670.93
101_I111_V0.9660.93
66_C116_E0.9630.93
54_V59_C0.9360.92
5_H12_K0.9350.92
21_D29_A0.9320.92
33_T56_E0.9310.91
88_E91_G0.9070.90
19_T49_R0.9070.90
77_K90_I0.9070.90
95_E99_R0.9030.90
31_L34_G0.8930.90
30_S39_F0.8640.88
29_A39_F0.8610.88
94_V98_R0.8560.88
103_R107_L0.8450.87
15_R85_F0.8380.87
78_V83_T0.8370.86
28_L114_V0.8360.86
98_R101_I0.8320.86
70_H78_V0.8270.86
85_F88_E0.8250.86
71_H79_P0.8240.86
122_R125_L0.8230.86
35_Q131_T0.8050.84
37_L61_I0.7950.84
64_H117_C0.7910.83
105_Q111_V0.7910.83
26_K29_A0.7820.82
30_S38_A0.7800.82
77_K80_A0.7790.82
104_L111_V0.7780.82
22_T26_K0.7770.82
66_C73_C0.7640.81
38_A52_F0.7630.81
61_I112_L0.7580.80
119_L127_D0.7430.79
19_T23_A0.7420.79
90_I94_V0.7360.79
5_H11_S0.7340.78
71_H75_L0.7280.78
28_L130_L0.7210.77
15_R112_L0.7140.76
73_C79_P0.7090.76
21_D41_V0.7060.76
121_G124_K0.7020.75
129_A132_E0.7000.75
29_A33_T0.6970.75
41_V52_F0.6970.75
37_L131_T0.6960.75
64_H73_C0.6850.73
46_L60_V0.6830.73
53_V60_V0.6760.72
46_L49_R0.6740.72
126_T129_A0.6730.72
114_V123_E0.6650.71
123_E126_T0.6610.71
58_R102_S0.6600.71
47_P100_D0.6560.70
68_W116_E0.6500.69
76_F79_P0.6480.69
33_T52_F0.6470.69
5_H8_A0.6450.69
11_S17_I0.6400.68
24_I41_V0.6370.68
95_E98_R0.6240.66
37_L59_C0.6230.66
123_E127_D0.6230.66
96_R112_L0.6150.65
128_E132_E0.6130.65
34_G39_F0.6090.64
35_Q125_L0.6060.64
118_A122_R0.6010.63
83_T88_E0.6010.63
17_I24_I0.6010.63
43_D60_V0.5970.63
35_Q128_E0.5930.62
72_H117_C0.5920.62
62_F101_I0.5900.62
17_I76_F0.5870.62
23_A85_F0.5850.61
33_T54_V0.5840.61
31_L125_L0.5810.61
126_T130_L0.5780.60
121_G125_L0.5710.60
65_G104_L0.5700.59
128_E131_T0.5700.59
100_D119_L0.5690.59
50_P100_D0.5640.59
33_T41_V0.5640.59
54_V109_W0.5620.58
67_F87_L0.5570.58
11_S16_A0.5570.58
79_P117_C0.5550.57
58_R108_G0.5530.57
42_Q52_F0.5510.57
67_F90_I0.5510.57
34_G53_V0.5430.56
17_I85_F0.5410.55
113_I117_C0.5390.55
58_R109_W0.5390.55
64_H70_H0.5380.55
78_V81_T0.5370.55
32_L90_I0.5330.54
24_I116_E0.5300.54
91_G94_V0.5280.54
27_R124_K0.5280.54
95_E111_V0.5210.53
59_C118_A0.5190.52
66_C82_R0.5150.52
90_I93_N0.5120.51
64_H72_H0.5100.51
121_G126_T0.5080.51
65_G68_W0.5070.51
63_T131_T0.5060.51
98_R102_S0.5050.51
27_R31_L0.5030.50
77_K85_F0.5030.50
24_I39_F0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1cw0A 1 0.9936 100 0.299 Contact Map
1vsrA 1 0.859 100 0.389 Contact Map
3r3pA 3 0.6282 99.9 0.679 Contact Map
3hrlA 1 0.5833 99.7 0.726 Contact Map
4oq2A 1 0.859 99.4 0.779 Contact Map
4parB 3 0.9231 98.4 0.852 Contact Map
4khaA 1 0.8077 19.9 0.955 Contact Map
1qyiA 1 0.6026 12.3 0.959 Contact Map
4b6at 1 0.3205 12 0.959 Contact Map
3jvdA 2 0.4936 11.4 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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