GREMLIN Database
OMPT - Protease 7
UniProt: P09169 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10673
Length: 317 (298)
Sequences: 165 (134)
Seq/√Len: 7.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_Y181_G4.7280.99
237_K241_Y3.7050.95
47_E64_W3.2840.91
62_L105_D3.2070.90
228_D243_S3.1710.90
60_S105_D3.1410.89
102_V118_E3.0100.87
105_D119_S2.5980.77
105_D232_H2.5420.76
245_V281_G2.5320.75
105_D230_D2.4780.74
25_L59_V2.3210.68
60_S230_D2.3070.68
60_S232_H2.2880.67
60_S119_S2.2680.66
62_L230_D2.2310.65
62_L232_H2.2090.64
47_E50_Y2.2020.64
165_G187_E2.1020.60
121_H241_Y2.0990.60
55_G243_S2.0750.59
62_L119_S2.0680.59
234_D239_I2.0410.58
101_M232_H1.9890.56
101_M230_D1.9830.56
190_I230_D1.9000.52
106_W232_H1.8800.51
62_L103_D1.8410.50
60_S103_D1.8400.50
106_W230_D1.8310.49
43_G66_F1.7940.48
13_P16_I1.7890.48
37_S63_D1.7830.48
191_G233_Y1.7700.47
241_Y285_L1.7660.47
261_V264_N1.7480.46
119_S232_H1.7410.46
119_S166_G1.7380.46
151_M202_G1.7310.45
47_E166_G1.7290.45
95_G265_A1.7210.45
171_S178_D1.7110.45
123_D216_G1.6870.44
39_G50_Y1.6820.44
50_Y64_W1.6750.43
127_N160_S1.6450.42
190_I232_H1.6300.41
50_Y175_G1.6220.41
63_D150_L1.6110.41
47_E60_S1.5950.40
47_E163_A1.5900.40
119_S230_D1.5860.40
64_W301_G1.5840.40
128_Y158_R1.5830.40
142_N209_Y1.5700.39
108_D116_T1.5640.39
243_S281_G1.5620.39
86_I262_T1.5380.38
105_D166_G1.5330.38
60_S106_W1.5250.37
103_D230_D1.5030.37
58_K61_Q1.5010.37
228_D313_L1.4970.36
261_V316_T1.4970.36
47_E232_H1.4760.36
41_L203_L1.4720.35
47_E62_L1.4400.34
72_I123_D1.4300.34
118_E167_S1.4300.34
78_W154_Y1.4290.34
47_E230_D1.4280.34
192_Y228_D1.4260.34
62_L106_W1.4220.34
64_W121_H1.4210.34
130_N191_G1.4200.34
166_G301_G1.4150.33
105_D190_I1.4090.33
131_E154_Y1.4060.33
47_E121_H1.4040.33
166_G281_G1.4000.33
42_S58_K1.3950.33
101_M190_I1.3860.32
104_Q118_E1.3840.32
64_W166_G1.3820.32
228_D287_D1.3820.32
212_F255_V1.3800.32
252_S275_R1.3720.32
59_V261_V1.3720.32
112_P172_S1.3640.32
103_D232_H1.3530.31
30_D267_V1.3470.31
34_A76_I1.3450.31
130_N158_R1.3260.30
268_Y312_G1.3260.30
213_E266_K1.3050.30
209_Y273_W1.2760.29
43_G64_W1.2730.28
116_T212_F1.2700.28
136_I257_A1.2700.28
101_M105_D1.2640.28
101_M106_W1.2590.28
178_D238_R1.2530.28
60_S166_G1.2520.28
103_D119_S1.2510.28
267_V310_T1.2490.28
154_Y220_Y1.2370.27
281_G302_I1.2360.27
185_N216_G1.2350.27
135_N200_Y1.2330.27
95_G268_Y1.2330.27
103_D106_W1.2270.27
104_Q276_V1.2260.27
103_D190_I1.2240.27
99_G203_L1.2230.27
12_T88_A1.2220.27
43_G221_S1.2210.27
141_L154_Y1.2180.27
171_S187_E1.2130.27
101_M119_S1.2110.26
54_E175_G1.2100.26
60_S101_M1.2070.26
49_V283_T1.1990.26
22_T140_L1.1970.26
263_P316_T1.1940.26
11_T15_A1.1760.25
72_I117_D1.1720.25
158_R193_K1.1560.25
35_D104_Q1.1370.24
130_N154_Y1.1350.24
115_W171_S1.1310.24
115_W124_T1.1270.24
60_S121_H1.1260.24
148_L294_D1.1250.24
115_W194_Q1.1130.24
47_E301_G1.1100.23
11_T269_V1.1050.23
283_T300_A1.1050.23
218_F308_I1.0890.23
170_Y237_K1.0860.23
47_E58_K1.0780.23
133_D250_Y1.0770.22
239_I285_L1.0710.22
172_S178_D1.0650.22
102_V120_R1.0640.22
62_L166_G1.0480.22
167_S181_G1.0470.22
62_L101_M1.0470.22
117_D300_A1.0360.21
133_D200_Y1.0350.21
126_L153_G1.0340.21
170_Y241_Y1.0320.21
84_I182_S1.0280.21
91_W154_Y1.0250.21
253_V313_L1.0230.21
122_P167_S1.0170.21
104_Q194_Q1.0150.21
75_A137_K1.0150.21
150_L189_A1.0150.21
49_V64_W1.0090.21
30_D211_D1.0080.21
121_H167_S1.0080.21
60_S190_I1.0070.21
194_Q301_G1.0070.21
116_T232_H0.9950.20
138_G156_E0.9880.20
91_W315_Y0.9870.20
105_D116_T0.9870.20
107_M282_N0.9830.20
49_V243_S0.9820.20
123_D264_N0.9790.20
93_T233_Y0.9790.20
129_A159_Y0.9780.20
234_D238_R0.9770.20
80_L271_G0.9750.20
106_W119_S0.9740.20
40_T59_V0.9680.20
98_G268_Y0.9640.19
121_H166_G0.9620.19
70_A95_G0.9580.19
37_S193_K0.9570.19
71_I312_G0.9570.19
124_T165_G0.9550.19
106_W190_I0.9550.19
104_Q301_G0.9490.19
65_K73_K0.9480.19
139_W149_G0.9460.19
43_G164_R0.9440.19
116_T166_G0.9360.19
76_I117_D0.9350.19
35_D67_N0.9270.19
47_E116_T0.9250.18
116_T230_D0.9240.18
49_V60_S0.9150.18
125_Q150_L0.9150.18
62_L190_I0.9040.18
213_E260_Y0.9040.18
156_E212_F0.9010.18
58_K259_Y0.8980.18
161_F279_K0.8970.18
66_F255_V0.8900.18
121_H232_H0.8820.17
43_G49_V0.8740.17
18_S29_P0.8690.17
86_I313_L0.8670.17
155_Q210_E0.8570.17
136_I146_Y0.8560.17
39_G259_Y0.8510.17
150_L265_A0.8510.17
26_S136_I0.8480.17
129_A199_P0.8440.17
166_G232_H0.8420.17
64_W168_Y0.8380.16
155_Q219_K0.8360.16
116_T119_S0.8360.16
14_I178_D0.8350.16
104_Q115_W0.8340.16
273_W277_T0.8330.16
185_N299_G0.8310.16
84_I271_G0.8290.16
62_L121_H0.8280.16
13_P25_L0.8270.16
210_E300_A0.8230.16
12_T76_I0.8230.16
123_D183_F0.8190.16
99_G226_S0.8170.16
115_W121_H0.8170.16
161_F170_Y0.8160.16
69_A74_G0.8150.16
159_Y240_T0.8140.16
88_A261_V0.8140.16
99_G137_K0.8100.16
121_H230_D0.8080.16
49_V192_Y0.8040.16
121_H228_D0.7960.16
184_P188_R0.7900.15
140_L184_P0.7870.15
138_G158_R0.7850.15
34_A247_D0.7850.15
93_T159_Y0.7820.15
129_A221_S0.7740.15
73_K270_E0.7730.15
16_I21_S0.7710.15
122_P150_L0.7680.15
40_T195_R0.7660.15
91_W200_Y0.7630.15
61_Q165_G0.7630.15
133_D196_F0.7600.15
127_N162_T0.7570.15
75_A276_V0.7560.15
193_K219_K0.7530.15
58_K124_T0.7520.15
238_R241_Y0.7500.15
66_F159_Y0.7500.15
32_I285_L0.7490.15
73_K213_E0.7490.15
161_F308_I0.7480.15
157_S233_Y0.7470.15
122_P269_V0.7460.15
159_Y227_S0.7460.15
13_P23_E0.7430.14
34_A83_Q0.7420.14
160_S191_G0.7400.14
41_L133_D0.7370.14
42_S70_A0.7330.14
189_A241_Y0.7320.14
242_R310_T0.7320.14
189_A237_K0.7300.14
295_Y310_T0.7240.14
262_T306_N0.7230.14
61_Q261_V0.7210.14
296_S316_T0.7210.14
189_A264_N0.7190.14
105_D121_H0.7170.14
170_Y228_D0.7150.14
243_S283_T0.7150.14
116_T190_I0.7140.14
69_A90_G0.7130.14
19_F99_G0.7120.14
265_A271_G0.7090.14
201_I299_G0.7080.14
43_G83_Q0.7060.14
106_W168_Y0.7050.14
91_W135_N0.7030.14
220_Y223_W0.7030.14
132_F144_P0.7000.14
153_G200_Y0.6990.14
48_R303_E0.6980.14
93_T126_L0.6980.14
187_E276_V0.6970.14
238_R289_N0.6950.14
56_G280_K0.6950.14
51_L59_V0.6900.13
84_I156_E0.6860.13
116_T170_Y0.6850.13
80_L193_K0.6840.13
164_R214_L0.6830.13
41_L200_Y0.6820.13
96_S200_Y0.6820.13
61_Q314_K0.6800.13
140_L183_F0.6770.13
166_G241_Y0.6770.13
47_E190_I0.6760.13
101_M186_G0.6760.13
100_N118_E0.6720.13
11_T253_V0.6710.13
77_N89_A0.6710.13
33_N214_L0.6660.13
74_G201_I0.6660.13
121_H190_I0.6650.13
193_K208_R0.6640.13
94_L116_T0.6620.13
231_E240_T0.6620.13
69_A278_N0.6620.13
205_G265_A0.6570.13
15_A18_S0.6520.13
169_I282_N0.6520.13
285_L299_G0.6490.13
179_D274_N0.6490.13
61_Q122_P0.6470.13
212_F286_Y0.6440.13
124_T259_Y0.6430.13
140_L309_T0.6420.13
49_V301_G0.6420.13
166_G230_D0.6410.13
171_S189_A0.6400.13
156_E310_T0.6380.12
47_E105_D0.6340.12
64_W117_D0.6320.12
216_G294_D0.6300.12
99_G108_D0.6300.12
70_A137_K0.6290.12
30_D255_V0.6280.12
98_G120_R0.6280.12
140_L148_L0.6280.12
44_K67_N0.6260.12
167_S183_F0.6240.12
193_K245_V0.6240.12
192_Y241_Y0.6230.12
78_W209_Y0.6200.12
77_N133_D0.6200.12
213_E226_S0.6170.12
229_N267_V0.6170.12
135_N198_M0.6140.12
77_N278_N0.6130.12
13_P257_A0.6110.12
202_G224_V0.6110.12
214_L282_N0.6090.12
286_Y316_T0.6070.12
124_T150_L0.6060.12
64_W192_Y0.6030.12
70_A308_I0.6020.12
46_K257_A0.6010.12
49_V62_L0.5990.12
60_S116_T0.5990.12
126_L216_G0.5970.12
82_P89_A0.5960.12
45_T104_Q0.5950.12
145_N150_L0.5920.12
38_L54_E0.5920.12
78_W207_Y0.5910.12
12_T17_S0.5910.12
115_W118_E0.5910.12
190_I241_Y0.5890.12
44_K104_Q0.5880.12
221_S233_Y0.5870.12
14_I19_F0.5860.12
54_E57_R0.5850.12
224_V237_K0.5850.12
129_A223_W0.5830.12
203_L270_E0.5820.12
166_G192_Y0.5810.12
116_T281_G0.5760.11
219_K259_Y0.5740.11
49_V119_S0.5730.11
131_E155_Q0.5730.11
209_Y251_Y0.5700.11
72_I309_T0.5660.11
13_P234_D0.5630.11
34_A148_L0.5630.11
18_S26_S0.5610.11
156_E255_V0.5610.11
308_I311_A0.5580.11
18_S23_E0.5580.11
68_N200_Y0.5580.11
18_S242_R0.5550.11
84_I118_E0.5540.11
15_A76_I0.5530.11
106_W259_Y0.5530.11
166_G194_Q0.5530.11
56_G116_T0.5520.11
224_V251_Y0.5510.11
48_R279_K0.5490.11
171_S175_G0.5470.11
86_I189_A0.5470.11
107_M296_S0.5460.11
15_A21_S0.5450.11
234_D290_N0.5440.11
87_G156_E0.5440.11
276_V308_I0.5430.11
189_A196_F0.5420.11
144_P182_S0.5420.11
32_I271_G0.5410.11
202_G315_Y0.5390.11
144_P226_S0.5390.11
123_D181_G0.5380.11
49_V121_H0.5380.11
66_F197_K0.5370.11
38_L175_G0.5360.11
161_F207_Y0.5360.11
163_A230_D0.5360.11
20_A80_L0.5360.11
136_I300_A0.5360.11
131_E157_S0.5330.11
49_V59_V0.5310.11
103_D116_T0.5310.11
142_N152_A0.5310.11
295_Y309_T0.5300.11
108_D242_R0.5290.11
37_S303_E0.5280.11
14_I18_S0.5260.11
47_E101_M0.5250.11
11_T261_V0.5240.11
13_P261_V0.5220.11
73_K79_D0.5210.11
163_A232_H0.5210.11
39_G44_K0.5210.11
91_W221_S0.5200.11
36_I84_I0.5180.11
32_I109_S0.5170.10
58_K304_N0.5150.10
282_N314_K0.5140.10
96_S211_D0.5140.10
165_G181_G0.5120.10
40_T151_M0.5100.10
65_K248_Q0.5090.10
42_S69_A0.5090.10
35_D218_F0.5080.10
154_Y197_K0.5070.10
198_M278_N0.5060.10
11_T31_N0.5030.10
43_G152_A0.5020.10
43_G108_D0.5020.10
39_G192_Y0.5020.10
71_I155_Q0.5010.10
47_E281_G0.5010.10
20_A188_R0.5000.10
144_P256_N0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2x55A 1 0.858 100 0.229 Contact Map
1i78A 2 0.9369 100 0.255 Contact Map
3nb3A 2 0.429 98.4 0.89 Contact Map
1p4tA 2 0.4574 96.7 0.923 Contact Map
2x27X 1 0.6467 96.5 0.924 Contact Map
3qq2A 2 0.7224 96.5 0.925 Contact Map
1uynX 1 0.7287 96.2 0.927 Contact Map
2jmmA 1 0.4479 96.1 0.927 Contact Map
3sltA 1 0.7508 95.8 0.929 Contact Map
4rlcA 1 0.4101 95.8 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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