GREMLIN Database
SPEE - Polyamine aminopropyl transferase
UniProt: P09158 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10963
Length: 288 (257)
Sequences: 2857 (1815)
Seq/√Len: 113.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_K102_E5.6071.00
179_K238_D4.0141.00
105_T152_F3.9291.00
23_N39_E3.7541.00
28_E112_G3.6041.00
83_I92_L3.2471.00
80_H103_S3.2121.00
103_S135_K3.1811.00
111_A115_S3.0371.00
264_Y269_H3.0361.00
114_V138_I2.8111.00
105_T137_V2.7301.00
37_I116_F2.6281.00
92_L134_F2.6121.00
22_D39_E2.5321.00
172_S176_E2.4721.00
178_C188_F2.4671.00
143_N147_Q2.4181.00
83_I95_V2.4121.00
84_I141_G2.3791.00
27_H34_D2.3581.00
92_L104_I2.2741.00
39_E45_R2.2691.00
172_S211_H2.2571.00
182_L186_G2.2291.00
26_Y112_G2.1631.00
105_T135_K2.1551.00
29_K34_D2.1441.00
145_V181_C2.1331.00
112_G115_S2.1231.00
22_D41_A2.0671.00
92_L129_Y2.0431.00
96_T104_I1.9981.00
30_T35_L1.9971.00
139_D147_Q1.9951.00
146_N177_G1.9511.00
118_R130_D1.9471.00
145_V177_G1.9421.00
95_V101_V1.9311.00
155_I182_L1.8921.00
115_S119_Q1.8851.00
104_I134_F1.8661.00
75_H78_A1.8651.00
155_I181_C1.8371.00
149_S180_R1.8331.00
185_G239_N1.8081.00
30_T112_G1.7741.00
111_A138_I1.7711.00
214_S238_D1.7641.00
72_L154_V1.7421.00
81_V95_V1.7151.00
265_N268_I1.7081.00
27_H36_I1.6871.00
148_T181_C1.6691.00
192_N234_A1.6601.00
271_A274_A1.6591.00
57_E123_N1.6531.00
82_L152_F1.6271.00
148_T151_T1.6061.00
155_I178_C1.5981.00
209_L236_A1.5971.00
143_N146_N1.5461.00
80_H183_N1.4681.00
37_I47_M1.4481.00
142_V168_S1.4451.00
81_V101_V1.4271.00
31_D111_A1.4211.00
71_P154_V1.4161.00
139_D143_N1.4091.00
20_A41_A1.3961.00
69_H98_H1.3791.00
26_Y116_F1.3711.00
82_L107_V1.3381.00
185_G238_D1.3351.00
114_V136_L1.3081.00
209_L234_A1.3020.99
55_T88_D1.3010.99
184_P238_D1.2970.99
68_T91_M1.2890.99
78_A100_N1.2780.99
38_F48_A1.2570.99
221_A233_F1.2450.99
106_M136_L1.2310.99
75_H154_V1.2040.99
144_F152_F1.1950.99
80_H150_Q1.1810.99
137_V144_F1.1460.99
157_S188_F1.1360.99
157_S174_F1.1150.98
185_G240_D1.1110.98
155_I186_G1.1090.98
37_I121_L1.1070.98
68_T156_I1.1060.98
267_A270_T1.0890.98
112_G116_F1.0870.98
202_A218_F1.0870.98
107_V144_F1.0770.98
94_E97_R1.0750.98
151_T183_N1.0690.98
254_F257_S1.0640.98
95_V104_I1.0630.98
206_H216_V1.0490.98
167_E171_T1.0470.98
184_P239_N1.0460.98
24_V36_I1.0420.98
177_G181_C1.0190.97
127_G130_D1.0130.97
154_V187_I1.0040.97
127_G131_D0.9850.97
144_F148_T0.9830.97
72_L95_V0.9770.96
215_D242_L0.9740.96
122_P127_G0.9730.96
142_V177_G0.9720.96
96_T134_F0.9710.96
139_D144_F0.9700.96
206_H210_S0.9610.96
80_H105_T0.9600.96
220_Q230_I0.9600.96
26_Y35_L0.9590.96
173_A176_E0.9560.96
252_A256_A0.9460.96
66_M272_A0.9440.96
268_I274_A0.9420.96
157_S178_C0.9370.95
148_T152_F0.9310.95
60_E93_R0.9300.95
215_D240_D0.9200.95
81_V154_V0.9200.95
30_T110_D0.9140.95
79_K183_N0.9110.95
14_Q20_A0.8990.94
267_A274_A0.8980.94
145_V178_C0.8970.94
180_R184_P0.8970.94
55_T124_H0.8940.94
106_M134_F0.8930.94
80_H151_T0.8920.94
69_H94_E0.8870.94
82_L145_V0.8870.94
96_T131_D0.8860.94
59_D225_T0.8810.94
83_I134_F0.8780.94
96_T133_R0.8750.93
70_V219_Y0.8740.93
162_P170_F0.8650.93
25_L120_Y0.8620.93
35_L116_F0.8590.93
265_N274_A0.8530.93
38_F46_V0.8520.92
129_Y134_F0.8500.92
57_E121_L0.8480.92
189_V219_Y0.8430.92
56_T225_T0.8430.92
149_S181_C0.8370.92
30_T113_V0.8360.92
150_Q183_N0.8300.91
72_L98_H0.8280.91
73_L98_H0.8170.91
190_A209_L0.8150.91
118_R129_Y0.8110.91
62_I221_A0.8050.90
67_M91_M0.8040.90
215_D237_T0.8030.90
84_I159_C0.8000.90
28_E31_D0.7980.90
131_D134_F0.7980.90
270_T274_A0.7960.90
72_L101_V0.7960.90
205_S208_K0.7930.90
92_L95_V0.7930.90
172_S208_K0.7900.89
179_K214_S0.7900.89
82_L144_F0.7890.89
216_V236_A0.7880.89
237_T241_A0.7880.89
95_V156_I0.7850.89
46_V53_V0.7810.89
40_N46_V0.7800.89
142_V173_A0.7780.89
246_S253_R0.7760.89
239_N242_L0.7760.89
171_T208_K0.7730.88
95_V154_V0.7670.88
86_G106_M0.7640.88
223_I226_Y0.7630.88
268_I271_A0.7580.87
63_Y158_D0.7570.87
268_I272_A0.7560.87
176_E180_R0.7550.87
150_Q184_P0.7540.87
24_V38_F0.7530.87
65_E69_H0.7520.87
82_L155_I0.7460.86
208_K211_H0.7460.86
157_S190_A0.7440.86
54_Q63_Y0.7440.86
174_F178_C0.7390.86
28_E115_S0.7370.86
203_I207_R0.7350.86
141_G159_C0.7330.86
209_L216_V0.7310.85
107_V139_D0.7280.85
78_A187_I0.7270.85
64_H91_M0.7260.85
68_T72_L0.7250.85
269_H273_F0.7220.85
188_F236_A0.7200.84
263_Y268_I0.7200.84
89_G114_V0.7190.84
190_A234_A0.7150.84
215_D241_A0.7140.84
101_V154_V0.7130.84
55_T121_L0.7060.83
19_F46_V0.7060.83
176_E212_Y0.7030.83
153_D183_N0.6990.83
40_N44_G0.6990.83
273_F276_P0.6950.82
202_A232_T0.6880.82
31_D112_G0.6870.82
53_V225_T0.6860.82
106_M114_V0.6830.81
224_P228_G0.6830.81
195_C231_M0.6820.81
75_H187_I0.6820.81
69_H133_R0.6800.81
253_R256_A0.6800.81
35_L171_T0.6790.81
71_P187_I0.6770.81
33_Q110_D0.6740.80
178_C208_K0.6720.80
217_G241_A0.6710.80
218_F232_T0.6710.80
204_D208_K0.6640.79
177_G180_R0.6640.79
72_L81_V0.6630.79
192_N232_T0.6590.79
150_Q181_C0.6580.79
101_V104_I0.6580.79
33_Q49_L0.6550.78
125_N129_Y0.6520.78
206_H234_A0.6500.78
98_H101_V0.6490.78
65_E94_E0.6480.78
61_F262_R0.6480.78
126_A130_D0.6450.77
159_C170_F0.6440.77
86_G110_D0.6420.77
30_T33_Q0.6420.77
81_V156_I0.6410.77
126_A129_Y0.6390.77
88_D91_M0.6380.77
68_T94_E0.6350.76
64_H68_T0.6330.76
197_L228_G0.6330.76
60_E64_H0.6300.76
78_A154_V0.6290.76
66_M219_Y0.6280.76
80_H102_E0.6270.75
122_P125_N0.6250.75
54_Q191_Q0.6230.75
254_F258_G0.6230.75
86_G94_E0.6210.75
117_C120_Y0.6200.75
35_L112_G0.6200.75
83_I86_G0.6160.74
176_E179_K0.6160.74
205_S209_L0.6150.74
20_A42_A0.6150.74
86_G89_G0.6100.73
109_I141_G0.6090.73
253_R258_G0.6070.73
22_D40_N0.6070.73
77_H185_G0.6060.73
66_M70_V0.6040.73
87_G175_Y0.6040.73
25_L113_V0.6030.73
253_R257_S0.6000.72
242_L245_L0.5960.72
68_T71_P0.5960.72
215_D239_N0.5960.72
55_T90_A0.5950.72
30_T64_H0.5950.72
255_L259_L0.5930.71
25_L39_E0.5910.71
66_M221_A0.5900.71
87_G113_V0.5880.71
30_T86_G0.5880.71
67_M232_T0.5870.71
48_A53_V0.5830.70
71_P189_V0.5800.70
89_G129_Y0.5790.70
168_S208_K0.5780.69
161_D191_Q0.5780.69
246_S252_A0.5770.69
255_L260_K0.5770.69
269_H272_A0.5770.69
158_D191_Q0.5760.69
71_P219_Y0.5760.69
63_Y161_D0.5720.69
257_S261_C0.5720.69
89_G192_N0.5700.68
151_T181_C0.5690.68
105_T144_F0.5690.68
222_A230_I0.5680.68
160_T191_Q0.5670.68
160_T170_F0.5670.68
264_Y275_L0.5660.68
37_I45_R0.5660.68
115_S118_R0.5660.68
161_D170_F0.5640.68
45_R57_E0.5630.67
73_L254_F0.5610.67
255_L266_P0.5610.67
170_F191_Q0.5600.67
88_D106_M0.5590.67
109_I140_D0.5590.67
164_G167_E0.5590.67
75_H79_K0.5570.67
258_G270_T0.5570.67
91_M156_I0.5540.66
221_A263_Y0.5540.66
109_I169_L0.5530.66
237_T240_D0.5520.66
258_G268_I0.5510.66
25_L45_R0.5490.65
64_H124_H0.5490.65
218_F234_A0.5490.65
28_E116_F0.5480.65
54_Q64_H0.5460.65
149_S184_P0.5460.65
68_T95_V0.5430.65
15_F19_F0.5420.64
194_V231_M0.5410.64
36_I48_A0.5390.64
16_G20_A0.5390.64
61_F64_H0.5380.64
64_H83_I0.5380.64
195_C229_G0.5380.64
49_L54_Q0.5360.64
195_C232_T0.5360.64
91_M106_M0.5350.63
44_G56_T0.5350.63
92_L106_M0.5340.63
267_A271_A0.5330.63
36_I54_Q0.5320.63
39_E120_Y0.5320.63
60_E63_Y0.5300.63
175_Y205_S0.5300.63
54_Q108_E0.5300.63
74_A242_L0.5280.62
24_V27_H0.5270.62
54_Q158_D0.5260.62
47_M121_L0.5260.62
52_V163_I0.5250.62
70_V231_M0.5220.62
46_V121_L0.5210.61
13_D20_A0.5210.61
55_T108_E0.5200.61
92_L193_G0.5200.61
141_G157_S0.5190.61
262_R271_A0.5180.61
254_F266_P0.5180.61
90_A106_M0.5180.61
162_P169_L0.5170.61
224_P229_G0.5170.61
88_D191_Q0.5170.61
206_H218_F0.5160.61
88_D108_E0.5160.61
153_D174_F0.5160.61
252_A267_A0.5150.61
45_R123_N0.5140.60
11_L127_G0.5140.60
254_F259_L0.5130.60
94_E161_D0.5120.60
266_P270_T0.5120.60
33_Q88_D0.5120.60
204_D207_R0.5110.60
214_S237_T0.5100.60
121_L124_H0.5080.60
129_Y136_L0.5080.60
67_M70_V0.5050.59
56_T59_D0.5040.59
148_T211_H0.5030.59
207_R210_S0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o4fA 4 0.9896 100 0.359 Contact Map
1uirA 4 0.9965 100 0.366 Contact Map
1inlA 3 0.9618 100 0.381 Contact Map
1xj5A 4 0.9826 100 0.382 Contact Map
2o07A 2 0.9757 100 0.387 Contact Map
2pt6A 2 0.9618 100 0.394 Contact Map
2i7cA 2 0.9618 100 0.398 Contact Map
2b2cA 2 0.8958 100 0.402 Contact Map
1iy9A 3 0.9514 100 0.407 Contact Map
1mjfA 2 0.9132 100 0.409 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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