GREMLIN Database
YMFS - Uncharacterized protein YmfS
UniProt: P09154 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14337
Length: 137 (113)
Sequences: 566 (458)
Seq/√Len: 43.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_G112_L4.5171.00
71_Q75_L3.6321.00
93_A109_L2.3731.00
93_A112_L2.3511.00
91_K113_E2.2261.00
99_E102_L2.1250.99
43_G55_K2.0800.99
97_L113_E2.0350.99
45_I53_S2.0330.99
20_I24_S1.9780.99
90_G109_L1.9660.99
32_W36_L1.8960.99
91_K117_L1.8850.99
35_L53_S1.8460.99
119_D122_S1.7500.98
90_G105_Y1.7320.98
109_L112_L1.7300.98
90_G93_A1.6830.97
92_A97_L1.6570.97
89_Q93_A1.6460.97
32_W45_I1.5740.96
94_L102_L1.5680.96
96_R113_E1.5630.96
130_T133_A1.5450.96
106_N110_D1.4980.95
38_S53_S1.4660.94
91_K97_L1.4380.93
69_N72_K1.4020.92
60_T63_D1.3800.92
39_Q45_I1.3740.92
82_F87_Q1.3520.91
90_G97_L1.3170.90
87_Q116_E1.3080.90
35_L45_I1.2880.89
96_R114_A1.2530.87
28_T31_H1.2370.87
32_W35_L1.2030.85
55_K60_T1.1990.85
96_R110_D1.1970.85
46_D54_I1.1860.84
89_Q105_Y1.1800.84
92_A105_Y1.1740.84
61_H65_V1.1680.83
88_W109_L1.1600.83
57_V60_T1.1490.82
39_Q53_S1.1480.82
91_K112_L1.1090.80
91_K116_E1.1080.80
37_K41_E1.0930.79
88_W94_L1.0820.78
97_L117_L1.0800.78
89_Q112_L1.0710.78
82_F88_W1.0620.77
87_Q112_L1.0470.76
89_Q109_L1.0380.75
30_E37_K1.0280.75
88_W117_L1.0190.74
80_T112_L1.0130.74
113_E117_L1.0090.73
88_W116_E1.0060.73
30_E33_Q0.9970.72
123_A126_I0.9940.72
80_T90_G0.9900.72
87_Q90_G0.9770.71
80_T93_A0.9740.71
78_D81_D0.9500.69
110_D114_A0.9490.69
98_K101_E0.9400.68
91_K101_E0.9330.67
109_L113_E0.9310.67
53_S56_E0.9190.66
91_K109_L0.9160.66
27_I36_L0.9140.66
69_N120_T0.8990.64
34_S58_I0.8890.64
90_G113_E0.8880.63
101_E113_E0.8850.63
65_V120_T0.8680.62
94_L99_E0.8640.61
80_T88_W0.8630.61
80_T87_Q0.8560.61
31_H50_F0.8490.60
30_E41_E0.8420.59
26_E29_A0.8390.59
49_V52_P0.8370.59
118_V126_I0.8350.59
76_I80_T0.8330.59
43_G46_D0.8300.58
84_N87_Q0.8260.58
113_E116_E0.8210.57
87_Q91_K0.8070.56
20_I27_I0.8010.56
84_N89_Q0.7920.55
91_K110_D0.7900.54
56_E59_R0.7890.54
96_R106_N0.7850.54
59_R64_E0.7820.54
110_D113_E0.7800.54
42_G45_I0.7780.53
46_D50_F0.7690.53
91_K96_R0.7650.52
51_P57_V0.7620.52
77_S81_D0.7510.51
35_L40_A0.7500.51
109_L117_L0.7460.50
92_A113_E0.7380.50
97_L101_E0.7270.49
88_W97_L0.7220.48
33_Q41_E0.7170.48
78_D83_I0.7100.47
90_G117_L0.7070.47
59_R62_D0.7040.46
33_Q37_K0.7030.46
93_A117_L0.7010.46
68_A123_A0.6980.46
48_S56_E0.6940.45
22_P41_E0.6750.44
79_A83_I0.6680.43
35_L39_Q0.6670.43
97_L116_E0.6610.42
114_A118_V0.6600.42
67_D70_F0.6600.42
87_Q94_L0.6580.42
41_E50_F0.6560.42
97_L109_L0.6530.42
80_T89_Q0.6480.41
31_H36_L0.6400.40
93_A98_K0.6360.40
76_I115_L0.6310.40
127_E133_A0.6300.39
117_L127_E0.6130.38
91_K106_N0.6110.38
120_T133_A0.6110.38
94_L116_E0.6100.38
92_A104_Q0.6100.38
47_F56_E0.6070.37
32_W38_S0.5970.36
127_E130_T0.5900.36
31_H34_S0.5870.36
83_I90_G0.5830.35
87_Q105_Y0.5790.35
96_R112_L0.5780.35
88_W91_K0.5700.34
46_D55_K0.5700.34
88_W108_W0.5690.34
115_L126_I0.5680.34
129_P132_P0.5630.34
84_N90_G0.5620.33
70_F74_M0.5530.33
79_A108_W0.5490.32
103_K127_E0.5480.32
71_Q74_M0.5470.32
65_V124_P0.5470.32
28_T45_I0.5420.32
92_A117_L0.5400.32
88_W112_L0.5390.32
80_T91_K0.5370.31
31_H37_K0.5350.31
83_I109_L0.5340.31
89_Q110_D0.5300.31
73_Q77_S0.5280.31
43_G60_T0.5270.31
112_L117_L0.5260.30
29_A33_Q0.5220.30
94_L108_W0.5190.30
21_P24_S0.5160.30
101_E117_L0.5150.30
35_L38_S0.5090.29
88_W113_E0.5070.29
30_E48_S0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kz6A 1 0.6642 99.7 0.647 Contact Map
4kysA 1 0.562 17.4 0.941 Contact Map
4rk9A 1 0.6423 8.1 0.949 Contact Map
2zyoA 1 0.5766 4 0.956 Contact Map
4r9fA 1 0.6131 3.9 0.956 Contact Map
2j9uA 1 0.438 3.8 0.957 Contact Map
3k8gA 1 0.2993 3.7 0.957 Contact Map
1ursA 1 0.5182 3.6 0.957 Contact Map
3thiA 1 0.5547 3.4 0.957 Contact Map
4r2fA 1 0.6496 3.4 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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