GREMLIN Database
TFAE - Tail fiber assembly protein homolog from lambdoid prophage e14
UniProt: P09153 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11120
Length: 200 (188)
Sequences: 486 (326)
Seq/√Len: 23.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_L178_I6.0421.00
138_Q142_L4.7791.00
158_Q175_L3.0921.00
156_K183_A2.9091.00
128_H132_V2.7860.99
156_K179_D2.7280.99
51_D64_R2.6510.99
75_P98_D2.4420.98
163_L179_D2.4390.98
110_S113_D2.3410.98
12_A16_G2.2150.97
49_C64_R2.0790.95
175_L178_I2.0390.95
158_Q178_I2.0250.95
179_D183_A2.0210.94
155_L175_L1.9780.94
36_E42_V1.9760.94
157_L163_L1.9570.93
161_R179_D1.9000.92
99_Y103_T1.9000.92
153_I163_L1.8920.92
163_L167_E1.8470.91
23_Y49_C1.8120.90
163_L183_A1.8020.90
180_A183_A1.7910.90
146_A174_V1.7490.89
167_E183_A1.7410.89
153_I175_L1.7140.88
156_K163_L1.6860.87
155_L158_Q1.6770.87
153_I156_K1.6390.85
95_A100_P1.6380.85
185_D188_T1.5920.84
179_D182_T1.5860.83
153_I179_D1.5760.83
155_L163_L1.5630.82
153_I183_A1.5480.82
81_T90_S1.5310.81
175_L179_D1.5150.80
147_M178_I1.4830.79
156_K175_L1.4820.79
157_L183_A1.4770.79
163_L175_L1.4760.79
175_L183_A1.4710.78
156_K182_T1.4580.78
82_V103_T1.4460.77
61_A96_P1.4400.77
161_R176_D1.4330.76
147_M155_L1.4230.76
116_D119_K1.3990.75
189_A192_V1.3860.74
57_K60_Y1.3830.74
167_E179_D1.3570.72
136_E139_R1.3240.70
153_I167_E1.3060.69
56_H62_I1.2960.69
154_Q158_Q1.2930.69
143_I151_S1.2890.68
153_I157_L1.2810.68
153_I182_T1.2780.68
165_Q168_T1.2750.67
154_Q175_L1.2730.67
110_S122_T1.2690.67
175_L181_V1.2620.67
122_T127_Q1.2470.66
172_N176_D1.2330.65
15_A37_Y1.2240.64
157_L178_I1.2200.64
57_K73_Y1.2200.64
101_E125_E1.2050.63
156_K167_E1.1680.60
77_H80_E1.1640.60
161_R175_L1.1510.59
16_G41_G1.1490.59
155_L183_A1.1440.59
167_E182_T1.1380.58
80_E99_Y1.1210.57
157_L179_D1.1180.57
108_P113_D1.1140.57
153_I178_I1.1060.56
135_A192_V1.0820.55
114_K123_D1.0750.54
135_A190_P1.0700.54
32_S63_C1.0600.53
76_D97_G1.0480.52
20_V30_Y1.0470.52
158_Q183_A1.0420.52
17_D54_G1.0350.51
38_L44_I1.0310.51
62_I73_Y1.0110.50
78_R97_G1.0060.49
139_R161_R1.0060.49
154_Q176_D1.0040.49
152_L182_T1.0000.49
157_L167_E0.9940.48
11_I17_D0.9900.48
156_K178_I0.9830.48
155_L179_D0.9750.47
45_P54_G0.9710.47
22_N39_A0.9660.46
16_G36_E0.9640.46
97_G104_T0.9620.46
134_A138_Q0.9610.46
65_S69_N0.9600.46
158_Q163_L0.9580.46
76_D115_W0.9550.46
84_S103_T0.9540.46
16_G42_V0.9530.45
12_A41_G0.9490.45
150_I156_K0.9480.45
161_R172_N0.9460.45
78_R115_W0.9390.44
153_I159_A0.9340.44
17_D49_C0.9200.43
41_G48_S0.9160.43
74_V96_P0.9160.43
23_Y32_S0.9120.43
112_Y130_A0.9120.43
97_G115_W0.9120.43
153_I171_L0.9090.42
149_S152_L0.9030.42
17_D23_Y0.8990.42
157_L180_A0.8940.41
167_E170_R0.8940.41
174_V198_P0.8920.41
90_S105_T0.8900.41
169_T193_I0.8840.41
43_G46_A0.8740.40
39_A43_G0.8710.40
100_P103_T0.8670.39
163_L182_T0.8630.39
158_Q164_T0.8600.39
49_C63_C0.8420.38
22_N34_S0.8410.38
181_V184_T0.8400.38
153_I158_Q0.8300.37
176_D179_D0.8280.37
63_C72_E0.8240.37
147_M175_L0.8230.37
138_Q141_S0.8170.36
156_K172_N0.8070.36
147_M150_I0.7990.35
160_G180_A0.7980.35
54_G62_I0.7960.35
11_I40_V0.7920.35
152_L178_I0.7910.34
176_D180_A0.7900.34
153_I164_T0.7720.33
113_D122_T0.7680.33
164_T167_E0.7660.33
20_V70_S0.7660.33
178_I183_A0.7660.33
47_C88_G0.7630.33
85_T92_E0.7590.32
82_V99_Y0.7580.32
18_V24_D0.7520.32
159_A163_L0.7510.32
11_I16_G0.7490.32
147_M156_K0.7460.32
174_V177_Y0.7440.32
172_N175_L0.7410.31
95_A102_N0.7400.31
77_H103_T0.7190.30
52_A74_V0.7140.30
164_T168_T0.7140.30
33_T39_A0.7130.30
78_R123_D0.7110.30
151_S158_Q0.7080.29
163_L180_A0.7060.29
76_D123_D0.7020.29
14_K26_E0.7000.29
196_E199_E0.6980.29
173_A176_D0.6970.29
32_S35_N0.6960.29
20_V31_I0.6890.28
164_T178_I0.6880.28
139_R150_I0.6850.28
150_I175_L0.6840.28
19_T35_N0.6830.28
79_G85_T0.6780.28
18_V37_Y0.6770.28
85_T102_N0.6760.28
19_T38_L0.6730.27
104_T115_W0.6720.27
47_C168_T0.6690.27
184_T194_W0.6690.27
154_Q170_R0.6660.27
11_I15_A0.6650.27
151_S155_L0.6610.27
11_I22_N0.6590.27
36_E93_I0.6570.26
158_Q179_D0.6560.26
195_P198_P0.6510.26
159_A174_V0.6510.26
145_A148_A0.6500.26
136_E186_T0.6500.26
71_W108_P0.6450.26
112_Y133_D0.6420.26
24_D47_C0.6410.26
34_S45_P0.6400.26
184_T192_V0.6400.26
22_N32_S0.6380.25
126_A130_A0.6370.25
152_L156_K0.6350.25
172_N179_D0.6320.25
155_L176_D0.6320.25
20_V34_S0.6300.25
12_A20_V0.6260.25
24_D44_I0.6250.25
91_K111_P0.6230.25
153_I174_V0.6220.25
150_I178_I0.6130.24
164_T182_T0.6050.24
188_T197_L0.6010.24
147_M153_I0.5940.23
99_Y105_T0.5910.23
16_G64_R0.5910.23
152_L155_L0.5900.23
57_K189_A0.5880.23
159_A164_T0.5880.23
51_D62_I0.5870.23
53_P108_P0.5850.23
193_I196_E0.5830.23
168_T172_N0.5820.23
139_R155_L0.5820.23
79_G115_W0.5820.23
155_L167_E0.5810.23
165_Q174_V0.5780.22
149_S174_V0.5770.22
108_P115_W0.5750.22
178_I182_T0.5720.22
11_I31_I0.5720.22
97_G100_P0.5680.22
78_R104_T0.5680.22
23_Y36_E0.5620.22
53_P97_G0.5610.22
29_E63_C0.5600.21
49_C68_F0.5570.21
144_D148_A0.5560.21
157_L175_L0.5560.21
82_V126_A0.5560.21
78_R108_P0.5530.21
186_T197_L0.5510.21
106_I127_Q0.5500.21
16_G49_C0.5450.21
69_N106_I0.5440.21
93_I96_P0.5440.21
139_R142_L0.5420.21
172_N178_I0.5410.21
166_A169_T0.5390.21
145_A197_L0.5340.20
11_I38_L0.5320.20
167_E172_N0.5300.20
91_K106_I0.5300.20
114_K119_K0.5300.20
82_V96_P0.5300.20
129_S166_A0.5290.20
128_H131_A0.5290.20
157_L182_T0.5270.20
66_A85_T0.5250.20
114_K118_E0.5240.20
156_K176_D0.5230.20
29_E53_P0.5220.20
167_E194_W0.5200.20
149_S153_I0.5180.20
100_P196_E0.5170.20
122_T128_H0.5160.19
75_P110_S0.5150.19
40_V101_E0.5150.19
156_K161_R0.5130.19
11_I41_G0.5130.19
186_T199_E0.5100.19
186_T189_A0.5070.19
109_L113_D0.5060.19
84_S88_G0.5060.19
11_I68_F0.5030.19
13_T16_G0.5020.19
101_E129_S0.5020.19
11_I49_C0.5010.19
37_Y43_G0.5010.19
139_R154_Q0.5000.19
112_Y115_W0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kz6A 1 0.485 99.7 0.751 Contact Map
3kvpA 3 0.235 59.9 0.943 Contact Map
2c7hA 1 0.265 15.1 0.959 Contact Map
2oizA 2 0.45 14.2 0.96 Contact Map
4dnyA 1 0.455 6.8 0.965 Contact Map
2z14A 2 0.21 6.6 0.965 Contact Map
3dsmA 1 0.465 6.4 0.965 Contact Map
3a1mA 5 0.285 6.3 0.966 Contact Map
1ri6A 1 0.255 6.1 0.966 Contact Map
4qtqA 1 0.535 6 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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