GREMLIN Database
NARG - Respiratory nitrate reductase 1 alpha chain
UniProt: P09152 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10638
Length: 1247 (1201)
Sequences: 669 (261)
Seq/√Len: 7.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_A150_K6.7141.00
508_A519_I6.4921.00
344_E353_G6.2121.00
985_H1032_E6.0331.00
851_L887_M5.4181.00
1127_D1157_A5.2731.00
1030_V1036_W5.2311.00
687_S692_S5.0110.99
141_E176_Y4.9910.99
337_M564_F4.8090.99
170_I785_I4.7180.99
529_N537_S4.5950.99
833_K836_E4.5230.99
528_D532_K4.4110.98
146_A706_H4.3010.98
877_L883_A4.2510.98
61_K75_Q4.2210.98
252_A288_I4.2060.98
316_R321_D4.1270.97
150_K706_H4.0740.97
811_S1001_Q4.0670.97
1052_M1199_I4.0650.97
332_R415_E3.9580.97
712_I779_T3.9240.96
69_V103_L3.9070.96
125_A138_S3.8570.96
210_I896_T3.7360.95
114_M119_M3.5210.93
248_S529_N3.5180.93
129_H138_S3.4680.93
859_A885_H3.4320.92
126_K168_E3.4230.92
308_L503_Y3.3920.92
322_N531_D3.3530.91
320_L484_L3.3440.91
689_K876_D3.2060.89
319_H331_V3.1810.89
326_Y570_Q3.1270.88
937_E941_K3.1060.88
674_E846_T3.0970.88
370_N396_G3.0790.87
771_T783_S3.0590.87
834_F896_T3.0080.86
685_V886_I3.0020.86
607_N610_S2.9920.86
738_G1178_T2.9860.85
976_S982_D2.9770.85
807_I963_T2.9650.85
868_K874_E2.9470.85
846_T888_V2.9410.85
873_G876_D2.9120.84
390_S393_F2.9040.84
670_A848_I2.8990.84
874_E882_T2.8660.83
699_Q758_Q2.8520.83
85_L246_N2.8480.83
169_L785_I2.8440.82
271_V274_K2.8430.82
908_E943_Q2.8370.82
969_V987_A2.8220.82
850_T886_I2.8040.81
296_L518_Q2.7840.81
198_V956_I2.7830.81
320_L479_L2.7660.81
271_V276_T2.7500.80
617_S701_E2.7390.80
460_R470_L2.7360.80
621_Y731_Y2.7290.80
103_L814_V2.7180.79
167_N829_A2.7130.79
848_I886_I2.6750.78
252_A286_A2.6690.78
268_F291_L2.6540.78
496_S499_D2.6440.77
179_K841_H2.6330.77
796_D949_A2.5870.76
541_V558_L2.5580.75
844_K894_P2.5480.75
649_R653_M2.5470.74
252_A268_F2.5300.74
374_K392_G2.5280.74
1155_V1161_M2.5190.74
114_M161_S2.5070.73
47_R59_S2.4940.73
1130_I1149_A2.4920.73
607_N656_L2.4900.73
123_R165_E2.4720.72
161_S166_V2.4720.72
563_I1045_L2.4720.72
617_S762_L2.4490.71
226_P1212_Y2.4440.71
329_D333_R2.4410.71
331_V337_M2.4250.71
617_S731_Y2.4160.70
324_S531_D2.4120.70
873_G882_T2.4120.70
547_H551_L2.4100.70
689_K874_E2.3940.70
128_L138_S2.3880.69
300_Q1159_M2.3850.69
378_F382_G2.3780.69
131_D841_H2.3750.69
1053_R1058_S2.3650.69
200_Y1209_F2.3500.68
895_A898_E2.3480.68
215_L608_S2.3480.68
614_N644_I2.3160.67
825_E949_A2.3140.67
915_K1017_E2.3100.67
121_M145_K2.2950.66
326_Y665_N2.2470.64
545_L558_L2.2320.64
326_Y534_H2.2230.64
251_I281_V2.2150.63
119_M161_S2.1970.63
458_V470_L2.1890.62
345_E348_G2.1810.62
311_G482_Y2.1700.62
426_E458_V2.1460.61
202_S900_F2.1370.60
280_A288_I2.1330.60
584_L587_Q2.1290.60
495_T499_D2.1260.60
539_I558_L2.1250.60
249_Y525_E2.1230.60
868_K873_G2.1220.60
603_A849_V2.1200.60
903_I955_M2.1160.60
616_S712_I2.1160.60
208_S595_F2.1120.59
359_A865_L2.1090.59
419_S422_G2.1060.59
703_G706_H2.1030.59
834_F894_P2.0990.59
1123_A1157_A2.0900.59
490_D493_C2.0800.58
268_F278_T2.0730.58
694_R756_D2.0670.58
426_E460_R2.0470.57
319_H337_M2.0450.57
929_R934_T2.0440.57
526_F537_S2.0410.57
1094_Q1163_Y2.0390.57
976_S1032_E2.0220.56
167_N830_I2.0040.55
280_A286_A2.0020.55
280_A289_A1.9950.55
175_V841_H1.9570.53
593_L952_A1.9560.53
354_R1050_Q1.9540.53
664_T696_A1.9450.53
1009_S1016_L1.9380.53
425_D459_K1.9350.52
374_K393_F1.9340.52
385_V414_T1.9270.52
898_E940_A1.9210.52
350_Y470_L1.9200.52
926_D930_K1.8880.51
671_G845_E1.8860.51
664_T672_E1.8820.50
121_M148_S1.8810.50
428_A458_V1.8730.50
528_D531_D1.8730.50
428_A470_L1.8700.50
455_K490_D1.8660.50
1040_S1045_L1.8520.49
902_S940_A1.8510.49
990_K993_E1.8470.49
913_G918_A1.8430.49
687_S690_E1.8420.49
846_T890_E1.8390.49
691_G871_K1.8360.49
138_S145_K1.8350.48
174_N206_Y1.8170.48
170_I830_I1.8120.48
246_N267_F1.8090.47
662_L850_T1.7950.47
962_E1010_S1.7860.47
878_I881_K1.7830.46
710_L717_L1.7800.46
731_Y762_L1.7760.46
663_G694_R1.7740.46
142_D145_K1.7640.46
377_A416_L1.7610.46
131_D175_V1.7550.45
138_S141_E1.7480.45
868_K882_T1.7440.45
248_S533_T1.7410.45
375_T390_S1.7400.45
615_H1167_E1.7300.44
821_K829_A1.7290.44
664_T693_I1.7260.44
357_R373_W1.7230.44
680_P848_I1.7220.44
140_I146_A1.7180.44
155_R736_E1.7120.44
673_A683_Y1.7100.44
663_G704_K1.7080.43
133_V175_V1.7010.43
688_L883_A1.6970.43
1090_L1155_V1.6940.43
689_K873_G1.6940.43
712_I769_V1.6880.43
1146_T1175_S1.6880.43
798_M957_L1.6570.41
248_S536_R1.6540.41
1112_G1117_V1.6520.41
75_Q650_A1.6520.41
684_T848_I1.6490.41
591_Q605_H1.6450.41
1024_N1027_Y1.6450.41
760_N763_E1.6440.41
876_D882_T1.6410.41
668_T671_G1.6400.41
350_Y428_A1.6390.41
176_Y181_Y1.6370.41
328_T475_Y1.6330.41
197_M586_P1.6310.40
1094_Q1097_G1.6310.40
421_L486_R1.6290.40
545_L551_L1.6130.40
681_V685_V1.6000.39
663_G696_A1.5960.39
323_P328_T1.5930.39
652_R869_D1.5930.39
541_V545_L1.5910.39
969_V991_E1.5890.39
1155_V1159_M1.5870.39
294_L521_R1.5860.39
252_A291_L1.5820.39
187_A215_L1.5800.39
494_A497_Y1.5790.39
252_A257_V1.5660.38
133_V841_H1.5570.38
653_M870_W1.5560.38
854_Q857_S1.5460.37
694_R698_E1.5460.37
252_A280_A1.5440.37
619_W701_E1.5400.37
1175_S1178_T1.5400.37
288_I291_L1.5390.37
670_A886_I1.5390.37
540_I545_L1.5370.37
494_A499_D1.5350.37
605_H1207_Y1.5330.37
946_L955_M1.5330.37
493_C497_Y1.5250.36
137_A141_E1.5250.36
255_S540_I1.5070.36
648_V652_R1.5050.36
903_I907_M1.4990.36
175_V837_V1.4960.35
489_N493_C1.4960.35
335_T563_I1.4950.35
200_Y595_F1.4850.35
546_N1162_M1.4800.35
652_R870_W1.4790.35
550_H1063_R1.4760.35
699_Q702_N1.4760.35
673_A676_A1.4720.35
201_A593_L1.4710.35
1176_E1228_M1.4710.35
912_N921_T1.4700.34
673_A677_G1.4690.34
339_M1040_S1.4670.34
732_L769_V1.4660.34
63_Y70_T1.4600.34
204_A321_D1.4580.34
339_M390_S1.4570.34
242_A267_F1.4550.34
828_K901_T1.4540.34
976_S984_T1.4530.34
121_M169_L1.4490.34
198_V953_A1.4450.34
647_N656_L1.4410.33
140_I176_Y1.4390.33
315_L482_Y1.4380.33
612_F710_L1.4370.33
644_I1218_N1.4370.33
547_H554_N1.4350.33
369_N396_G1.4310.33
897_Y901_T1.4300.33
671_G675_K1.4220.33
684_T693_I1.4180.33
141_E180_N1.4110.32
475_Y564_F1.4080.32
29_N622_E1.4080.32
190_S968_A1.4060.32
1046_Y1053_R1.4050.32
929_R943_Q1.4040.32
455_K489_N1.4030.32
124_E128_L1.4010.32
669_I672_E1.4010.32
648_V754_E1.3990.32
286_A289_A1.3890.32
1145_L1162_M1.3850.31
814_V817_A1.3820.31
403_L596_A1.3770.31
1104_D1109_L1.3760.31
162_S165_E1.3710.31
404_E981_R1.3690.31
564_F1045_L1.3680.31
664_T687_S1.3670.31
619_W632_P1.3630.31
665_N1036_W1.3620.31
892_D895_A1.3620.31
294_L522_I1.3600.31
595_F605_H1.3570.31
868_K875_C1.3560.31
502_A703_G1.3550.30
650_A949_A1.3500.30
314_M561_M1.3430.30
475_Y479_L1.3410.30
231_T1045_L1.3370.30
878_I882_T1.3350.30
837_V841_H1.3350.30
610_S647_N1.3340.30
1146_T1227_K1.3320.30
400_K881_K1.3300.30
33_E98_S1.3260.30
661_Q953_A1.3240.29
702_N706_H1.3220.29
197_M800_T1.3220.29
678_M686_K1.3210.29
316_R320_L1.3200.29
345_E350_Y1.3140.29
146_A762_L1.3120.29
817_A820_A1.3070.29
282_T289_A1.3060.29
339_M393_F1.3010.29
353_G1046_Y1.2990.29
395_W860_E1.2940.28
562_L859_A1.2920.28
377_A414_T1.2900.28
614_N697_A1.2890.28
373_W391_I1.2820.28
685_V874_E1.2780.28
550_H968_A1.2780.28
1039_L1203_A1.2730.28
150_K762_L1.2720.28
114_M785_I1.2680.28
908_E925_M1.2670.28
989_N992_D1.2660.28
976_S985_H1.2660.28
251_I681_V1.2660.28
973_A984_T1.2650.28
844_K890_E1.2630.27
331_V564_F1.2630.27
210_I834_F1.2600.27
1044_Q1047_Q1.2570.27
140_I150_K1.2570.27
551_L1215_V1.2560.27
202_S828_K1.2540.27
462_Q466_G1.2530.27
492_N497_Y1.2480.27
902_S935_K1.2470.27
935_K945_M1.2440.27
743_D1178_T1.2420.27
972_W1028_T1.2400.27
370_N861_L1.2380.27
945_M948_T1.2380.27
428_A460_R1.2360.27
121_M139_I1.2340.27
672_E683_Y1.2340.27
868_K881_K1.2330.27
48_S62_I1.2310.26
1121_S1157_A1.2300.26
610_S650_A1.2290.26
310_M561_M1.2280.26
388_N730_K1.2280.26
712_I754_E1.2250.26
600_Q899_R1.2210.26
567_C848_I1.2160.26
727_F739_I1.2140.26
342_M353_G1.2130.26
947_N951_D1.2130.26
689_K881_K1.2110.26
232_W1043_Q1.2100.26
247_S1027_Y1.2080.26
369_N397_E1.2070.26
562_L568_V1.2070.26
124_E148_S1.2030.26
212_G334_Y1.2000.26
851_L885_H1.1990.25
1145_L1188_V1.1980.25
451_V633_M1.1940.25
719_G1065_P1.1940.25
703_G708_R1.1930.25
166_V783_S1.1920.25
253_W773_D1.1870.25
311_G564_F1.1840.25
607_N647_N1.1830.25
373_W395_W1.1830.25
88_H242_A1.1750.25
359_A372_E1.1750.25
498_D516_R1.1720.25
653_M867_V1.1720.25
207_L214_C1.1710.25
900_F1097_G1.1680.25
889_V902_S1.1670.25
134_E138_S1.1670.25
600_Q603_A1.1660.24
431_G453_L1.1650.24
870_W877_L1.1640.24
399_G911_G1.1630.24
854_Q908_E1.1620.24
1146_T1229_K1.1600.24
809_P1000_I1.1600.24
421_L488_L1.1570.24
215_L546_N1.1560.24
361_L384_M1.1560.24
869_D877_L1.1520.24
876_D883_A1.1490.24
610_S656_L1.1460.24
391_I1203_A1.1450.24
325_Q531_D1.1440.24
658_S1162_M1.1390.24
848_I1227_K1.1390.24
178_I210_I1.1330.24
718_L1165_A1.1330.24
506_A516_R1.1300.23
144_D147_K1.1300.23
898_E939_P1.1260.23
715_S903_I1.1250.23
503_Y557_G1.1210.23
960_A1007_I1.1200.23
868_K876_D1.1200.23
363_D674_E1.1180.23
945_M951_D1.1180.23
698_E871_K1.1130.23
616_S728_M1.1130.23
800_T996_R1.1120.23
743_D902_S1.1080.23
971_A1223_V1.1070.23
652_R871_K1.1060.23
248_S274_K1.1050.23
484_L494_A1.1050.23
239_P433_P1.1020.23
503_Y1061_V1.1000.23
661_Q850_T1.1000.23
384_M461_L1.0990.23
706_H738_G1.0970.23
735_T888_V1.0960.22
656_L1198_M1.0950.22
529_N871_K1.0940.22
98_S1163_Y1.0890.22
736_E1180_Q1.0890.22
667_L847_D1.0890.22
839_V894_P1.0890.22
938_G942_G1.0880.22
124_E145_K1.0850.22
334_Y1032_E1.0840.22
1076_G1084_E1.0840.22
404_E857_S1.0830.22
1034_I1037_R1.0830.22
247_S848_I1.0800.22
815_D1167_E1.0790.22
699_Q756_D1.0790.22
334_Y1030_V1.0750.22
455_K493_C1.0750.22
316_R484_L1.0710.22
378_F383_E1.0710.22
681_V684_T1.0710.22
187_A213_T1.0710.22
500_V510_Q1.0690.22
187_A611_Y1.0680.22
828_K897_Y1.0680.22
376_V386_A1.0660.22
354_R360_D1.0660.22
536_R1100_S1.0660.22
121_M1193_P1.0660.22
663_G702_N1.0660.22
979_T982_D1.0650.22
828_K900_F1.0640.22
718_L952_A1.0620.22
259_Q287_E1.0590.21
326_Y531_D1.0570.21
164_Q807_I1.0570.21
486_R1063_R1.0560.21
94_P781_L1.0550.21
832_K897_Y1.0510.21
537_S570_Q1.0500.21
251_I255_S1.0490.21
785_I819_E1.0490.21
395_W916_G1.0480.21
319_H475_Y1.0480.21
430_V835_S1.0460.21
492_N496_S1.0440.21
923_S966_Q1.0440.21
960_A1088_N1.0430.21
1129_G1227_K1.0380.21
126_K138_S1.0370.21
326_Y953_A1.0360.21
830_I834_F1.0350.21
166_V169_L1.0340.21
1054_D1218_N1.0320.21
206_Y222_C1.0310.21
24_Q513_G1.0310.21
29_N32_W1.0310.21
276_T280_A1.0310.21
326_Y537_S1.0310.21
1123_A1127_D1.0300.21
322_N325_Q1.0300.21
596_A896_T1.0270.21
62_I356_L1.0270.21
307_A557_G1.0260.21
679_N682_D1.0260.21
1205_L1212_Y1.0250.21
546_N1043_Q1.0240.21
685_V689_K1.0230.21
337_M949_A1.0210.20
296_L322_N1.0170.20
799_N810_L1.0140.20
162_S735_T1.0140.20
653_M883_A1.0130.20
689_K875_C1.0120.20
421_L424_Q1.0110.20
98_S622_E1.0110.20
571_S1021_V1.0110.20
99_Y791_T1.0090.20
592_P907_M1.0090.20
147_K150_K1.0040.20
59_S75_Q1.0040.20
877_L886_I1.0030.20
907_M921_T1.0000.20
919_W967_V0.9990.20
821_K825_E0.9990.20
427_I458_V0.9980.20
320_L475_Y0.9960.20
253_W307_A0.9940.20
926_D929_R0.9940.20
696_A1160_T0.9940.20
969_V1008_I0.9930.20
227_A1120_L0.9930.20
814_V820_A0.9910.20
239_P576_A0.9900.20
250_I268_F0.9900.20
1046_Y1058_S0.9890.20
593_L946_L0.9880.20
234_E1037_R0.9870.20
121_M124_E0.9860.20
61_K76_T0.9850.20
307_A773_D0.9810.19
616_S769_V0.9800.19
117_R152_A0.9770.19
395_W1032_E0.9760.19
710_L766_L0.9760.19
584_L590_W0.9740.19
553_M568_V0.9730.19
69_V814_V0.9700.19
292_C933_Y0.9660.19
268_F288_I0.9660.19
150_K733_L0.9650.19
1021_V1031_H0.9640.19
98_S107_N0.9620.19
1145_L1167_E0.9620.19
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789_T801_S0.5180.10
300_Q960_A0.5180.10
500_V1180_Q0.5180.10
805_P1017_E0.5170.10
1107_L1110_T0.5170.10
33_E610_S0.5170.10
986_L1229_K0.5160.10
99_Y106_A0.5160.10
575_W609_T0.5160.10
249_Y536_R0.5150.10
129_H785_I0.5150.10
146_A181_Y0.5150.10
113_M1026_G0.5150.10
911_G1013_W0.5150.10
68_L851_L0.5150.10
249_Y1022_S0.5150.10
730_K1180_Q0.5150.10
430_V800_T0.5140.10
560_N972_W0.5140.10
591_Q702_N0.5140.10
130_S138_S0.5140.10
204_A460_R0.5140.10
976_S996_R0.5130.10
617_S933_Y0.5130.10
610_S820_A0.5130.10
762_L1136_I0.5130.10
9_R13_Q0.5130.10
596_A987_A0.5130.10
150_K176_Y0.5120.10
326_Y533_T0.5120.10
862_A942_G0.5120.10
73_T1094_Q0.5120.10
66_N1168_R0.5120.10
522_I1030_V0.5120.10
369_N485_E0.5120.10
57_S307_A0.5120.10
609_T805_P0.5120.10
756_D1059_L0.5120.10
268_F1039_L0.5120.10
206_Y541_V0.5110.10
353_G877_L0.5110.10
915_K1034_I0.5110.10
982_D988_L0.5110.10
66_N731_Y0.5110.10
829_A833_K0.5110.10
782_Y1223_V0.5110.10
181_Y350_Y0.5100.10
319_H770_V0.5100.10
863_Q1174_G0.5100.10
308_L1191_I0.5100.10
424_Q427_I0.5100.10
798_M858_A0.5100.10
282_T668_T0.5100.10
166_V897_Y0.5100.10
588_T962_E0.5090.10
342_M1046_Y0.5090.10
268_F280_A0.5090.10
386_A832_K0.5090.10
970_K1212_Y0.5090.10
197_M963_T0.5090.10
124_E1136_I0.5090.10
800_T861_L0.5090.10
1009_S1094_Q0.5090.10
337_M648_V0.5090.10
375_T382_G0.5090.10
375_T718_L0.5090.10
848_I977_E0.5090.10
399_G729_L0.5090.10
452_L502_A0.5090.10
693_I915_K0.5090.10
601_R1051_W0.5080.10
297_A300_Q0.5080.10
139_I1122_E0.5080.10
176_Y895_A0.5080.10
1003_Q1094_Q0.5080.10
642_H653_M0.5070.10
824_W876_D0.5070.10
332_R814_V0.5070.10
186_V709_N0.5070.10
672_E829_A0.5060.10
21_G1198_M0.5060.10
191_P392_G0.5060.10
276_T731_Y0.5060.10
150_K181_Y0.5050.10
250_I282_T0.5050.10
584_L1154_R0.5050.10
419_S470_L0.5050.10
360_D717_L0.5050.10
593_L652_R0.5050.10
725_H729_L0.5050.10
608_S1040_S0.5040.10
620_R761_G0.5040.10
731_Y933_Y0.5040.10
88_H113_M0.5040.10
209_L967_V0.5040.10
43_D52_V0.5030.10
596_A728_M0.5030.10
171_A325_Q0.5030.10
899_R1146_T0.5030.10
81_T174_N0.5030.10
760_N934_T0.5020.10
508_A512_T0.5020.10
170_I519_I0.5020.10
137_A322_N0.5020.10
88_H1013_W0.5020.10
266_H270_E0.5020.10
353_G1053_R0.5020.10
286_A621_Y0.5020.10
817_A1060_L0.5020.10
279_V781_L0.5010.10
278_T531_D0.5010.10
388_N821_K0.5010.10
875_C949_A0.5010.10
230_Q273_Y0.5010.10
276_T694_R0.5000.10
558_L1188_V0.5000.10
20_D952_A0.5000.10
267_F615_H0.5000.10
378_F1146_T0.5000.10
608_S888_V0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ivfA 1 0.7137 100 0.728 Contact Map
1h0hA 1 0.7033 100 0.868 Contact Map
1kqfA 3 0.6977 100 0.874 Contact Map
2vpzA 1 0.5782 100 0.88 Contact Map
2napA 1 0.5702 100 0.88 Contact Map
3ml1A 1 0.6303 100 0.88 Contact Map
2e7zA 1 0.5718 100 0.88 Contact Map
1eu1A 1 0.5822 100 0.881 Contact Map
2iv2X 1 0.5437 100 0.884 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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