LEU1 - ECOLI - GREMLIN Contacts

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LEU1 - 2-isopropylmalate synthase

UniProt:	P09151	Sequences: MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11226
Length:	523 (493)
Sequences:	4117 (2092)
Seq/√Len:	94.2

ECOLI - LEU1
BACSU - LEU1
SULSO - Q980Z1 HOSA LEU1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
48_P	72_A	3.858	1.00
82_D	128_R	3.757	1.00
181_A	220_A	3.712	1.00
120_E	124_Y	3.442	1.00
201_V	217_A	3.436	1.00
188_Y	199_I	3.411	1.00
114_T	117_E	3.369	1.00
392_R	413_A	3.244	1.00
302_D	306_K	3.212	1.00
155_V	166_I	3.027	1.00
122_A	154_V	2.901	1.00
449_Y	488_S	2.827	1.00
104_P	147_P	2.765	1.00
481_A	490_K	2.726	1.00
104_P	115_L	2.694	1.00
394_D	413_A	2.617	1.00
178_F	219_H	2.603	1.00
116_D	153_R	2.602	1.00
464_V	487_S	2.589	1.00
78_E	82_D	2.547	1.00
3_Q	223_R	2.546	1.00
123_I	161_A	2.537	1.00
52_P	56_E	2.533	1.00
315_T	318_S	2.510	1.00
148_I	186_G	2.510	1.00
130_R	164_T	2.502	1.00
60_T	64_Q	2.473	1.00
156_E	192_P	2.467	1.00
208_G	243_E	2.466	1.00
185_S	189_E	2.452	1.00
203_T	214_S	2.418	1.00
107_I	115_L	2.410	1.00
78_E	124_Y	2.398	1.00
239_C	244_V	2.383	1.00
38_M	269_T	2.381	1.00
123_I	127_K	2.379	1.00
122_A	158_A	2.363	1.00
342_D	347_K	2.340	1.00
113_S	121_R	2.275	1.00
168_I	187_L	2.208	1.00
115_L	153_R	2.190	1.00
265_E	268_R	2.184	1.00
421_E	438_R	2.166	1.00
481_A	486_E	2.163	1.00
119_I	154_V	2.163	1.00
4_Q	260_A	2.143	1.00
413_A	416_E	2.080	1.00
102_T	146_T	2.054	1.00
432_V	489_A	2.013	1.00
36_E	67_N	2.012	1.00
34_A	37_R	2.000	1.00
78_E	128_R	1.975	1.00
36_E	68_S	1.963	1.00
59_Q	63_R	1.952	1.00
186_G	190_R	1.942	1.00
30_Q	275_Q	1.934	1.00
394_D	418_V	1.933	1.00
194_I	199_I	1.930	1.00
119_I	153_R	1.899	1.00
123_I	157_A	1.891	1.00
445_E	469_N	1.857	1.00
82_D	132_Y	1.844	1.00
245_I	261_I	1.835	1.00
113_S	117_E	1.812	1.00
138_F	154_V	1.803	1.00
126_V	136_V	1.782	1.00
304_V	324_I	1.777	1.00
181_A	219_H	1.774	1.00
110_K	141_E	1.753	1.00
185_S	220_A	1.749	1.00
270_S	281_I	1.741	1.00
107_I	147_P	1.711	1.00
66_K	92_E	1.707	1.00
7_I	40_V	1.702	1.00
411_K	418_V	1.694	1.00
115_L	150_D	1.690	1.00
170_D	213_N	1.683	1.00
107_I	150_D	1.683	1.00
109_T	307_N	1.670	1.00
116_D	119_I	1.667	1.00
107_I	146_T	1.666	1.00
63_R	90_V	1.665	1.00
123_I	158_A	1.658	1.00
6_I	198_I	1.652	1.00
413_A	418_V	1.650	1.00
40_V	261_I	1.645	1.00
145_R	179_E	1.627	1.00
262_N	265_E	1.621	1.00
199_I	222_A	1.609	1.00
56_E	60_T	1.607	1.00
88_L	94_F	1.589	1.00
145_R	174_Y	1.583	1.00
152_A	187_L	1.582	1.00
469_N	472_G	1.582	1.00
116_D	120_E	1.570	1.00
117_E	120_E	1.569	1.00
193_N	197_A	1.569	1.00
426_N	430_D	1.555	1.00
72_A	84_A	1.553	1.00
337_V	356_L	1.552	1.00
123_I	160_N	1.546	1.00
119_I	150_D	1.544	1.00
411_K	420_A	1.543	1.00
60_T	63_R	1.541	1.00
45_V	58_V	1.531	1.00
364_A	371_F	1.527	1.00
468_A	495_V	1.525	1.00
181_A	185_S	1.524	1.00
59_Q	90_V	1.517	1.00
159_I	166_I	1.494	1.00
37_R	265_E	1.494	1.00
85_A	133_T	1.490	1.00
150_D	154_V	1.489	1.00
83_V	86_E	1.488	1.00
32_A	57_S	1.485	1.00
293_F	319_I	1.481	1.00
128_R	132_Y	1.477	1.00
198_I	223_R	1.476	1.00
363_L	367_K	1.476	1.00
390_H	415_G	1.473	1.00
140_C	155_V	1.461	1.00
218_V	225_V	1.453	1.00
55_F	83_V	1.452	1.00
31_I	273_V	1.440	1.00
214_S	218_V	1.440	1.00
339_H	342_D	1.439	1.00
409_A	422_A	1.438	1.00
115_L	147_P	1.438	1.00
168_I	183_I	1.436	1.00
25_V	60_T	1.430	0.99
155_V	168_I	1.422	0.99
149_A	152_A	1.417	0.99
34_A	269_T	1.416	0.99
214_S	225_V	1.413	0.99
152_A	186_G	1.413	0.99
104_P	108_A	1.403	0.99
101_A	142_D	1.398	0.99
34_A	272_L	1.391	0.99
426_N	482_T	1.390	0.99
53_G	365_D	1.378	0.99
205_D	208_G	1.378	0.99
48_P	58_V	1.377	0.99
61_I	70_V	1.368	0.99
230_N	270_S	1.364	0.99
101_A	106_H	1.361	0.99
76_C	98_T	1.357	0.99
85_A	125_M	1.356	0.99
389_E	392_R	1.355	0.99
349_S	352_N	1.354	0.99
99_F	299_I	1.347	0.99
100_I	138_F	1.343	0.99
106_H	142_D	1.340	0.99
156_E	190_R	1.336	0.99
113_S	118_V	1.334	0.99
41_D	67_N	1.334	0.99
107_I	118_V	1.331	0.99
184_I	201_V	1.329	0.99
341_M	380_F	1.325	0.99
23_L	31_I	1.321	0.99
157_A	160_N	1.300	0.99
394_D	411_K	1.294	0.99
215_L	247_A	1.289	0.99
6_I	42_V	1.283	0.99
42_V	135_D	1.280	0.99
180_F	201_V	1.277	0.99
52_P	83_V	1.274	0.99
214_S	244_V	1.272	0.99
156_E	159_I	1.269	0.99
447_V	469_N	1.261	0.99
159_I	197_A	1.260	0.99
423_A	434_Q	1.260	0.99
132_Y	135_D	1.255	0.99
182_G	186_G	1.252	0.99
122_A	157_A	1.246	0.99
152_A	156_E	1.242	0.99
432_V	485_V	1.241	0.99
227_G	245_I	1.237	0.99
126_V	161_A	1.237	0.99
33_L	64_Q	1.233	0.98
156_E	160_N	1.225	0.98
37_R	268_R	1.223	0.98
414_C	417_E	1.215	0.98
296_S	331_R	1.190	0.98
193_N	196_K	1.183	0.98
258_H	261_I	1.175	0.98
110_K	302_D	1.169	0.98
350_E	354_D	1.169	0.98
214_S	239_C	1.168	0.98
211_V	244_V	1.168	0.98
6_I	165_T	1.167	0.98
484_I	488_S	1.166	0.98
407_T	422_A	1.163	0.98
144_G	175_T	1.152	0.98
428_P	483_D	1.151	0.98
105_M	109_T	1.149	0.98
104_P	107_I	1.146	0.98
156_E	191_V	1.143	0.98
23_L	276_I	1.135	0.97
338_K	342_D	1.132	0.97
5_V	257_V	1.126	0.97
127_K	161_A	1.118	0.97
102_T	154_V	1.112	0.97
50_S	331_R	1.111	0.97
26_K	60_T	1.109	0.97
135_D	164_T	1.103	0.97
218_V	257_V	1.099	0.97
53_G	330_S	1.097	0.97
453_A	462_G	1.096	0.97
429_V	446_L	1.093	0.97
86_E	89_K	1.088	0.97
56_E	59_Q	1.086	0.97
453_A	457_G	1.084	0.97
208_G	286_A	1.083	0.97
71_C	95_R	1.082	0.97
410_V	421_E	1.081	0.97
470_Y	499_I	1.080	0.97
208_G	240_S	1.078	0.96
180_F	184_I	1.076	0.96
88_L	96_I	1.075	0.96
391_F	414_C	1.074	0.96
8_F	71_C	1.074	0.96
82_D	86_E	1.071	0.96
29_L	64_Q	1.071	0.96
98_T	162_G	1.070	0.96
159_I	192_P	1.061	0.96
112_R	306_K	1.054	0.96
7_I	245_I	1.050	0.96
111_L	311_Y	1.050	0.96
58_V	72_A	1.049	0.96
272_L	276_I	1.047	0.96
184_I	220_A	1.047	0.96
211_V	239_C	1.046	0.96
178_F	182_G	1.043	0.96
301_Q	336_A	1.039	0.96
181_A	216_A	1.039	0.96
101_A	141_E	1.038	0.96
137_E	200_S	1.037	0.96
343_E	373_Y	1.037	0.96
148_I	183_I	1.035	0.96
149_A	153_R	1.035	0.96
152_A	190_R	1.034	0.96
23_L	277_C	1.034	0.96
296_S	329_T	1.031	0.95
18_A	21_A	1.029	0.95
69_R	93_A	1.029	0.95
214_S	227_G	1.027	0.95
93_A	134_D	1.022	0.95
124_Y	128_R	1.018	0.95
153_R	157_A	1.011	0.95
19_L	291_G	1.011	0.95
216_A	220_A	1.003	0.95
245_I	263_H	0.994	0.94
156_E	193_N	0.989	0.94
166_I	199_I	0.988	0.94
34_A	265_E	0.986	0.94
205_D	210_A	0.983	0.94
4_Q	258_H	0.981	0.94
34_A	268_R	0.980	0.94
4_Q	41_D	0.975	0.94
128_R	131_N	0.972	0.94
76_C	125_M	0.969	0.94
140_C	151_L	0.968	0.94
3_Q	257_V	0.959	0.93
340_R	343_E	0.954	0.93
246_M	314_M	0.952	0.93
159_I	193_N	0.952	0.93
362_K	366_K	0.951	0.93
69_R	135_D	0.950	0.93
8_F	97_H	0.949	0.93
10_T	106_H	0.945	0.93
444_V	496_L	0.943	0.93
211_V	214_S	0.943	0.93
16_E	23_L	0.943	0.93
216_A	219_H	0.942	0.93
346_Y	465_D	0.941	0.93
182_G	185_S	0.936	0.92
397_S	401_G	0.936	0.92
348_E	356_L	0.932	0.92
201_V	218_V	0.931	0.92
452_T	465_D	0.928	0.92
29_L	60_T	0.925	0.92
131_N	135_D	0.924	0.92
422_A	438_R	0.920	0.92
29_L	33_L	0.920	0.92
111_L	141_E	0.919	0.92
427_G	449_Y	0.915	0.92
160_N	192_P	0.911	0.91
390_H	414_C	0.908	0.91
187_L	191_V	0.904	0.91
232_I	279_M	0.903	0.91
249_K	261_I	0.901	0.91
372_D	375_L	0.900	0.91
143_A	187_L	0.899	0.91
397_S	409_A	0.891	0.90
149_A	186_G	0.890	0.90
154_V	158_A	0.890	0.90
463_Q	480_L	0.889	0.90
104_P	146_T	0.888	0.90
282_P	285_K	0.888	0.90
141_E	311_Y	0.883	0.90
140_C	168_I	0.880	0.90
357_Y	361_L	0.879	0.90
135_D	165_T	0.879	0.90
229_M	273_V	0.870	0.89
85_A	94_F	0.870	0.89
120_E	123_I	0.870	0.89
49_V	79_K	0.869	0.89
152_A	192_P	0.869	0.89
103_S	142_D	0.869	0.89
363_L	379_A	0.868	0.89
401_G	407_T	0.867	0.89
71_C	97_H	0.866	0.89
421_E	439_I	0.866	0.89
165_T	196_K	0.861	0.89
218_V	248_I	0.858	0.89
184_I	187_L	0.858	0.89
21_A	278_N	0.856	0.89
436_I	489_A	0.855	0.89
98_T	125_M	0.854	0.89
101_A	111_L	0.847	0.88
108_A	114_T	0.847	0.88
41_D	260_A	0.846	0.88
126_V	158_A	0.846	0.88
249_K	258_H	0.846	0.88
40_V	245_I	0.845	0.88
281_I	288_V	0.845	0.88
468_A	475_F	0.843	0.88
466_I	492_M	0.843	0.88
21_A	31_I	0.843	0.88
350_E	353_L	0.838	0.88
52_P	362_K	0.838	0.88
160_N	193_N	0.838	0.88
176_M	219_H	0.838	0.88
443_N	470_Y	0.838	0.88
27_E	278_N	0.837	0.88
341_M	376_E	0.835	0.87
115_L	146_T	0.834	0.87
354_D	358_D	0.833	0.87
317_E	323_Q	0.831	0.87
338_K	350_E	0.830	0.87
103_S	106_H	0.826	0.87
23_L	273_V	0.826	0.87
119_I	157_A	0.826	0.87
98_T	126_V	0.824	0.87
142_D	145_R	0.821	0.87
82_D	135_D	0.821	0.87
187_L	199_I	0.820	0.86
395_Y	411_K	0.819	0.86
467_V	474_R	0.816	0.86
249_K	318_S	0.815	0.86
430_D	434_Q	0.814	0.86
339_H	343_E	0.813	0.86
161_A	164_T	0.813	0.86
32_A	36_E	0.813	0.86
69_R	94_F	0.811	0.86
360_F	379_A	0.810	0.86
175_T	179_E	0.810	0.86
358_D	362_K	0.809	0.86
186_G	189_E	0.808	0.86
144_G	174_Y	0.807	0.86
100_I	140_C	0.807	0.86
97_H	139_S	0.803	0.85
115_L	149_A	0.802	0.85
393_L	493_V	0.801	0.85
447_V	474_R	0.799	0.85
188_Y	191_V	0.797	0.85
352_N	355_N	0.795	0.85
176_M	255_L	0.794	0.85
61_I	64_Q	0.793	0.85
166_I	197_A	0.793	0.85
240_S	243_E	0.792	0.85
184_I	199_I	0.788	0.84
101_A	110_K	0.788	0.84
139_S	169_P	0.786	0.84
18_A	279_M	0.786	0.84
18_A	284_N	0.785	0.84
163_A	193_N	0.784	0.84
155_V	191_V	0.783	0.84
433_Y	437_N	0.781	0.84
397_S	407_T	0.781	0.84
227_G	241_L	0.780	0.84
301_Q	332_S	0.780	0.84
33_L	37_R	0.779	0.84
335_A	339_H	0.779	0.84
16_E	331_R	0.777	0.83
155_V	187_L	0.777	0.83
475_F	499_I	0.775	0.83
106_H	145_R	0.775	0.83
32_A	61_I	0.772	0.83
119_I	123_I	0.771	0.83
355_N	359_A	0.767	0.83
24_S	368_G	0.766	0.82
211_V	243_E	0.766	0.82
203_T	239_C	0.766	0.82
170_D	180_F	0.764	0.82
77_V	121_R	0.762	0.82
427_G	484_I	0.761	0.82
58_V	70_V	0.761	0.82
38_M	245_I	0.760	0.82
146_T	155_V	0.760	0.82
149_A	190_R	0.759	0.82
188_Y	223_R	0.758	0.82
246_M	287_I	0.758	0.82
121_R	125_M	0.757	0.82
427_G	462_G	0.756	0.82
122_A	127_K	0.753	0.81
209_L	247_A	0.751	0.81
7_I	214_S	0.751	0.81
18_A	232_I	0.744	0.81
13_R	17_Q	0.743	0.81
340_R	376_E	0.742	0.80
175_T	180_F	0.742	0.80
43_M	68_S	0.738	0.80
243_E	286_A	0.737	0.80
47_F	299_I	0.735	0.80
166_I	193_N	0.735	0.80
21_A	232_I	0.735	0.80
400_S	483_D	0.733	0.80
130_R	163_A	0.731	0.79
359_A	383_K	0.730	0.79
374_D	378_L	0.730	0.79
428_P	484_I	0.727	0.79
178_F	181_A	0.725	0.79
356_L	384_Q	0.725	0.79
36_E	66_K	0.724	0.79
396_F	489_A	0.723	0.79
344_M	373_Y	0.722	0.79
451_L	462_G	0.719	0.78
341_M	348_E	0.718	0.78
378_L	382_G	0.718	0.78
229_M	242_E	0.718	0.78
118_V	142_D	0.717	0.78
89_K	92_E	0.717	0.78
29_L	61_I	0.716	0.78
137_E	224_Q	0.716	0.78
461_L	482_T	0.716	0.78
120_E	127_K	0.714	0.78
90_V	94_F	0.712	0.78
21_A	279_M	0.711	0.78
144_G	183_I	0.709	0.77
144_G	180_F	0.708	0.77
367_K	375_L	0.708	0.77
242_E	246_M	0.706	0.77
327_N	331_R	0.705	0.77
355_N	358_D	0.705	0.77
97_H	167_N	0.705	0.77
246_M	263_H	0.704	0.77
232_I	277_C	0.703	0.77
71_C	137_E	0.702	0.77
407_T	424_N	0.701	0.77
391_F	493_V	0.701	0.77
178_F	216_A	0.700	0.76
203_T	244_V	0.700	0.76
353_L	356_L	0.697	0.76
35_L	43_M	0.696	0.76
455_G	460_A	0.694	0.76
393_L	483_D	0.694	0.76
152_A	191_V	0.693	0.76
391_F	412_L	0.691	0.76
279_M	282_P	0.691	0.76
156_E	197_A	0.691	0.76
282_P	286_A	0.689	0.75
432_V	492_M	0.689	0.75
98_T	129_A	0.687	0.75
427_G	488_S	0.687	0.75
124_Y	127_K	0.686	0.75
334_R	354_D	0.685	0.75
205_D	282_P	0.685	0.75
247_A	287_I	0.684	0.75
46_G	58_V	0.683	0.75
168_I	180_F	0.683	0.75
96_I	133_T	0.682	0.75
270_S	290_S	0.682	0.75
30_Q	268_R	0.680	0.74
110_K	311_Y	0.678	0.74
50_S	77_V	0.677	0.74
102_T	151_L	0.677	0.74
348_E	380_F	0.675	0.74
316_P	324_I	0.675	0.74
101_A	118_V	0.675	0.74
108_A	115_L	0.673	0.74
52_P	358_D	0.673	0.74
5_V	223_R	0.673	0.74
338_K	353_L	0.672	0.74
411_K	424_N	0.668	0.73
375_L	378_L	0.667	0.73
246_M	266_I	0.666	0.73
414_C	419_K	0.665	0.73
50_S	330_S	0.662	0.72
306_K	338_K	0.661	0.72
427_G	460_A	0.661	0.72
137_E	167_N	0.659	0.72
10_T	142_D	0.658	0.72
426_N	458_K	0.657	0.72
430_D	484_I	0.657	0.72
433_Y	492_M	0.655	0.72
437_N	458_K	0.655	0.72
49_V	83_V	0.655	0.72
448_K	452_T	0.653	0.71
39_G	262_N	0.653	0.71
420_A	424_N	0.652	0.71
330_S	361_L	0.651	0.71
36_E	70_V	0.650	0.71
215_L	257_V	0.650	0.71
131_N	134_D	0.649	0.71
88_L	132_Y	0.649	0.71
155_V	183_I	0.648	0.71
243_E	285_K	0.647	0.71
266_I	324_I	0.646	0.71
108_A	112_R	0.645	0.70
485_V	488_S	0.644	0.70
351_Y	467_V	0.643	0.70
356_L	379_A	0.642	0.70
454_K	460_A	0.641	0.70
429_V	488_S	0.641	0.70
344_M	377_A	0.639	0.70
130_R	134_D	0.639	0.70
95_R	135_D	0.638	0.70
242_E	285_K	0.636	0.69
110_K	310_N	0.635	0.69
88_L	93_A	0.635	0.69
62_A	91_A	0.633	0.69
107_I	113_S	0.633	0.69
210_A	248_I	0.632	0.69
429_V	492_M	0.632	0.69
104_P	150_D	0.631	0.69
165_T	224_Q	0.630	0.69
101_A	150_D	0.630	0.69
269_T	272_L	0.629	0.69
47_F	73_L	0.629	0.69
454_K	480_L	0.627	0.68
85_A	128_R	0.626	0.68
143_A	183_I	0.624	0.68
283_A	290_S	0.624	0.68
437_N	443_N	0.622	0.68
39_G	67_N	0.621	0.68
437_N	492_M	0.621	0.68
427_G	451_L	0.620	0.67
8_F	142_D	0.620	0.67
18_A	23_L	0.619	0.67
444_V	495_V	0.617	0.67
271_Q	275_Q	0.616	0.67
85_A	89_K	0.616	0.67
127_K	131_N	0.616	0.67
355_N	498_N	0.616	0.67
405_I	424_N	0.615	0.67
346_Y	463_Q	0.615	0.67
10_T	126_V	0.614	0.67
432_V	435_A	0.613	0.67
5_V	248_I	0.613	0.67
75_R	99_F	0.613	0.67
130_R	293_F	0.612	0.66
296_S	330_S	0.612	0.66
120_E	153_R	0.611	0.66
157_A	161_A	0.611	0.66
463_Q	478_V	0.608	0.66
468_A	499_I	0.608	0.66
123_I	154_V	0.607	0.66
88_L	91_A	0.607	0.66
432_V	436_I	0.606	0.66
409_A	420_A	0.606	0.66
390_H	497_N	0.606	0.66
98_T	136_V	0.604	0.65
393_L	396_F	0.603	0.65
107_I	114_T	0.601	0.65
38_M	266_I	0.601	0.65
230_N	273_V	0.600	0.65
40_V	227_G	0.599	0.65
383_K	498_N	0.598	0.65
444_V	468_A	0.597	0.65
449_Y	484_I	0.597	0.65
86_E	128_R	0.597	0.65
454_K	461_L	0.597	0.65
119_I	122_A	0.596	0.64
24_S	27_E	0.595	0.64
175_T	183_I	0.595	0.64
85_A	132_Y	0.595	0.64
391_F	440_T	0.595	0.64
22_S	330_S	0.593	0.64
240_S	285_K	0.591	0.64
428_P	479_G	0.590	0.64
85_A	88_L	0.590	0.64
419_K	439_I	0.589	0.63
158_A	180_F	0.589	0.63
331_R	361_L	0.589	0.63
412_L	421_E	0.589	0.63
26_K	30_Q	0.589	0.63
153_R	156_E	0.587	0.63
106_H	118_V	0.585	0.63
415_G	419_K	0.584	0.63
374_D	377_A	0.583	0.63
346_Y	377_A	0.583	0.63
451_L	458_K	0.583	0.63
337_V	357_Y	0.581	0.62
43_M	70_V	0.581	0.62
183_I	187_L	0.581	0.62
249_K	259_T	0.580	0.62
452_T	463_Q	0.580	0.62
314_M	318_S	0.580	0.62
406_A	483_D	0.580	0.62
149_A	358_D	0.579	0.62
270_S	288_V	0.578	0.62
144_G	148_I	0.578	0.62
36_E	64_Q	0.577	0.62
391_F	500_W	0.576	0.62
165_T	198_I	0.575	0.62
359_A	362_K	0.575	0.62
359_A	363_L	0.574	0.62
446_L	453_A	0.574	0.62
182_G	220_A	0.573	0.61
410_V	432_V	0.573	0.61
305_L	342_D	0.573	0.61
230_N	281_I	0.572	0.61
486_E	490_K	0.572	0.61
14_D	17_Q	0.572	0.61
139_S	172_V	0.572	0.61
444_V	448_K	0.571	0.61
8_F	106_H	0.571	0.61
170_D	174_Y	0.570	0.61
179_E	183_I	0.570	0.61
104_P	145_R	0.569	0.61
267_W	271_Q	0.568	0.61
129_A	136_V	0.568	0.61
101_A	146_T	0.567	0.61
337_V	376_E	0.566	0.60
180_F	217_A	0.566	0.60
219_H	255_L	0.565	0.60
267_W	322_N	0.564	0.60
335_A	451_L	0.563	0.60
399_Q	407_T	0.563	0.60
451_L	464_V	0.562	0.60
67_N	92_E	0.562	0.60
428_P	485_V	0.561	0.60
423_A	438_R	0.561	0.60
121_R	124_Y	0.560	0.60
30_Q	272_L	0.559	0.59
264_Q	318_S	0.559	0.59
74_A	99_F	0.557	0.59
403_N	407_T	0.557	0.59
363_L	375_L	0.557	0.59
341_M	346_Y	0.557	0.59
461_L	480_L	0.557	0.59
239_C	307_N	0.556	0.59
191_V	199_I	0.556	0.59
381_I	386_E	0.555	0.59
479_G	490_K	0.555	0.59
118_V	121_R	0.554	0.59
46_G	142_D	0.553	0.59
205_D	240_S	0.552	0.59
143_A	287_I	0.552	0.59
21_A	276_I	0.552	0.59
178_F	185_S	0.550	0.58
408_A	431_A	0.550	0.58
160_N	190_R	0.549	0.58
82_D	131_N	0.548	0.58
105_M	307_N	0.548	0.58
328_L	360_F	0.548	0.58
205_D	265_E	0.546	0.58
144_G	170_D	0.546	0.58
304_V	326_L	0.545	0.58
173_G	213_N	0.545	0.58
303_G	311_Y	0.544	0.57
201_V	222_A	0.543	0.57
267_W	290_S	0.542	0.57
389_E	497_N	0.541	0.57
241_L	266_I	0.541	0.57
405_I	409_A	0.540	0.57
148_I	179_E	0.539	0.57
73_L	139_S	0.538	0.57
27_E	275_Q	0.538	0.57
42_V	71_C	0.538	0.57
113_S	150_D	0.537	0.56
371_F	375_L	0.537	0.56
55_F	58_V	0.537	0.56
225_V	239_C	0.536	0.56
229_M	269_T	0.536	0.56
99_F	139_S	0.536	0.56
25_V	53_G	0.536	0.56
93_A	96_I	0.533	0.56
165_T	223_R	0.533	0.56
76_C	100_I	0.533	0.56
228_A	241_L	0.532	0.56
435_A	439_I	0.532	0.56
218_V	244_V	0.532	0.56
137_E	226_E	0.529	0.55
448_K	464_V	0.529	0.55
100_I	341_M	0.529	0.55
192_P	197_A	0.529	0.55
351_Y	354_D	0.529	0.55
102_T	144_G	0.528	0.55
210_A	358_D	0.528	0.55
469_N	474_R	0.527	0.55
126_V	163_A	0.527	0.55
332_S	336_A	0.525	0.55
363_L	371_F	0.523	0.55
340_R	466_I	0.523	0.55
101_A	104_P	0.523	0.55
48_P	140_C	0.523	0.55
117_E	126_V	0.522	0.54
42_V	95_R	0.521	0.54
405_I	438_R	0.521	0.54
74_A	84_A	0.520	0.54
112_R	302_D	0.520	0.54
379_A	383_K	0.518	0.54
111_L	138_F	0.517	0.54
47_F	75_R	0.517	0.54
259_T	262_N	0.516	0.54
79_K	83_V	0.515	0.53
326_L	339_H	0.515	0.53
114_T	120_E	0.515	0.53
288_V	293_F	0.514	0.53
368_G	428_P	0.512	0.53
25_V	29_L	0.512	0.53
133_T	136_V	0.512	0.53
462_G	484_I	0.512	0.53
40_V	269_T	0.512	0.53
267_W	293_F	0.511	0.53
176_M	232_I	0.511	0.53
101_A	121_R	0.511	0.53
269_T	273_V	0.510	0.53
21_A	273_V	0.509	0.53
207_L	287_I	0.509	0.53
305_L	338_K	0.508	0.52
341_M	382_G	0.508	0.52
176_M	216_A	0.508	0.52
85_A	126_V	0.506	0.52
10_T	14_D	0.506	0.52
462_G	482_T	0.505	0.52
188_Y	194_I	0.505	0.52
451_L	488_S	0.504	0.52
137_E	165_T	0.504	0.52
430_D	458_K	0.504	0.52
101_A	139_S	0.503	0.52
8_F	145_R	0.503	0.52
75_R	299_I	0.503	0.52
8_F	224_Q	0.502	0.52
227_G	240_S	0.502	0.52
396_F	486_E	0.502	0.52
395_Y	402_S	0.501	0.51
154_V	157_A	0.500	0.51

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3hq1A	2	0.9216	100	0.244	Contact Map
4ov4A	2	0.7017	100	0.401	Contact Map
3rmjA	2	0.5908	100	0.418	Contact Map
2ztjA	2	0.5927	100	0.424	Contact Map
3ivsA	2	0.6807	100	0.439	Contact Map
3bleA	2	0.5679	100	0.518	Contact Map
3eegA	2	0.522	100	0.536	Contact Map
2qf7A	4	0.8528	100	0.59	Contact Map
3ewbX	2	0.5163	100	0.611	Contact Map
2cw6A	5	0.5296	100	0.615	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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