GREMLIN Database
GAL7 - Galactose-1-phosphate uridylyltransferase
UniProt: P09148 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10366
Length: 348 (319)
Sequences: 1444 (918)
Seq/√Len: 51.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
216_T254_D4.9661.00
239_A251_Q4.8461.00
195_S200_D4.2091.00
196_P199_V3.9741.00
215_E238_K3.8201.00
333_E337_A3.7871.00
52_C115_H3.6571.00
128_T253_S3.6521.00
52_C55_C3.6281.00
199_V294_Q3.5531.00
214_V258_A3.3871.00
261_K265_R3.2841.00
206_L220_L3.2411.00
218_H254_D3.0451.00
196_P240_H2.9791.00
55_C115_H2.9571.00
172_N316_Y2.8991.00
132_K252_R2.8741.00
199_V240_H2.8691.00
242_L246_D2.7191.00
196_P294_Q2.7161.00
260_K264_S2.7111.00
109_I169_I2.7001.00
19_G185_L2.6551.00
128_T132_K2.5421.00
220_L238_K2.5171.00
247_L295_L2.5161.00
107_R137_Q2.4341.00
202_V220_L2.4031.00
189_Y200_D2.3101.00
14_Y19_G2.3021.00
135_Q252_R2.2981.00
182_E298_H2.2781.00
233_T262_L2.2281.00
221_A262_L2.1491.00
123_S126_A2.1321.00
216_T257_L2.0211.00
127_L260_K1.9380.99
214_V261_K1.9290.99
248_T251_Q1.9080.99
223_V227_A1.8990.99
198_L236_L1.8940.99
240_H294_Q1.8820.99
114_D117_K1.8530.99
243_R246_D1.8510.99
74_V133_T1.8440.99
231_F334_R1.8310.99
94_D204_R1.8130.99
119_L127_L1.8000.99
277_S315_G1.7840.99
147_W176_P1.7710.99
187_K191_A1.7670.99
218_H250_A1.7430.99
182_E281_H1.7400.99
206_L215_E1.7100.99
76_T105_T1.7070.99
280_W297_A1.7040.99
255_L297_A1.6910.99
206_L238_K1.6540.98
142_G148_V1.6370.98
326_L331_A1.6280.98
213_V233_T1.6120.98
20_Q181_R1.5380.97
206_L212_T1.5060.97
189_Y193_Q1.5020.97
132_K253_S1.4730.96
255_L278_M1.4710.96
135_Q244_I1.4660.96
131_V134_W1.4390.96
181_R184_R1.4280.96
205_E211_R1.4210.96
221_A233_T1.4040.95
124_V260_K1.4010.95
222_V236_L1.3990.95
269_L335_L1.3910.95
97_M204_R1.3820.95
174_F321_E1.3780.95
180_E184_R1.3770.95
241_V295_L1.3720.95
286_N290_N1.3600.94
139_A245_T1.3350.94
48_H58_N1.3160.93
183_D292_H1.3160.93
231_F274_F1.3130.93
214_V257_L1.3100.93
216_T258_A1.2900.93
47_A114_D1.2860.93
202_V212_T1.2740.92
10_P83_M1.2670.92
212_T220_L1.2630.92
72_T133_T1.2590.92
23_L82_L1.2320.91
137_Q169_I1.2240.91
128_T252_R1.2200.91
28_R31_R1.2150.90
231_F331_A1.2110.90
12_R21_W1.2110.90
75_F110_C1.1990.90
219_W235_L1.1940.90
130_I263_T1.1840.89
111_F152_E1.1820.89
157_A310_R1.1780.89
19_G188_E1.1740.89
281_H298_H1.1730.89
14_Y18_T1.1590.88
198_L222_V1.1550.88
176_P179_A1.1540.88
212_T222_V1.1490.88
137_Q140_E1.1490.88
147_W179_A1.1450.88
131_V256_A1.1380.87
241_V247_L1.1380.87
138_T150_V1.1360.87
188_E192_E1.1350.87
202_V238_K1.1270.87
316_Y320_A1.1120.86
146_P286_N1.1080.86
232_E298_H1.0990.85
142_G285_F1.0970.85
270_F274_F1.0940.85
203_Q207_A1.0780.84
244_I295_L1.0750.84
261_K264_S1.0700.84
158_M277_S1.0700.84
138_T282_G1.0690.84
327_T331_A1.0640.83
280_W295_L1.0560.83
18_T181_R1.0560.83
241_V251_Q1.0490.82
17_L198_L1.0350.82
257_L260_K1.0280.81
218_H251_Q1.0220.81
154_K267_D1.0210.81
50_P57_G1.0200.81
182_E293_W1.0140.80
59_V62_T1.0110.80
219_W295_L1.0070.80
263_T299_F1.0030.80
154_K273_S1.0000.79
287_G290_N0.9910.79
209_G215_E0.9880.78
131_V259_L0.9810.78
85_D103_R0.9710.77
264_S268_N0.9680.77
34_Q163_P0.9670.77
239_A248_T0.9630.77
242_L291_Q0.9610.77
257_L261_K0.9580.76
11_H99_C0.9520.76
124_V127_L0.9480.76
231_F270_F0.9460.75
190_F292_H0.9420.75
54_L60_R0.9420.75
213_V223_V0.9410.75
152_E165_P0.9330.74
87_P101_S0.9300.74
123_S127_L0.9290.74
182_E296_H0.9280.74
103_R173_S0.9260.74
214_V262_L0.9180.73
134_W167_G0.9160.73
111_F167_G0.9160.73
266_Y299_F0.9130.73
234_L298_H0.9110.73
99_C225_Y0.9050.72
117_K121_E0.9030.72
190_F196_P0.8920.71
286_N291_Q0.8910.71
142_G245_T0.8900.71
102_A174_F0.8880.71
74_V137_Q0.8860.70
138_T280_W0.8830.70
80_A83_M0.8810.70
202_V222_V0.8740.69
81_A323_Q0.8720.69
219_W280_W0.8700.69
57_G68_D0.8620.68
154_K160_C0.8610.68
124_V256_A0.8590.68
330_Q333_E0.8580.68
83_M86_T0.8550.68
72_T130_I0.8540.68
210_S333_E0.8540.68
14_Y98_R0.8540.68
265_R338_V0.8530.68
105_T144_T0.8530.68
231_F266_Y0.8520.67
231_F301_P0.8520.67
111_F130_I0.8500.67
195_S203_Q0.8490.67
86_T101_S0.8490.67
221_A235_L0.8420.67
132_K249_D0.8410.66
332_A336_R0.8400.66
278_M297_A0.8400.66
187_K292_H0.8390.66
134_W278_M0.8380.66
15_N226_W0.8350.66
185_L188_E0.8330.66
24_V327_T0.8330.66
95_P204_R0.8320.66
123_S260_K0.8290.65
32_P79_F0.8270.65
333_E336_R0.8270.65
268_N271_Q0.8270.65
59_V65_K0.8260.65
135_Q139_A0.8210.65
31_R314_V0.8200.64
186_Q198_L0.8150.64
117_K126_A0.8150.64
250_A253_S0.8090.63
76_T80_A0.8070.63
63_G66_N0.8070.63
266_Y274_F0.8050.63
48_H56_A0.7920.62
158_M314_V0.7890.61
259_L299_F0.7890.61
209_G212_T0.7850.61
184_R188_E0.7840.61
202_V206_L0.7820.61
58_N61_V0.7810.61
57_G60_R0.7800.61
54_L57_G0.7770.60
23_L324_R0.7750.60
34_Q156_A0.7740.60
107_R141_L0.7720.60
152_E167_G0.7720.60
14_Y21_W0.7720.60
47_A116_S0.7710.60
49_D52_C0.7680.59
149_Q319_L0.7620.59
120_P260_K0.7520.58
77_N168_Q0.7500.58
107_R169_I0.7500.58
86_T103_R0.7490.57
74_V109_I0.7440.57
219_W255_L0.7410.57
128_T249_D0.7370.56
74_V107_R0.7350.56
10_P102_A0.7350.56
102_A173_S0.7330.56
186_Q293_W0.7300.56
60_R63_G0.7290.55
124_V257_L0.7280.55
141_L171_A0.7270.55
93_H98_R0.7260.55
9_H87_P0.7230.55
213_V281_H0.7220.55
128_T131_V0.7200.54
87_P95_P0.7200.54
244_I282_G0.7190.54
53_F162_N0.7150.54
316_Y323_Q0.7150.54
50_P54_L0.7120.54
90_P93_H0.7120.54
82_L171_A0.7100.53
132_K135_Q0.7080.53
126_A129_E0.7060.53
200_D203_Q0.7060.53
106_S270_F0.7050.53
139_A188_E0.7040.53
183_D187_K0.7030.53
33_W161_S0.7020.53
237_P247_L0.7020.53
277_S314_V0.7020.53
272_C308_T0.7000.52
272_C307_A0.6980.52
311_K325_D0.6960.52
141_L169_I0.6940.52
70_T73_Y0.6920.52
54_L110_C0.6920.52
204_R207_A0.6880.51
228_A322_T0.6860.51
189_Y197_M0.6850.51
188_E191_A0.6850.51
82_L102_A0.6830.51
78_D162_N0.6800.50
52_C58_N0.6760.50
160_C277_S0.6760.50
177_N321_E0.6760.50
68_D113_P0.6750.50
316_Y319_L0.6720.49
14_Y185_L0.6700.49
133_T136_E0.6700.49
84_S103_R0.6690.49
55_C60_R0.6690.49
122_L130_I0.6680.49
112_S115_H0.6670.49
306_S310_R0.6660.49
190_F194_K0.6660.49
241_V246_D0.6650.49
20_Q178_E0.6640.49
242_L283_A0.6630.49
10_P265_R0.6600.48
177_N322_T0.6600.48
138_T244_I0.6580.48
137_Q141_L0.6570.48
82_L141_L0.6550.48
141_L148_V0.6540.48
259_L278_M0.6530.48
225_Y235_L0.6510.47
90_P95_P0.6500.47
201_Y222_V0.6490.47
184_R187_K0.6480.47
334_R338_V0.6470.47
24_V323_Q0.6460.47
215_E220_L0.6450.47
109_I167_G0.6440.47
228_A328_A0.6400.46
222_V234_L0.6390.46
134_W150_V0.6390.46
69_Y152_E0.6390.46
75_F152_E0.6370.46
183_D293_W0.6370.46
36_A156_A0.6350.46
207_A220_L0.6310.45
235_L259_L0.6310.45
262_L266_Y0.6300.45
24_V219_W0.6270.45
219_W263_T0.6270.45
97_M201_Y0.6260.45
182_E186_Q0.6250.45
147_W219_W0.6250.45
254_D261_K0.6250.45
12_R102_A0.6250.45
144_T225_Y0.6240.45
117_K127_L0.6240.45
109_I112_S0.6210.44
77_N161_S0.6190.44
160_C170_W0.6190.44
179_A281_H0.6180.44
149_Q316_Y0.6170.44
278_M299_F0.6160.44
214_V221_A0.6150.44
148_V285_F0.6140.44
175_L187_K0.6120.43
254_D257_L0.6120.43
28_R77_N0.6120.43
244_I255_L0.6110.43
92_S98_R0.6110.43
127_L130_I0.6110.43
175_L180_E0.6090.43
124_V128_T0.6080.43
102_A172_N0.6060.43
212_T215_E0.6060.43
155_G276_Y0.6050.43
136_E291_Q0.6040.42
49_D55_C0.6030.42
204_R208_D0.6020.42
165_P186_Q0.6010.42
51_D55_C0.6000.42
91_E246_D0.6000.42
32_P57_G0.6000.42
148_V171_A0.6000.42
304_L309_V0.6000.42
298_H319_L0.6000.42
189_Y195_S0.5990.42
52_C57_G0.5950.42
199_V237_P0.5940.41
51_D54_L0.5940.41
122_L276_Y0.5930.41
176_P230_P0.5920.41
57_G63_G0.5920.41
242_L290_N0.5910.41
231_F294_Q0.5910.41
178_E300_Y0.5900.41
198_L201_Y0.5900.41
128_T135_Q0.5900.41
125_A253_S0.5890.41
111_F158_M0.5880.41
120_P264_S0.5860.41
147_W294_Q0.5860.41
145_Y282_G0.5850.41
123_S307_A0.5840.40
88_D93_H0.5830.40
85_D93_H0.5820.40
18_T185_L0.5800.40
199_V202_V0.5790.40
72_T122_L0.5790.40
54_L115_H0.5790.40
286_N292_H0.5790.40
270_F273_S0.5780.40
138_T243_R0.5780.40
270_F331_A0.5780.40
200_D233_T0.5780.40
269_L308_T0.5760.40
52_C112_S0.5740.39
334_R337_A0.5710.39
29_A269_L0.5700.39
246_D283_A0.5700.39
175_L179_A0.5680.39
18_T178_E0.5680.39
264_S338_V0.5660.39
32_P161_S0.5650.39
51_D59_V0.5650.39
305_R311_K0.5630.38
107_R171_A0.5620.38
31_R161_S0.5610.38
119_L122_L0.5610.38
89_A250_A0.5600.38
269_L338_V0.5580.38
288_E292_H0.5570.38
24_V324_R0.5550.38
281_H296_H0.5540.38
136_E139_A0.5540.38
188_E250_A0.5530.37
217_E250_A0.5530.37
268_N338_V0.5530.37
105_T145_Y0.5510.37
76_T144_T0.5480.37
218_H239_A0.5470.37
35_G170_W0.5470.37
190_F291_Q0.5460.37
29_A80_A0.5460.37
34_Q161_S0.5450.37
254_D258_A0.5430.36
148_V156_A0.5420.36
130_I133_T0.5400.36
89_A192_E0.5400.36
18_T327_T0.5390.36
158_M170_W0.5380.36
235_L262_L0.5370.36
102_A146_P0.5370.36
315_G318_M0.5330.35
249_D287_G0.5330.35
119_L278_M0.5310.35
30_K330_Q0.5310.35
302_P311_K0.5310.35
183_D212_T0.5300.35
64_D73_Y0.5300.35
186_Q190_F0.5290.35
56_A113_P0.5290.35
125_A129_E0.5260.35
26_P232_E0.5260.35
21_W100_Q0.5250.35
255_L319_L0.5240.35
106_S158_M0.5230.35
12_R324_R0.5230.35
147_W282_G0.5230.35
69_Y110_C0.5220.34
10_P27_H0.5220.34
266_Y272_C0.5220.34
98_R194_K0.5220.34
80_A106_S0.5210.34
223_V332_A0.5200.34
16_P185_L0.5190.34
72_T137_Q0.5190.34
13_R329_E0.5190.34
120_P154_K0.5180.34
106_S152_E0.5170.34
288_E291_Q0.5160.34
117_K213_V0.5160.34
176_P303_L0.5150.34
278_M282_G0.5140.34
243_R282_G0.5130.34
10_P86_T0.5120.34
17_L197_M0.5120.34
297_A313_M0.5110.33
10_P29_A0.5100.33
75_F111_F0.5100.33
33_W306_S0.5080.33
125_A189_Y0.5080.33
232_E296_H0.5070.33
121_E154_K0.5070.33
228_A234_L0.5070.33
113_P270_F0.5060.33
57_G70_T0.5060.33
95_P192_E0.5060.33
220_L271_Q0.5060.33
15_N130_I0.5060.33
49_D54_L0.5060.33
61_V106_S0.5060.33
66_N69_Y0.5050.33
140_E144_T0.5040.33
98_R210_S0.5040.33
36_A157_A0.5020.33
25_S75_F0.5010.32
59_V73_Y0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gupA 2 0.9971 100 0.232 Contact Map
1z84A 2 0.8649 100 0.303 Contact Map
4qvuA 4 0.6092 100 0.575 Contact Map
4i5tA 2 0.7414 99.9 0.801 Contact Map
3ksvA 2 0.3994 99.9 0.81 Contact Map
3o0mA 2 0.3937 99.9 0.812 Contact Map
1y23A 2 0.4023 99.9 0.813 Contact Map
3anoA 4 0.4885 99.9 0.814 Contact Map
3l7xA 2 0.4425 99.9 0.814 Contact Map
3lb5A 2 0.3937 99.9 0.818 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0106 seconds.