GREMLIN Database
GALE - UDP-glucose 4-epimerase
UniProt: P09147 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10362
Length: 338 (293)
Sequences: 55321 (38421)
Seq/√Len: 2244.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_G29_I3.1841.00
275_A319_D2.8561.00
242_G261_L2.7111.00
2_R26_D2.7061.00
257_H305_K2.6231.00
19_Q241_D2.6231.00
259_Y309_E2.4811.00
66_T113_A2.4491.00
98_D102_N2.4481.00
122_S243_H2.2691.00
76_T247_M2.2481.00
92_K95_E2.2201.00
317_T320_E2.1871.00
278_K319_D2.1711.00
79_H121_F2.1251.00
30_L57_G2.1221.00
118_N171_S2.0971.00
6_T79_H2.0851.00
241_D315_T2.0651.00
19_Q23_N2.0541.00
279_A323_Q2.0351.00
307_D313_R1.9921.00
61_N64_L1.9861.00
19_Q244_V1.9761.00
181_V321_M1.9751.00
137_V140_F1.9661.00
78_I247_M1.9501.00
304_S308_R1.9471.00
177_Y243_H1.9371.00
57_G64_L1.9131.00
28_I53_T1.8701.00
270_L274_N1.8631.00
23_N248_E1.8381.00
241_D245_V1.8331.00
4_L74_I1.8231.00
237_M324_D1.8221.00
275_A278_K1.8181.00
160_L172_I1.7841.00
5_V17_C1.7781.00
28_I74_I1.7731.00
175_L246_A1.7541.00
26_D53_T1.7431.00
60_R98_D1.7011.00
268_S271_D1.6961.00
264_G307_D1.6781.00
28_I55_V1.6761.00
214_S287_H1.6511.00
16_T240_A1.6311.00
16_T78_I1.6071.00
66_T110_A1.5841.00
2_R28_I1.5791.00
235_H324_D1.5771.00
33_L54_F1.5521.00
62_E109_S1.5491.00
105_L159_I1.5381.00
19_Q22_Q1.5221.00
23_N244_V1.5221.00
206_Q210_G1.5201.00
306_A310_L1.5091.00
102_N105_L1.5011.00
303_A307_D1.4911.00
210_G213_D1.4891.00
323_Q327_H1.4831.00
123_S127_V1.4821.00
105_L109_S1.4761.00
16_T80_F1.4681.00
244_V248_E1.4411.00
154_L158_Q1.4331.00
235_H321_M1.4231.00
75_D117_K1.4211.00
97_Y155_M1.4081.00
138_E305_K1.3991.00
177_Y239_L1.3851.00
104_T156_V1.3821.00
149_Y153_K1.3771.00
3_V25_H1.3761.00
216_A287_H1.3691.00
18_V184_H1.3661.00
12_I180_P1.3641.00
271_D274_N1.3601.00
275_A279_A1.3601.00
64_L67_E1.3531.00
128_Y260_N1.3521.00
94_L98_D1.3501.00
118_N173_A1.3481.00
19_Q240_A1.3361.00
78_I243_H1.3271.00
245_V249_K1.3271.00
178_F301_A1.3241.00
270_L288_F1.3241.00
142_T154_L1.3171.00
79_H104_T1.3081.00
25_H248_E1.3021.00
17_C29_I1.2971.00
66_T114_A1.2881.00
100_N152_S1.2851.00
236_V240_A1.2831.00
80_F122_S1.2791.00
232_D264_G1.2781.00
320_E323_Q1.2711.00
175_L243_H1.2701.00
158_Q161_T1.2661.00
62_E66_T1.2521.00
62_E106_R1.2501.00
316_R324_D1.2431.00
8_G17_C1.2351.00
122_S177_Y1.2351.00
77_V111_M1.2351.00
230_V266_G1.2331.00
207_V213_D1.2221.00
320_E324_D1.1901.00
257_H309_E1.1881.00
214_S285_N1.1881.00
164_Q172_I1.1861.00
121_F156_V1.1801.00
108_I163_L1.1791.00
234_I239_L1.1741.00
59_I103_G1.1571.00
109_S112_R1.1571.00
137_V302_D1.1521.00
70_H114_A1.1391.00
107_L119_F1.1371.00
136_Y140_F1.1371.00
109_S113_A1.1201.00
303_A314_V1.1201.00
69_L74_I1.1171.00
111_M119_F1.1121.00
9_S31_D1.1101.00
267_N318_L1.1081.00
20_L244_V1.1061.00
139_S305_K1.1031.00
305_K309_E1.1031.00
176_R258_I1.0971.00
161_T174_L1.0921.00
69_L77_V1.0891.00
4_L30_L1.0881.00
67_E70_H1.0871.00
3_V20_L1.0861.00
59_I81_A1.0801.00
228_T270_L1.0741.00
29_I52_P1.0731.00
18_V22_Q1.0671.00
151_K155_M1.0551.00
277_S283_P1.0531.00
242_G306_A1.0481.00
121_F160_L1.0351.00
15_H237_M1.0331.00
159_I162_D1.0311.00
66_T70_H1.0271.00
19_Q237_M1.0261.00
262_G301_A1.0241.00
274_N277_S1.0241.00
121_F174_L1.0221.00
21_L52_P1.0141.00
133_K137_V1.0141.00
161_T258_I1.0131.00
108_I119_F1.0121.00
14_S184_H1.0101.00
88_E92_K1.0061.00
289_A292_R1.0001.00
171_S255_G0.9961.00
235_H316_R0.9921.00
176_R260_N0.9891.00
80_F243_H0.9881.00
228_T268_S0.9851.00
319_D323_Q0.9821.00
241_D312_W0.9821.00
157_E176_R0.9711.00
238_D263_A0.9701.00
280_C326_W0.9651.00
3_V76_T0.9631.00
161_T172_I0.9581.00
111_M116_V0.9581.00
55_V68_I0.9571.00
120_I175_L0.9521.00
266_G298_A0.9511.00
99_N103_G0.9511.00
83_L99_N0.9481.00
279_A326_W0.9481.00
63_A66_T0.9471.00
21_L51_H0.9401.00
63_A67_E0.9391.00
266_G300_W0.9391.00
64_L68_I0.9331.00
65_M110_A0.9301.00
119_F160_L0.9271.00
133_K140_F0.9261.00
180_P239_L0.9241.00
11_Y236_V0.9201.00
30_L68_I0.9191.00
181_V235_H0.9151.00
110_A114_A0.9151.00
11_Y182_G0.9111.00
259_Y305_K0.9111.00
48_G52_P0.9051.00
102_N106_R0.8991.00
267_N271_D0.8981.00
62_E113_A0.8951.00
200_L204_I0.8921.00
15_H236_V0.8921.00
112_R168_P0.8891.00
235_H238_D0.8881.00
33_L36_S0.8841.00
262_G303_A0.8821.00
180_P234_I0.8821.00
230_V298_A0.8821.00
324_D327_H0.8811.00
2_R74_I0.8801.00
173_A246_A0.8781.00
108_I160_L0.8781.00
241_D316_R0.8761.00
2_R25_H0.8741.00
30_L65_M0.8741.00
69_L110_A0.8711.00
112_R170_W0.8701.00
245_V248_E0.8681.00
249_K253_K0.8661.00
34_C56_E0.8621.00
30_L64_L0.8611.00
106_R109_S0.8581.00
28_I73_A0.8571.00
237_M316_R0.8551.00
162_D166_A0.8551.00
279_A319_D0.8521.00
32_N58_D0.8511.00
245_V310_L0.8511.00
161_T165_K0.8481.00
110_A113_A0.8481.00
242_G312_W0.8481.00
97_Y101_V0.8471.00
123_S157_E0.8461.00
174_L258_I0.8451.00
6_T107_L0.8431.00
109_S163_L0.8361.00
175_L261_L0.8301.00
254_P257_H0.8281.00
17_C27_V0.8271.00
279_A322_A0.8241.00
134_I140_F0.8221.00
230_V268_S0.8201.00
101_V155_M0.8201.00
33_L56_E0.8131.00
246_A310_L0.8131.00
212_R215_L0.8071.00
69_L114_A0.8071.00
76_T118_N0.8071.00
108_I159_I0.8061.00
3_V78_I0.8041.00
21_L27_V0.8041.00
16_T20_L0.8031.00
97_Y102_N0.8031.00
2_R75_D0.7991.00
6_T81_A0.7991.00
31_D54_F0.7971.00
207_V210_G0.7941.00
227_G270_L0.7931.00
112_R166_A0.7911.00
304_S307_D0.7881.00
183_A324_D0.7861.00
125_A178_F0.7841.00
15_H18_V0.7781.00
264_G303_A0.7751.00
15_H19_Q0.7711.00
274_N278_K0.7691.00
203_Y206_Q0.7681.00
277_S282_K0.7641.00
206_Q209_V0.7641.00
265_V317_T0.7621.00
69_L111_M0.7581.00
96_Y152_S0.7531.00
316_R320_E0.7531.00
15_H240_A0.7521.00
216_A289_A0.7511.00
158_Q162_D0.7461.00
106_R110_A0.7461.00
127_V157_E0.7451.00
3_V247_M0.7451.00
93_P151_K0.7431.00
155_M158_Q0.7411.00
77_V107_L0.7401.00
325_T328_W0.7381.00
97_Y152_S0.7381.00
117_K171_S0.7371.00
104_T160_L0.7321.00
60_R99_N0.7291.00
261_L306_A0.7281.00
203_Y207_V0.7271.00
305_K308_R0.7251.00
241_D244_V0.7231.00
79_H107_L0.7191.00
25_H75_D0.7191.00
95_E98_D0.7181.00
145_P150_G0.7171.00
138_E306_A0.7161.00
178_F262_G0.7161.00
286_Y289_A0.7161.00
283_P286_Y0.7151.00
199_N202_P0.7141.00
238_D241_D0.7131.00
205_A209_V0.7101.00
58_D61_N0.7081.00
83_L96_Y0.7071.00
279_A327_H0.7061.00
245_V312_W0.7031.00
61_N65_M0.7021.00
246_A306_A0.7021.00
16_T243_H0.6991.00
112_R163_L0.6991.00
20_L247_M0.6971.00
267_N272_V0.6951.00
12_I239_L0.6931.00
90_V148_P0.6901.00
103_G106_R0.6891.00
4_L57_G0.6881.00
26_D51_H0.6881.00
196_I199_N0.6861.00
83_L95_E0.6841.00
272_V318_L0.6811.00
271_D275_A0.6771.00
275_A318_L0.6751.00
95_E99_N0.6751.00
125_A301_A0.6731.00
245_V311_N0.6721.00
163_L168_P0.6691.00
104_T108_I0.6681.00
70_H73_A0.6661.00
162_D165_K0.6651.00
65_M106_R0.6651.00
4_L77_V0.6621.00
277_S284_V0.6621.00
132_P140_F0.6621.00
14_S18_V0.6561.00
77_V119_F0.6561.00
172_I256_V0.6551.00
238_D315_T0.6451.00
83_L100_N0.6441.00
135_P302_D0.6431.00
254_P309_E0.6391.00
156_V160_L0.6381.00
316_R321_M0.6371.00
151_K158_Q0.6371.00
183_A235_H0.6351.00
249_K254_P0.6341.00
24_G51_H0.6331.00
155_M159_I0.6311.00
49_G52_P0.6281.00
2_R73_A0.6241.00
208_A277_S0.6221.00
307_D314_V0.6211.00
89_S96_Y0.6181.00
147_S150_G0.6151.00
126_T150_G0.6141.00
177_Y180_P0.6141.00
296_L299_Y0.6141.00
138_E260_N0.6131.00
25_H76_T0.6121.00
15_H184_H0.6041.00
120_I247_M0.6041.00
76_T117_K0.6021.00
199_N203_Y0.6021.00
97_Y151_K0.6011.00
175_L242_G0.6011.00
205_A276_F0.6001.00
232_D263_A0.5991.00
160_L174_L0.5991.00
23_N241_D0.5961.00
275_A322_A0.5951.00
124_S153_K0.5931.00
205_A326_W0.5891.00
197_P200_L0.5851.00
159_I163_L0.5851.00
120_I243_H0.5831.00
112_R169_D0.5821.00
229_G269_V0.5811.00
80_F177_Y0.5801.00
179_N231_R0.5761.00
48_G51_H0.5761.00
82_G100_N0.5751.00
212_R282_K0.5731.00
277_S280_C0.5701.00
287_H290_P0.5691.00
4_L68_I0.5661.00
265_V319_D0.5651.00
315_T320_E0.5641.00
131_Q136_Y0.5631.00
79_H119_F0.5621.00
219_G227_G0.5611.00
100_N149_Y0.5601.00
18_V237_M0.5601.00
212_R216_A0.5601.00
240_A244_V0.5591.00
151_K162_D0.5571.00
164_Q256_V0.5571.00
152_S156_V0.5561.00
124_S127_V0.5481.00
76_T120_I0.5481.00
230_V300_W0.5471.00
68_I74_I0.5461.00
135_P300_W0.5441.00
20_L78_I0.5421.00
201_M272_V0.5411.00
28_I68_I0.5391.00
16_T244_V0.5371.00
17_C21_L0.5351.00
161_T164_Q0.5351.00
4_L69_L0.5341.00
9_S33_L0.5321.00
202_P206_Q0.5311.00
306_A314_V0.5301.00
163_L170_W0.5291.00
29_I54_F0.5271.00
127_V142_T0.5261.00
183_A237_M0.5261.00
23_N245_V0.5251.00
185_P199_N0.5251.00
148_P152_S0.5241.00
104_T121_F0.5241.00
259_Y306_A0.5231.00
93_P148_P0.5231.00
55_V64_L0.5231.00
129_G144_T0.5231.00
174_L256_V0.5221.00
232_D266_G0.5211.00
137_V304_S0.5211.00
120_I246_A0.5181.00
213_D216_A0.5171.00
208_A215_L0.5171.00
145_P154_L0.5161.00
111_M114_A0.5161.00
148_P151_K0.5151.00
181_V263_A0.5121.00
77_V116_V0.5111.00
134_I298_A0.5101.00
184_H328_W0.5101.00
267_N275_A0.5071.00
239_L261_L0.5051.00
287_H291_R0.5041.00
123_S176_R0.5031.00
219_G226_D0.5031.00
9_S29_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1udbA 2 1 100 0.178 Contact Map
1ek6A 2 0.9941 100 0.194 Contact Map
3enkA 2 0.9941 100 0.197 Contact Map
3rufA 2 0.932 100 0.199 Contact Map
1sb8A 2 0.9349 100 0.201 Contact Map
2c20A 2 0.9704 100 0.201 Contact Map
4lisA 2 0.9911 100 0.202 Contact Map
1oc2A 2 0.926 100 0.207 Contact Map
1z45A 2 0.9527 100 0.209 Contact Map
1gy8A 2 0.9882 100 0.211 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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