GREMLIN Database
HEMX - Putative uroporphyrinogen-III C-methyltransferase
UniProt: P09127 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10433
Length: 393 (344)
Sequences: 745 (590)
Seq/√Len: 31.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_A188_I5.2701.00
56_G60_Q4.1491.00
166_D181_R4.0621.00
198_D201_G3.7831.00
313_V328_L3.5671.00
54_L58_G3.3991.00
41_A45_A3.3871.00
133_W166_D3.1981.00
139_D354_E3.0451.00
151_S168_S2.8501.00
310_S328_L2.7841.00
306_L331_V2.7741.00
217_R324_T2.7721.00
273_P312_W2.6441.00
309_V331_V2.5801.00
205_K330_E2.5701.00
165_A184_I2.5421.00
209_L327_F2.5411.00
57_W60_Q2.5021.00
239_I245_N2.4620.99
247_Q250_W2.4120.99
34_N38_I2.3980.99
133_W137_Q2.3800.99
183_A187_D2.2930.99
299_E303_R2.2530.99
49_A53_G2.2330.99
161_L291_A2.2090.99
273_P282_N2.2000.99
143_K289_V2.1690.99
314_R328_L2.1660.99
278_Y282_N2.1630.99
281_E284_R2.1020.98
163_K192_S2.0970.98
36_A40_S2.0840.98
55_Y59_K2.0670.98
165_A344_P2.0370.98
33_N36_A1.9470.97
203_I291_A1.9300.97
279_L282_N1.9080.97
202_I337_Q1.9050.97
204_L309_V1.8930.97
281_E288_L1.8360.96
132_T136_A1.8260.96
302_Y339_I1.8110.96
245_N257_F1.7730.95
280_R317_Y1.7730.95
214_D284_R1.7710.95
197_V339_I1.7570.95
142_V350_Q1.7520.95
187_D216_L1.7370.94
49_A52_I1.6880.94
278_Y281_E1.6600.93
52_I55_Y1.6600.93
43_A50_A1.6510.93
34_N40_S1.6430.93
18_V26_A1.6320.92
148_K152_D1.6140.92
44_I60_Q1.6130.92
213_V319_T1.5820.91
186_D348_Q1.5650.91
41_A53_G1.5540.90
148_K288_L1.5520.90
43_A54_L1.5390.90
161_L165_A1.5150.89
276_D280_R1.5090.89
140_F152_D1.5080.89
105_N109_E1.4860.88
54_L57_W1.4710.88
104_A107_Q1.4700.88
23_Q27_T1.4330.86
48_L55_Y1.4060.85
169_L181_R1.3930.85
217_R318_D1.3930.85
20_T23_Q1.3920.85
142_V184_I1.3910.85
213_V233_E1.3850.84
55_Y58_G1.3850.84
138_A166_D1.3780.84
139_D350_Q1.3720.84
161_L289_V1.3690.84
147_R257_F1.3600.83
303_R335_S1.3430.82
108_Q180_V1.3410.82
136_A139_D1.3320.82
149_L155_V1.3280.82
51_G60_Q1.3270.82
198_D273_P1.3250.81
166_D201_G1.3230.81
49_A56_G1.3220.81
282_N316_Y1.3200.81
50_A59_K1.3160.81
247_Q251_Q1.3040.80
182_R294_V1.3040.80
202_I349_S1.2930.80
49_A74_N1.2870.80
133_W161_L1.2810.79
21_T26_A1.2520.78
152_D291_A1.2490.77
23_Q28_E1.2340.77
148_K305_A1.2310.76
137_Q158_A1.2280.76
143_K269_P1.2250.76
137_Q181_R1.2200.76
298_Q321_D1.2170.76
181_R201_G1.2110.75
235_L245_N1.2080.75
286_R308_N1.2020.75
151_S269_P1.1960.74
25_V33_N1.1910.74
48_L52_I1.1900.74
174_D305_A1.1860.74
19_D22_S1.1810.73
100_Q105_N1.1700.73
146_G347_L1.1690.73
52_I232_G1.1630.72
147_R157_T1.1600.72
149_L154_D1.1550.72
137_Q302_Y1.1520.71
19_D27_T1.1440.71
118_V317_Y1.1400.71
282_N312_W1.1340.70
128_S168_S1.1250.70
236_S248_K1.1240.69
64_N329_D1.1220.69
146_G281_E1.1140.69
192_S335_S1.1140.69
243_R246_L1.1130.69
250_W254_M1.1120.69
103_Q345_E1.1100.69
270_L280_R1.1080.68
125_I175_P1.1040.68
238_S244_I1.1040.68
142_V353_L1.1040.68
39_L46_I1.0960.68
142_V187_D1.0930.67
22_S213_V1.0920.67
139_D147_R1.0880.67
35_T38_I1.0820.67
201_G309_V1.0820.67
187_D347_L1.0820.67
21_T25_V1.0700.66
279_L328_L1.0640.65
19_D26_A1.0600.65
310_S332_D1.0540.64
33_N37_L1.0530.64
140_F143_K1.0520.64
107_Q110_T1.0490.64
21_T28_E1.0480.64
165_A181_R1.0480.64
149_L175_P1.0440.64
148_K154_D1.0440.64
28_E260_I1.0380.63
69_S102_K1.0360.63
129_D288_L1.0280.62
134_L172_M1.0230.62
133_W201_G1.0200.62
60_Q313_V1.0180.62
272_A346_T1.0180.62
285_S295_P1.0120.61
62_A65_Q1.0110.61
146_G166_D1.0100.61
184_I316_Y1.0080.61
84_E87_K1.0070.61
244_I258_I1.0070.61
49_A55_Y1.0030.61
161_L257_F1.0010.60
217_R321_D1.0000.60
339_I349_S0.9990.60
85_S334_L0.9980.60
24_P27_T0.9960.60
275_Q278_Y0.9920.60
72_L100_Q0.9910.60
189_A341_M0.9910.60
148_K157_T0.9880.59
187_D349_S0.9830.59
177_L316_Y0.9800.59
31_S36_A0.9800.59
177_L356_L0.9740.58
187_D288_L0.9690.58
198_D278_Y0.9670.58
94_I98_A0.9670.58
315_A335_S0.9670.58
44_I48_L0.9660.58
189_A316_Y0.9640.57
166_D198_D0.9620.57
242_W298_Q0.9610.57
25_V28_E0.9610.57
126_S137_Q0.9600.57
93_I330_E0.9590.57
22_S26_A0.9570.57
318_D324_T0.9570.57
133_W138_A0.9560.57
169_L286_R0.9520.56
153_Q207_N0.9480.56
135_L274_N0.9480.56
147_R150_W0.9380.55
238_S245_N0.9370.55
184_I206_L0.9370.55
149_L158_A0.9350.55
207_N268_V0.9300.55
151_S175_P0.9300.55
50_A57_W0.9260.54
166_D302_Y0.9240.54
168_S286_R0.9220.54
122_V149_L0.9220.54
172_M313_V0.9210.54
163_K355_K0.9180.54
214_D282_N0.9170.54
154_D174_D0.9140.53
22_S29_K0.9130.53
101_L104_A0.9120.53
33_N65_Q0.9100.53
133_W181_R0.9080.53
38_I42_V0.9020.52
246_L250_W0.8990.52
238_S241_E0.8980.52
270_L282_N0.8900.51
143_K291_A0.8900.51
65_Q79_L0.8860.51
93_I97_Q0.8860.51
205_K333_Q0.8840.51
166_D185_T0.8830.51
45_A56_G0.8810.51
281_E305_A0.8770.50
205_K331_V0.8760.50
245_N347_L0.8760.50
91_E95_K0.8740.50
37_L62_A0.8690.50
273_P278_Y0.8670.50
154_D305_A0.8640.49
50_A54_L0.8610.49
144_L160_A0.8590.49
142_V347_L0.8590.49
72_L77_T0.8590.49
124_T317_Y0.8560.49
43_A59_K0.8520.48
32_K232_G0.8520.48
183_A242_W0.8500.48
136_A181_R0.8480.48
133_W349_S0.8480.48
269_P292_Q0.8470.48
160_A164_S0.8470.48
96_Q321_D0.8430.48
168_S288_L0.8430.48
88_A186_D0.8420.48
19_D24_P0.8410.47
267_A280_R0.8390.47
151_S261_R0.8330.47
69_S84_E0.8300.47
162_L292_Q0.8260.46
187_D353_L0.8230.46
129_D147_R0.8210.46
87_K90_L0.8200.46
136_A168_S0.8170.45
269_P312_W0.8170.45
177_L357_M0.8120.45
31_S93_I0.8110.45
187_D245_N0.8100.45
174_D177_L0.8100.45
91_E348_Q0.8080.45
18_V28_E0.8070.45
153_Q297_H0.8060.45
76_L98_A0.8010.44
20_T29_K0.7990.44
131_K261_R0.7970.44
154_D157_T0.7970.44
201_G324_T0.7880.43
97_Q132_T0.7870.43
232_G348_Q0.7860.43
177_L217_R0.7860.43
146_G350_Q0.7860.43
180_V187_D0.7820.43
133_W140_F0.7810.43
32_K78_A0.7810.43
145_A317_Y0.7790.42
89_E93_I0.7790.42
281_E295_P0.7780.42
41_A54_L0.7760.42
239_I246_L0.7750.42
154_D269_P0.7740.42
48_L54_L0.7740.42
280_R352_M0.7730.42
277_I281_E0.7720.42
52_I61_Q0.7680.42
96_Q109_E0.7630.41
168_S218_L0.7620.41
260_I331_V0.7610.41
54_L59_K0.7610.41
27_T237_S0.7580.41
201_G264_D0.7570.41
272_A275_Q0.7540.40
275_Q316_Y0.7520.40
21_T31_S0.7500.40
224_D284_R0.7490.40
329_D332_D0.7490.40
148_K346_T0.7490.40
64_N74_N0.7470.40
298_Q301_T0.7470.40
102_K105_N0.7460.40
170_A356_L0.7460.40
62_A66_T0.7440.40
118_V318_D0.7430.40
236_S245_N0.7390.39
136_A288_L0.7360.39
104_A332_D0.7360.39
277_I291_A0.7330.39
28_E351_A0.7330.39
147_R292_Q0.7330.39
70_D313_V0.7310.39
147_R151_S0.7310.39
286_R289_V0.7310.39
135_L177_L0.7300.39
141_L174_D0.7290.38
31_S41_A0.7270.38
172_M181_R0.7220.38
90_L94_I0.7220.38
272_A317_Y0.7200.38
112_A195_S0.7200.38
100_Q110_T0.7170.38
202_I309_V0.7160.37
35_T306_L0.7160.37
32_K47_A0.7150.37
57_W141_L0.7150.37
95_K98_A0.7110.37
259_T271_L0.7060.37
261_R294_V0.7040.37
180_V353_L0.7040.37
122_V154_D0.7030.36
54_L60_Q0.7020.36
67_A76_L0.6990.36
37_L180_V0.6980.36
40_S54_L0.6960.36
59_K202_I0.6950.36
19_D23_Q0.6950.36
210_S296_R0.6940.36
202_I356_L0.6940.36
302_Y334_L0.6900.36
147_R294_V0.6890.35
31_S99_A0.6880.35
43_A46_I0.6870.35
71_A100_Q0.6870.35
135_L142_V0.6860.35
57_W111_L0.6860.35
149_L160_A0.6850.35
26_A96_Q0.6850.35
198_D288_L0.6840.35
77_T80_Q0.6840.35
114_Q262_R0.6820.35
220_D298_Q0.6820.35
142_V346_T0.6800.35
90_L97_Q0.6770.35
146_G187_D0.6760.34
25_V34_N0.6750.34
46_I197_V0.6750.34
155_V191_L0.6740.34
21_T30_K0.6720.34
18_V21_T0.6720.34
330_E333_Q0.6700.34
272_A280_R0.6680.34
19_D28_E0.6670.34
81_K84_E0.6620.33
146_G283_I0.6600.33
57_W88_A0.6580.33
133_W136_A0.6580.33
73_A76_L0.6570.33
137_Q172_M0.6540.33
154_D158_A0.6530.33
116_D119_Q0.6530.33
229_D234_E0.6530.33
140_F259_T0.6520.33
141_L148_K0.6520.33
103_Q190_S0.6510.33
141_L289_V0.6500.33
262_R296_R0.6490.32
218_L281_E0.6490.32
133_W302_Y0.6470.32
220_D291_A0.6460.32
154_D181_R0.6450.32
129_D276_D0.6450.32
206_L308_N0.6440.32
136_A218_L0.6430.32
102_K331_V0.6430.32
28_E329_D0.6430.32
130_A147_R0.6420.32
46_I188_I0.6420.32
278_Y318_D0.6390.32
243_R250_W0.6340.31
50_A225_G0.6340.31
133_W174_D0.6320.31
42_V52_I0.6320.31
76_L79_L0.6310.31
38_I108_Q0.6300.31
72_L78_A0.6290.31
40_S44_I0.6280.31
272_A338_N0.6250.31
46_I50_A0.6250.31
236_S257_F0.6240.31
124_T298_Q0.6240.31
18_V35_T0.6230.31
73_A79_L0.6190.30
19_D30_K0.6170.30
18_V25_V0.6160.30
146_G203_I0.6150.30
146_G353_L0.6150.30
224_D238_S0.6150.30
46_I49_A0.6150.30
206_L290_A0.6110.30
40_S258_I0.6090.30
133_W198_D0.6090.30
244_I311_T0.6070.30
231_D234_E0.6070.30
142_V356_L0.6040.29
260_I326_A0.6040.29
82_A107_Q0.6030.29
43_A58_G0.6030.29
139_D148_K0.6010.29
146_G201_G0.5990.29
68_T72_L0.5990.29
135_L357_M0.5970.29
262_R282_N0.5970.29
50_A55_Y0.5970.29
165_A312_W0.5960.29
281_E348_Q0.5950.29
298_Q349_S0.5950.29
156_T327_F0.5950.29
241_E244_I0.5930.29
23_Q26_A0.5930.29
291_A305_A0.5910.28
229_D233_E0.5910.28
78_A84_E0.5900.28
213_V327_F0.5880.28
245_N250_W0.5870.28
348_Q352_M0.5860.28
71_A91_E0.5830.28
307_E310_S0.5810.28
147_R187_D0.5800.28
137_Q276_D0.5800.28
324_T352_M0.5780.28
192_S261_R0.5770.28
18_V22_S0.5730.27
23_Q44_I0.5720.27
95_K107_Q0.5710.27
257_F295_P0.5690.27
280_R318_D0.5690.27
154_D353_L0.5690.27
147_R286_R0.5680.27
182_R219_A0.5680.27
61_Q155_V0.5670.27
195_S210_S0.5670.27
18_V29_K0.5670.27
260_I307_E0.5670.27
310_S335_S0.5650.27
92_G103_Q0.5650.27
96_Q107_Q0.5620.27
129_D132_T0.5610.27
271_L334_L0.5570.26
250_W253_F0.5570.26
160_A298_Q0.5540.26
254_M306_L0.5530.26
313_V327_F0.5520.26
245_N298_Q0.5520.26
263_R282_N0.5500.26
147_R161_L0.5500.26
147_R258_I0.5490.26
23_Q29_K0.5480.26
86_Q94_I0.5470.26
165_A172_M0.5470.26
103_Q246_L0.5470.26
133_W288_L0.5460.26
251_Q254_M0.5440.25
85_S96_Q0.5410.25
69_S72_L0.5410.25
200_D301_T0.5410.25
75_Q233_E0.5400.25
99_A103_Q0.5390.25
185_T208_Q0.5380.25
36_A39_L0.5380.25
226_S244_I0.5370.25
144_L260_I0.5370.25
231_D283_I0.5370.25
272_A312_W0.5360.25
79_L87_K0.5350.25
22_S27_T0.5350.25
148_K347_L0.5340.25
114_Q119_Q0.5340.25
140_F174_D0.5330.25
159_A193_A0.5320.25
305_A352_M0.5310.25
124_T137_Q0.5290.25
217_R331_V0.5290.25
52_I239_I0.5280.24
281_E286_R0.5240.24
23_Q46_I0.5200.24
108_Q222_D0.5200.24
198_D279_L0.5190.24
56_G59_K0.5180.24
148_K203_I0.5170.24
136_A146_G0.5170.24
168_S203_I0.5160.24
96_Q167_A0.5160.24
146_G349_S0.5140.24
278_Y291_A0.5130.24
141_L165_A0.5120.24
174_D263_R0.5110.23
31_S34_N0.5100.23
332_D335_S0.5100.23
124_T195_S0.5100.23
47_A215_N0.5100.23
137_Q166_D0.5100.23
138_A332_D0.5090.23
270_L273_P0.5090.23
279_L312_W0.5060.23
130_A151_S0.5050.23
131_K358_Q0.5040.23
152_D278_Y0.5020.23
40_S57_W0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j6da 3 0.0305 37.6 0.96 Contact Map
4cgkA 3 0.5852 33.6 0.961 Contact Map
4v3iA 2 0.0433 31.4 0.961 Contact Map
2rpaA 1 0.1756 26.5 0.963 Contact Map
3fymA 1 0.0382 21.3 0.964 Contact Map
1x8yA 2 0.1883 20.9 0.964 Contact Map
3tyyA 2 0.1908 17.8 0.965 Contact Map
1gk4A 2 0.2036 14.8 0.967 Contact Map
2xdjA 3 0.1756 12.9 0.968 Contact Map
1scfA 4 0 11.9 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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