GREMLIN Database
HEM4 - Uroporphyrinogen-III synthase
UniProt: P09126 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10430
Length: 246 (234)
Sequences: 3959 (3093)
Seq/√Len: 202.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_L24_Q4.4341.00
213_V219_A3.9221.00
53_S153_T3.6831.00
135_N159_Q3.4231.00
187_G221_L3.1031.00
128_R151_E2.5451.00
55_L85_F2.5451.00
219_A232_V2.5411.00
133_R154_F2.4701.00
53_S130_L2.4401.00
191_Q221_L2.4291.00
181_M212_L2.4181.00
144_T147_A2.3731.00
35_S161_C2.3431.00
18_R22_L2.1631.00
35_S159_Q2.1201.00
44_A70_Q2.1131.00
86_A92_A2.1061.00
190_L222_A2.0491.00
68_Q98_V2.0331.00
54_D127_K2.0101.00
33_E163_I1.9971.00
163_I192_Q1.9821.00
116_L144_T1.9561.00
58_A64_V1.9111.00
18_R239_D1.9111.00
213_V222_A1.8671.00
211_L227_W1.8411.00
65_A94_A1.8071.00
133_R137_G1.7971.00
84_Y100_G1.7961.00
219_A223_R1.7221.00
16_V28_H1.7111.00
34_F160_R1.6921.00
194_W225_L1.6661.00
104_L118_L1.6561.00
220_K223_R1.6531.00
233_A240_A1.6431.00
111_I114_V1.6281.00
55_L83_D1.6221.00
213_V232_V1.6131.00
94_A97_T1.6021.00
124_I127_K1.5911.00
112_S141_I1.5871.00
36_P66_F1.5851.00
55_L129_A1.5841.00
11_A62_H1.5781.00
113_E138_R1.5701.00
77_K81_L1.5691.00
58_A67_A1.5611.00
220_K224_E1.5601.00
184_V193_L1.5521.00
5_V16_V1.5401.00
16_V26_A1.5371.00
34_F62_H1.5301.00
128_R153_T1.5191.00
191_Q225_L1.5181.00
185_T189_M1.5101.00
139_E143_D1.5021.00
85_F115_L1.4831.00
5_V12_G1.4671.00
236_A240_A1.4601.00
120_E148_R1.4361.00
142_G146_T1.4151.00
235_N240_A1.3991.00
222_A229_D1.3941.00
4_L179_V1.3891.00
66_F157_C1.3841.00
221_L224_E1.3811.00
214_V218_L1.3801.00
184_V190_L1.3701.00
211_L222_A1.3561.00
143_D146_T1.3421.00
61_Q90_T1.3191.00
107_Q118_L1.3171.00
212_L231_K1.3151.00
142_G154_F1.3081.00
135_N156_E1.3011.00
54_D128_R1.2891.00
17_S21_T1.2851.00
17_S20_R1.2791.00
124_I150_A1.2711.00
92_A96_H1.2641.00
215_S218_L1.2631.00
33_E161_C1.2541.00
162_A195_S1.2541.00
222_A227_W1.2541.00
183_V241_L1.2371.00
16_V20_R1.2251.00
49_A52_E1.2251.00
212_L241_L1.2221.00
181_M210_R1.2181.00
20_R26_A1.1951.00
86_A105_Y1.1911.00
52_E128_R1.1851.00
237_D240_A1.1711.00
19_L26_A1.1561.00
160_R188_E1.1541.00
221_L225_L1.1531.00
184_V211_L1.1321.00
113_E140_L1.1231.00
162_A192_Q1.0971.00
31_L192_Q1.0791.00
79_P82_P1.0791.00
56_L84_Y1.0731.00
187_G217_R1.0721.00
92_A105_Y1.0681.00
131_I142_G1.0621.00
194_W227_W1.0571.00
13_E28_H1.0471.00
104_L115_L1.0471.00
45_D49_A1.0471.00
231_K244_A1.0401.00
129_A150_A1.0361.00
123_N127_K1.0301.00
216_E236_A1.0211.00
5_V19_L1.0131.00
210_R231_K1.0061.00
56_L132_L1.0051.00
64_V94_A1.0021.00
137_G154_F0.9951.00
140_L144_T0.9881.00
64_V91_T0.9841.00
168_A172_M0.9811.00
3_I181_M0.9781.00
27_W179_V0.9771.00
18_R21_T0.9630.99
112_S140_L0.9580.99
49_A153_T0.9540.99
187_G218_L0.9490.99
96_H101_Q0.9460.99
77_K80_R0.9450.99
136_G188_E0.9440.99
57_F119_P0.9360.99
55_L104_L0.9350.99
216_E220_K0.9220.99
31_L196_L0.9150.99
9_S12_G0.9060.99
37_G159_Q0.9060.99
89_R110_E0.9040.99
65_A97_T0.8950.99
116_L148_R0.8910.99
86_A95_L0.8910.99
9_S13_E0.8880.99
87_I112_S0.8860.99
144_T148_R0.8730.99
61_Q94_A0.8730.99
32_I160_R0.8560.99
112_S160_R0.8540.99
136_G160_R0.8500.99
93_L97_T0.8410.99
212_L244_A0.8400.99
183_V212_L0.8290.98
34_F66_F0.8290.98
111_I216_E0.8230.98
7_R10_P0.8220.98
62_H66_F0.8200.98
58_A132_L0.8200.98
185_T238_N0.8190.98
43_L157_C0.8180.98
146_T152_V0.8160.98
57_F115_L0.8160.98
131_I141_I0.8150.98
130_L155_C0.8150.98
172_M176_A0.8100.98
37_G156_E0.8060.98
45_D48_A0.8060.98
104_L120_E0.8050.98
222_A226_G0.8040.98
126_G150_A0.8020.98
83_D103_I0.8000.98
112_S116_L0.7980.98
63_A131_I0.7950.98
132_L157_C0.7950.98
12_G28_H0.7930.98
69_S98_V0.7900.98
67_A132_L0.7890.98
211_L230_I0.7880.98
138_R217_R0.7820.98
173_R178_E0.7800.98
15_L183_V0.7780.98
182_V209_C0.7780.98
5_V26_A0.7770.98
171_A175_Q0.7750.98
86_A102_K0.7750.98
96_H102_K0.7730.98
233_A244_A0.7620.97
234_D243_R0.7620.97
65_A69_S0.7610.97
192_Q196_L0.7600.97
62_H65_A0.7570.97
15_L19_L0.7560.97
106_P110_E0.7520.97
90_T93_L0.7520.97
223_R228_Q0.7520.97
7_R189_M0.7500.97
120_E144_T0.7480.97
108_D114_V0.7450.97
5_V28_H0.7420.97
94_A98_V0.7390.97
5_V183_V0.7370.97
116_L140_L0.7320.97
63_A132_L0.7310.97
165_Y196_L0.7290.96
87_I115_L0.7280.96
33_E164_H0.7260.96
66_F69_S0.7260.96
5_V10_P0.7250.96
143_D147_A0.7240.96
58_A84_Y0.7240.96
188_E215_S0.7230.96
233_A236_A0.7200.96
112_S137_G0.7190.96
198_P201_Y0.7150.96
134_G156_E0.7150.96
108_D111_I0.7150.96
223_R232_V0.7140.96
32_I192_Q0.7140.96
115_L119_P0.7070.96
13_E17_S0.7070.96
110_E237_D0.7060.96
31_L193_L0.7050.96
131_I152_V0.7040.96
32_I186_S0.6990.96
55_L119_P0.6940.95
57_F141_I0.6920.95
42_Q45_D0.6910.95
110_E236_A0.6910.95
67_A157_C0.6870.95
134_G157_C0.6860.95
44_A48_A0.6840.95
116_L119_P0.6820.95
7_R11_A0.6770.95
110_E114_V0.6770.95
111_I217_R0.6750.95
133_R156_E0.6620.94
210_R230_I0.6600.94
216_E232_V0.6590.94
111_I236_A0.6580.94
85_F185_T0.6580.94
56_L130_L0.6540.94
9_S28_H0.6520.94
112_S217_R0.6480.93
15_L185_T0.6470.93
48_A74_Q0.6470.93
87_I91_T0.6470.93
121_L148_R0.6460.93
8_P34_F0.6430.93
190_L225_L0.6390.93
117_Q144_T0.6380.93
133_R139_E0.6360.93
93_L96_H0.6360.93
145_L150_A0.6350.93
191_Q224_E0.6340.93
136_G156_E0.6340.93
100_G103_I0.6340.93
85_F104_L0.6280.92
217_R236_A0.6270.92
146_T151_E0.6260.92
118_L122_Q0.6210.92
77_K82_P0.6190.92
32_I188_E0.6190.92
133_R142_G0.6160.92
169_E173_R0.6130.91
42_Q46_Q0.6060.91
3_I6_T0.6040.91
240_A244_A0.6030.91
114_V117_Q0.5990.90
29_F165_Y0.5960.90
134_G188_E0.5940.90
137_G160_R0.5930.90
132_L155_C0.5930.90
36_P69_S0.5920.90
139_E154_F0.5910.90
85_F106_P0.5900.90
29_F167_G0.5900.90
43_L70_Q0.5890.90
116_L141_I0.5850.89
132_L137_G0.5840.89
57_F85_F0.5810.89
191_Q195_S0.5810.89
123_N150_A0.5790.89
183_V242_L0.5780.89
131_I154_F0.5780.89
131_I137_G0.5770.89
39_Q42_Q0.5770.89
12_G16_V0.5760.89
138_R160_R0.5740.88
95_L100_G0.5730.88
44_A74_Q0.5720.88
23_G26_A0.5690.88
9_S15_L0.5670.88
184_V189_M0.5670.88
21_T73_Q0.5650.88
58_A131_I0.5640.88
163_I166_D0.5640.88
87_I134_G0.5640.88
131_I185_T0.5620.87
27_W173_R0.5580.87
137_G217_R0.5570.87
182_V211_L0.5570.87
88_G91_T0.5570.87
112_S138_R0.5560.87
181_M231_K0.5540.87
99_S102_K0.5530.87
116_L120_E0.5510.86
57_F145_L0.5510.86
70_Q73_Q0.5480.86
134_G160_R0.5460.86
166_D169_E0.5440.86
58_A86_A0.5440.86
18_R242_L0.5430.86
112_S188_E0.5400.85
206_L209_C0.5370.85
46_Q153_T0.5360.85
57_F150_A0.5350.85
119_P122_Q0.5350.85
44_A73_Q0.5330.84
55_L118_L0.5330.84
32_I189_M0.5290.84
11_A61_Q0.5290.84
89_R237_D0.5260.84
59_L160_R0.5240.83
41_P45_D0.5230.83
6_T15_L0.5230.83
140_L143_D0.5220.83
20_R25_V0.5220.83
55_L127_K0.5210.83
240_A243_R0.5170.83
119_P148_R0.5170.83
63_A160_R0.5170.83
60_S91_T0.5150.82
14_E17_S0.5140.82
86_A91_T0.5130.82
85_F118_L0.5130.82
13_E66_F0.5120.82
34_F61_Q0.5110.82
190_L213_V0.5100.82
235_N243_R0.5090.82
223_R229_D0.5080.82
103_I106_P0.5070.81
8_P11_A0.5070.81
19_L22_L0.5070.81
47_L50_L0.5050.81
63_A137_G0.5040.81
160_R192_Q0.5030.81
58_A91_T0.5020.81
31_L163_I0.5020.81
139_E142_G0.5000.81
136_G191_Q0.5000.81
211_L229_D0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3re1A 1 0.9837 100 0.12 Contact Map
3mw8A 1 0.9512 100 0.142 Contact Map
3d8tA 1 0.9675 100 0.142 Contact Map
4es6A 1 0.9797 100 0.143 Contact Map
1wcwA 1 0.9675 100 0.145 Contact Map
1jr2A 1 0.9797 100 0.145 Contact Map
3p9zA 1 0.8374 100 0.246 Contact Map
2fepA 2 0.9309 96.2 0.879 Contact Map
3gv0A 2 0.9309 96.1 0.88 Contact Map
3qk7A 2 0.9187 96.1 0.88 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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