GREMLIN Database
XYLB - Xylulose kinase
UniProt: P09099 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11075
Length: 484 (469)
Sequences: 12486 (8510)
Seq/√Len: 392.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_D196_R4.3161.00
104_E137_R3.9331.00
18_N22_E3.5371.00
14_V55_A3.4041.00
107_L137_R3.3361.00
374_A469_R2.9471.00
404_Q408_D2.9351.00
178_D181_K2.9241.00
374_A378_D2.8681.00
381_H412_Q2.8601.00
118_I185_S2.8561.00
413_Q456_L2.7891.00
90_L142_I2.7611.00
34_S92_P2.7611.00
29_E54_R2.7541.00
349_F361_L2.7311.00
177_L202_L2.7101.00
441_S444_E2.6971.00
27_Q58_A2.6331.00
389_S415_D2.6231.00
29_E58_A2.6191.00
440_K444_E2.6091.00
91_R139_E2.5511.00
204_E207_E2.5481.00
49_W159_R2.5231.00
85_A147_D2.4691.00
400_E453_Q2.4601.00
46_E159_R2.4521.00
84_D145_Q2.4281.00
16_L59_L2.4191.00
183_D196_R2.3911.00
189_L196_R2.3791.00
374_A466_Q2.3411.00
178_D185_S2.2691.00
186_D190_Q2.2211.00
231_G236_A2.1851.00
163_E201_A2.1721.00
157_R230_G2.1491.00
15_I425_A2.1441.00
5_I52_T2.1161.00
325_E360_E2.1091.00
148_K164_F2.0791.00
11_G28_T2.0671.00
213_L216_V2.0441.00
458_D461_R2.0381.00
297_C365_V2.0261.00
107_L111_R1.9831.00
320_A360_E1.9741.00
411_G462_Y1.9671.00
46_E88_R1.9471.00
161_T227_V1.9361.00
32_T47_Q1.9341.00
58_A62_Q1.9251.00
357_G360_E1.9231.00
329_F349_F1.9161.00
328_W471_T1.9151.00
392_L403_R1.9141.00
257_G294_A1.9031.00
418_T450_P1.9031.00
3_I56_M1.9021.00
37_H40_W1.8941.00
381_H386_K1.8921.00
469_R473_R1.8581.00
3_I14_V1.8461.00
7_L12_V1.8241.00
301_A365_V1.7901.00
118_I187_V1.7761.00
133_L137_R1.7711.00
203_Y207_E1.7631.00
415_D454_S1.7401.00
82_L135_V1.7311.00
165_A203_Y1.7151.00
87_Q158_L1.7031.00
84_D88_R1.6931.00
106_T110_A1.6721.00
315_A319_Q1.6601.00
408_D461_R1.6571.00
208_I211_A1.6521.00
228_V435_A1.6481.00
248_Q389_S1.6421.00
408_D458_D1.6341.00
208_I228_V1.6111.00
413_Q454_S1.5981.00
371_Y468_R1.5911.00
103_Q107_L1.5801.00
299_D303_K1.5761.00
462_Y466_Q1.5741.00
16_L63_H1.5681.00
81_T152_P1.5561.00
82_L198_Q1.5511.00
378_D473_R1.5301.00
460_Q463_A1.5181.00
34_S47_Q1.5181.00
246_A264_E1.5121.00
346_K353_T1.5101.00
141_E144_R1.5071.00
180_A266_F1.4911.00
44_D47_Q1.4731.00
320_A359_N1.4701.00
378_D381_H1.4691.00
25_A62_Q1.4491.00
27_Q59_L1.4481.00
157_R209_T1.4381.00
433_Q439_E1.4371.00
27_Q55_A1.4291.00
310_V313_L1.4291.00
59_L63_H1.4291.00
363_R367_E1.4261.00
2_Y433_Q1.4161.00
25_A59_L1.4131.00
46_E50_Q1.4061.00
134_W138_H1.4001.00
2_Y438_P1.3861.00
418_T452_E1.3821.00
400_E416_Y1.3751.00
401_Y405_M1.3741.00
83_L150_L1.3721.00
49_W53_D1.3711.00
400_E455_H1.3691.00
70_A432_A1.3681.00
195_S198_Q1.3641.00
161_T210_G1.3631.00
316_A319_Q1.3561.00
211_A224_T1.3561.00
155_Y159_R1.3551.00
253_L406_L1.3441.00
389_S413_Q1.3401.00
25_A63_H1.3391.00
77_M232_G1.3341.00
109_E114_Q1.3341.00
168_M182_R1.3341.00
5_I56_M1.3331.00
370_G405_M1.3281.00
329_F333_L1.3071.00
370_G409_I1.3061.00
251_L406_L1.3051.00
102_A106_T1.3011.00
189_L199_M1.2951.00
12_V52_T1.2881.00
249_A387_P1.2881.00
329_F365_V1.2711.00
312_A315_A1.2681.00
157_R165_A1.2641.00
291_M372_A1.2601.00
317_A401_Y1.2591.00
104_E133_L1.2511.00
370_G406_L1.2491.00
19_E438_P1.2481.00
129_A192_C1.2461.00
139_E142_I1.2331.00
463_A467_P1.2311.00
203_Y209_T1.2251.00
136_Q143_F1.2231.00
79_G93_A1.2201.00
12_V51_A1.2111.00
416_Y455_H1.2071.00
208_I226_P1.2041.00
309_N313_L1.2041.00
111_R191_A1.2011.00
309_N312_A1.1911.00
50_Q54_R1.1901.00
405_M409_I1.1811.00
378_D469_R1.1811.00
350_F475_L1.1801.00
87_Q164_F1.1781.00
231_G431_L1.1731.00
403_R455_H1.1651.00
323_S326_P1.1651.00
375_D473_R1.1641.00
411_G466_Q1.1561.00
5_I14_V1.1561.00
17_L23_V1.1561.00
2_Y436_A1.1551.00
105_C123_M1.1541.00
305_T361_L1.1531.00
60_G65_L1.1511.00
245_D446_L1.1511.00
42_E92_P1.1501.00
44_D92_P1.1491.00
335_G338_T1.1481.00
143_F146_I1.1481.00
60_G63_H1.1441.00
187_V190_Q1.1431.00
327_V356_H1.1431.00
54_R58_A1.1391.00
150_L164_F1.1371.00
165_A209_T1.1361.00
312_A316_A1.1361.00
82_L146_I1.1351.00
374_A410_S1.1331.00
248_Q391_T1.1261.00
208_I435_A1.1231.00
466_Q470_E1.1191.00
245_D248_Q1.1191.00
461_R464_A1.1141.00
451_L454_S1.1141.00
311_P314_I1.1051.00
356_H360_E1.1041.00
48_W152_P1.1021.00
293_S297_C1.1001.00
168_M202_L1.0951.00
141_E145_Q1.0951.00
52_T156_L1.0911.00
352_L356_H1.0821.00
112_V115_S1.0811.00
146_I198_Q1.0781.00
391_T415_D1.0751.00
103_Q106_T1.0741.00
245_D443_I1.0731.00
168_M177_L1.0711.00
117_V268_S1.0671.00
45_P81_T1.0651.00
33_V43_Q1.0651.00
70_A436_A1.0651.00
293_S296_S1.0611.00
82_L132_L1.0601.00
17_L429_A1.0551.00
73_I157_R1.0521.00
247_N388_Q1.0521.00
471_T474_R1.0491.00
106_T109_E1.0461.00
316_A358_P1.0411.00
47_Q50_Q1.0371.00
430_R445_L1.0361.00
104_E138_H1.0321.00
100_R134_W1.0311.00
245_D388_Q1.0281.00
314_I399_S1.0281.00
91_R142_I1.0271.00
41_S97_N1.0261.00
377_M410_S1.0251.00
27_Q62_Q1.0251.00
434_I445_L1.0241.00
189_L194_L1.0181.00
31_L51_A1.0171.00
371_Y409_I1.0171.00
369_V396_G1.0141.00
308_S312_A1.0111.00
52_T56_M1.0111.00
433_Q438_P1.0051.00
129_A175_M1.0031.00
70_A228_V1.0011.00
313_L317_A0.9981.00
347_G352_L0.9961.00
398_R420_G0.9951.00
249_A261_A0.9931.00
53_D57_K0.9911.00
107_L110_A0.9901.00
336_E339_P0.9891.00
458_D462_Y0.9881.00
245_D447_P0.9881.00
317_A320_A0.9841.00
104_E107_L0.9801.00
74_A424_P0.9791.00
58_A61_D0.9781.00
14_V59_L0.9761.00
132_L149_V0.9761.00
430_R449_L0.9761.00
57_K61_D0.9751.00
71_L225_V0.9701.00
297_C329_F0.9671.00
352_L361_L0.9661.00
18_N24_V0.9651.00
315_A318_Q0.9621.00
396_G402_W0.9591.00
306_G358_P0.9571.00
16_L68_V0.9561.00
168_M280_A0.9531.00
314_I362_A0.9521.00
182_R204_E0.9461.00
3_I16_L0.9411.00
113_P191_A0.9391.00
88_R159_R0.9381.00
316_A359_N0.9381.00
146_I149_V0.9371.00
332_Y335_G0.9351.00
69_K436_A0.9311.00
271_E382_A0.9301.00
374_A409_I0.9301.00
82_L149_V0.9291.00
166_S171_A0.9291.00
158_L164_F0.9281.00
250_M393_I0.9271.00
211_A226_P0.9261.00
444_E447_P0.9241.00
259_Y377_M0.9231.00
411_G464_A0.9231.00
317_A359_N0.9211.00
117_V180_A0.9201.00
140_P144_R0.9201.00
177_L181_K0.9181.00
17_L426_L0.9181.00
142_I145_Q0.9171.00
265_G284_R0.9161.00
363_R401_Y0.9141.00
228_V436_A0.9121.00
3_I68_V0.9091.00
107_L133_L0.9081.00
371_Y469_R0.9061.00
60_G68_V0.9061.00
439_E445_L0.9061.00
329_F364_A0.9051.00
459_A462_Y0.9011.00
317_A362_A0.9001.00
319_Q359_N0.8971.00
147_D197_D0.8941.00
389_S454_S0.8931.00
410_S413_Q0.8931.00
459_A464_A0.8921.00
257_G373_L0.8921.00
72_G228_V0.8831.00
378_D382_A0.8831.00
154_D166_S0.8821.00
64_S67_D0.8811.00
133_L136_Q0.8781.00
390_V410_S0.8761.00
91_R135_V0.8751.00
68_V225_V0.8741.00
129_A176_W0.8741.00
168_M204_E0.8741.00
180_A268_S0.8711.00
7_L156_L0.8701.00
308_S314_I0.8681.00
162_G213_L0.8641.00
315_A400_E0.8641.00
135_V142_I0.8631.00
80_A149_V0.8581.00
328_W350_F0.8581.00
459_A463_A0.8551.00
73_I156_L0.8541.00
29_E55_A0.8491.00
316_A320_A0.8481.00
203_Y229_A0.8451.00
184_W199_M0.8411.00
166_S200_P0.8401.00
78_H173_G0.8391.00
105_C125_P0.8341.00
165_A201_A0.8331.00
237_G393_I0.8321.00
169_S279_H0.8311.00
171_A184_W0.8281.00
99_G124_M0.8251.00
404_Q458_D0.8241.00
318_Q401_Y0.8201.00
214_P224_T0.8181.00
377_M381_H0.8171.00
77_M170_D0.8171.00
264_E284_R0.8171.00
83_L87_Q0.8131.00
66_Q223_A0.8121.00
30_K299_D0.8121.00
467_P470_E0.8121.00
105_C130_P0.8101.00
151_L174_T0.8071.00
434_I442_L0.8061.00
73_I160_M0.8051.00
324_A328_W0.8041.00
109_E123_M0.8001.00
349_F365_V0.7991.00
56_M60_G0.7981.00
183_D201_A0.7981.00
7_L52_T0.7971.00
397_A420_G0.7951.00
321_D324_A0.7941.00
212_L225_V0.7911.00
332_Y336_E0.7901.00
90_L145_Q0.7891.00
392_L416_Y0.7881.00
301_A362_A0.7841.00
415_D451_L0.7841.00
234_N258_V0.7831.00
77_M288_M0.7821.00
261_A380_V0.7811.00
313_L316_A0.7801.00
69_K438_P0.7781.00
366_L405_M0.7781.00
133_L193_D0.7771.00
366_L399_S0.7751.00
249_A390_V0.7731.00
23_V26_A0.7721.00
31_L43_Q0.7721.00
313_L362_A0.7721.00
439_E448_Q0.7721.00
132_L176_W0.7711.00
300_W303_K0.7711.00
335_G339_P0.7711.00
45_P92_P0.7701.00
322_E363_R0.7691.00
153_K230_G0.7681.00
258_V290_V0.7681.00
26_A421_D0.7671.00
103_Q138_H0.7651.00
30_K302_A0.7621.00
392_L406_L0.7601.00
311_P315_A0.7581.00
96_W256_S0.7581.00
444_E448_Q0.7561.00
451_L457_P0.7541.00
42_E100_R0.7521.00
29_E51_A0.7521.00
375_D469_R0.7491.00
468_R471_T0.7481.00
84_D90_L0.7481.00
251_L373_L0.7471.00
310_V317_A0.7471.00
251_L257_G0.7421.00
83_L164_F0.7421.00
294_A369_V0.7411.00
177_L182_R0.7371.00
187_V191_A0.7361.00
50_Q53_D0.7351.00
103_Q137_R0.7351.00
47_Q51_A0.7341.00
370_G402_W0.7341.00
53_D216_V0.7321.00
4_G72_G0.7311.00
379_V382_A0.7311.00
298_L314_I0.7301.00
20_Q448_Q0.7291.00
183_D186_D0.7291.00
321_D325_E0.7291.00
70_A226_P0.7281.00
46_E155_Y0.7281.00
82_L90_L0.7271.00
467_P471_T0.7271.00
17_L419_G0.7261.00
166_S202_L0.7241.00
463_A468_R0.7231.00
9_T95_L0.7231.00
326_P468_R0.7201.00
314_I401_Y0.7191.00
53_D159_R0.7191.00
71_L212_L0.7181.00
374_A473_R0.7181.00
46_E89_V0.7171.00
237_G424_P0.7171.00
241_V250_M0.7161.00
301_A361_L0.7141.00
241_V393_I0.7111.00
118_I178_D0.7091.00
52_T55_A0.7061.00
317_A321_D0.7051.00
216_V224_T0.7041.00
19_E69_K0.7031.00
243_M250_M0.7021.00
81_T93_A0.7011.00
169_S231_G0.6991.00
157_R161_T0.6981.00
212_L222_M0.6981.00
266_F275_H0.6961.00
392_L414_L0.6961.00
433_Q437_N0.6961.00
434_I441_S0.6961.00
397_A403_R0.6951.00
301_A305_T0.6941.00
178_D183_D0.6921.00
85_A145_Q0.6900.99
310_V314_I0.6890.99
185_S188_M0.6890.99
233_D255_T0.6890.99
209_T229_A0.6880.99
83_L155_Y0.6870.99
7_L51_A0.6870.99
190_Q196_R0.6850.99
243_M248_Q0.6850.99
12_V31_L0.6850.99
87_Q147_D0.6850.99
390_V412_Q0.6850.99
289_S376_G0.6850.99
456_L459_A0.6830.99
84_D147_D0.6830.99
216_V221_G0.6820.99
388_Q412_Q0.6820.99
106_T344_Q0.6820.99
83_L158_L0.6790.99
56_M59_L0.6780.99
461_R466_Q0.6770.99
345_A348_V0.6770.99
94_I100_R0.6750.99
211_A214_P0.6740.99
308_S311_P0.6720.99
326_P367_E0.6710.99
155_Y158_L0.6710.99
324_A360_E0.6700.99
263_S267_L0.6700.99
144_R148_K0.6670.99
466_Q469_R0.6640.99
404_Q455_H0.6640.99
222_M225_V0.6640.99
36_P40_W0.6630.99
205_G230_G0.6610.99
251_L390_V0.6590.99
15_I23_V0.6580.99
367_E405_M0.6570.99
182_R280_A0.6550.99
49_W216_V0.6540.99
83_L148_K0.6510.99
322_E464_A0.6500.99
75_G170_D0.6480.99
123_M175_M0.6470.99
390_V414_L0.6460.99
399_S402_W0.6460.99
272_S288_M0.6460.99
54_R57_K0.6460.99
46_E92_P0.6440.99
340_H473_R0.6420.99
443_I446_L0.6410.99
389_S412_Q0.6390.99
133_L143_F0.6390.99
80_A128_T0.6360.99
430_R434_I0.6360.99
430_R448_Q0.6320.99
190_Q195_S0.6320.99
464_A468_R0.6310.99
108_L192_C0.6300.99
314_I317_A0.6290.99
119_T188_M0.6270.99
445_L449_L0.6270.99
17_L425_A0.6240.99
257_G406_L0.6200.99
403_R416_Y0.6200.99
334_S354_H0.6190.99
387_P412_Q0.6190.99
76_Q96_W0.6170.99
340_H375_D0.6170.99
154_D164_F0.6160.99
323_S363_R0.6160.99
101_C130_P0.6150.99
75_G152_P0.6150.99
132_L198_Q0.6150.99
325_E355_Q0.6140.99
153_K170_D0.6140.99
416_Y452_E0.6130.99
188_M192_C0.6130.99
176_W199_M0.6130.99
332_Y338_T0.6120.99
133_L192_C0.6120.99
382_A473_R0.6110.99
68_V222_M0.6100.99
321_D360_E0.6090.99
340_H476_Y0.6080.99
81_T89_V0.6070.99
307_L312_A0.6070.99
470_E473_R0.6030.99
291_M376_G0.6030.99
169_S205_G0.6030.99
441_S447_P0.6020.99
94_I135_V0.6010.99
329_F368_G0.5990.99
363_R405_M0.5990.99
434_I439_E0.5960.99
208_I436_A0.5960.99
260_F286_H0.5950.99
204_E280_A0.5950.99
330_L476_Y0.5940.98
326_P363_R0.5940.98
253_L392_L0.5940.98
325_E356_H0.5940.98
226_P436_A0.5910.98
323_S360_E0.5910.98
53_D56_M0.5890.98
145_Q148_K0.5880.98
23_V419_G0.5880.98
242_G446_L0.5880.98
346_K350_F0.5870.98
190_Q193_D0.5870.98
112_V188_M0.5870.98
26_A62_Q0.5870.98
240_G423_G0.5820.98
463_A466_Q0.5820.98
232_G235_A0.5810.98
108_L130_P0.5800.98
143_F195_S0.5800.98
234_N252_S0.5790.98
326_P360_E0.5780.98
320_A325_E0.5780.98
42_E91_R0.5780.98
276_S286_H0.5770.98
413_Q457_P0.5770.98
46_E49_W0.5750.98
434_I437_N0.5750.98
143_F193_D0.5750.98
320_A363_R0.5740.98
411_G459_A0.5730.98
323_S327_V0.5730.98
174_T184_W0.5730.98
127_F173_G0.5720.98
143_F147_D0.5710.98
320_A324_A0.5710.98
71_L227_V0.5690.98
367_E371_Y0.5680.98
130_P175_M0.5680.98
45_P93_A0.5670.98
172_A278_C0.5660.98
400_E404_Q0.5650.98
369_V402_W0.5650.98
452_E457_P0.5640.98
216_V222_M0.5640.98
206_S435_A0.5640.98
330_L348_V0.5630.98
194_L199_M0.5620.98
136_Q193_D0.5590.98
44_D50_Q0.5580.98
290_V337_R0.5570.98
205_G231_G0.5570.98
121_N127_F0.5570.98
16_L65_L0.5570.98
88_R145_Q0.5560.98
77_M173_G0.5560.98
40_W94_I0.5560.98
162_G215_E0.5530.98
188_M191_A0.5530.98
324_A363_R0.5520.98
304_L357_G0.5510.98
226_P229_A0.5510.98
89_V92_P0.5490.98
111_R133_L0.5480.97
87_Q148_K0.5470.97
102_A125_P0.5470.97
79_G95_L0.5460.97
299_D310_V0.5460.97
248_Q446_L0.5460.97
333_L336_E0.5450.97
100_R138_H0.5450.97
238_A260_F0.5440.97
445_L448_Q0.5430.97
279_H282_P0.5430.97
314_I366_L0.5420.97
201_A207_E0.5420.97
336_E342_N0.5420.97
331_P335_G0.5410.97
51_A54_R0.5410.97
324_A367_E0.5400.97
35_R41_S0.5390.97
163_E203_Y0.5390.97
157_R229_A0.5390.97
125_P343_P0.5390.97
48_W93_A0.5380.97
10_S13_K0.5370.97
82_L91_R0.5370.97
163_E211_A0.5360.97
406_L410_S0.5360.97
404_Q407_A0.5350.97
397_A416_Y0.5350.97
419_G426_L0.5350.97
74_A428_A0.5350.97
22_E450_P0.5330.97
261_A387_P0.5330.97
255_T296_S0.5320.97
41_S95_L0.5320.97
206_S282_P0.5320.97
407_A414_L0.5310.97
2_Y69_K0.5310.97
239_V430_R0.5300.97
326_P471_T0.5300.97
425_A428_A0.5300.97
342_N345_A0.5300.97
40_W100_R0.5260.97
327_V361_L0.5250.97
238_A278_C0.5250.97
28_T421_D0.5250.97
466_Q473_R0.5250.97
259_Y376_G0.5230.97
57_K60_G0.5220.97
331_P368_G0.5210.97
154_D200_P0.5200.97
248_Q388_Q0.5190.97
206_S434_I0.5190.97
168_M205_G0.5180.96
251_L259_Y0.5170.96
263_S287_L0.5160.96
9_T96_W0.5160.96
442_L446_L0.5160.96
15_I426_L0.5150.96
328_W371_Y0.5140.96
249_A377_M0.5140.96
78_H256_S0.5140.96
418_T451_L0.5140.96
443_I447_P0.5110.96
150_L158_L0.5110.96
22_E418_T0.5100.96
233_D395_G0.5100.96
169_S235_A0.5090.96
144_R147_D0.5080.96
151_L170_D0.5060.96
239_V279_H0.5060.96
80_A135_V0.5060.96
405_M468_R0.5060.96
252_S393_I0.5050.96
302_A310_V0.5050.96
411_G461_R0.5050.96
242_G449_L0.5050.96
257_G291_M0.5040.96
175_M192_C0.5040.96
119_T185_S0.5040.96
180_A183_D0.5040.96
371_Y471_T0.5040.96
266_F285_W0.5030.96
76_Q232_G0.5030.96
250_M260_F0.5020.96
373_L406_L0.5020.96
323_S468_R0.5000.96
213_L224_T0.5000.96
318_Q400_E0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2itmA 2 0.9814 100 0.099 Contact Map
3ll3A 2 0.9917 100 0.109 Contact Map
3ifrA 2 0.9855 100 0.129 Contact Map
3hz6A 1 0.9793 100 0.132 Contact Map
3qdkA 2 0.9959 100 0.141 Contact Map
3wxlA 2 0.9917 100 0.147 Contact Map
3g25A 3 0.9876 100 0.148 Contact Map
3h3nX 3 0.9876 100 0.149 Contact Map
3ezwA 3 0.9876 100 0.149 Contact Map
2d4wA 2 0.9855 100 0.15 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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