GREMLIN Database
AVTA - Valine--pyruvate aminotransferase
UniProt: P09053 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10107
Length: 417 (349)
Sequences: 41653 (28695)
Seq/√Len: 1536.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
173_H210_Q3.1361.00
55_T59_E3.1271.00
312_Q395_P3.0001.00
362_R407_E2.9521.00
103_T109_A2.8861.00
311_Y315_Q2.8421.00
198_D202_L2.8011.00
128_K151_V2.7641.00
400_A404_I2.6851.00
316_E399_E2.6831.00
331_L344_W2.6011.00
82_L294_K2.4801.00
48_D52_T2.4751.00
358_R361_A2.4621.00
118_A150_F2.4141.00
88_R94_D2.3861.00
262_A267_I2.3221.00
78_E290_C2.2571.00
320_I402_V2.1851.00
400_A403_K2.1351.00
351_T354_Q2.1001.00
257_C289_M2.0811.00
111_F115_N2.0751.00
202_L206_A2.0341.00
197_T200_E2.0321.00
212_G240_N1.9951.00
52_T56_D1.9921.00
81_T85_G1.9631.00
35_L401_G1.9401.00
170_D203_K1.9191.00
158_E200_E1.8901.00
354_Q358_R1.8841.00
85_G294_K1.8651.00
319_A323_R1.8611.00
208_A215_L1.8541.00
320_I323_R1.8171.00
122_A181_G1.8171.00
320_I403_K1.8141.00
171_F175_H1.8081.00
166_K200_E1.8041.00
173_H203_K1.7921.00
113_L242_V1.7651.00
81_T97_P1.7471.00
322_R332_I1.7321.00
315_Q319_A1.7171.00
220_A246_S1.7161.00
318_I322_R1.7141.00
84_A97_P1.7081.00
316_E395_P1.6961.00
56_D291_E1.6701.00
216_V244_C1.6681.00
320_I406_A1.6591.00
316_E320_I1.6501.00
168_H171_F1.6431.00
128_K177_G1.6251.00
113_L216_V1.6171.00
77_T81_T1.6121.00
317_T341_L1.5971.00
203_K206_A1.5961.00
106_S244_C1.5951.00
366_M387_M1.5891.00
394_E397_K1.5881.00
128_K180_T1.5881.00
128_K153_A1.5831.00
145_L150_F1.5751.00
95_I261_I1.5661.00
99_N264_E1.5601.00
352_T370_H1.5601.00
51_Q55_T1.5441.00
87_L261_I1.5431.00
320_I324_Y1.5311.00
134_A154_R1.5241.00
206_A210_Q1.5151.00
182_M216_V1.4951.00
318_I334_K1.4841.00
395_P399_E1.4801.00
78_E294_K1.4801.00
199_E202_L1.4781.00
342_W369_G1.4691.00
173_H211_H1.4511.00
317_T402_V1.4461.00
208_A213_I1.4461.00
82_L85_G1.4431.00
260_I270_I1.4321.00
171_F174_L1.4321.00
323_R406_A1.4161.00
242_V262_A1.4151.00
169_V207_L1.4081.00
83_L259_I1.4061.00
141_A146_E1.3971.00
247_L289_M1.3961.00
318_I341_L1.3951.00
176_I180_T1.3911.00
282_G285_G1.3791.00
128_K179_E1.3711.00
309_F395_P1.3701.00
362_R404_I1.3671.00
169_V203_K1.3641.00
98_Q264_E1.3631.00
83_L102_L1.3611.00
134_A156_N1.3411.00
318_I332_I1.3331.00
207_L211_H1.3321.00
357_Q360_K1.3241.00
309_F312_Q1.3051.00
403_K407_E1.3041.00
303_E308_P1.2981.00
358_R408_E1.2941.00
82_L290_C1.2941.00
52_T55_T1.2911.00
85_G89_E1.2831.00
207_L213_I1.2781.00
53_L291_E1.2741.00
76_K287_A1.2661.00
399_E403_K1.2631.00
324_Y406_A1.2571.00
54_L58_L1.2551.00
74_Q271_T1.2531.00
54_L288_M1.2511.00
114_F118_A1.2481.00
101_A267_I1.2471.00
156_N171_F1.2451.00
206_A209_N1.2441.00
303_E307_K1.2431.00
308_P311_Y1.2401.00
351_T384_H1.2301.00
51_Q59_E1.2231.00
359_L405_L1.2211.00
74_Q80_L1.2151.00
30_P363_G1.2071.00
158_E168_H1.2061.00
80_L84_A1.2061.00
355_L358_R1.2061.00
344_W386_C1.2051.00
114_F145_L1.2021.00
83_L100_I1.2011.00
357_Q361_A1.1981.00
200_E203_K1.1921.00
274_N278_S1.1911.00
269_A272_N1.1901.00
108_S274_N1.1751.00
354_Q357_Q1.1751.00
296_N300_R1.1721.00
177_G180_T1.1711.00
245_M259_I1.1691.00
87_L259_I1.1691.00
290_C294_K1.1691.00
343_L389_M1.1521.00
346_K385_Q1.1481.00
114_F184_C1.1461.00
56_D60_S1.1451.00
308_P312_Q1.1431.00
78_E287_A1.1341.00
314_V318_I1.1321.00
198_D231_S1.1311.00
51_Q58_L1.1181.00
118_A129_V1.1131.00
115_N148_D1.1021.00
26_G29_T1.1001.00
48_D51_Q1.0971.00
309_F313_R1.0941.00
96_E264_E1.0931.00
199_E203_K1.0861.00
235_P238_N1.0851.00
116_L273_M1.0841.00
84_A100_I1.0831.00
104_N108_S1.0761.00
131_F152_S1.0741.00
344_W385_Q1.0721.00
242_V260_I1.0711.00
320_I399_E1.0691.00
205_D237_W1.0661.00
239_P263_N1.0661.00
291_E294_K1.0651.00
356_Y366_M1.0581.00
353_K357_Q1.0511.00
268_T272_N1.0451.00
205_D215_L1.0451.00
322_R334_K1.0431.00
78_E81_T1.0421.00
130_L155_P1.0411.00
77_T80_L1.0361.00
112_Y274_N1.0341.00
317_T398_I1.0341.00
96_E99_N1.0331.00
314_V391_Y1.0331.00
173_H207_L1.0301.00
319_A399_E1.0291.00
77_T97_P1.0271.00
99_N267_I1.0221.00
141_A154_R1.0191.00
352_T385_Q1.0161.00
209_N239_P1.0151.00
49_Y295_R1.0071.00
53_L56_D1.0041.00
364_V405_L1.0031.00
389_M401_G1.0021.00
145_L152_S1.0011.00
397_K400_A1.0011.00
170_D174_L1.0011.00
84_A96_E0.9991.00
119_G122_A0.9931.00
79_L102_L0.9921.00
359_L366_M0.9861.00
109_A244_C0.9841.00
355_L387_M0.9831.00
214_P242_V0.9811.00
324_Y329_R0.9801.00
236_L239_P0.9791.00
117_F214_P0.9761.00
120_R149_L0.9731.00
226_P336_E0.9711.00
396_E399_E0.9691.00
155_P175_H0.9681.00
40_P310_Y0.9671.00
53_L57_M0.9631.00
209_N238_N0.9611.00
324_Y403_K0.9551.00
353_K370_H0.9471.00
116_L270_I0.9411.00
330_C343_L0.9391.00
104_N282_G0.9371.00
100_I261_I0.9351.00
221_Y340_F0.9341.00
291_E295_R0.9331.00
214_P240_N0.9331.00
205_D241_I0.9271.00
352_T356_Y0.9261.00
146_E152_S0.9241.00
233_A241_I0.9231.00
109_A260_I0.9231.00
113_L270_I0.9191.00
244_C260_I0.9181.00
99_N238_N0.9171.00
31_G363_G0.9151.00
324_Y402_V0.8971.00
101_A270_I0.8971.00
316_E319_A0.8961.00
44_P309_F0.8951.00
330_C345_F0.8941.00
319_A322_R0.8911.00
106_S220_A0.8891.00
315_Q334_K0.8881.00
35_L398_I0.8831.00
358_R362_R0.8831.00
136_E186_S0.8821.00
313_R395_P0.8811.00
158_E171_F0.8771.00
107_Q139_G0.8761.00
76_K290_C0.8761.00
106_S246_S0.8751.00
305_V308_P0.8691.00
86_M91_L0.8691.00
215_L233_A0.8651.00
317_T320_I0.8641.00
202_L237_W0.8611.00
52_T59_E0.8601.00
316_E402_V0.8581.00
267_I271_T0.8581.00
167_Y200_E0.8401.00
264_E268_T0.8401.00
314_V335_P0.8361.00
234_R237_W0.8281.00
56_D59_E0.8251.00
393_P397_K0.8251.00
169_V204_L0.8241.00
129_V145_L0.8201.00
214_P266_I0.8191.00
313_R316_E0.8191.00
169_V200_E0.8191.00
274_N281_P0.8151.00
105_G256_R0.8151.00
49_Y291_E0.8141.00
79_L83_L0.8141.00
366_M389_M0.8131.00
158_E163_G0.8121.00
224_P227_G0.8111.00
108_S278_S0.8091.00
362_R408_E0.8081.00
163_G171_F0.8081.00
209_N240_N0.8081.00
219_N243_L0.8071.00
118_A122_A0.8051.00
305_V309_F0.8031.00
31_G397_K0.8021.00
130_L180_T0.8001.00
130_L172_E0.7971.00
165_F197_T0.7941.00
242_V266_I0.7901.00
122_A180_T0.7891.00
47_Q50_F0.7861.00
317_T391_Y0.7861.00
198_D229_I0.7841.00
364_V404_I0.7831.00
262_A270_I0.7821.00
170_D173_H0.7821.00
224_P230_F0.7801.00
176_I207_L0.7781.00
31_G400_A0.7731.00
57_M288_M0.7731.00
89_E297_D0.7721.00
345_F387_M0.7711.00
117_F182_M0.7681.00
49_Y52_T0.7651.00
247_L259_I0.7631.00
257_C281_P0.7621.00
226_P314_V0.7611.00
331_L346_K0.7591.00
86_M250_L0.7591.00
209_N236_L0.7571.00
134_A375_G0.7551.00
237_W241_I0.7551.00
85_G88_R0.7521.00
287_A290_C0.7491.00
107_Q137_Y0.7481.00
49_Y297_D0.7471.00
312_Q315_Q0.7461.00
356_Y368_P0.7451.00
130_L175_H0.7431.00
140_Y183_I0.7401.00
67_L287_A0.7361.00
114_F182_M0.7361.00
355_L359_L0.7351.00
108_S112_Y0.7301.00
306_I310_Y0.7301.00
315_Q318_I0.7261.00
226_P311_Y0.7241.00
112_Y273_M0.7231.00
183_I213_I0.7211.00
38_G221_Y0.7211.00
316_E398_I0.7201.00
80_L97_P0.7201.00
172_E207_L0.7191.00
239_P265_K0.7171.00
46_M50_F0.7161.00
353_K368_P0.7161.00
229_I232_E0.7161.00
352_T368_P0.7151.00
101_A260_I0.7141.00
190_N221_Y0.7131.00
369_G386_C0.7131.00
364_V401_G0.7101.00
237_W240_N0.7081.00
168_H200_E0.7081.00
169_V173_H0.7041.00
41_A313_R0.7031.00
131_F145_L0.7021.00
113_L244_C0.7001.00
114_F150_F0.6981.00
238_N241_I0.6981.00
82_L293_I0.6981.00
54_L284_I0.6951.00
102_L286_P0.6941.00
356_Y387_M0.6921.00
153_A177_G0.6911.00
45_E51_Q0.6901.00
91_L222_G0.6891.00
34_M39_N0.6881.00
158_E164_Q0.6861.00
140_Y145_L0.6841.00
102_L257_C0.6841.00
103_T260_I0.6831.00
355_L408_E0.6811.00
129_V150_F0.6801.00
112_Y270_I0.6781.00
317_T389_M0.6761.00
165_F200_E0.6741.00
86_M222_G0.6741.00
84_A95_I0.6741.00
209_N237_W0.6711.00
352_T355_L0.6691.00
301_L306_I0.6671.00
128_K176_I0.6651.00
323_R399_E0.6641.00
157_I189_T0.6631.00
184_C216_V0.6611.00
257_C285_G0.6561.00
142_D146_E0.6501.00
369_G372_F0.6471.00
60_S291_E0.6441.00
312_Q316_E0.6441.00
155_P171_F0.6441.00
134_A373_F0.6431.00
185_V201_L0.6421.00
53_L288_M0.6421.00
114_F148_D0.6421.00
189_T192_T0.6411.00
55_T58_L0.6381.00
343_L386_C0.6371.00
87_L243_L0.6371.00
195_V337_G0.6371.00
228_I336_E0.6361.00
46_M49_Y0.6341.00
225_F311_Y0.6321.00
50_F292_M0.6301.00
342_W386_C0.6281.00
111_F143_A0.6281.00
208_A212_G0.6271.00
403_K406_A0.6261.00
75_G80_L0.6251.00
107_Q279_L0.6251.00
359_L408_E0.6241.00
49_Y301_L0.6191.00
46_M301_L0.6191.00
230_F233_A0.6161.00
215_L237_W0.6121.00
110_F143_A0.6111.00
301_L305_V0.6051.00
321_I343_L0.6051.00
166_K197_T0.6031.00
223_V307_K0.6021.00
50_F252_L0.6011.00
198_D235_P0.6011.00
132_P167_Y0.6011.00
111_F148_D0.5961.00
101_A262_A0.5941.00
188_P337_G0.5931.00
101_A271_T0.5931.00
332_I341_L0.5931.00
187_R219_N0.5911.00
225_F314_V0.5901.00
36_G365_L0.5901.00
217_I243_L0.5901.00
331_L347_D0.5891.00
330_C409_I0.5871.00
33_I400_A0.5851.00
46_M51_Q0.5831.00
404_I407_E0.5821.00
263_N266_I0.5821.00
180_T213_I0.5811.00
262_A266_I0.5801.00
118_A182_M0.5801.00
302_S307_K0.5791.00
153_A175_H0.5791.00
81_T294_K0.5791.00
344_W347_D0.5781.00
297_D300_R0.5771.00
350_I358_R0.5761.00
248_S256_R0.5761.00
225_F391_Y0.5751.00
121_R151_V0.5741.00
89_E294_K0.5711.00
271_T274_N0.5711.00
172_E183_I0.5711.00
265_K268_T0.5711.00
196_I200_E0.5691.00
38_G340_F0.5691.00
130_L179_E0.5681.00
287_A291_E0.5681.00
398_I401_G0.5671.00
76_K286_P0.5661.00
227_G230_F0.5661.00
118_A181_G0.5651.00
164_Q336_E0.5651.00
187_R195_V0.5651.00
314_V334_K0.5641.00
208_A211_H0.5611.00
288_M291_E0.5601.00
122_A179_E0.5601.00
104_N281_P0.5601.00
247_L293_I0.5591.00
131_F141_A0.5571.00
400_A407_E0.5571.00
80_L98_Q0.5561.00
322_R331_L0.5541.00
201_L217_I0.5531.00
307_K311_Y0.5521.00
172_E204_L0.5511.00
350_I355_L0.5481.00
71_D76_K0.5471.00
35_L389_M0.5461.00
88_R92_G0.5451.00
236_L240_N0.5451.00
111_F277_I0.5441.00
122_A128_K0.5421.00
29_T363_G0.5421.00
26_G30_P0.5421.00
167_Y172_E0.5411.00
115_N273_M0.5411.00
260_I267_I0.5411.00
33_I404_I0.5411.00
130_L183_I0.5401.00
156_N168_H0.5391.00
313_R398_I0.5391.00
342_W388_R0.5391.00
232_E243_L0.5381.00
79_L289_M0.5351.00
228_I231_S0.5351.00
196_I201_L0.5351.00
320_I398_I0.5341.00
198_D234_R0.5341.00
156_N175_H0.5341.00
114_F143_A0.5331.00
402_V406_A0.5331.00
300_R305_V0.5311.00
310_Y339_I0.5311.00
158_E165_F0.5271.00
329_R346_K0.5271.00
32_A365_L0.5241.00
194_N336_E0.5231.00
205_D236_L0.5231.00
205_D233_A0.5211.00
155_P167_Y0.5211.00
41_A44_P0.5201.00
132_P155_P0.5201.00
283_G287_A0.5191.00
356_Y360_K0.5191.00
268_T271_T0.5181.00
81_T84_A0.5181.00
300_R303_E0.5161.00
183_I208_A0.5161.00
222_G245_M0.5151.00
352_T387_M0.5141.00
76_K283_G0.5131.00
190_N388_R0.5131.00
99_N262_A0.5091.00
131_F154_R0.5071.00
72_G77_T0.5071.00
40_P313_R0.5061.00
129_V182_M0.5051.00
143_A148_D0.5021.00
235_P239_P0.5021.00
71_D283_G0.5011.00
351_T370_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3g7qA 2 0.9185 100 0.305 Contact Map
3if2A 2 0.9928 100 0.306 Contact Map
1vp4A 2 0.9472 100 0.313 Contact Map
2r2nA 2 0.9376 100 0.321 Contact Map
3pplA 2 0.9329 100 0.324 Contact Map
4je5A 2 0.9616 100 0.324 Contact Map
2zc0A 4 0.9329 100 0.327 Contact Map
3ez1A 2 0.9113 100 0.33 Contact Map
3dydA 2 0.8825 100 0.335 Contact Map
2zyjA 2 0.9257 100 0.343 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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