GREMLIN Database
EX3 - Exodeoxyribonuclease III
UniProt: P09030 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11073
Length: 268 (249)
Sequences: 5765 (3451)
Seq/√Len: 218.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_L94_A3.6761.00
2_K265_T3.2891.00
31_G149_M3.1601.00
218_K221_D3.1531.00
245_G263_W2.8381.00
198_T233_A2.6411.00
130_Q186_W2.4641.00
242_V267_R2.3511.00
4_V263_W2.3341.00
53_N72_T2.3091.00
247_D263_W2.2681.00
181_P185_E2.1181.00
198_T241_C2.0871.00
168_R181_P2.0371.00
145_P236_P2.0091.00
5_S262_V1.9951.00
133_Q189_R1.9711.00
58_G87_A1.9631.00
191_M232_L1.9441.00
97_P102_N1.9431.00
156_P188_D1.8941.00
243_E265_T1.8921.00
84_D127_Q1.8661.00
211_S262_V1.8541.00
31_G105_V1.8451.00
196_V235_Q1.8451.00
201_H238_A1.8441.00
21_I25_H1.8391.00
235_Q238_A1.8281.00
95_E144_N1.8191.00
209_R248_Y1.8001.00
32_L35_T1.7741.00
146_V195_L1.7731.00
187_M232_L1.7631.00
74_I97_P1.7631.00
141_K236_P1.7571.00
11_L37_V1.7561.00
127_Q131_N1.7341.00
202_A241_C1.6811.00
231_L264_A1.6401.00
199_F209_R1.6281.00
242_V265_T1.6181.00
116_R180_L1.6001.00
206_T209_R1.5751.00
163_I166_E1.5281.00
203_N206_T1.5021.00
233_A241_C1.4961.00
165_E168_R1.4951.00
115_S216_R1.4891.00
185_E189_R1.4871.00
38_H41_M1.4561.00
196_V201_H1.4521.00
196_V238_A1.4421.00
27_P30_I1.4371.00
75_A95_E1.4211.00
95_E104_T1.4141.00
80_F91_I1.4111.00
218_K222_D1.3971.00
8_I32_L1.3881.00
241_C264_A1.3851.00
188_D192_S1.3821.00
149_M231_L1.3801.00
156_P230_L1.3781.00
115_S118_H1.3621.00
20_A23_E1.3591.00
38_H60_K1.3571.00
187_M230_L1.3561.00
145_P240_C1.3551.00
158_D168_R1.3471.00
136_L148_I1.3441.00
12_R41_M1.3401.00
19_E23_E1.3281.00
23_E50_L1.3191.00
29_V105_V1.3161.00
22_V30_I1.3141.00
139_E142_R1.3101.00
37_V42_F1.3071.00
133_Q137_E1.3021.00
137_E193_W1.2871.00
44_L48_A1.2851.00
73_P96_I1.2801.00
53_N71_E1.2751.00
31_G107_N1.2731.00
108_G148_I1.2721.00
106_I136_L1.2711.00
3_F147_L1.2701.00
203_N209_R1.2701.00
162_G224_R1.2671.00
67_L107_N1.2591.00
234_S237_L1.2521.00
117_D123_P1.2381.00
157_T188_D1.2311.00
201_H241_C1.2201.00
46_E49_K1.1991.00
114_E118_H1.1851.00
45_E49_K1.1831.00
35_T39_D1.1821.00
155_S161_I1.1791.00
233_A266_F1.1751.00
126_A182_E1.1751.00
39_D56_Y1.1731.00
31_G67_L1.1701.00
25_H247_D1.1691.00
132_L148_I1.1641.00
186_W189_R1.1551.00
133_Q193_W1.1511.00
217_S224_R1.1511.00
130_Q189_R1.1441.00
26_Q70_K1.1421.00
3_F105_V1.1351.00
129_Y154_I1.1331.00
219_G224_R1.1301.00
3_F29_V1.1171.00
202_A243_E1.1131.00
147_L231_L1.1081.00
136_L195_L1.0961.00
55_F76_V1.0831.00
81_P86_E1.0831.00
135_Y139_E1.0811.00
233_A238_A1.0791.00
123_P127_Q1.0771.00
85_E131_N1.0761.00
21_I247_D1.0731.00
28_D70_K1.0581.00
148_I152_M1.0561.00
137_E141_K1.0481.00
155_S179_F1.0481.00
37_V41_M1.0451.00
104_T144_N1.0411.00
158_D179_F1.0401.00
202_A244_T1.0371.00
244_T264_A1.0341.00
223_N248_Y1.0331.00
130_Q134_N1.0321.00
15_P46_E1.0271.00
231_L266_F1.0271.00
82_G131_N1.0211.00
108_G152_M1.0151.00
69_T94_A1.0061.00
110_F129_Y1.0021.00
198_T244_T0.9941.00
108_G132_L0.9941.00
127_Q130_Q0.9901.00
15_P19_E0.9841.00
199_F244_T0.9801.00
88_Q121_K0.9781.00
211_S246_I0.9771.00
148_I232_L0.9761.00
75_A104_T0.9761.00
22_V27_P0.9711.00
104_T143_D0.9691.00
29_V103_V0.9691.00
126_A186_W0.9671.00
29_V96_I0.9601.00
73_P76_V0.9581.00
57_H78_R0.9571.00
188_D191_M0.9521.00
93_M104_T0.9481.00
57_H79_G0.9471.00
122_F180_L0.9421.00
20_A24_K0.9391.00
45_E48_A0.9310.99
6_F18_L0.9300.99
209_R246_I0.9270.99
1_M265_T0.9140.99
147_L233_A0.9020.99
169_K176_K0.8960.99
129_Y186_W0.8960.99
211_S244_T0.8930.99
69_T72_T0.8840.99
4_V25_H0.8790.99
71_E97_P0.8750.99
55_F78_R0.8730.99
164_G179_F0.8730.99
133_Q190_L0.8710.99
102_N145_P0.8660.99
55_F73_P0.8620.99
59_Q62_H0.8560.99
4_V247_D0.8550.99
78_R92_I0.8490.99
18_L47_V0.8440.99
159_L206_T0.8410.99
5_S244_T0.8370.99
49_K54_V0.8360.99
19_E50_L0.8360.99
238_A241_C0.8340.99
246_I260_A0.8330.99
163_I224_R0.8310.99
4_V27_P0.8300.99
139_E143_D0.8300.99
137_E195_L0.8280.99
158_D164_G0.8260.99
185_E188_D0.8250.99
32_L68_L0.8250.99
220_F251_R0.8220.99
161_I226_L0.8200.99
145_P234_S0.8190.99
91_I106_I0.8140.99
250_I260_A0.8140.99
93_M106_I0.8110.99
105_V231_L0.8100.99
5_S33_Q0.8080.99
84_D131_N0.8040.99
110_F128_F0.8020.98
10_G13_A0.7990.98
69_T73_P0.7980.98
54_V68_L0.7980.98
35_T66_A0.7980.98
169_K181_P0.7960.98
85_E124_A0.7890.98
134_N137_E0.7880.98
199_F211_S0.7880.98
102_N240_C0.7870.98
203_N243_E0.7860.98
161_I167_N0.7850.98
199_F246_I0.7850.98
18_L30_I0.7850.98
69_T96_I0.7740.98
59_Q63_Y0.7700.98
83_D87_A0.7690.98
213_F260_A0.7690.98
178_S226_L0.7690.98
180_L183_E0.7650.98
209_R245_G0.7630.98
199_F206_T0.7540.98
2_K25_H0.7500.98
113_G122_F0.7480.98
233_A237_L0.7440.98
29_V71_E0.7430.98
24_K249_E0.7410.97
73_P94_A0.7380.97
91_I135_Y0.7360.97
167_N226_L0.7350.97
55_F92_I0.7340.97
55_F69_T0.7310.97
48_A53_N0.7290.97
107_N149_M0.7230.97
133_Q186_W0.7230.97
213_F223_N0.7220.97
74_I95_E0.7140.97
93_M135_Y0.7140.97
145_P237_L0.7090.97
158_D165_E0.7050.97
67_L105_V0.7050.97
126_A130_Q0.7040.97
203_N245_G0.6980.96
33_Q107_N0.6960.96
240_C267_R0.6950.96
4_V21_I0.6940.96
77_R93_M0.6910.96
91_I132_L0.6900.96
202_A208_D0.6890.96
231_L262_V0.6880.96
80_F135_Y0.6880.96
205_Q209_R0.6870.96
10_G61_G0.6840.96
118_H123_P0.6820.96
208_D223_N0.6790.96
139_E146_V0.6780.96
155_S226_L0.6770.96
3_F31_G0.6750.96
110_F152_M0.6720.96
204_P209_R0.6720.96
53_N73_P0.6720.96
6_F256_P0.6700.95
189_R192_S0.6670.95
54_V57_H0.6660.95
167_N176_K0.6600.95
12_R37_V0.6570.95
30_I68_L0.6570.95
168_R179_F0.6540.95
164_G168_R0.6500.95
233_A264_A0.6490.95
187_M191_M0.6470.95
121_K124_A0.6450.94
106_I146_V0.6450.94
13_A16_H0.6430.94
256_P260_A0.6430.94
67_L92_I0.6390.94
140_L236_P0.6360.94
75_A78_R0.6360.94
16_H20_A0.6350.94
57_H92_I0.6330.94
152_M232_L0.6330.94
147_L266_F0.6320.94
183_E212_W0.6320.94
24_K250_I0.6300.94
23_E26_Q0.6260.94
44_L56_Y0.6250.94
140_L234_S0.6230.93
125_K129_Y0.6220.93
182_E185_E0.6210.93
163_I167_N0.6210.93
137_E189_R0.6200.93
241_C266_F0.6170.93
34_E151_D0.6170.93
131_N134_N0.6160.93
77_R135_Y0.6120.93
151_D258_D0.6120.93
91_I108_G0.6120.93
52_Y70_K0.6080.93
53_N69_T0.6080.93
44_L54_V0.6040.92
16_H19_E0.6020.92
114_E176_K0.6010.92
220_F260_A0.5980.92
11_L18_L0.5970.92
217_S222_D0.5970.92
15_P42_F0.5960.92
115_S176_K0.5950.92
243_E263_W0.5950.92
51_G71_E0.5930.92
203_N244_T0.5930.92
10_G62_H0.5920.92
162_G167_N0.5910.91
162_G166_E0.5900.91
109_Y151_D0.5890.91
219_G222_D0.5870.91
105_V147_L0.5850.91
152_M230_L0.5850.91
35_T38_H0.5840.91
22_V52_Y0.5820.91
49_K68_L0.5810.91
80_F131_N0.5810.91
19_E49_K0.5780.91
71_E96_I0.5780.91
178_S183_E0.5770.91
6_F112_Q0.5770.91
77_R104_T0.5750.90
122_F182_E0.5740.90
136_L190_L0.5730.90
159_L205_Q0.5720.90
35_T56_Y0.5710.90
104_T139_E0.5700.90
199_F202_A0.5690.90
113_G125_K0.5690.90
81_P135_Y0.5680.90
132_L136_L0.5670.90
148_I190_L0.5660.90
162_G226_L0.5620.89
7_N153_N0.5580.89
125_K186_W0.5520.88
162_G210_F0.5500.88
34_E153_N0.5480.88
201_H239_E0.5470.88
109_Y153_N0.5460.88
235_Q239_E0.5430.88
29_V69_T0.5420.88
65_V92_I0.5400.87
220_F248_Y0.5400.87
132_L135_Y0.5390.87
74_I103_V0.5370.87
91_I128_F0.5370.87
197_D227_R0.5360.87
13_A17_Q0.5360.87
198_T238_A0.5350.87
2_K263_W0.5280.86
251_R256_P0.5280.86
34_E109_Y0.5270.86
126_A129_Y0.5250.86
116_R122_F0.5210.86
1_M4_V0.5180.85
200_R246_I0.5170.85
85_E127_Q0.5150.85
29_V94_A0.5130.85
167_N178_S0.5090.84
2_K26_Q0.5080.84
106_I110_F0.5080.84
202_A242_V0.5060.84
179_F226_L0.5030.83
47_V54_V0.5020.83
50_L54_V0.5020.83
21_I250_I0.5010.83
114_E152_M0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j63A 1 0.9664 100 0.377 Contact Map
1akoA 1 0.9851 100 0.382 Contact Map
2voaA 1 0.9515 100 0.383 Contact Map
2jc4A 1 0.9552 100 0.383 Contact Map
2jc5A 1 0.9366 100 0.384 Contact Map
1hd7A 1 0.8843 100 0.386 Contact Map
3g91A 1 0.9366 100 0.386 Contact Map
4f1rA 1 0.9328 100 0.389 Contact Map
4jg3A 1 0.9366 100 0.392 Contact Map
4qheA 1 0.9366 100 0.434 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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