GREMLIN Database
PURK - N5-carboxyaminoimidazole ribonucleotide synthase
UniProt: P09029 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10796
Length: 355 (332)
Sequences: 22193 (11950)
Seq/√Len: 655.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_D137_N3.6481.00
96_P154_Q3.1451.00
107_P140_E3.1321.00
3_Q26_A3.1201.00
102_E105_E3.0081.00
136_A139_T2.9961.00
208_E212_A2.8681.00
322_D327_R2.7761.00
59_T75_P2.6171.00
115_E137_N2.5951.00
209_M212_A2.5441.00
98_Q112_R2.4561.00
264_R269_L2.3831.00
324_D327_R2.3671.00
211_S215_Q2.3521.00
89_K216_E2.2931.00
204_A208_E2.2661.00
19_A22_P2.2311.00
230_T233_G2.1421.00
135_R139_T2.1401.00
200_A204_A2.0771.00
87_F213_I2.0561.00
199_N202_Q1.9621.00
133_R155_G1.9331.00
255_S277_N1.9281.00
301_H304_W1.9211.00
59_T63_A1.9151.00
109_V112_R1.8881.00
168_R174_T1.8821.00
60_R64_R1.8561.00
109_V113_L1.8551.00
82_T85_Q1.8491.00
170_F220_V1.8451.00
6_V17_R1.8281.00
85_Q89_K1.8211.00
260_E264_R1.8151.00
209_M234_L1.8021.00
323_S327_R1.8021.00
137_N140_E1.7911.00
303_H306_D1.7781.00
194_A253_G1.7701.00
157_N231_P1.7581.00
135_R157_N1.7411.00
103_R140_E1.7371.00
61_E64_R1.7351.00
75_P82_T1.7161.00
301_H305_Y1.7051.00
22_P260_E1.7021.00
140_E144_A1.6931.00
20_G27_V1.6741.00
103_R107_P1.6681.00
301_H306_D1.6531.00
202_Q205_Q1.6401.00
103_R144_A1.6381.00
107_P137_N1.6291.00
70_N73_V1.6191.00
167_A261_L1.6071.00
304_W307_K1.6041.00
19_A260_E1.5911.00
46_I65_H1.5901.00
283_I332_L1.5901.00
85_Q88_D1.5851.00
81_L85_Q1.5721.00
205_Q209_M1.5711.00
212_A215_Q1.5551.00
54_P78_A1.5531.00
98_Q109_V1.5421.00
90_L216_E1.5291.00
76_I86_L1.5271.00
108_A112_R1.5141.00
86_L216_E1.5101.00
81_L99_L1.5051.00
117_A152_V1.4991.00
205_Q208_E1.4761.00
110_F115_E1.4651.00
141_Q145_E1.4601.00
4_V67_A1.4541.00
122_R149_E1.4541.00
86_L90_L1.4451.00
167_A222_V1.4421.00
202_Q229_V1.4371.00
76_I82_T1.4341.00
169_G173_S1.4311.00
162_V229_V1.4311.00
101_A105_E1.4181.00
84_K153_E1.4131.00
88_D96_P1.4081.00
60_R63_A1.4011.00
204_A207_E1.4001.00
252_N319_N1.3921.00
292_Y295_L1.3841.00
87_F236_I1.3741.00
54_P57_A1.3691.00
86_L89_K1.3571.00
302_L305_Y1.3501.00
107_P111_D1.3421.00
79_D122_R1.3381.00
14_R43_Q1.3221.00
255_S275_V1.3221.00
110_F117_A1.3161.00
154_Q235_L1.3141.00
85_Q97_W1.3081.00
108_A111_D1.3061.00
252_N321_T1.3031.00
156_I237_N1.3021.00
72_D76_I1.2931.00
300_V303_H1.2821.00
53_W57_A1.2771.00
164_L206_A1.2731.00
37_A43_Q1.2731.00
62_L70_N1.2721.00
166_G214_M1.2641.00
18_Q22_P1.2591.00
105_E108_A1.2561.00
83_Q87_F1.2561.00
115_E136_A1.2461.00
326_S330_A1.2441.00
104_S107_P1.2431.00
101_A149_E1.2391.00
46_I61_E1.2371.00
4_V25_I1.2351.00
103_R143_P1.2301.00
4_V20_G1.2301.00
301_H308_E1.2171.00
118_I133_R1.2151.00
302_L306_D1.2091.00
59_T72_D1.2091.00
167_A265_A1.2051.00
88_D94_T1.1981.00
62_L71_R1.1971.00
104_S108_A1.1931.00
52_R56_T1.1891.00
5_C30_V1.1871.00
306_D309_V1.1861.00
176_F207_E1.1861.00
203_Q207_E1.1821.00
303_H307_K1.1791.00
286_I313_R1.1741.00
171_D270_P1.1731.00
77_I239_L1.1711.00
23_L264_R1.1681.00
53_W56_T1.1651.00
144_A148_G1.1611.00
100_L109_V1.1581.00
207_E211_S1.1581.00
322_D331_T1.1571.00
84_K94_T1.1531.00
333_E337_P1.1471.00
3_Q28_W1.1381.00
198_A202_Q1.1381.00
327_R331_T1.1371.00
214_M217_L1.1361.00
200_A203_Q1.1331.00
166_G210_L1.1281.00
81_L122_R1.1251.00
99_L149_E1.1241.00
31_G36_P1.1231.00
24_G260_E1.1201.00
322_D328_L1.1161.00
25_I267_T1.1161.00
320_L332_L1.1001.00
96_P113_L1.0931.00
132_W145_E1.0901.00
318_L335_L1.0891.00
166_G225_M1.0811.00
52_R57_A1.0761.00
174_T211_S1.0731.00
201_Q205_Q1.0681.00
93_P209_M1.0661.00
52_R55_E1.0591.00
16_L47_T1.0541.00
272_P276_V1.0431.00
143_P147_Y1.0381.00
132_W146_C1.0381.00
70_N220_V1.0301.00
251_Q319_N1.0301.00
213_I217_L1.0211.00
118_I155_G1.0211.00
27_V42_Q1.0181.00
100_L106_W1.0161.00
208_E211_S1.0121.00
229_V234_L1.0111.00
111_D140_E1.0071.00
23_L257_S1.0071.00
329_T333_E1.0021.00
72_D75_P0.9941.00
88_D97_W0.9911.00
205_Q233_G0.9901.00
294_W297_L0.9891.00
331_T334_A0.9871.00
334_A337_P0.9841.00
166_G223_M0.9811.00
288_S291_N0.9761.00
243_V258_Q0.9761.00
261_L264_R0.9731.00
303_H308_E0.9731.00
160_G181_H0.9721.00
256_I261_L0.9651.00
141_Q144_A0.9621.00
21_E43_Q0.9611.00
92_L236_I0.9581.00
158_F231_P0.9571.00
96_P112_R0.9571.00
113_L117_A0.9511.00
330_A334_A0.9511.00
132_W142_L0.9501.00
225_M239_L0.9501.00
210_L227_C0.9501.00
66_P267_T0.9481.00
157_N230_T0.9451.00
168_R215_Q0.9401.00
191_T194_A0.9391.00
213_I216_E0.9391.00
4_V263_L0.9381.00
59_T62_L0.9371.00
23_L260_E0.9361.00
178_P203_Q0.9331.00
138_E141_Q0.9301.00
20_G263_L0.9261.00
320_L335_L0.9231.00
174_T215_Q0.9151.00
167_A177_Y0.9131.00
59_T71_R0.9091.00
164_L207_E0.8991.00
103_R147_Y0.8981.00
33_D36_P0.8971.00
210_L225_M0.8851.00
47_T262_H0.8831.00
164_L210_L0.8821.00
81_L149_E0.8791.00
3_Q44_S0.8711.00
118_I131_Q0.8691.00
160_G229_V0.8691.00
302_L307_K0.8681.00
212_A216_E0.8661.00
3_Q27_V0.8651.00
293_D297_L0.8601.00
119_V150_C0.8591.00
178_P194_A0.8581.00
168_R214_M0.8551.00
77_I217_L0.8531.00
264_R267_T0.8511.00
185_Q190_R0.8511.00
66_P170_F0.8451.00
293_D296_K0.8421.00
6_V20_G0.8411.00
17_R27_V0.8401.00
134_L142_L0.8401.00
143_P150_C0.8351.00
214_M223_M0.8351.00
117_A134_L0.8311.00
62_L220_V0.8291.00
305_Y308_E0.8241.00
201_Q204_A0.8241.00
73_V218_G0.8231.00
106_W143_P0.8221.00
156_I235_L0.8191.00
181_H197_Q0.8161.00
162_V206_A0.8111.00
228_F237_N0.8101.00
119_V142_L0.8091.00
263_L267_T0.8091.00
286_I291_N0.8071.00
21_E27_V0.8061.00
173_S215_Q0.8041.00
29_P40_P0.8031.00
70_N218_G0.8001.00
205_Q234_L0.7991.00
206_A234_L0.7971.00
51_E54_P0.7971.00
88_D98_Q0.7941.00
282_M290_V0.7931.00
37_A42_Q0.7841.00
283_I291_N0.7831.00
273_Q276_V0.7821.00
320_L328_L0.7821.00
281_V328_L0.7811.00
294_W298_P0.7811.00
300_V306_D0.7731.00
20_G47_T0.7711.00
305_Y309_V0.7681.00
300_V305_Y0.7671.00
164_L179_L0.7651.00
193_V325_T0.7621.00
14_R40_P0.7601.00
301_H309_V0.7601.00
119_V134_L0.7581.00
279_P323_S0.7581.00
277_N321_T0.7521.00
37_A41_F0.7511.00
61_E66_P0.7461.00
165_V222_V0.7441.00
327_R330_A0.7441.00
17_R43_Q0.7411.00
301_H307_K0.7401.00
145_E148_G0.7401.00
282_M285_L0.7321.00
220_V265_A0.7291.00
171_D268_D0.7281.00
213_I239_L0.7281.00
169_G271_L0.7281.00
146_C150_C0.7241.00
105_E109_V0.7241.00
36_P39_V0.7231.00
300_V304_W0.7181.00
58_L62_L0.7151.00
20_G25_I0.7141.00
198_A203_Q0.7131.00
283_I290_V0.7131.00
30_V41_F0.7121.00
295_L328_L0.7101.00
281_V290_V0.7091.00
82_T86_L0.7061.00
113_L154_Q0.7061.00
122_R151_I0.7051.00
284_N287_G0.7031.00
286_I290_V0.7021.00
175_V274_P0.7011.00
110_F114_G0.6991.00
281_V329_T0.6971.00
176_F211_S0.6961.00
81_L151_I0.6961.00
62_L72_D0.6961.00
98_Q105_E0.6931.00
276_V279_P0.6921.00
183_L191_T0.6911.00
262_H266_I0.6911.00
45_V48_A0.6891.00
119_V143_P0.6861.00
168_R220_V0.6851.00
173_S270_P0.6821.00
165_V224_A0.6791.00
326_S329_T0.6761.00
85_Q99_L0.6741.00
164_L227_C0.6741.00
296_K299_L0.6731.00
106_W152_V0.6721.00
19_A23_L0.6711.00
292_Y297_L0.6701.00
156_I230_T0.6691.00
238_E242_R0.6641.00
114_G137_N0.6621.00
142_L146_C0.6611.00
61_E65_H0.6601.00
31_G41_F0.6601.00
79_D149_E0.6591.00
185_Q189_L0.6571.00
219_Y223_M0.6551.00
193_V196_P0.6541.00
164_L176_F0.6531.00
229_V233_G0.6521.00
174_T214_M0.6521.00
17_R40_P0.6501.00
39_V43_Q0.6491.00
177_Y258_Q0.6481.00
27_V31_G0.6471.00
304_W308_E0.6461.00
103_R106_W0.6441.00
230_T235_L0.6441.00
332_L336_I0.6431.00
180_T192_S0.6431.00
109_V152_V0.6351.00
119_V152_V0.6341.00
281_V291_N0.6321.00
209_M227_C0.6321.00
285_L288_S0.6301.00
107_P144_A0.6291.00
71_R75_P0.6281.00
294_W299_L0.6261.00
142_L145_E0.6251.00
179_L196_P0.6221.00
79_D82_T0.6211.00
73_V220_V0.6201.00
31_G34_A0.6191.00
86_L217_L0.6161.00
147_Y150_C0.6161.00
178_P253_G0.6151.00
181_H196_P0.6151.00
283_I317_H0.6141.00
175_V273_Q0.6141.00
282_M286_I0.6131.00
232_Q235_L0.6131.00
328_L332_L0.6101.00
190_R286_I0.6101.00
209_M213_I0.6101.00
225_M236_I0.6081.00
80_R120_K0.6071.00
300_V307_K0.6061.00
192_S196_P0.6061.00
179_L203_Q0.6051.00
166_G176_F0.6051.00
76_I89_K0.6041.00
279_P321_T0.6041.00
87_F239_L0.6031.00
34_A37_A0.6021.00
93_P235_L0.6021.00
134_L139_T0.6021.00
24_G263_L0.5991.00
292_Y296_K0.5981.00
154_Q230_T0.5971.00
29_P42_Q0.5951.00
282_M291_N0.5941.00
287_G291_N0.5931.00
110_F143_P0.5931.00
287_G290_V0.5911.00
102_E143_P0.5911.00
23_L263_L0.5901.00
165_V180_T0.5901.00
116_L155_G0.5891.00
229_V232_Q0.5891.00
289_D292_Y0.5891.00
162_V196_P0.5881.00
210_L214_M0.5881.00
107_P110_F0.5861.00
180_T196_P0.5861.00
202_Q234_L0.5851.00
283_I288_S0.5841.00
300_V308_E0.5841.00
44_S48_A0.5831.00
249_W252_N0.5821.00
40_P43_Q0.5801.00
251_Q257_S0.5801.00
179_L198_A0.5791.00
325_T329_T0.5771.00
285_L290_V0.5761.00
83_Q236_I0.5761.00
166_G174_T0.5751.00
185_Q188_I0.5731.00
177_Y254_A0.5711.00
258_Q262_H0.5691.00
222_V243_V0.5661.00
303_H309_V0.5641.00
115_E135_R0.5621.00
72_D218_G0.5611.00
19_A257_S0.5611.00
162_V227_C0.5591.00
74_F241_P0.5551.00
199_N229_V0.5541.00
194_A197_Q0.5541.00
55_E78_A0.5531.00
281_V288_S0.5521.00
162_V198_A0.5511.00
72_D82_T0.5501.00
110_F113_L0.5501.00
281_V286_I0.5481.00
92_L209_M0.5481.00
139_T142_L0.5471.00
261_L274_P0.5461.00
320_L331_T0.5451.00
30_V40_P0.5451.00
282_M287_G0.5431.00
194_A249_W0.5421.00
58_L61_E0.5391.00
263_L266_I0.5391.00
199_N233_G0.5371.00
256_I272_P0.5361.00
181_H193_V0.5351.00
115_E134_L0.5341.00
254_A276_V0.5341.00
169_G268_D0.5341.00
135_R155_G0.5331.00
12_L243_V0.5321.00
304_W309_V0.5310.99
95_A237_N0.5310.99
267_T270_P0.5290.99
84_K97_W0.5290.99
206_A227_C0.5270.99
106_W109_V0.5260.99
84_K88_D0.5250.99
132_W141_Q0.5210.99
35_E40_P0.5200.99
248_H282_M0.5190.99
14_R39_V0.5160.99
30_V37_A0.5140.99
186_D312_G0.5130.99
73_V76_I0.5130.99
191_T283_I0.5120.99
272_P275_V0.5120.99
278_N321_T0.5120.99
73_V77_I0.5110.99
95_A156_I0.5110.99
160_G196_P0.5100.99
130_G238_E0.5090.99
99_L122_R0.5090.99
183_L190_R0.5080.99
264_R272_P0.5070.99
219_Y241_P0.5060.99
302_L309_V0.5050.99
25_I28_W0.5050.99
192_S249_W0.5040.99
286_I336_I0.5030.99
33_D37_A0.5030.99
87_F92_L0.5020.99
67_A266_I0.5020.99
103_R148_G0.5020.99
38_A41_F0.5010.99
42_Q307_K0.5000.99
248_H319_N0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ethA 2 0.9803 100 0.276 Contact Map
2dwcA 4 0.9606 100 0.299 Contact Map
3ax6A 2 0.9183 100 0.303 Contact Map
4mamA 2 0.9746 100 0.307 Contact Map
3aw8A 2 0.9493 100 0.317 Contact Map
1kjqA 2 0.9493 100 0.323 Contact Map
4e4tA 2 0.9634 100 0.325 Contact Map
3orqA 2 0.9493 100 0.327 Contact Map
3q2oA 2 0.9577 100 0.33 Contact Map
4rcnA 6 0.9183 100 0.335 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0118 seconds.