PT1 - ECOLI - GREMLIN Contacts

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PT1 - Phosphoenolpyruvate-protein phosphotransferase

UniProt:	P08839	Sequences: MISGILASPGIAFGKALLLKEDEIVIDRKKISADQVDQEVERFLSGRAKASAQLETIKTKAGETFGEEKEAIFEGHIMLLEDEELEQEIIALIKDKHMTADAAAHEVIEGQASALEELDDEYLKERAADVRDIGKRLLRNILGLKIIDLSAIQDEVILVAADLTPSETAQLNLKKVLGFITDAGGRTSHTSIMARSLELPAIVGTGSVTSQVKNDDYLILDAVNNQVYVNPTNEVIDKMRAVQEQVASEKAELAKLKDLPAITLDGHQVEVCANIGTVRDVEGAERNGAEGVGLYRTEFLFMDRDALPTEEEQFAAYKAVAEACGSQAVIVRTMDIGGDKELPYMNFPKEENPFLGWRAIRIAMDRREILRDQLRAILRASAFGKLRIMFPMIISVEEVRALRKEIEIYKQELRDEGKAFDESIEIGVMVETPAAATIARHLAKEVDFFSIGTNDLTQYTLAVDRGNDMISHLYQPMSPSVLNLIKQVIDASHAEGKWTGMCGELAGDERATLLLLGMGLDEFSMSAISIPRIKKIIRNTNFEDAKVLAEQALAQPTTDELMTLVNKFIEEKTIC	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10789
Length:	575 (521)
Sequences:	6070 (3545)
Seq/√Len:	155.3

ECOLI - PT1 PTFX2 PTFX1 PT1P PPSA
BACSU - PT1
HALSA - Q9HSA1
SULSO - Q97ZL2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
486_K	490_D	5.228	1.00
400_R	445_E	5.174	1.00
178_G	220_L	5.157	1.00
493_H	521_D	3.604	1.00
314_F	383_F	3.073	1.00
436_A	484_L	3.048	1.00
371_R	408_I	3.020	1.00
318_K	383_F	2.989	1.00
492_S	499_T	2.903	1.00
324_C	329_V	2.875	1.00
387_R	425_E	2.797	1.00
357_W	365_D	2.744	1.00
44_L	90_I	2.726	1.00
321_A	386_L	2.686	1.00
155_E	177_L	2.665	1.00
501_M	520_L	2.587	1.00
460_T	484_L	2.562	1.00
232_T	235_V	2.558	1.00
403_R	445_E	2.534	1.00
439_A	491_A	2.521	1.00
377_I	386_L	2.455	1.00
318_K	322_E	2.449	1.00
444_K	495_E	2.408	1.00
437_T	484_L	2.382	1.00
414_R	420_F	2.378	1.00
371_R	405_E	2.354	1.00
469_M	473_L	2.350	1.00
414_R	422_E	2.344	1.00
40_V	94_K	2.290	1.00
390_F	402_L	2.270	1.00
440_R	494_A	2.264	1.00
541_N	544_D	2.244	1.00
42_R	101_D	2.227	1.00
360_I	393_I	2.188	1.00
16_A	218_L	2.177	1.00
143_G	154_D	2.160	1.00
53_Q	140_N	2.152	1.00
282_E	286_R	2.139	1.00
488_V	499_T	2.137	1.00
202_I	222_A	2.106	1.00
390_F	406_I	2.090	1.00
43_F	89_I	2.078	1.00
360_I	402_L	2.065	1.00
212_V	229_V	2.047	1.00
264_L	541_N	2.039	1.00
333_T	390_F	2.034	1.00
374_L	406_I	2.032	1.00
100_A	265_D	2.019	1.00
284_A	289_A	2.015	1.00
208_V	212_V	2.012	1.00
483_N	491_A	2.007	1.00
512_T	533_I	1.990	1.00
269_V	516_L	1.990	1.00
328_A	387_R	1.978	1.00
309_T	312_E	1.973	1.00
320_V	329_V	1.945	1.00
470_I	473_L	1.922	1.00
50_A	140_N	1.907	1.00
285_E	327_Q	1.894	1.00
213_K	216_D	1.880	1.00
363_A	370_L	1.855	1.00
51_S	81_E	1.850	1.00
501_M	515_L	1.846	1.00
157_I	218_L	1.836	1.00
93_I	100_A	1.836	1.00
304_R	312_E	1.830	1.00
399_V	446_V	1.824	1.00
267_H	542_F	1.820	1.00
273_A	289_A	1.818	1.00
394_I	432_T	1.810	1.00
16_A	212_V	1.809	1.00
331_V	377_I	1.786	1.00
430_V	435_A	1.784	1.00
292_V	324_C	1.783	1.00
403_R	407_E	1.780	1.00
401_A	404_K	1.774	1.00
87_Q	91_A	1.770	1.00
161_A	183_A	1.763	1.00
440_R	483_N	1.762	1.00
161_A	182_D	1.744	1.00
487_Q	491_A	1.744	1.00
180_I	220_L	1.704	1.00
371_R	412_E	1.699	1.00
438_I	441_H	1.698	1.00
159_V	218_L	1.695	1.00
520_L	523_F	1.687	1.00
99_T	102_A	1.679	1.00
273_A	284_A	1.675	1.00
338_G	354_F	1.672	1.00
259_L	538_R	1.667	1.00
451_I	485_I	1.666	1.00
217_Y	236_I	1.663	1.00
105_H	109_E	1.658	1.00
440_R	491_A	1.657	1.00
35_Q	38_Q	1.653	1.00
216_D	230_N	1.646	1.00
108_I	134_G	1.634	1.00
138_L	212_V	1.631	1.00
430_V	488_V	1.622	1.00
428_V	442_L	1.609	1.00
513_L	540_T	1.602	1.00
443_A	449_F	1.600	1.00
500_G	522_E	1.598	1.00
333_T	363_A	1.597	1.00
441_H	483_N	1.596	1.00
267_H	521_D	1.592	1.00
489_I	499_T	1.584	1.00
37_D	94_K	1.583	1.00
390_F	403_R	1.581	1.00
432_T	459_Y	1.580	1.00
157_I	178_G	1.576	1.00
507_G	525_M	1.575	1.00
451_I	520_L	1.553	1.00
513_L	543_E	1.544	1.00
443_A	497_K	1.543	1.00
180_I	227_V	1.540	1.00
490_D	494_A	1.536	1.00
405_E	408_I	1.529	1.00
104_A	137_L	1.524	1.00
438_I	442_L	1.511	1.00
295_Y	320_V	1.504	1.00
182_D	209_T	1.483	1.00
261_A	534_K	1.473	1.00
461_L	481_V	1.470	1.00
330_I	387_R	1.454	1.00
40_V	90_I	1.450	1.00
364_M	401_A	1.448	1.00
90_I	94_K	1.448	1.00
321_A	377_I	1.447	1.00
370_L	402_L	1.446	1.00
113_S	116_E	1.439	1.00
270_E	290_E	1.422	1.00
202_I	227_V	1.419	1.00
375_R	416_E	1.419	1.00
305_D	308_P	1.415	1.00
514_L	518_M	1.410	1.00
330_I	500_G	1.409	1.00
425_E	498_W	1.408	1.00
256_L	538_R	1.408	1.00
311_E	315_A	1.406	1.00
300_L	316_A	1.406	1.00
396_V	445_E	1.399	1.00
469_M	472_H	1.398	1.00
485_I	518_M	1.397	1.00
281_V	285_E	1.396	1.00
271_V	537_I	1.386	1.00
182_D	205_T	1.370	1.00
271_V	534_K	1.368	1.00
439_A	449_F	1.367	1.00
512_T	537_I	1.358	1.00
159_V	180_I	1.357	1.00
180_I	205_T	1.350	1.00
310_E	379_R	1.346	1.00
404_K	408_I	1.343	1.00
271_V	530_I	1.339	1.00
116_E	131_R	1.336	1.00
41_E	45_S	1.330	1.00
486_K	518_M	1.328	1.00
435_A	442_L	1.325	1.00
217_Y	231_P	1.321	1.00
314_F	379_R	1.316	1.00
94_K	258_D	1.312	1.00
290_E	327_Q	1.310	1.00
39_E	42_R	1.306	1.00
43_F	47_R	1.302	1.00
378_L	406_I	1.299	1.00
474_Y	479_P	1.294	1.00
485_I	520_L	1.287	1.00
16_A	159_V	1.280	1.00
451_I	488_V	1.276	1.00
483_N	487_Q	1.274	1.00
92_L	106_E	1.274	1.00
428_V	446_V	1.273	1.00
330_I	498_W	1.273	1.00
56_T	60_K	1.268	1.00
112_A	116_E	1.266	1.00
289_A	530_I	1.265	1.00
39_E	100_A	1.265	1.00
52_A	55_E	1.259	1.00
53_Q	56_T	1.235	1.00
222_A	226_Q	1.235	1.00
157_I	220_L	1.232	1.00
365_D	469_M	1.228	1.00
179_F	194_A	1.225	1.00
394_I	434_A	1.222	1.00
400_R	403_R	1.218	1.00
513_L	517_G	1.217	1.00
6_L	54_L	1.210	1.00
154_D	175_K	1.203	1.00
414_R	421_D	1.201	1.00
145_K	214_N	1.179	1.00
132_D	166_S	1.176	1.00
281_V	323_A	1.173	1.00
489_I	520_L	1.168	1.00
285_E	323_A	1.162	1.00
440_R	495_E	1.159	1.00
272_C	291_G	1.158	1.00
380_A	386_L	1.158	1.00
116_E	120_D	1.154	1.00
326_S	385_K	1.152	1.00
42_R	45_S	1.150	1.00
413_L	416_E	1.149	1.00
357_W	469_M	1.149	1.00
52_A	56_T	1.148	1.00
282_E	323_A	1.148	1.00
48_A	52_A	1.142	1.00
438_I	483_N	1.141	1.00
278_V	316_A	1.138	1.00
403_R	447_D	1.136	1.00
432_T	462_A	1.134	1.00
408_I	412_E	1.132	1.00
491_A	494_A	1.131	1.00
115_L	118_L	1.128	1.00
483_N	486_K	1.128	1.00
389_M	450_S	1.123	1.00
216_D	229_V	1.120	1.00
118_L	123_L	1.116	1.00
406_I	426_I	1.115	1.00
207_S	211_Q	1.113	1.00
505_L	511_A	1.113	1.00
396_V	400_R	1.113	1.00
489_I	523_F	1.112	1.00
306_A	309_T	1.109	1.00
377_I	388_I	1.107	0.99
390_F	426_I	1.107	0.99
407_E	426_I	1.104	0.99
319_A	323_A	1.104	0.99
91_A	95_D	1.102	0.99
234_E	238_K	1.098	0.99
254_A	257_K	1.094	0.99
461_L	478_S	1.090	0.99
262_I	268_Q	1.090	0.99
350_E	467_N	1.089	0.99
281_V	284_A	1.088	0.99
476_P	479_P	1.087	0.99
460_T	481_V	1.077	0.99
314_F	318_K	1.074	0.99
273_A	530_I	1.069	0.99
13_F	219_I	1.068	0.99
283_G	286_R	1.058	0.99
381_S	421_D	1.057	0.99
261_A	290_E	1.052	0.99
310_E	372_D	1.052	0.99
98_M	106_E	1.049	0.99
112_A	131_R	1.046	0.99
221_D	224_N	1.044	0.99
267_H	290_E	1.044	0.99
516_L	537_I	1.042	0.99
153_Q	156_V	1.039	0.99
102_A	106_E	1.036	0.99
15_K	154_D	1.033	0.99
223_V	226_Q	1.032	0.99
54_L	58_K	1.031	0.99
148_D	151_A	1.029	0.99
252_E	255_K	1.027	0.99
434_A	480_S	1.026	0.99
182_D	210_S	1.024	0.99
271_V	523_F	1.021	0.99
155_E	175_K	1.015	0.99
485_I	488_V	1.015	0.99
68_E	71_A	1.013	0.99
116_E	119_D	1.012	0.99
218_L	227_V	1.010	0.99
449_F	492_S	1.010	0.99
221_D	226_Q	1.007	0.99
182_D	207_S	1.006	0.99
55_E	77_I	1.005	0.99
403_R	426_I	1.002	0.99
260_P	268_Q	0.996	0.99
491_A	495_E	0.995	0.99
202_I	220_L	0.991	0.99
49_K	140_N	0.990	0.99
10_G	17_L	0.989	0.99
268_Q	290_E	0.988	0.99
375_R	412_E	0.988	0.99
475_Q	478_S	0.985	0.99
333_T	388_I	0.983	0.99
55_E	59_T	0.983	0.99
379_R	413_L	0.982	0.99
222_A	225_N	0.981	0.99
58_K	74_E	0.977	0.99
168_T	197_L	0.975	0.99
487_Q	490_D	0.964	0.99
453_T	501_M	0.964	0.99
535_K	539_N	0.964	0.99
152_I	156_V	0.963	0.99
54_L	77_I	0.961	0.99
305_D	309_T	0.959	0.99
272_C	522_E	0.957	0.99
374_L	378_L	0.956	0.99
400_R	404_K	0.950	0.98
104_A	266_G	0.948	0.98
263_T	267_H	0.946	0.98
219_I	228_Y	0.945	0.98
310_E	375_R	0.944	0.98
390_F	399_V	0.942	0.98
525_M	533_I	0.942	0.98
258_D	288_G	0.941	0.98
507_G	529_S	0.940	0.98
80_L	137_L	0.940	0.98
153_Q	175_K	0.937	0.98
388_I	406_I	0.936	0.98
492_S	497_K	0.934	0.98
127_A	131_R	0.933	0.98
56_T	59_T	0.932	0.98
385_K	425_E	0.927	0.98
428_V	435_A	0.925	0.98
101_D	142_L	0.922	0.98
138_L	142_L	0.918	0.98
367_R	401_A	0.918	0.98
122_Y	126_R	0.917	0.98
437_T	487_Q	0.912	0.98
311_E	379_R	0.912	0.98
119_D	124_K	0.912	0.98
117_E	120_D	0.910	0.98
212_V	218_L	0.909	0.98
13_F	217_Y	0.905	0.98
398_E	473_L	0.903	0.98
357_W	470_I	0.902	0.98
477_M	511_A	0.901	0.98
14_G	177_L	0.900	0.98
59_T	62_G	0.900	0.98
99_T	103_A	0.895	0.98
397_E	400_R	0.894	0.98
401_A	405_E	0.893	0.98
268_Q	516_L	0.891	0.98
135_K	138_L	0.890	0.98
307_L	310_E	0.890	0.98
279_R	303_D	0.886	0.98
421_D	424_I	0.885	0.98
98_M	102_A	0.884	0.98
441_H	444_K	0.884	0.98
307_L	345_M	0.883	0.97
439_A	488_V	0.882	0.97
442_L	449_F	0.882	0.97
437_T	483_N	0.882	0.97
467_N	470_I	0.879	0.97
415_D	421_D	0.878	0.97
367_R	408_I	0.876	0.97
355_L	459_Y	0.874	0.97
290_E	534_K	0.873	0.97
252_E	535_K	0.872	0.97
88_E	107_V	0.871	0.97
41_E	44_L	0.865	0.97
264_L	267_H	0.864	0.97
485_I	515_L	0.863	0.97
107_V	259_L	0.860	0.97
536_I	539_N	0.860	0.97
486_K	517_G	0.858	0.97
101_D	266_G	0.858	0.97
457_T	481_V	0.858	0.97
145_K	149_L	0.856	0.97
378_L	413_L	0.852	0.97
370_L	405_E	0.848	0.97
89_I	104_A	0.848	0.97
92_L	97_H	0.846	0.97
307_L	344_Y	0.843	0.97
61_A	66_G	0.842	0.97
437_T	460_T	0.842	0.97
207_S	210_S	0.839	0.97
279_R	319_A	0.835	0.96
333_T	377_I	0.834	0.96
13_F	236_I	0.834	0.96
285_E	325_G	0.831	0.96
498_W	522_E	0.829	0.96
357_W	362_I	0.828	0.96
121_E	125_E	0.828	0.96
120_D	123_L	0.827	0.96
351_E	466_G	0.826	0.96
336_I	342_L	0.825	0.96
92_L	110_G	0.823	0.96
474_Y	477_M	0.821	0.96
15_K	155_E	0.820	0.96
482_L	514_L	0.818	0.96
414_R	417_G	0.817	0.96
439_A	443_A	0.816	0.96
272_C	498_W	0.815	0.96
277_T	280_D	0.813	0.96
436_A	460_T	0.813	0.96
31_I	97_H	0.812	0.96
261_A	531_P	0.812	0.96
402_L	426_I	0.810	0.96
40_V	44_L	0.805	0.96
182_D	208_V	0.804	0.96
43_F	93_I	0.804	0.96
375_R	379_R	0.803	0.96
360_I	390_F	0.802	0.96
44_L	48_A	0.799	0.95
60_K	64_T	0.798	0.95
29_K	99_T	0.795	0.95
200_P	308_P	0.794	0.95
38_Q	41_E	0.793	0.95
49_K	52_A	0.792	0.95
513_L	536_I	0.789	0.95
291_G	328_A	0.787	0.95
55_E	58_K	0.786	0.95
272_C	387_R	0.785	0.95
412_E	415_D	0.785	0.95
152_I	155_E	0.784	0.95
281_V	324_C	0.784	0.95
22_D	46_G	0.782	0.95
137_L	140_N	0.782	0.95
430_V	442_L	0.782	0.95
162_D	190_T	0.782	0.95
396_V	442_L	0.781	0.95
88_E	92_L	0.781	0.95
48_A	51_S	0.781	0.95
489_I	493_H	0.781	0.95
282_E	319_A	0.780	0.95
53_Q	136_R	0.780	0.95
285_E	324_C	0.779	0.95
11_I	219_I	0.779	0.95
441_H	479_P	0.779	0.95
136_R	140_N	0.778	0.95
399_V	428_V	0.777	0.95
370_L	374_L	0.777	0.95
42_R	141_I	0.776	0.95
109_E	113_S	0.776	0.95
133_I	186_R	0.775	0.95
447_D	497_K	0.774	0.95
276_G	280_D	0.764	0.94
87_Q	255_K	0.763	0.94
126_R	129_D	0.762	0.94
525_M	530_I	0.761	0.94
474_Y	478_S	0.760	0.94
100_A	266_G	0.759	0.94
457_T	505_L	0.759	0.94
50_A	136_R	0.757	0.94
305_D	310_E	0.757	0.94
315_A	319_A	0.757	0.94
180_I	202_I	0.754	0.94
306_A	310_E	0.754	0.94
50_A	58_K	0.753	0.94
350_E	353_P	0.752	0.94
130_V	205_T	0.750	0.94
365_D	472_H	0.749	0.94
110_G	113_S	0.749	0.94
212_V	216_D	0.748	0.94
395_S	461_L	0.745	0.93
396_V	438_I	0.743	0.93
432_T	435_A	0.743	0.93
182_D	206_G	0.741	0.93
88_E	110_G	0.741	0.93
399_V	406_I	0.739	0.93
397_E	478_S	0.739	0.93
87_Q	90_I	0.738	0.93
163_L	179_F	0.738	0.93
331_V	386_L	0.737	0.93
85_L	108_I	0.734	0.93
121_E	124_K	0.731	0.93
66_G	70_E	0.730	0.93
179_F	201_A	0.730	0.93
101_D	141_I	0.729	0.93
381_S	424_I	0.728	0.93
433_P	462_A	0.727	0.93
71_A	74_E	0.726	0.93
536_I	540_T	0.726	0.93
397_E	401_A	0.726	0.93
501_M	523_F	0.724	0.92
163_L	168_T	0.724	0.92
428_V	449_F	0.723	0.92
53_Q	57_I	0.722	0.92
129_D	138_L	0.721	0.92
404_K	407_E	0.721	0.92
430_V	436_A	0.721	0.92
436_A	439_A	0.720	0.92
51_S	55_E	0.719	0.92
390_F	393_I	0.719	0.92
488_V	491_A	0.719	0.92
491_A	497_K	0.717	0.92
288_G	534_K	0.716	0.92
50_A	54_L	0.714	0.92
459_Y	462_A	0.711	0.92
407_E	445_E	0.710	0.92
446_V	497_K	0.709	0.92
132_D	136_R	0.709	0.92
394_I	463_V	0.709	0.92
403_R	446_V	0.709	0.92
45_S	48_A	0.709	0.92
479_P	482_L	0.707	0.92
321_A	331_V	0.707	0.92
261_A	537_I	0.706	0.92
446_V	449_F	0.703	0.91
284_A	324_C	0.700	0.91
218_L	229_V	0.699	0.91
301_F	313_Q	0.699	0.91
378_L	424_I	0.698	0.91
126_R	136_R	0.697	0.91
533_I	536_I	0.696	0.91
476_P	505_L	0.695	0.91
235_V	238_K	0.694	0.91
233_N	237_D	0.693	0.91
104_A	138_L	0.693	0.91
278_V	281_V	0.692	0.91
334_M	369_I	0.692	0.91
382_A	421_D	0.692	0.91
451_I	499_T	0.692	0.91
17_L	156_V	0.690	0.91
50_A	57_I	0.689	0.91
321_A	329_V	0.689	0.91
67_E	72_I	0.687	0.90
168_T	201_A	0.684	0.90
122_Y	125_E	0.683	0.90
490_D	518_M	0.681	0.90
51_S	77_I	0.681	0.90
413_L	417_G	0.681	0.90
266_G	541_N	0.679	0.90
498_W	521_D	0.678	0.90
348_P	469_M	0.678	0.90
328_A	425_E	0.677	0.90
70_E	73_F	0.677	0.90
393_I	428_V	0.677	0.90
414_R	419_A	0.676	0.90
359_A	393_I	0.675	0.90
84_E	87_Q	0.674	0.90
395_S	478_S	0.671	0.89
139_R	142_L	0.671	0.89
271_V	525_M	0.671	0.89
7_A	190_T	0.668	0.89
507_G	533_I	0.667	0.89
302_M	307_L	0.665	0.89
92_L	98_M	0.665	0.89
37_D	41_E	0.664	0.89
378_L	388_I	0.663	0.89
54_L	62_G	0.663	0.89
181_T	201_A	0.663	0.89
141_I	231_P	0.662	0.89
57_I	61_A	0.660	0.89
284_A	288_G	0.657	0.88
420_F	424_I	0.657	0.88
443_A	491_A	0.655	0.88
394_I	399_V	0.655	0.88
512_T	536_I	0.653	0.88
47_R	137_L	0.652	0.88
457_T	476_P	0.652	0.88
54_L	57_I	0.651	0.88
171_L	176_V	0.650	0.88
128_A	228_Y	0.649	0.88
85_L	89_I	0.649	0.88
346_N	349_K	0.647	0.88
147_I	151_A	0.647	0.88
168_T	190_T	0.645	0.87
443_A	495_E	0.642	0.87
58_K	62_G	0.642	0.87
92_L	107_V	0.641	0.87
117_E	121_E	0.641	0.87
159_V	212_V	0.639	0.87
263_T	516_L	0.639	0.87
118_L	126_R	0.639	0.87
38_Q	42_R	0.639	0.87
116_E	121_E	0.638	0.87
93_I	262_I	0.636	0.87
394_I	461_L	0.633	0.86
256_L	260_P	0.632	0.86
171_L	179_F	0.631	0.86
323_A	326_S	0.628	0.86
317_Y	373_Q	0.627	0.86
382_A	420_F	0.627	0.86
3_S	226_Q	0.626	0.86
399_V	403_R	0.626	0.86
260_P	263_T	0.622	0.85
449_F	497_K	0.622	0.85
36_V	97_H	0.621	0.85
402_L	405_E	0.620	0.85
125_E	185_G	0.618	0.85
108_I	130_V	0.618	0.85
73_F	76_H	0.618	0.85
501_M	506_A	0.617	0.85
163_L	181_T	0.617	0.85
481_V	485_I	0.617	0.85
195_R	507_G	0.617	0.85
18_L	58_K	0.617	0.85
121_E	229_V	0.616	0.85
489_I	518_M	0.616	0.85
88_E	91_A	0.616	0.85
102_A	105_H	0.615	0.85
420_F	423_S	0.615	0.85
61_A	73_F	0.615	0.85
264_L	534_K	0.614	0.85
317_Y	377_I	0.614	0.85
159_V	227_V	0.612	0.85
514_L	517_G	0.611	0.84
219_I	231_P	0.611	0.84
287_N	531_P	0.611	0.84
419_A	422_E	0.611	0.84
162_D	183_A	0.609	0.84
399_V	445_E	0.608	0.84
6_L	222_A	0.607	0.84
67_E	70_E	0.606	0.84
366_R	369_I	0.605	0.84
17_L	214_N	0.605	0.84
362_I	366_R	0.605	0.84
395_S	463_V	0.604	0.84
313_Q	317_Y	0.603	0.84
93_I	103_A	0.603	0.84
220_L	227_V	0.602	0.84
399_V	402_L	0.602	0.84
49_K	53_Q	0.601	0.84
107_V	110_G	0.601	0.84
484_L	488_V	0.601	0.84
395_S	438_I	0.601	0.84
367_R	371_R	0.600	0.83
261_A	271_V	0.600	0.83
262_I	538_R	0.599	0.83
471_S	479_P	0.599	0.83
275_I	284_A	0.598	0.83
129_D	136_R	0.597	0.83
479_P	483_N	0.597	0.83
470_I	479_P	0.596	0.83
205_T	227_V	0.596	0.83
176_V	199_L	0.596	0.83
269_V	523_F	0.595	0.83
129_D	133_I	0.594	0.83
412_E	416_E	0.593	0.83
168_T	179_F	0.593	0.83
123_L	126_R	0.593	0.83
385_K	421_D	0.591	0.82
322_E	383_F	0.591	0.82
133_I	137_L	0.591	0.82
531_P	534_K	0.590	0.82
516_L	542_F	0.589	0.82
534_K	538_R	0.588	0.82
272_C	330_I	0.588	0.82
118_L	122_Y	0.588	0.82
181_T	203_V	0.587	0.82
438_I	480_S	0.586	0.82
116_E	127_A	0.583	0.82
508_D	512_T	0.583	0.82
168_T	181_T	0.581	0.81
149_L	154_D	0.580	0.81
341_E	349_K	0.580	0.81
427_G	448_F	0.580	0.81
501_M	511_A	0.579	0.81
278_V	319_A	0.578	0.81
67_E	71_A	0.578	0.81
31_I	35_Q	0.578	0.81
395_S	473_L	0.578	0.81
504_E	526_S	0.577	0.81
353_P	458_Q	0.576	0.81
276_G	295_Y	0.575	0.81
432_T	461_L	0.575	0.81
451_I	489_I	0.574	0.81
417_G	420_F	0.574	0.81
86_E	89_I	0.573	0.81
311_E	314_F	0.573	0.81
149_L	152_I	0.572	0.80
263_T	537_I	0.572	0.80
374_L	402_L	0.569	0.80
118_L	121_E	0.569	0.80
65_F	69_K	0.568	0.80
438_I	478_S	0.568	0.80
137_L	142_L	0.566	0.80
406_I	424_I	0.566	0.80
57_I	72_I	0.566	0.80
44_L	52_A	0.566	0.80
120_D	124_K	0.564	0.79
202_I	225_N	0.564	0.79
457_T	475_Q	0.563	0.79
382_A	422_E	0.563	0.79
22_D	42_R	0.563	0.79
62_G	74_E	0.563	0.79
270_E	425_E	0.563	0.79
307_L	372_D	0.563	0.79
62_G	67_E	0.563	0.79
46_G	50_A	0.563	0.79
333_T	402_L	0.562	0.79
283_G	287_N	0.561	0.79
317_Y	388_I	0.561	0.79
479_P	517_G	0.560	0.79
256_L	259_L	0.559	0.79
475_Q	479_P	0.559	0.79
127_A	130_V	0.559	0.79
525_M	529_S	0.558	0.79
253_L	256_L	0.557	0.79
38_Q	46_G	0.557	0.79
79_L	130_V	0.556	0.79
477_M	510_R	0.556	0.79
179_F	190_T	0.553	0.78
120_D	126_R	0.553	0.78
330_I	448_F	0.553	0.78
319_A	322_E	0.553	0.78
368_E	372_D	0.553	0.78
268_Q	541_N	0.553	0.78
346_N	362_I	0.552	0.78
89_I	137_L	0.552	0.78
42_R	46_G	0.551	0.78
195_R	504_E	0.551	0.78
257_K	286_R	0.550	0.78
20_K	214_N	0.550	0.78
197_L	277_T	0.550	0.78
396_V	444_K	0.550	0.78
7_A	203_V	0.550	0.78
500_G	521_D	0.549	0.78
158_L	179_F	0.548	0.78
321_A	382_A	0.548	0.78
36_V	40_V	0.547	0.77
310_E	314_F	0.547	0.77
334_M	362_I	0.545	0.77
57_I	60_K	0.545	0.77
76_H	80_L	0.545	0.77
133_I	138_L	0.544	0.77
388_I	424_I	0.542	0.77
259_L	262_I	0.541	0.77
281_V	329_V	0.541	0.77
15_K	217_Y	0.540	0.77
488_V	497_K	0.539	0.76
123_L	127_A	0.536	0.76
325_G	329_V	0.536	0.76
167_E	181_T	0.535	0.76
270_E	498_W	0.534	0.76
157_I	177_L	0.534	0.76
163_L	190_T	0.534	0.76
63_E	67_E	0.533	0.76
430_V	492_S	0.533	0.76
407_E	424_I	0.533	0.76
89_I	107_V	0.533	0.76
439_A	511_A	0.533	0.76
16_A	216_D	0.532	0.75
352_N	458_Q	0.531	0.75
336_I	344_Y	0.531	0.75
328_A	385_K	0.531	0.75
145_K	148_D	0.531	0.75
387_R	498_W	0.531	0.75
159_V	209_T	0.531	0.75
64_T	70_E	0.531	0.75
58_K	61_A	0.530	0.75
449_F	488_V	0.529	0.75
64_T	67_E	0.529	0.75
37_D	40_V	0.526	0.75
506_A	523_F	0.526	0.75
280_D	284_A	0.525	0.75
228_Y	235_V	0.524	0.74
466_G	501_M	0.524	0.74
333_T	370_L	0.523	0.74
126_R	138_L	0.522	0.74
321_A	385_K	0.522	0.74
195_R	292_V	0.522	0.74
441_H	445_E	0.521	0.74
28_R	102_A	0.520	0.74
351_E	468_D	0.520	0.74
273_A	281_V	0.520	0.74
191_S	201_A	0.520	0.74
119_D	126_R	0.519	0.74
363_A	402_L	0.518	0.74
359_A	457_T	0.518	0.74
367_R	405_E	0.517	0.73
482_L	511_A	0.517	0.73
20_K	23_E	0.516	0.73
486_K	489_I	0.516	0.73
525_M	537_I	0.516	0.73
511_A	515_L	0.516	0.73
509_E	533_I	0.516	0.73
436_A	488_V	0.514	0.73
496_G	499_T	0.513	0.73
516_L	523_F	0.512	0.73
28_R	98_M	0.512	0.73
425_E	447_D	0.511	0.73
395_S	399_V	0.511	0.73
502_C	524_S	0.511	0.73
65_F	70_E	0.511	0.73
361_R	427_G	0.510	0.72
461_L	480_S	0.510	0.72
146_I	153_Q	0.510	0.72
402_L	406_I	0.509	0.72
257_K	261_A	0.509	0.72
505_L	515_L	0.509	0.72
116_E	124_K	0.507	0.72
396_V	399_V	0.506	0.72
521_D	542_F	0.506	0.72
94_K	97_H	0.505	0.72
150_S	155_E	0.505	0.72
382_A	414_R	0.505	0.72
381_S	414_R	0.504	0.72
23_E	26_I	0.503	0.71
58_K	70_E	0.503	0.71
459_Y	463_V	0.503	0.71
234_E	237_D	0.502	0.71
201_A	222_A	0.502	0.71
256_L	531_P	0.501	0.71
307_L	342_L	0.501	0.71
443_A	492_S	0.501	0.71
18_L	214_N	0.500	0.71

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2hwgA	2	0.9948	100	0.179	Contact Map
2wqdA	2	0.9878	100	0.19	Contact Map
1kblA	2	0.8957	100	0.337	Contact Map
1vbgA	2	0.8922	100	0.344	Contact Map
2x0sA	2	0.9252	100	0.352	Contact Map
2olsA	2	0.7443	100	0.43	Contact Map
2xz9A	2	0.5513	100	0.547	Contact Map
1zymA	2	0.4313	100	0.679	Contact Map
4l9zA	5	0.4835	100	0.783	Contact Map
3qqwA	3	0.4887	100	0.784	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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