PTV3B - ECOLI - GREMLIN Contacts

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PTV3B - PTS system beta-glucoside-specific EIIBCA component

UniProt:	P08722	Sequences: MTELARKIVAGVGGADNIVSLMHCATRLRFKLKDESKAQAEVLKKTPGIIMVVESGGQFQVVIGNHVADVFLAVNSVAGLDEKAQQAPENDDKGNLLNRFVYVISGIFTPLIGLMAATGILKGMLALALTFQWTTEQSGTYLILFSASDALFWFFPIILGYTAGKRFGGNPFTAMVIGGALVHPLILTAFENGQKADALGLDFLGIPVTLLNYSSSVIPIIFSAWLCSILERRLNAWLPSAIKNFFTPLLCLMVITPVTFLLVGPLSTWISELIAAGYLWLYQAVPAFAGAVMGGFWQIFVMFGLHWGLVPLCINNFTVLGYDTMIPLLMPAIMAQVGAALGVFLCERDAQKKVVAGSAALTSLFGITEPAVYGVNLPRKYPFVIACISGALGATIIGYAQTKVYSFGLPSIFTFMQTIPSTGIDFTVWASVIGGVIAIGCAFVGTVMLHFITAKRQPAQGAPQEKTPEVITPPEQGGICSPMTGEIVPLIHVADTTFASGLLGKGIAILPSVGEVRSPVAGRIASLFATLHAIGIESDDGVEILIHVGIDTVKLDGKFFSAHVNVGDKVNTGDRLISFDIPAIREAGFDLTTPVLISNSDDFTDVLPHGTAQISAGEPLLSIIR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10115
Length:	625 (609)
Sequences:	1559 (1209)
Seq/√Len:	49.0

ECOLI - PTV3B PTIBC PTTBC PTYBC
BACSU - PTV3B PTSBC PTXBC PTTBC SACX

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
548_V	577_I	5.600	1.00
501_G	505_K	5.132	1.00
539_D	569_K	4.544	1.00
521_A	571_N	4.506	1.00
565_N	568_D	4.359	1.00
520_V	538_S	4.259	1.00
559_F	583_A	3.914	1.00
563_H	575_R	3.908	1.00
525_A	537_E	3.826	1.00
515_E	575_R	3.736	1.00
561_S	578_S	3.711	1.00
389_S	441_C	3.623	1.00
558_K	587_A	3.357	1.00
484_T	513_V	3.334	1.00
514_G	581_I	3.309	1.00
342_G	443_F	3.285	1.00
494_A	590_D	3.224	1.00
223_S	259_T	3.183	1.00
568_D	574_D	3.153	1.00
563_H	578_S	3.122	1.00
520_V	536_I	3.078	1.00
396_I	437_I	3.072	1.00
515_E	578_S	3.060	1.00
39_Q	42_V	2.961	1.00
483_M	516_V	2.945	1.00
3_E	7_K	2.814	1.00
554_K	589_F	2.808	1.00
295_G	391_A	2.786	1.00
517_R	575_R	2.781	1.00
571_N	574_D	2.719	1.00
510_L	590_D	2.704	1.00
531_L	562_A	2.666	1.00
581_I	585_R	2.663	1.00
316_N	323_D	2.661	1.00
94_G	99_R	2.654	1.00
516_V	546_I	2.639	1.00
521_A	572_T	2.628	1.00
524_I	536_I	2.603	1.00
493_V	508_A	2.603	1.00
227_C	251_C	2.585	1.00
581_I	591_L	2.557	1.00
160_G	174_A	2.555	1.00
481_S	509_I	2.530	1.00
583_A	586_E	2.514	1.00
9_V	74_V	2.508	1.00
11_G	39_Q	2.478	1.00
523_R	569_K	2.410	1.00
35_E	54_E	2.395	1.00
234_L	250_L	2.386	1.00
51_M	62_V	2.348	1.00
488_V	592_T	2.323	1.00
579_F	584_I	2.296	1.00
161_Y	175_M	2.291	1.00
396_I	430_A	2.269	1.00
522_G	536_I	2.255	1.00
491_I	501_G	2.222	1.00
494_A	592_T	2.210	1.00
483_M	593_T	2.207	1.00
527_L	562_A	2.200	1.00
15_A	79_G	2.190	1.00
510_L	585_R	2.182	1.00
486_E	510_L	2.179	1.00
583_A	587_A	2.171	1.00
392_L	441_C	2.151	1.00
555_L	559_F	2.139	1.00
40_A	59_F	2.123	1.00
550_I	594_P	2.097	1.00
480_C	572_T	2.075	1.00
250_L	254_V	2.063	1.00
582_P	586_E	2.045	1.00
517_R	616_A	2.044	1.00
43_L	46_T	2.038	1.00
544_I	597_I	2.028	1.00
294_G	390_G	2.024	1.00
558_K	583_A	2.011	1.00
591_L	594_P	2.000	1.00
280_W	284_A	1.986	0.99
505_K	605_D	1.977	0.99
41_E	44_K	1.973	0.99
73_A	76_S	1.943	0.99
479_I	520_V	1.941	0.99
157_I	179_G	1.936	0.99
161_Y	171_P	1.917	0.99
32_L	38_A	1.913	0.99
4_L	46_T	1.912	0.99
575_R	578_S	1.910	0.99
385_I	449_L	1.886	0.99
521_A	539_D	1.878	0.99
40_A	54_E	1.869	0.99
341_L	360_A	1.866	0.99
489_P	492_H	1.863	0.99
551_D	554_K	1.859	0.99
103_V	167_F	1.848	0.99
582_P	585_R	1.843	0.99
102_Y	166_R	1.841	0.99
124_M	128_A	1.840	0.99
444_V	448_M	1.836	0.99
347_E	352_K	1.835	0.99
47_P	351_Q	1.832	0.99
527_L	566_V	1.827	0.99
336_Q	376_N	1.785	0.99
397_I	434_G	1.748	0.99
21_L	74_V	1.738	0.99
157_I	175_M	1.725	0.98
18_I	78_A	1.717	0.98
432_V	436_V	1.717	0.98
11_G	42_V	1.700	0.98
337_V	363_S	1.676	0.98
143_I	208_V	1.667	0.98
559_F	587_A	1.666	0.98
21_L	30_F	1.664	0.98
19_V	33_K	1.638	0.98
34_D	37_K	1.637	0.98
165_K	171_P	1.633	0.98
484_T	512_S	1.623	0.98
518_S	521_A	1.623	0.98
515_E	563_H	1.613	0.98
235_N	243_K	1.609	0.98
477_G	542_V	1.606	0.98
484_T	616_A	1.606	0.98
372_V	383_F	1.606	0.98
400_A	430_A	1.605	0.98
226_L	258_V	1.600	0.98
164_G	224_A	1.583	0.97
338_G	439_I	1.568	0.97
222_F	267_S	1.568	0.97
516_V	579_F	1.557	0.97
520_V	544_I	1.557	0.97
614_I	618_E	1.546	0.97
559_F	589_F	1.546	0.97
7_K	46_T	1.544	0.97
555_L	558_K	1.538	0.97
96_L	99_R	1.533	0.97
160_G	178_G	1.532	0.97
501_G	600_S	1.529	0.97
497_T	502_L	1.518	0.97
507_I	620_L	1.496	0.96
508_A	592_T	1.491	0.96
128_A	133_W	1.483	0.96
230_L	255_I	1.482	0.96
331_P	397_I	1.481	0.96
510_L	591_L	1.475	0.96
531_L	563_H	1.473	0.96
523_R	537_E	1.471	0.96
189_A	201_L	1.470	0.96
30_F	61_V	1.467	0.96
40_A	44_K	1.467	0.96
518_S	572_T	1.465	0.96
477_G	540_D	1.463	0.96
483_M	594_P	1.460	0.96
600_S	606_V	1.459	0.96
6_R	10_A	1.449	0.96
349_D	352_K	1.441	0.95
162_T	172_F	1.439	0.95
11_G	46_T	1.438	0.95
595_V	620_L	1.433	0.95
487_I	507_I	1.429	0.95
358_S	362_T	1.428	0.95
338_G	442_A	1.426	0.95
242_I	246_F	1.424	0.95
513_V	581_I	1.405	0.95
96_L	100_F	1.399	0.95
71_F	75_N	1.397	0.95
178_G	220_I	1.394	0.94
18_I	80_L	1.394	0.94
527_L	531_L	1.393	0.94
322_Y	403_K	1.391	0.94
484_T	615_S	1.389	0.94
330_M	431_S	1.380	0.94
108_F	217_V	1.378	0.94
379_R	451_F	1.361	0.94
344_F	357_G	1.360	0.94
272_E	276_A	1.358	0.94
513_V	579_F	1.352	0.94
226_L	263_V	1.337	0.93
121_L	148_S	1.336	0.93
169_G	224_A	1.324	0.93
164_G	174_A	1.316	0.93
497_T	503_L	1.314	0.93
20_S	31_K	1.312	0.92
396_I	400_A	1.310	0.92
111_L	155_F	1.309	0.92
352_K	379_R	1.298	0.92
584_I	587_A	1.292	0.92
285_V	288_F	1.285	0.92
122_K	149_D	1.281	0.92
531_L	561_S	1.279	0.91
563_H	574_D	1.273	0.91
392_L	437_I	1.273	0.91
524_I	534_I	1.269	0.91
150_A	179_G	1.268	0.91
267_S	271_S	1.264	0.91
290_G	294_G	1.262	0.91
23_H	71_F	1.256	0.91
225_W	228_S	1.256	0.91
118_T	151_L	1.243	0.90
107_I	221_I	1.238	0.90
73_A	77_V	1.236	0.90
534_I	577_I	1.225	0.90
562_A	577_I	1.221	0.89
486_E	512_S	1.209	0.89
12_V	32_L	1.208	0.89
514_G	582_P	1.208	0.89
298_Q	333_I	1.207	0.89
488_V	493_V	1.202	0.89
330_M	414_T	1.195	0.88
118_T	150_A	1.187	0.88
615_S	618_E	1.180	0.88
180_A	256_T	1.172	0.87
555_L	594_P	1.171	0.87
278_Y	324_T	1.168	0.87
111_L	162_T	1.165	0.87
384_V	388_I	1.163	0.87
345_L	443_F	1.163	0.87
300_F	309_L	1.159	0.87
125_L	141_Y	1.152	0.87
389_S	442_A	1.148	0.86
440_G	444_V	1.147	0.86
208_V	261_L	1.147	0.86
225_W	229_I	1.145	0.86
486_E	613_Q	1.144	0.86
51_M	303_F	1.143	0.86
430_A	433_I	1.136	0.86
609_H	622_S	1.134	0.86
555_L	583_A	1.131	0.85
508_A	594_P	1.122	0.85
604_T	607_L	1.120	0.85
522_G	538_S	1.118	0.85
488_V	510_L	1.116	0.85
542_V	603_F	1.112	0.84
235_N	247_T	1.105	0.84
154_F	184_P	1.104	0.84
487_I	620_L	1.101	0.84
599_N	603_F	1.089	0.83
149_D	183_H	1.085	0.83
121_L	249_L	1.084	0.83
54_E	59_F	1.083	0.83
147_A	256_T	1.083	0.83
490_L	506_G	1.080	0.83
21_L	75_N	1.078	0.83
379_R	382_P	1.075	0.82
164_G	169_G	1.075	0.82
174_A	178_G	1.070	0.82
273_L	277_G	1.070	0.82
607_L	622_S	1.069	0.82
169_G	174_A	1.068	0.82
529_A	556_D	1.067	0.82
503_L	596_L	1.062	0.82
240_S	243_K	1.061	0.82
478_G	619_P	1.061	0.82
274_I	300_F	1.059	0.81
381_Y	452_I	1.055	0.81
340_A	371_A	1.054	0.81
520_V	542_V	1.051	0.81
524_I	570_V	1.049	0.81
9_V	77_V	1.049	0.81
290_G	394_A	1.045	0.81
233_R	237_W	1.042	0.80
42_V	46_T	1.033	0.80
531_L	534_I	1.030	0.80
507_I	608_P	1.027	0.79
507_I	595_V	1.024	0.79
396_I	434_G	1.024	0.79
600_S	603_F	1.023	0.79
336_Q	368_T	1.022	0.79
536_I	546_I	1.021	0.79
496_T	500_S	1.016	0.79
30_F	74_V	1.012	0.78
159_L	220_I	1.010	0.78
381_Y	450_H	1.010	0.78
596_L	600_S	1.008	0.78
527_L	577_I	1.008	0.78
147_A	180_A	1.008	0.78
62_V	303_F	1.001	0.78
393_G	438_A	0.998	0.77
555_L	591_L	0.998	0.77
512_S	613_Q	0.997	0.77
493_V	592_T	0.995	0.77
290_G	395_T	0.993	0.77
8_I	43_L	0.990	0.77
153_W	214_S	0.990	0.77
483_M	595_V	0.989	0.77
486_E	612_A	0.989	0.77
505_K	600_S	0.987	0.77
120_I	246_F	0.986	0.77
518_S	536_I	0.986	0.77
291_A	395_T	0.985	0.76
238_L	246_F	0.983	0.76
164_G	171_P	0.982	0.76
525_A	536_I	0.982	0.76
157_I	178_G	0.981	0.76
281_L	292_V	0.978	0.76
167_F	225_W	0.972	0.76
483_M	579_F	0.970	0.75
338_G	364_L	0.969	0.75
290_G	328_L	0.967	0.75
521_A	536_I	0.965	0.75
302_M	372_V	0.965	0.75
6_R	77_V	0.965	0.75
163_A	221_I	0.964	0.75
7_K	10_A	0.963	0.75
548_V	579_F	0.962	0.75
483_M	581_I	0.960	0.75
529_A	566_V	0.959	0.75
15_A	78_A	0.954	0.74
127_L	131_F	0.954	0.74
477_G	538_S	0.953	0.74
443_F	447_V	0.952	0.74
346_C	451_F	0.950	0.74
293_M	309_L	0.950	0.74
160_G	224_A	0.949	0.74
332_A	336_Q	0.947	0.74
393_G	437_I	0.945	0.73
120_I	249_L	0.944	0.73
169_G	227_C	0.939	0.73
389_S	392_L	0.933	0.72
527_L	534_I	0.932	0.72
609_H	612_A	0.927	0.72
91_D	99_R	0.927	0.72
353_K	357_G	0.923	0.72
382_P	446_T	0.923	0.72
376_N	382_P	0.920	0.71
161_Y	165_K	0.916	0.71
9_V	78_A	0.912	0.71
490_L	493_V	0.909	0.71
103_V	107_I	0.907	0.70
161_Y	172_F	0.904	0.70
516_V	593_T	0.903	0.70
408_G	417_Q	0.902	0.70
168_G	232_R	0.901	0.70
167_F	228_S	0.900	0.70
135_T	138_S	0.899	0.70
513_V	517_R	0.899	0.70
524_I	564_V	0.898	0.70
445_G	449_L	0.897	0.69
277_G	281_L	0.896	0.69
385_I	389_S	0.894	0.69
182_V	214_S	0.892	0.69
484_T	617_G	0.892	0.69
168_G	174_A	0.891	0.69
299_I	303_F	0.890	0.69
168_G	224_A	0.890	0.69
53_V	62_V	0.890	0.69
269_W	273_L	0.889	0.69
338_G	342_G	0.887	0.69
43_L	59_F	0.885	0.68
343_V	451_F	0.884	0.68
488_V	508_A	0.882	0.68
481_S	620_L	0.881	0.68
349_D	453_T	0.881	0.68
476_Q	604_T	0.872	0.67
343_V	347_E	0.871	0.67
385_I	445_G	0.870	0.67
123_G	290_G	0.870	0.67
490_L	501_G	0.866	0.67
346_C	381_Y	0.865	0.67
298_Q	372_V	0.861	0.66
230_L	254_V	0.857	0.66
299_I	387_C	0.854	0.66
383_F	387_C	0.853	0.66
289_A	323_D	0.853	0.66
436_V	580_D	0.852	0.65
523_R	539_D	0.847	0.65
203_F	257_P	0.845	0.65
479_I	595_V	0.845	0.65
469_E	586_E	0.843	0.65
360_A	364_L	0.843	0.65
402_T	428_V	0.842	0.65
4_L	8_I	0.841	0.64
115_M	307_W	0.838	0.64
299_I	383_F	0.838	0.64
143_I	260_F	0.834	0.64
510_L	592_T	0.833	0.64
562_A	566_V	0.832	0.64
505_K	603_F	0.830	0.63
572_T	575_R	0.828	0.63
229_I	233_R	0.826	0.63
169_G	229_I	0.825	0.63
151_L	158_I	0.825	0.63
529_A	548_V	0.824	0.63
514_G	578_S	0.824	0.63
266_L	271_S	0.824	0.63
163_A	167_F	0.822	0.63
481_S	614_I	0.820	0.62
339_A	376_N	0.820	0.62
563_H	577_I	0.820	0.62
246_F	250_L	0.818	0.62
163_A	225_W	0.818	0.62
483_M	591_L	0.817	0.62
158_I	179_G	0.817	0.62
4_L	48_G	0.814	0.62
35_E	59_F	0.813	0.62
177_I	220_I	0.811	0.62
439_I	442_A	0.810	0.62
342_G	447_V	0.809	0.61
43_L	61_V	0.809	0.61
612_A	621_L	0.809	0.61
294_G	328_L	0.807	0.61
170_N	231_E	0.804	0.61
429_W	433_I	0.803	0.61
224_A	260_F	0.803	0.61
581_I	584_I	0.801	0.61
11_G	43_L	0.801	0.61
396_I	433_I	0.801	0.61
224_A	228_S	0.799	0.60
66_H	69_D	0.799	0.60
389_S	393_G	0.799	0.60
483_M	509_I	0.799	0.60
339_A	386_A	0.798	0.60
334_M	337_V	0.797	0.60
344_F	353_K	0.796	0.60
275_A	308_G	0.796	0.60
319_V	322_Y	0.796	0.60
491_I	544_I	0.795	0.60
576_L	597_I	0.792	0.60
63_I	70_V	0.791	0.60
415_F	435_G	0.789	0.59
140_T	204_L	0.788	0.59
392_L	396_I	0.785	0.59
177_I	252_L	0.785	0.59
97_L	100_F	0.784	0.59
298_Q	383_F	0.782	0.59
229_I	232_R	0.776	0.58
177_I	223_S	0.776	0.58
315_N	318_T	0.775	0.58
144_L	204_L	0.773	0.58
441_C	445_G	0.772	0.58
160_G	175_M	0.772	0.58
402_T	434_G	0.772	0.58
101_V	377_L	0.771	0.58
393_G	439_I	0.769	0.58
388_I	445_G	0.768	0.57
234_L	238_L	0.768	0.57
9_V	18_I	0.766	0.57
437_I	441_C	0.765	0.57
25_A	367_I	0.764	0.57
410_P	414_T	0.764	0.57
538_S	570_V	0.763	0.57
37_K	558_K	0.759	0.57
585_R	591_L	0.757	0.56
335_A	389_S	0.756	0.56
527_L	620_L	0.756	0.56
100_F	103_V	0.756	0.56
497_T	554_K	0.753	0.56
315_N	319_V	0.752	0.56
339_A	382_P	0.750	0.56
120_I	123_G	0.749	0.56
548_V	593_T	0.749	0.56
123_G	298_Q	0.748	0.55
160_G	168_G	0.746	0.55
492_H	512_S	0.745	0.55
115_M	452_I	0.745	0.55
487_I	609_H	0.743	0.55
226_L	255_I	0.742	0.55
287_A	399_Y	0.742	0.55
186_I	190_F	0.741	0.55
118_T	249_L	0.740	0.55
400_A	437_I	0.739	0.55
336_Q	386_A	0.738	0.54
46_T	49_I	0.738	0.54
347_E	453_T	0.738	0.54
395_T	399_Y	0.736	0.54
352_K	375_V	0.736	0.54
389_S	445_G	0.735	0.54
394_A	416_M	0.734	0.54
8_I	63_I	0.731	0.54
208_V	556_D	0.731	0.54
526_S	554_K	0.730	0.54
555_L	589_F	0.729	0.54
292_V	296_F	0.727	0.53
105_S	307_W	0.726	0.53
480_C	617_G	0.726	0.53
515_E	616_A	0.725	0.53
142_L	189_A	0.724	0.53
238_L	242_I	0.723	0.53
169_G	231_E	0.723	0.53
492_H	611_T	0.722	0.53
5_A	74_V	0.722	0.53
612_A	622_S	0.722	0.53
238_L	247_T	0.721	0.53
339_A	385_I	0.721	0.53
186_I	260_F	0.720	0.53
117_A	178_G	0.720	0.53
5_A	77_V	0.720	0.53
343_V	382_P	0.718	0.52
12_V	38_A	0.718	0.52
95_N	98_N	0.718	0.52
298_Q	387_C	0.717	0.52
180_A	260_F	0.717	0.52
514_G	575_R	0.716	0.52
271_S	305_L	0.714	0.52
352_K	453_T	0.712	0.52
293_M	300_F	0.711	0.52
614_I	620_L	0.710	0.52
494_A	499_A	0.710	0.52
404_V	417_Q	0.709	0.51
310_V	313_C	0.705	0.51
332_A	372_V	0.705	0.51
33_K	59_F	0.704	0.51
584_I	589_F	0.703	0.51
478_G	620_L	0.702	0.51
313_C	323_D	0.702	0.51
216_S	220_I	0.702	0.51
505_K	606_V	0.702	0.51
41_E	463_P	0.701	0.51
543_E	598_S	0.699	0.50
345_L	447_V	0.699	0.50
90_N	99_R	0.699	0.50
309_L	313_C	0.698	0.50
275_A	309_L	0.696	0.50
494_A	550_I	0.695	0.50
487_I	614_I	0.695	0.50
516_V	548_V	0.694	0.50
600_S	604_T	0.693	0.50
107_I	167_F	0.690	0.50
159_L	217_V	0.690	0.50
278_Y	312_L	0.690	0.50
25_A	410_P	0.690	0.50
438_A	442_A	0.689	0.49
337_V	360_A	0.687	0.49
144_L	203_F	0.684	0.49
340_A	344_F	0.683	0.49
93_K	99_R	0.683	0.49
129_L	136_E	0.683	0.49
493_V	590_D	0.683	0.49
10_A	39_Q	0.683	0.49
548_V	604_T	0.682	0.49
287_A	395_T	0.682	0.49
518_S	538_S	0.682	0.49
72_L	168_G	0.680	0.49
161_Y	170_N	0.680	0.49
535_G	598_S	0.680	0.49
509_I	584_I	0.677	0.48
177_I	181_L	0.676	0.48
349_D	456_R	0.676	0.48
146_S	183_H	0.674	0.48
84_A	89_E	0.674	0.48
139_G	202_D	0.673	0.48
603_F	606_V	0.673	0.48
37_K	43_L	0.672	0.48
339_A	389_S	0.672	0.48
347_E	353_K	0.670	0.48
544_I	616_A	0.666	0.47
493_V	506_G	0.666	0.47
385_I	446_T	0.666	0.47
44_K	378_P	0.666	0.47
596_L	602_D	0.665	0.47
509_I	595_V	0.664	0.47
405_Y	419_I	0.663	0.47
488_V	494_A	0.662	0.47
35_E	57_G	0.662	0.47
405_Y	431_S	0.661	0.47
348_R	448_M	0.659	0.46
106_G	166_R	0.658	0.46
522_G	572_T	0.658	0.46
74_V	78_A	0.653	0.46
523_R	566_V	0.651	0.46
335_A	386_A	0.651	0.46
107_I	123_G	0.650	0.46
149_D	243_K	0.649	0.45
376_N	386_A	0.649	0.45
609_H	620_L	0.649	0.45
25_A	53_V	0.648	0.45
479_I	544_I	0.647	0.45
580_D	583_A	0.647	0.45
188_T	192_N	0.647	0.45
503_L	598_S	0.646	0.45
342_G	446_T	0.645	0.45
75_N	80_L	0.644	0.45
16_D	37_K	0.644	0.45
203_F	261_L	0.644	0.45
531_L	559_F	0.643	0.45
122_K	183_H	0.643	0.45
465_E	469_E	0.642	0.45
350_A	353_K	0.642	0.45
245_F	331_P	0.642	0.45
536_I	606_V	0.642	0.45
12_V	30_F	0.641	0.45
277_G	280_W	0.641	0.45
230_L	234_L	0.641	0.45
340_A	376_N	0.641	0.45
170_N	367_I	0.641	0.45
21_L	528_F	0.640	0.45
25_A	108_F	0.640	0.45
512_S	581_I	0.640	0.45
327_P	408_G	0.639	0.44
282_Y	328_L	0.637	0.44
40_A	52_V	0.637	0.44
600_S	621_L	0.637	0.44
95_N	99_R	0.637	0.44
503_L	526_S	0.636	0.44
410_P	417_Q	0.636	0.44
358_S	367_I	0.635	0.44
242_I	442_A	0.635	0.44
32_L	59_F	0.633	0.44
582_P	615_S	0.633	0.44
38_A	52_V	0.632	0.44
332_A	368_T	0.631	0.44
402_T	430_A	0.628	0.43
10_A	16_D	0.626	0.43
41_E	45_K	0.626	0.43
162_T	365_F	0.625	0.43
174_A	224_A	0.624	0.43
334_M	439_I	0.624	0.43
445_G	448_M	0.623	0.43
4_L	70_V	0.622	0.43
127_L	130_T	0.622	0.43
344_F	356_A	0.622	0.43
554_K	578_S	0.621	0.43
10_A	615_S	0.620	0.43
287_A	291_A	0.620	0.43
480_C	619_P	0.619	0.42
537_E	601_D	0.617	0.42
494_A	510_L	0.617	0.42
329_L	333_I	0.615	0.42
474_P	477_G	0.615	0.42
92_D	95_N	0.615	0.42
591_L	595_V	0.614	0.42
476_Q	622_S	0.614	0.42
500_S	592_T	0.613	0.42
190_F	214_S	0.613	0.42
43_L	49_I	0.612	0.42
548_V	562_A	0.612	0.42
347_E	379_R	0.611	0.42
298_Q	332_A	0.611	0.42
596_L	603_F	0.611	0.42
526_S	566_V	0.610	0.42
153_W	159_L	0.610	0.42
558_K	589_F	0.610	0.42
150_A	178_G	0.609	0.41
407_F	411_S	0.609	0.41
270_I	273_L	0.609	0.41
465_E	586_E	0.609	0.41
296_F	387_C	0.608	0.41
360_A	363_S	0.606	0.41
158_I	176_V	0.606	0.41
242_I	365_F	0.606	0.41
336_Q	371_A	0.605	0.41
597_I	606_V	0.603	0.41
190_F	383_F	0.603	0.41
479_I	618_E	0.603	0.41
244_N	247_T	0.602	0.41
538_S	542_V	0.602	0.41
372_V	386_A	0.601	0.41
367_I	410_P	0.601	0.41
484_T	515_E	0.601	0.41
68_A	72_L	0.600	0.41
105_S	176_V	0.599	0.40
368_T	371_A	0.599	0.40
525_A	544_I	0.598	0.40
115_M	385_I	0.598	0.40
507_I	559_F	0.598	0.40
566_V	601_D	0.596	0.40
484_T	614_I	0.596	0.40
507_I	510_L	0.595	0.40
554_K	585_R	0.595	0.40
42_V	45_K	0.594	0.40
479_I	542_V	0.593	0.40
336_Q	387_C	0.593	0.40
228_S	232_R	0.593	0.40
113_G	333_I	0.592	0.40
25_A	409_L	0.592	0.40
237_W	288_F	0.590	0.40
525_A	601_D	0.589	0.39
546_I	594_P	0.589	0.39
69_D	235_N	0.589	0.39
457_Q	460_Q	0.588	0.39
325_M	329_L	0.587	0.39
429_W	432_V	0.587	0.39
397_I	402_T	0.586	0.39
468_P	471_I	0.584	0.39
493_V	499_A	0.584	0.39
500_S	531_L	0.584	0.39
160_G	169_G	0.584	0.39
463_P	471_I	0.584	0.39
50_I	62_V	0.583	0.39
19_V	31_K	0.583	0.39
343_V	450_H	0.582	0.39
468_P	480_C	0.582	0.39
12_V	61_V	0.582	0.39
429_W	561_S	0.581	0.39
139_G	203_F	0.581	0.39
526_S	535_G	0.581	0.39
243_K	247_T	0.580	0.39
496_T	503_L	0.580	0.39
332_A	390_G	0.579	0.39
486_E	494_A	0.579	0.39
129_L	141_Y	0.579	0.39
459_A	462_A	0.579	0.39
531_L	565_N	0.579	0.39
297_W	333_I	0.579	0.39
282_Y	289_A	0.578	0.38
218_I	267_S	0.578	0.38
562_A	568_D	0.578	0.38
470_V	475_E	0.578	0.38
203_F	208_V	0.577	0.38
98_N	102_Y	0.576	0.38
107_I	231_E	0.576	0.38
38_A	59_F	0.575	0.38
222_F	263_V	0.574	0.38
571_N	585_R	0.574	0.38
21_L	503_L	0.574	0.38
213_Y	219_P	0.573	0.38
389_S	414_T	0.572	0.38
139_G	201_L	0.572	0.38
139_G	142_L	0.572	0.38
324_T	327_P	0.572	0.38
297_W	307_W	0.571	0.38
230_L	258_V	0.571	0.38
488_V	590_D	0.571	0.38
187_L	191_E	0.571	0.38
150_A	176_V	0.570	0.38
124_M	242_I	0.570	0.38
338_G	441_C	0.570	0.38
298_Q	376_N	0.568	0.37
263_V	277_G	0.568	0.37
333_I	411_S	0.568	0.37
502_L	529_A	0.567	0.37
357_G	361_L	0.566	0.37
611_T	621_L	0.566	0.37
486_E	513_V	0.565	0.37
169_G	251_C	0.565	0.37
528_F	556_D	0.564	0.37
336_Q	363_S	0.563	0.37
458_P	613_Q	0.563	0.37
34_D	43_L	0.563	0.37
7_K	42_V	0.563	0.37
245_F	413_F	0.562	0.37
542_V	599_N	0.561	0.37
375_V	379_R	0.561	0.37
126_A	404_V	0.561	0.37
252_L	395_T	0.561	0.37
520_V	572_T	0.560	0.37
192_N	200_G	0.560	0.37
578_S	591_L	0.560	0.37
124_M	127_L	0.559	0.37
546_I	595_V	0.559	0.37
355_V	359_A	0.558	0.37
544_I	591_L	0.558	0.37
168_G	178_G	0.557	0.36
333_I	376_N	0.557	0.36
114_L	418_T	0.557	0.36
530_T	577_I	0.556	0.36
125_L	145_F	0.556	0.36
68_A	144_L	0.556	0.36
140_T	143_I	0.555	0.36
118_T	244_N	0.555	0.36
144_L	253_M	0.555	0.36
25_A	333_I	0.554	0.36
172_F	415_F	0.554	0.36
358_S	409_L	0.553	0.36
45_K	457_Q	0.553	0.36
528_F	594_P	0.553	0.36
6_R	518_S	0.552	0.36
227_C	415_F	0.551	0.36
571_N	602_D	0.551	0.36
501_G	506_G	0.551	0.36
313_C	409_L	0.550	0.36
89_E	92_D	0.550	0.36
332_A	386_A	0.550	0.36
363_S	368_T	0.550	0.36
160_G	339_A	0.549	0.36
247_T	410_P	0.549	0.36
169_G	228_S	0.549	0.36
334_M	338_G	0.549	0.36
515_E	561_S	0.548	0.36
561_S	585_R	0.547	0.35
245_F	410_P	0.546	0.35
218_I	223_S	0.546	0.35
341_L	344_F	0.546	0.35
49_I	63_I	0.545	0.35
3_E	6_R	0.545	0.35
490_L	594_P	0.545	0.35
297_W	309_L	0.545	0.35
142_L	186_I	0.545	0.35
160_G	182_V	0.545	0.35
462_A	466_K	0.544	0.35
394_A	398_G	0.544	0.35
230_L	250_L	0.544	0.35
330_M	333_I	0.543	0.35
478_G	622_S	0.543	0.35
363_S	371_A	0.542	0.35
342_G	450_H	0.540	0.35
242_I	410_P	0.540	0.35
528_F	577_I	0.540	0.35
548_V	619_P	0.540	0.35
52_V	245_F	0.540	0.35
115_M	378_P	0.539	0.35
158_I	442_A	0.539	0.35
333_I	371_A	0.538	0.35
262_L	266_L	0.538	0.35
113_G	116_A	0.538	0.35
405_Y	421_S	0.538	0.35
46_T	351_Q	0.538	0.35
294_G	417_Q	0.537	0.35
117_A	334_M	0.537	0.35
584_I	593_T	0.537	0.35
343_V	379_R	0.537	0.35
297_W	303_F	0.537	0.35
481_S	594_P	0.537	0.35
550_I	591_L	0.537	0.35
580_D	593_T	0.536	0.34
116_A	379_R	0.536	0.34
507_I	621_L	0.535	0.34
213_Y	368_T	0.535	0.34
115_M	180_A	0.534	0.34
166_R	267_S	0.534	0.34
520_V	531_L	0.534	0.34
473_P	604_T	0.533	0.34
270_I	305_L	0.533	0.34
534_I	570_V	0.532	0.34
303_F	307_W	0.532	0.34
512_S	605_D	0.532	0.34
384_V	390_G	0.532	0.34
508_A	590_D	0.532	0.34
347_E	375_V	0.532	0.34
140_T	207_P	0.532	0.34
66_H	240_S	0.532	0.34
535_G	566_V	0.532	0.34
392_L	515_E	0.531	0.34
255_I	259_T	0.530	0.34
482_P	595_V	0.530	0.34
113_G	307_W	0.530	0.34
343_V	352_K	0.529	0.34
522_G	569_K	0.529	0.34
176_V	252_L	0.529	0.34
295_G	299_I	0.529	0.34
267_S	354_V	0.528	0.34
405_Y	420_P	0.528	0.34
125_L	128_A	0.528	0.34
476_Q	607_L	0.528	0.34
165_K	172_F	0.528	0.34
562_A	578_S	0.527	0.34
527_L	564_V	0.527	0.34
150_A	153_W	0.527	0.34
524_I	577_I	0.526	0.34
556_D	587_A	0.526	0.34
259_T	597_I	0.525	0.33
18_I	613_Q	0.525	0.33
465_E	470_V	0.524	0.33
332_A	410_P	0.524	0.33
250_L	465_E	0.524	0.33
143_I	201_L	0.523	0.33
123_G	409_L	0.523	0.33
143_I	315_N	0.523	0.33
308_G	316_N	0.523	0.33
348_R	604_T	0.522	0.33
53_V	497_T	0.522	0.33
462_A	467_T	0.522	0.33
326_I	407_F	0.521	0.33
390_G	393_G	0.521	0.33
30_F	63_I	0.521	0.33
388_I	465_E	0.520	0.33
534_I	546_I	0.520	0.33
298_Q	303_F	0.520	0.33
274_I	308_G	0.519	0.33
234_L	258_V	0.518	0.33
7_K	49_I	0.518	0.33
544_I	603_F	0.517	0.33
550_I	590_D	0.517	0.33
586_E	611_T	0.517	0.33
398_G	428_V	0.516	0.33
548_V	606_V	0.516	0.33
564_V	568_D	0.516	0.33
153_W	215_S	0.515	0.33
45_K	597_I	0.515	0.33
92_D	96_L	0.514	0.32
358_S	410_P	0.514	0.32
333_I	386_A	0.514	0.32
497_T	566_V	0.514	0.32
410_P	413_F	0.514	0.32
569_K	572_T	0.514	0.32
161_Y	224_A	0.513	0.32
415_F	432_V	0.513	0.32
41_E	470_V	0.513	0.32
559_F	603_F	0.512	0.32
109_T	116_A	0.512	0.32
53_V	496_T	0.511	0.32
255_I	258_V	0.510	0.32
234_L	247_T	0.509	0.32
209_T	215_S	0.509	0.32
508_A	593_T	0.509	0.32
513_V	605_D	0.508	0.32
108_F	123_G	0.508	0.32
218_I	327_P	0.508	0.32
203_F	256_T	0.507	0.32
125_L	249_L	0.507	0.32
569_K	574_D	0.507	0.32
120_I	365_F	0.506	0.32
125_L	144_L	0.506	0.32
108_F	250_L	0.506	0.32
51_M	113_G	0.506	0.32
74_V	79_G	0.505	0.32
10_A	585_R	0.505	0.32
129_L	134_T	0.505	0.32
202_D	499_A	0.505	0.32
484_T	586_E	0.505	0.32
331_P	438_A	0.505	0.32
520_V	570_V	0.505	0.32
153_W	187_L	0.504	0.32
247_T	409_L	0.504	0.32
456_R	461_G	0.503	0.32
517_R	574_D	0.503	0.32
406_S	417_Q	0.503	0.32
582_P	587_A	0.503	0.32
577_I	594_P	0.502	0.31
559_F	562_A	0.502	0.31
393_G	434_G	0.502	0.31
111_L	322_Y	0.501	0.31
563_H	594_P	0.501	0.31
123_G	328_L	0.501	0.31
81_D	90_N	0.501	0.31
221_I	300_F	0.501	0.31
115_M	275_A	0.500	0.31

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2gprA	1	0.2464	100	0.764	Contact Map
1f3zA	2	0.2384	100	0.765	Contact Map
3qnqA	2	0.6112	100	0.766	Contact Map
3ourB	1	0.2384	100	0.768	Contact Map
1ax3A	1	0.2576	100	0.769	Contact Map
3ipjA	1	0.1424	100	0.881	Contact Map
1ibaA	1	0.1232	100	0.885	Contact Map
3bp3A	1	0.1264	100	0.885	Contact Map
1dczA	1	0.1232	98.7	0.955	Contact Map
2d5dA	1	0.112	98.6	0.955	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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