GREMLIN Database
AK3 - Lysine-sensitive aspartokinase 3
UniProt: P08660 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10550
Length: 449 (344)
Sequences: 4222 (2349)
Seq/√Len: 126.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
188_E192_R4.6881.00
135_V178_L4.6271.00
405_E446_N4.2731.00
435_D438_Q4.1521.00
209_A217_V4.0301.00
181_T208_L3.9801.00
281_D284_A3.2901.00
242_E290_C3.2241.00
216_R275_F3.2001.00
251_M392_I3.1791.00
275_F288_L3.1411.00
127_V137_A2.8831.00
408_G412_P2.8651.00
224_P281_D2.7841.00
309_T355_T2.7791.00
304_L436_A2.7691.00
140_F173_R2.7061.00
385_G433_G2.6991.00
389_V443_L2.6821.00
123_T182_Q2.5581.00
330_G334_R2.5561.00
213_H270_S2.5031.00
241_D285_G2.4061.00
148_T194_T2.3841.00
306_R437_E2.2881.00
150_D188_E2.2711.00
396_L401_G2.2541.00
306_R433_G2.2481.00
218_D275_F2.2381.00
224_P284_A2.1801.00
131_R136_Q2.1721.00
240_I243_I2.1681.00
326_A333_A2.1001.00
112_D153_G2.0691.00
147_R165_L2.0201.00
438_Q441_Q2.0061.00
327_E373_E1.9941.00
129_I133_R1.9561.00
246_A268_V1.9531.00
208_L212_L1.9511.00
432_P435_D1.9201.00
111_T115_V1.9031.00
363_D367_T1.8821.00
143_R193_T1.8601.00
236_A445_S1.8511.00
206_A217_V1.8341.00
412_P446_N1.8061.00
355_T384_E1.8041.00
368_Q371_L1.7751.00
410_L439_V1.7641.00
101_A104_L1.7591.00
138_Q179_V1.7431.00
267_A274_V1.7421.00
325_L349_V1.7251.00
413_F417_M1.7241.00
406_V429_F1.7221.00
358_S382_V1.6891.00
152_F155_A1.6721.00
142_V145_V1.6501.00
271_D291_N1.6261.00
302_L440_V1.6251.00
355_T433_G1.5871.00
147_R189_N1.5861.00
147_R187_S1.5831.00
130_L135_V1.5761.00
148_T186_G1.5631.00
334_R373_E1.5571.00
318_M323_G1.5541.00
229_T304_L1.5021.00
389_V439_V1.4991.00
221_T276_V1.4951.00
116_S193_T1.4811.00
406_V443_L1.4731.00
377_L380_V1.4711.00
341_L430_L1.4541.00
148_T152_F1.4421.00
218_D277_G1.4251.00
128_E131_R1.4211.00
224_P227_Y1.4151.00
311_L353_L1.4071.00
409_V446_N1.4021.00
313_L328_V1.3901.00
162_L166_A1.3831.00
389_V440_V1.3701.00
166_A208_L1.3681.00
217_V267_A1.3421.00
334_R369_S1.3301.00
224_P278_S1.3241.00
401_G424_S1.3081.00
331_I335_H1.2971.00
311_L363_D1.2961.00
368_Q372_M1.2951.00
304_L440_V1.2941.00
114_L124_L1.2841.00
168_L172_P1.2791.00
216_R288_L1.2781.00
117_H121_M1.2741.00
385_G432_P1.2701.00
387_A436_A1.2671.00
243_I300_R1.2601.00
188_E194_T1.2531.00
140_F179_V1.2421.00
109_A192_R1.2391.00
437_E441_Q1.2321.00
164_E168_L1.2150.99
409_V442_K1.2060.99
364_T368_Q1.2040.99
242_E288_L1.1990.99
364_T382_V1.1980.99
126_F130_L1.1970.99
391_L406_V1.1960.99
325_L342_I1.1890.99
233_V440_V1.1840.99
107_S131_R1.1830.99
138_Q177_G1.1800.99
359_T384_E1.1720.99
312_T350_A1.1690.99
116_S120_L1.1630.99
136_Q177_G1.1600.99
204_T208_L1.1590.99
228_T444_H1.1520.99
309_T384_E1.1460.99
142_V182_Q1.1430.99
367_T370_L1.1350.99
99_A114_L1.1340.99
387_A433_G1.1270.99
362_G365_L1.1240.99
127_V139_W1.1230.99
150_D155_A1.1200.99
137_A178_L1.1170.99
413_F438_Q1.1130.99
130_L180_I1.1130.99
97_V100_E1.1070.99
309_T358_S1.1060.99
146_M162_L1.1020.99
310_L418_I1.1020.99
108_P153_G1.0990.99
371_L375_S1.0930.99
142_V181_T1.0900.99
172_P175_N1.0870.99
306_R436_A1.0840.99
93_E97_V1.0720.99
403_G407_F1.0680.99
404_K411_E1.0670.99
103_A132_E1.0660.99
138_Q169_Q1.0630.99
150_D190_K1.0600.98
389_V431_V1.0590.98
329_F339_V1.0580.98
325_L344_T1.0570.98
202_D222_D1.0510.98
112_D195_T1.0510.98
148_T155_A1.0500.98
362_G367_T1.0500.98
223_V258_V1.0490.98
130_L178_L1.0450.98
210_E272_I1.0380.98
152_F188_E1.0380.98
341_L428_C1.0360.98
239_R284_A1.0330.98
227_Y237_A1.0320.98
331_I370_L1.0310.98
419_C430_L1.0250.98
147_R166_A1.0210.98
259_L289_V1.0210.98
264_L274_V1.0180.98
328_V349_V1.0160.98
227_Y259_L1.0150.98
143_R187_S1.0060.98
307_N355_T0.9950.98
235_S441_Q0.9920.98
396_L402_V0.9890.98
365_L368_Q0.9860.98
340_D352_T0.9810.98
127_V131_R0.9800.97
169_Q173_R0.9800.97
155_A194_T0.9750.97
386_L430_L0.9750.97
396_L424_S0.9730.97
305_R308_Q0.9730.97
123_T139_W0.9570.97
325_L339_V0.9560.97
124_L128_E0.9540.97
242_E294_E0.9540.97
259_L274_V0.9530.97
163_A167_A0.9490.97
371_L377_L0.9490.97
365_L369_S0.9490.97
366_L370_L0.9440.97
162_L207_L0.9420.97
233_V304_L0.9400.97
332_L337_I0.9340.97
318_M324_F0.9330.97
388_L430_L0.9300.97
307_N356_T0.9290.97
146_M204_T0.9250.96
131_R137_A0.9250.96
170_L179_V0.9230.96
345_S350_A0.9100.96
147_R191_G0.9080.96
335_H369_S0.9070.96
139_W182_Q0.9050.96
408_G446_N0.9050.96
309_T353_L0.8960.96
383_E416_R0.8960.96
149_N152_F0.8960.96
391_L427_L0.8950.96
126_F180_I0.8880.96
390_A428_C0.8870.95
372_M375_S0.8860.95
383_E386_L0.8820.95
112_D186_G0.8800.95
324_F349_V0.8780.95
420_Y424_S0.8750.95
136_Q176_E0.8750.95
142_V185_I0.8740.95
326_A330_G0.8730.95
242_E292_K0.8710.95
229_T302_L0.8680.95
229_T440_V0.8650.95
322_R325_L0.8640.95
362_G370_L0.8600.95
401_G414_N0.8600.95
317_N378_C0.8550.94
200_G222_D0.8530.94
172_P176_E0.8520.94
138_Q173_R0.8490.94
329_F349_V0.8490.94
165_L168_L0.8450.94
332_L339_V0.8350.94
102_A132_E0.8340.94
323_G344_T0.8320.94
141_D193_T0.8250.93
149_N155_A0.8250.93
174_L179_V0.8250.93
332_L351_L0.8210.93
311_L380_V0.8180.93
221_T279_S0.8170.93
204_T266_P0.8160.93
318_M348_S0.8150.93
179_V182_Q0.8140.93
93_E96_T0.8090.93
264_L289_V0.8060.93
238_K242_E0.8050.93
154_R357_G0.8020.92
108_P362_G0.8010.92
306_R387_A0.7980.92
307_N433_G0.7970.92
221_T258_V0.7950.92
112_D152_F0.7920.92
233_V306_R0.7920.92
266_P421_G0.7910.92
341_L421_G0.7890.92
320_H416_R0.7890.92
335_H362_G0.7840.92
406_V427_L0.7830.91
318_M346_E0.7810.91
397_S424_S0.7750.91
441_Q445_S0.7700.91
370_L374_L0.7690.91
196_L222_D0.7680.91
440_V446_N0.7620.90
95_I117_H0.7600.90
320_H325_L0.7580.90
173_R179_V0.7540.90
412_P445_S0.7530.90
121_M124_L0.7530.90
254_F390_A0.7530.90
234_V440_V0.7500.90
112_D194_T0.7460.89
137_A180_I0.7400.89
184_F201_S0.7390.89
367_T380_V0.7390.89
149_N156_E0.7380.89
117_H120_L0.7380.89
149_N154_R0.7380.89
242_E293_T0.7370.89
193_T210_E0.7350.89
388_L428_C0.7350.89
144_K187_S0.7320.88
219_I257_K0.7320.88
228_T238_K0.7320.88
329_F338_S0.7310.88
229_T234_V0.7290.88
127_V180_I0.7280.88
116_S168_L0.7270.88
278_S281_D0.7270.88
151_R336_N0.7260.88
403_G424_S0.7240.88
369_S373_E0.7190.88
125_L179_V0.7180.88
323_G338_S0.7160.87
174_L177_G0.7150.87
434_E438_Q0.7150.87
414_N435_D0.7150.87
226_I258_V0.7150.87
96_T100_E0.7080.87
402_V447_L0.7080.87
120_L139_W0.7070.87
251_M440_V0.7070.87
118_G198_R0.7050.87
438_Q442_K0.7020.86
205_A217_V0.7010.86
262_A265_L0.7000.86
308_Q340_D0.6990.86
308_Q354_D0.6960.86
244_A247_E0.6960.86
162_L165_L0.6950.86
129_I132_E0.6910.85
150_D189_N0.6910.85
261_P266_P0.6890.85
432_P442_K0.6890.85
196_L200_G0.6890.85
147_R164_E0.6880.85
328_V351_L0.6870.85
282_P285_G0.6860.85
396_L427_L0.6860.85
123_T180_I0.6850.85
199_G263_T0.6830.85
94_N97_V0.6830.85
339_V342_I0.6820.85
273_P288_L0.6810.85
228_T237_A0.6810.85
322_R416_R0.6810.85
439_V442_K0.6810.85
383_E432_P0.6800.85
130_L137_A0.6790.84
267_A270_S0.6760.84
431_V439_V0.6750.84
249_A344_T0.6730.84
141_D145_V0.6700.84
311_L337_I0.6700.84
184_F198_R0.6700.84
265_L269_R0.6670.83
97_V101_A0.6660.83
323_G416_R0.6640.83
119_E198_R0.6640.83
401_G404_K0.6630.83
173_R176_E0.6630.83
335_H365_L0.6620.83
363_D366_L0.6600.83
385_G434_E0.6590.83
354_D357_G0.6590.83
203_Y263_T0.6590.83
323_G349_V0.6580.83
277_G282_P0.6580.83
170_L212_L0.6580.83
367_T371_L0.6560.82
210_E270_S0.6530.82
424_S427_L0.6520.82
245_F289_V0.6480.82
111_T153_G0.6480.82
387_A431_V0.6480.82
98_L102_A0.6470.82
366_L371_L0.6470.82
260_H266_P0.6460.81
337_I363_D0.6460.81
297_P300_R0.6450.81
227_Y239_R0.6440.81
404_K408_G0.6440.81
413_F442_K0.6430.81
340_D388_L0.6430.81
163_A166_A0.6430.81
291_N391_L0.6400.81
216_R277_G0.6400.81
413_F435_D0.6370.81
141_D187_S0.6370.81
366_L369_S0.6360.80
167_A212_L0.6360.80
152_F186_G0.6350.80
418_I432_P0.6340.80
106_T111_T0.6330.80
206_A263_T0.6320.80
238_K297_P0.6320.80
380_V443_L0.6320.80
197_G444_H0.6300.80
151_R154_R0.6300.80
320_H347_V0.6280.80
408_G411_E0.6260.79
162_L211_A0.6230.79
410_L429_F0.6230.79
412_P434_E0.6210.79
150_D194_T0.6200.79
310_L350_A0.6200.79
332_L358_S0.6180.79
377_L381_E0.6160.78
169_Q172_P0.6150.78
226_I248_A0.6150.78
221_T301_A0.6120.78
372_M385_G0.6100.78
219_I258_V0.6080.77
350_A419_C0.6030.77
365_L375_S0.6030.77
402_V427_L0.6030.77
343_T419_C0.6020.77
263_T266_P0.6010.77
107_S147_R0.5980.76
142_V196_L0.5980.76
304_L387_A0.5960.76
146_M208_L0.5960.76
250_E407_F0.5950.76
298_L395_D0.5940.76
341_L352_T0.5930.76
226_I287_T0.5920.76
321_S324_F0.5890.75
323_G326_A0.5890.75
145_V167_A0.5870.75
112_D148_T0.5870.75
339_V353_L0.5860.75
219_I222_D0.5840.75
244_A291_N0.5830.74
229_T444_H0.5830.74
323_G346_E0.5820.74
409_V418_I0.5790.74
304_L389_V0.5780.74
325_L420_Y0.5780.74
337_I362_G0.5770.74
113_E193_T0.5760.74
225_G239_R0.5760.74
298_L402_V0.5760.74
275_F284_A0.5750.73
144_K169_Q0.5730.73
219_I226_I0.5720.73
203_Y210_E0.5720.73
113_E139_W0.5720.73
318_M338_S0.5710.73
120_L143_R0.5710.73
394_N425_H0.5700.73
120_L141_D0.5700.73
370_L377_L0.5690.73
303_A415_I0.5680.72
397_S400_C0.5670.72
415_I442_K0.5670.72
220_W248_A0.5650.72
154_R336_N0.5640.72
251_M291_N0.5620.72
383_E418_I0.5600.71
109_A129_I0.5570.71
112_D197_G0.5550.71
325_L340_D0.5540.71
325_L347_V0.5520.70
416_R420_Y0.5520.70
195_T201_S0.5520.70
365_L370_L0.5520.70
252_A386_L0.5510.70
259_L264_L0.5490.70
346_E378_C0.5490.70
131_R134_D0.5490.70
248_A254_F0.5480.70
324_F346_E0.5480.70
213_H294_E0.5470.70
195_T200_G0.5470.70
369_S372_M0.5460.70
190_K366_L0.5450.69
99_A124_L0.5440.69
308_Q352_T0.5440.69
199_G257_K0.5440.69
345_S352_T0.5440.69
95_I110_L0.5430.69
338_S349_V0.5420.69
141_D182_Q0.5390.69
420_Y427_L0.5390.69
105_A109_A0.5380.68
414_N424_S0.5380.68
140_F169_Q0.5380.68
152_F194_T0.5370.68
256_A259_L0.5340.68
250_E253_T0.5320.68
225_G230_D0.5310.67
260_H263_T0.5310.67
401_G423_S0.5310.67
300_R303_A0.5310.67
442_K445_S0.5280.67
251_M310_L0.5260.67
101_A415_I0.5250.67
108_P356_T0.5240.66
152_F190_K0.5230.66
95_I102_A0.5220.66
147_R188_E0.5220.66
261_P308_Q0.5210.66
416_R432_P0.5210.66
98_L103_A0.5200.66
355_T385_G0.5190.66
263_T270_S0.5180.66
135_V176_E0.5180.66
324_F344_T0.5180.66
290_C293_T0.5170.65
229_T238_K0.5170.65
146_M152_F0.5160.65
123_T127_V0.5150.65
107_S172_P0.5150.65
362_G366_L0.5140.65
181_T204_T0.5140.65
210_E269_R0.5130.65
203_Y254_F0.5130.65
227_Y230_D0.5120.65
330_G408_G0.5120.65
329_F342_I0.5120.65
263_T267_A0.5120.65
321_S327_E0.5110.64
343_T347_V0.5100.64
131_R178_L0.5100.64
310_L383_E0.5090.64
165_L189_N0.5080.64
325_L416_R0.5070.64
225_G256_A0.5050.64
233_V441_Q0.5050.64
311_L358_S0.5040.63
184_F195_T0.5040.63
210_E350_A0.5030.63
379_R384_E0.5030.63
404_K409_V0.5030.63
328_V380_V0.5030.63
146_M153_G0.5010.63
260_H274_V0.5000.63
140_F145_V0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j0wA 2 0.9955 100 0.191 Contact Map
2cdqA 2 0.9889 100 0.259 Contact Map
3c1mA 3 0.9844 100 0.285 Contact Map
3tviA 2 0.9488 100 0.296 Contact Map
3l76A 2 0.8508 100 0.358 Contact Map
3ab4A 7 0.8218 100 0.362 Contact Map
4ab7A 3 0.755 100 0.702 Contact Map
2j4jA 5 0.4566 100 0.756 Contact Map
3d2mA 5 0.7483 100 0.758 Contact Map
2a1fA 5 0.4989 100 0.759 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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