GREMLIN Database
DNAJ - Chaperone protein DnaJ
UniProt: P08622 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10240
Length: 376 (348)
Sequences: 5279 (3371)
Seq/√Len: 180.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_E20_E3.9461.00
146_V199_K3.5341.00
18_E60_S3.4311.00
163_T185_H3.1371.00
129_V310_V3.1351.00
273_M278_G3.1321.00
336_R343_E3.0721.00
153_K195_D2.9691.00
30_M36_R2.9651.00
133_T215_K2.9161.00
159_Q194_K2.8911.00
133_T213_S2.8431.00
279_E290_K2.7821.00
153_K198_N2.5781.00
261_N312_S2.5701.00
126_E253_H2.5391.00
264_Y324_R2.5271.00
268_P328_E2.5261.00
263_L321_L2.4941.00
124_T251_K2.4281.00
338_K342_Q2.3521.00
137_R209_S2.3021.00
122_E251_K2.2661.00
135_E211_T2.2641.00
64_A68_Q2.2581.00
169_Q180_Q2.2211.00
4_Q49_E2.1751.00
162_P185_H2.1651.00
266_E324_R2.1221.00
299_T329_T2.1191.00
127_E134_K2.1091.00
44_E48_K2.0941.00
210_K231_E2.0611.00
266_E326_V2.0281.00
340_L343_E2.0081.00
142_E208_R1.9891.00
334_N337_Q1.9831.00
302_L322_L1.9681.00
336_R339_Q1.9471.00
122_E249_Q1.9461.00
279_E292_K1.9221.00
41_K44_E1.8991.00
297_T325_V1.8901.00
171_Q178_A1.8401.00
28_L50_I1.8381.00
37_N43_A1.8381.00
339_Q343_E1.8031.00
281_E288_R1.8031.00
222_T249_Q1.7981.00
61_Q65_A1.7851.00
4_Q9_I1.7721.00
270_N273_M1.7571.00
271_F275_A1.7561.00
118_R247_Q1.7501.00
120_N249_Q1.7371.00
65_A74_F1.7291.00
304_R320_D1.7281.00
127_E132_V1.7261.00
115_A233_E1.7091.00
135_E213_S1.7081.00
163_T184_P1.6951.00
146_V153_K1.6911.00
61_Q64_A1.6901.00
124_T127_E1.6761.00
303_F325_V1.6651.00
268_P326_V1.6581.00
72_A75_E1.6391.00
145_D199_K1.6371.00
4_Q8_E1.6301.00
222_T250_V1.6141.00
286_D318_Q1.6061.00
145_D208_R1.6021.00
13_S20_E1.5981.00
281_E290_K1.5961.00
32_Y50_I1.5831.00
28_L31_K1.5571.00
6_Y52_E1.5561.00
275_A341_L1.5541.00
16_A21_I1.5511.00
6_Y56_V1.5441.00
158_P191_T1.5221.00
173_R176_F1.5221.00
3_K71_H1.5031.00
336_R347_S1.5001.00
343_E346_E1.4931.00
170_V184_P1.4691.00
152_A156_T1.4591.00
220_V224_D1.4581.00
38_Q42_E1.4281.00
137_R211_T1.3921.00
273_M345_Q1.3911.00
12_V21_I1.3891.00
65_A69_Y1.3861.00
129_V285_L1.3771.00
263_L310_V1.3751.00
269_I274_A1.3731.00
125_L263_L1.3711.00
141_L205_R1.3531.00
344_L348_F1.3501.00
60_S63_R1.3431.00
145_D206_V1.3331.00
341_L344_L1.3291.00
220_V248_V1.3221.00
5_D8_E1.3111.00
302_L324_R1.3051.00
197_C200_C1.2931.00
255_I265_C1.2911.00
156_T195_D1.2891.00
294_P303_F1.2861.00
185_H199_K1.2841.00
289_V308_K1.2831.00
28_L32_Y1.2761.00
143_E148_H1.2701.00
224_D313_V1.2651.00
15_T20_E1.2621.00
32_Y46_K1.2331.00
121_M248_V1.2221.00
225_R245_Y1.2221.00
38_Q41_K1.2141.00
3_K8_E1.2101.00
19_R23_K1.2021.00
176_F179_V1.2011.00
139_P207_E1.1981.00
311_K318_Q1.1921.00
140_T210_K1.1851.00
264_Y322_L1.1741.00
259_E262_N1.1631.00
272_A275_A1.1571.00
221_D261_N1.1561.00
46_K49_E1.1541.00
121_M216_I1.1511.00
172_M181_Q1.1491.00
339_Q342_Q1.1421.00
25_Y51_K1.1341.00
271_F329_T1.1291.00
335_E342_Q1.1261.00
125_L310_V1.1231.00
89_D95_G1.1171.00
267_V280_I1.1121.00
307_G320_D1.1031.00
228_L246_V1.0971.00
27_R30_M1.0951.00
228_L231_E1.0911.00
291_L323_C1.0881.00
171_Q180_Q1.0881.00
5_D14_K1.0791.00
128_A250_V1.0791.00
284_T289_V1.0751.00
275_A329_T1.0731.00
123_L128_A1.0731.00
265_C321_L1.0721.00
120_N247_Q1.0681.00
162_P192_L1.0671.00
262_N322_L1.0621.00
336_R340_L1.0611.00
291_L303_F1.0611.00
86_G89_D1.0591.00
185_H192_L1.0581.00
52_E71_H1.0581.00
69_Y73_A1.0551.00
65_A73_A1.0531.00
269_I293_V1.0501.00
299_T326_V1.0481.00
71_H74_F1.0391.00
342_Q345_Q1.0381.00
41_K45_A1.0381.00
285_L321_L1.0361.00
37_N40_D1.0331.00
255_I283_P1.0331.00
141_L207_E1.0301.00
252_Q257_E1.0291.00
3_K52_E1.0250.99
225_R247_Q1.0240.99
139_P209_S1.0230.99
144_C147_C1.0170.99
160_T165_H1.0140.99
29_A47_F1.0120.99
273_M280_I1.0100.99
160_T191_T1.0050.99
130_R310_V1.0000.99
128_A221_D0.9960.99
342_Q346_E0.9910.99
128_A310_V0.9780.99
32_Y37_N0.9770.99
38_Q43_A0.9660.99
11_G24_A0.9650.99
146_V163_T0.9640.99
42_E45_A0.9580.99
337_Q344_L0.9560.99
146_V154_P0.9530.99
144_C200_C0.9460.99
113_R116_D0.9450.99
199_K206_V0.9400.99
289_V305_M0.9380.99
227_R245_Y0.9350.99
9_I49_E0.9300.99
142_E210_K0.9290.99
126_E130_R0.9290.99
164_C168_G0.9250.99
125_L128_A0.9240.99
51_K55_E0.9170.99
92_D95_G0.9110.99
262_N320_D0.9090.99
335_E339_Q0.9080.99
144_C197_C0.9080.99
129_V318_Q0.9070.99
55_E58_T0.9010.99
304_R322_L0.9010.99
4_Q71_H0.9010.99
27_R31_K0.9010.99
297_T303_F0.8980.99
340_L344_L0.8970.99
257_E266_E0.8910.99
167_S171_Q0.8890.99
12_V15_T0.8870.99
112_A236_E0.8780.98
306_R320_D0.8780.98
283_P288_R0.8720.98
150_S154_P0.8690.98
216_I248_V0.8670.98
183_C186_C0.8660.98
312_S317_A0.8640.98
118_R225_R0.8580.98
163_T170_V0.8570.98
88_A92_D0.8560.98
154_P157_Q0.8550.98
300_G326_V0.8530.98
271_F341_L0.8500.98
221_D224_D0.8480.98
128_A220_V0.8460.98
275_A333_L0.8450.98
162_P165_H0.8440.98
85_G89_D0.8430.98
265_C283_P0.8420.98
272_A344_L0.8420.98
140_T231_E0.8390.98
87_G90_F0.8340.98
92_D96_D0.8300.98
261_N310_V0.8280.98
91_S95_G0.8280.98
65_A72_A0.8260.98
205_R236_E0.8260.98
272_A345_Q0.8250.98
349_G352_T0.8240.98
305_M321_L0.8240.98
312_S315_G0.8240.98
47_F51_K0.8230.98
152_A158_P0.8220.98
155_G158_P0.8210.98
153_K156_T0.8190.98
333_L337_Q0.8170.97
147_C161_C0.8160.97
123_L127_E0.8140.97
293_V325_V0.8120.97
189_R237_H0.8060.97
343_E347_S0.8030.97
337_Q341_L0.8010.97
93_I96_D0.8000.97
119_Y136_I0.8000.97
125_L129_V0.8000.97
9_I50_I0.7980.97
108_R111_A0.7970.97
60_S64_A0.7960.97
109_Q237_H0.7960.97
173_R177_F0.7940.97
161_C164_C0.7940.97
295_G338_K0.7910.97
59_D62_K0.7900.97
235_G240_P0.7900.97
140_T233_E0.7810.97
212_L231_E0.7780.97
218_A311_K0.7760.97
102_F105_G0.7760.97
189_R192_L0.7700.96
214_V246_V0.7700.96
159_Q162_P0.7680.96
161_C183_C0.7650.96
45_A49_E0.7640.96
111_A240_P0.7640.96
81_G84_F0.7610.96
337_Q347_S0.7600.96
267_V325_V0.7570.96
159_Q192_L0.7550.96
154_P195_D0.7550.96
130_R286_D0.7480.96
125_L253_H0.7480.96
308_K318_Q0.7450.96
164_C190_G0.7430.96
335_E338_K0.7430.96
198_N201_H0.7410.96
337_Q348_F0.7400.96
90_F96_D0.7400.96
291_L305_M0.7400.96
164_C183_C0.7390.95
265_C323_C0.7380.95
74_F78_G0.7360.95
125_L250_V0.7350.95
121_M246_V0.7330.95
147_C200_C0.7310.95
217_P220_V0.7290.95
203_H236_E0.7280.95
28_L46_K0.7280.95
282_V321_L0.7280.95
40_D44_E0.7280.95
182_T187_Q0.7270.95
54_Y58_T0.7260.95
129_V284_T0.7240.95
90_F93_I0.7210.95
340_L347_S0.7210.95
272_A341_L0.7200.95
104_G107_G0.7150.95
152_A193_I0.7120.94
88_A91_S0.7120.94
259_E264_Y0.7110.94
147_C164_C0.7110.94
12_V63_R0.7110.94
150_S155_G0.7100.94
86_G91_S0.7050.94
164_C186_C0.7040.94
110_R237_H0.7020.94
88_A95_G0.7020.94
100_D103_G0.7000.94
31_K46_K0.6990.94
90_F95_G0.6990.94
144_C164_C0.6980.94
65_A68_Q0.6960.94
345_Q349_G0.6960.94
214_V228_L0.6920.94
6_Y71_H0.6910.94
328_E331_V0.6910.94
146_V198_N0.6910.94
73_A76_Q0.6890.93
56_V74_F0.6890.93
140_T208_R0.6880.93
121_M134_K0.6850.93
93_I97_V0.6840.93
170_V173_R0.6820.93
147_C183_C0.6810.93
222_T252_Q0.6810.93
278_G293_V0.6800.93
85_G88_A0.6790.93
123_L220_V0.6780.93
212_L228_L0.6780.93
288_R308_K0.6750.93
197_C202_G0.6740.93
334_N347_S0.6710.93
12_V20_E0.6700.93
144_C149_G0.6680.92
45_A48_K0.6680.92
25_Y55_E0.6650.92
226_I248_V0.6650.92
166_G190_G0.6640.92
236_E239_A0.6630.92
125_L130_R0.6620.92
32_Y43_A0.6560.92
123_L250_V0.6530.92
116_D245_Y0.6520.91
43_A46_K0.6520.91
264_Y302_L0.6500.91
130_R318_Q0.6500.91
147_C197_C0.6480.91
71_H75_E0.6460.91
286_D308_K0.6460.91
184_P187_Q0.6460.91
3_K9_I0.6460.91
61_Q68_Q0.6460.91
298_Q329_T0.6450.91
274_A277_G0.6440.91
345_Q350_G0.6440.91
46_K50_I0.6430.91
193_I196_P0.6390.91
40_D43_A0.6370.91
255_I268_P0.6350.90
123_L132_V0.6350.90
257_E264_Y0.6350.90
168_G190_G0.6340.90
158_P195_D0.6340.90
8_E13_S0.6330.90
117_L233_E0.6320.90
297_T301_K0.6320.90
305_M308_K0.6300.90
147_C202_G0.6290.90
29_A36_R0.6260.90
172_M179_V0.6250.90
75_E78_G0.6250.90
3_K49_E0.6200.89
18_E58_T0.6180.89
166_G183_C0.6170.89
72_A76_Q0.6170.89
298_Q331_V0.6170.89
205_R234_A0.6160.89
141_L203_H0.6150.89
79_M82_G0.6140.89
63_R66_Y0.6130.89
253_H256_F0.6120.89
113_R240_P0.6120.89
88_A93_I0.6100.89
183_C190_G0.6070.88
183_C188_G0.6060.88
37_N42_E0.6050.88
267_V323_C0.6050.88
3_K75_E0.6000.88
204_G217_P0.5990.88
86_G90_F0.5990.88
91_S96_D0.5950.87
174_Q177_F0.5950.87
23_K27_R0.5940.87
173_R178_A0.5920.87
119_Y246_V0.5890.87
345_Q352_T0.5880.87
40_D46_K0.5870.87
167_S181_Q0.5860.87
8_E14_K0.5860.87
113_R243_D0.5850.86
277_G296_E0.5850.86
235_G238_G0.5850.86
114_G232_G0.5840.86
169_Q173_R0.5840.86
298_Q301_K0.5840.86
19_R26_K0.5830.86
73_A77_G0.5820.86
143_E234_A0.5810.86
170_V174_Q0.5780.86
117_L140_T0.5770.86
52_E55_E0.5770.86
230_G243_D0.5760.86
138_I244_L0.5710.85
37_N41_K0.5710.85
275_A296_E0.5700.85
141_L233_E0.5700.85
284_T310_V0.5700.85
107_G110_R0.5670.85
89_D92_D0.5650.84
168_G186_C0.5650.84
274_A327_V0.5640.84
164_C188_G0.5640.84
333_L341_L0.5640.84
91_S98_F0.5630.84
272_A348_F0.5630.84
168_G183_C0.5630.84
151_G202_G0.5620.84
144_C166_G0.5610.84
195_D198_N0.5610.84
253_H265_C0.5590.84
78_G82_G0.5590.84
140_T234_A0.5590.84
158_P193_I0.5590.84
186_C200_C0.5580.84
329_T341_L0.5570.84
86_G96_D0.5550.83
256_F285_L0.5550.83
232_G239_A0.5540.83
161_C168_G0.5530.83
257_E324_R0.5530.83
32_Y38_Q0.5520.83
147_C151_G0.5510.83
265_C268_P0.5500.83
144_C186_C0.5500.83
299_T327_V0.5500.83
145_D148_H0.5490.83
87_G93_I0.5470.83
161_C186_C0.5470.83
161_C188_G0.5460.82
144_C202_G0.5450.82
116_D242_G0.5450.82
174_Q179_V0.5440.82
265_C282_V0.5430.82
26_K30_M0.5420.82
131_G161_C0.5400.82
105_G108_R0.5400.82
161_C166_G0.5390.82
203_H206_V0.5390.82
149_G161_C0.5370.81
149_G202_G0.5370.81
166_G188_G0.5360.81
150_S158_P0.5350.81
140_T241_A0.5350.81
269_I325_V0.5350.81
270_N278_G0.5340.81
186_C197_C0.5340.81
89_D93_I0.5340.81
5_D71_H0.5330.81
181_Q184_P0.5330.81
114_G235_G0.5330.81
152_A196_P0.5330.81
268_P272_A0.5320.81
78_G81_G0.5320.81
274_A298_Q0.5310.81
116_D227_R0.5310.81
74_F79_M0.5310.81
9_I71_H0.5280.80
131_G164_C0.5270.80
283_P321_L0.5260.80
285_L310_V0.5260.80
274_A296_E0.5260.80
91_S97_V0.5240.80
151_G161_C0.5230.80
129_V132_V0.5220.80
166_G186_C0.5220.80
62_K65_A0.5190.79
80_G83_G0.5170.79
130_R218_A0.5170.79
183_C200_C0.5170.79
42_E46_K0.5150.79
148_H154_P0.5150.79
235_G239_A0.5110.78
152_A157_Q0.5110.78
144_C190_G0.5090.78
149_G200_C0.5060.77
171_Q176_F0.5050.77
173_R179_V0.5050.77
74_F77_G0.5030.77
161_C190_G0.5030.77
138_I210_K0.5020.77
8_E71_H0.5020.77
69_Y72_A0.5010.77
227_R243_D0.5010.77
272_A276_L0.5010.77
144_C161_C0.5010.77
154_P158_P0.5010.77
147_C166_G0.5000.77
127_E130_R0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lz8A 2 0.5027 100 0.312 Contact Map
4j80A 2 0.7101 100 0.346 Contact Map
1nltA 1 0.5824 100 0.455 Contact Map
2q2gA 3 0.4628 100 0.593 Contact Map
3agxA 2 0.4628 100 0.594 Contact Map
1c3gA 2 0.4468 100 0.609 Contact Map
1bq0A 1 0.2048 100 0.732 Contact Map
4j7zA 1 0.2739 100 0.736 Contact Map
2ctqA 1 0.2553 99.9 0.76 Contact Map
2yuaA 1 0.2287 99.9 0.764 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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