DNAJ - ECOLI - GREMLIN Contacts

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DNAJ - Chaperone protein DnaJ

UniProt:	P08622	Sequences: MAKQDYYEILGVSKTAEEREIRKAYKRLAMKYHPDRNQGDKEAEAKFKEIKEAYEVLTDSQKRAAYDQYGHAAFEQGGMGGGGFGGGADFSDIFGDVFGDIFGGGRGRQRAARGADLRYNMELTLEEAVRGVTKEIRIPTLEECDVCHGSGAKPGTQPQTCPTCHGSGQVQMRQGFFAVQQTCPHCQGRGTLIKDPCNKCHGHGRVERSKTLSVKIPAGVDTGDRIRLAGEGEAGEHGAPAGDLYVQVQVKQHPIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVKLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNERQKQLLQELQESFGGPTGEHNSPRSKSFFDGVKKFFDDLTR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10240
Length:	376 (348)
Sequences:	5279 (3371)
Seq/√Len:	180.7

ECOLI - DNAJ CBPA
BACSU - DNAJ
HALSA - DNAJ

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
17_E	20_E	3.946	1.00
146_V	199_K	3.534	1.00
18_E	60_S	3.431	1.00
163_T	185_H	3.137	1.00
129_V	310_V	3.135	1.00
273_M	278_G	3.132	1.00
336_R	343_E	3.072	1.00
153_K	195_D	2.969	1.00
30_M	36_R	2.965	1.00
133_T	215_K	2.916	1.00
159_Q	194_K	2.891	1.00
133_T	213_S	2.843	1.00
279_E	290_K	2.782	1.00
153_K	198_N	2.578	1.00
261_N	312_S	2.570	1.00
126_E	253_H	2.539	1.00
264_Y	324_R	2.527	1.00
268_P	328_E	2.526	1.00
263_L	321_L	2.494	1.00
124_T	251_K	2.428	1.00
338_K	342_Q	2.352	1.00
137_R	209_S	2.302	1.00
122_E	251_K	2.266	1.00
135_E	211_T	2.264	1.00
64_A	68_Q	2.258	1.00
169_Q	180_Q	2.221	1.00
4_Q	49_E	2.175	1.00
162_P	185_H	2.165	1.00
266_E	324_R	2.122	1.00
299_T	329_T	2.119	1.00
127_E	134_K	2.109	1.00
44_E	48_K	2.094	1.00
210_K	231_E	2.061	1.00
266_E	326_V	2.028	1.00
340_L	343_E	2.008	1.00
142_E	208_R	1.989	1.00
334_N	337_Q	1.983	1.00
302_L	322_L	1.968	1.00
336_R	339_Q	1.947	1.00
122_E	249_Q	1.946	1.00
279_E	292_K	1.922	1.00
41_K	44_E	1.899	1.00
297_T	325_V	1.890	1.00
171_Q	178_A	1.840	1.00
28_L	50_I	1.838	1.00
37_N	43_A	1.838	1.00
339_Q	343_E	1.803	1.00
281_E	288_R	1.803	1.00
222_T	249_Q	1.798	1.00
61_Q	65_A	1.785	1.00
4_Q	9_I	1.772	1.00
270_N	273_M	1.757	1.00
271_F	275_A	1.756	1.00
118_R	247_Q	1.750	1.00
120_N	249_Q	1.737	1.00
65_A	74_F	1.729	1.00
304_R	320_D	1.728	1.00
127_E	132_V	1.726	1.00
115_A	233_E	1.709	1.00
135_E	213_S	1.708	1.00
163_T	184_P	1.695	1.00
146_V	153_K	1.691	1.00
61_Q	64_A	1.690	1.00
124_T	127_E	1.676	1.00
303_F	325_V	1.665	1.00
268_P	326_V	1.658	1.00
72_A	75_E	1.639	1.00
145_D	199_K	1.637	1.00
4_Q	8_E	1.630	1.00
222_T	250_V	1.614	1.00
286_D	318_Q	1.606	1.00
145_D	208_R	1.602	1.00
13_S	20_E	1.598	1.00
281_E	290_K	1.596	1.00
32_Y	50_I	1.583	1.00
28_L	31_K	1.557	1.00
6_Y	52_E	1.556	1.00
275_A	341_L	1.554	1.00
16_A	21_I	1.551	1.00
6_Y	56_V	1.544	1.00
158_P	191_T	1.522	1.00
173_R	176_F	1.522	1.00
3_K	71_H	1.503	1.00
336_R	347_S	1.500	1.00
343_E	346_E	1.493	1.00
170_V	184_P	1.469	1.00
152_A	156_T	1.459	1.00
220_V	224_D	1.458	1.00
38_Q	42_E	1.428	1.00
137_R	211_T	1.392	1.00
273_M	345_Q	1.391	1.00
12_V	21_I	1.389	1.00
65_A	69_Y	1.386	1.00
129_V	285_L	1.377	1.00
263_L	310_V	1.375	1.00
269_I	274_A	1.373	1.00
125_L	263_L	1.371	1.00
141_L	205_R	1.353	1.00
344_L	348_F	1.350	1.00
60_S	63_R	1.343	1.00
145_D	206_V	1.333	1.00
341_L	344_L	1.329	1.00
220_V	248_V	1.322	1.00
5_D	8_E	1.311	1.00
302_L	324_R	1.305	1.00
197_C	200_C	1.293	1.00
255_I	265_C	1.291	1.00
156_T	195_D	1.289	1.00
294_P	303_F	1.286	1.00
185_H	199_K	1.284	1.00
289_V	308_K	1.283	1.00
28_L	32_Y	1.276	1.00
143_E	148_H	1.270	1.00
224_D	313_V	1.265	1.00
15_T	20_E	1.262	1.00
32_Y	46_K	1.233	1.00
121_M	248_V	1.222	1.00
225_R	245_Y	1.222	1.00
38_Q	41_K	1.214	1.00
3_K	8_E	1.210	1.00
19_R	23_K	1.202	1.00
176_F	179_V	1.201	1.00
139_P	207_E	1.198	1.00
311_K	318_Q	1.192	1.00
140_T	210_K	1.185	1.00
264_Y	322_L	1.174	1.00
259_E	262_N	1.163	1.00
272_A	275_A	1.157	1.00
221_D	261_N	1.156	1.00
46_K	49_E	1.154	1.00
121_M	216_I	1.151	1.00
172_M	181_Q	1.149	1.00
339_Q	342_Q	1.142	1.00
25_Y	51_K	1.134	1.00
271_F	329_T	1.129	1.00
335_E	342_Q	1.126	1.00
125_L	310_V	1.123	1.00
89_D	95_G	1.117	1.00
267_V	280_I	1.112	1.00
307_G	320_D	1.103	1.00
228_L	246_V	1.097	1.00
27_R	30_M	1.095	1.00
228_L	231_E	1.091	1.00
291_L	323_C	1.088	1.00
171_Q	180_Q	1.088	1.00
5_D	14_K	1.079	1.00
128_A	250_V	1.079	1.00
284_T	289_V	1.075	1.00
275_A	329_T	1.073	1.00
123_L	128_A	1.073	1.00
265_C	321_L	1.072	1.00
120_N	247_Q	1.068	1.00
162_P	192_L	1.067	1.00
262_N	322_L	1.062	1.00
336_R	340_L	1.061	1.00
291_L	303_F	1.061	1.00
86_G	89_D	1.059	1.00
185_H	192_L	1.058	1.00
52_E	71_H	1.058	1.00
69_Y	73_A	1.055	1.00
65_A	73_A	1.053	1.00
269_I	293_V	1.050	1.00
299_T	326_V	1.048	1.00
71_H	74_F	1.039	1.00
342_Q	345_Q	1.038	1.00
41_K	45_A	1.038	1.00
285_L	321_L	1.036	1.00
37_N	40_D	1.033	1.00
255_I	283_P	1.033	1.00
141_L	207_E	1.030	1.00
252_Q	257_E	1.029	1.00
3_K	52_E	1.025	0.99
225_R	247_Q	1.024	0.99
139_P	209_S	1.023	0.99
144_C	147_C	1.017	0.99
160_T	165_H	1.014	0.99
29_A	47_F	1.012	0.99
273_M	280_I	1.010	0.99
160_T	191_T	1.005	0.99
130_R	310_V	1.000	0.99
128_A	221_D	0.996	0.99
342_Q	346_E	0.991	0.99
128_A	310_V	0.978	0.99
32_Y	37_N	0.977	0.99
38_Q	43_A	0.966	0.99
11_G	24_A	0.965	0.99
146_V	163_T	0.964	0.99
42_E	45_A	0.958	0.99
337_Q	344_L	0.956	0.99
146_V	154_P	0.953	0.99
144_C	200_C	0.946	0.99
113_R	116_D	0.945	0.99
199_K	206_V	0.940	0.99
289_V	305_M	0.938	0.99
227_R	245_Y	0.935	0.99
9_I	49_E	0.930	0.99
142_E	210_K	0.929	0.99
126_E	130_R	0.929	0.99
164_C	168_G	0.925	0.99
125_L	128_A	0.924	0.99
51_K	55_E	0.917	0.99
92_D	95_G	0.911	0.99
262_N	320_D	0.909	0.99
335_E	339_Q	0.908	0.99
144_C	197_C	0.908	0.99
129_V	318_Q	0.907	0.99
55_E	58_T	0.901	0.99
304_R	322_L	0.901	0.99
4_Q	71_H	0.901	0.99
27_R	31_K	0.901	0.99
297_T	303_F	0.898	0.99
340_L	344_L	0.897	0.99
257_E	266_E	0.891	0.99
167_S	171_Q	0.889	0.99
12_V	15_T	0.887	0.99
112_A	236_E	0.878	0.98
306_R	320_D	0.878	0.98
283_P	288_R	0.872	0.98
150_S	154_P	0.869	0.98
216_I	248_V	0.867	0.98
183_C	186_C	0.866	0.98
312_S	317_A	0.864	0.98
118_R	225_R	0.858	0.98
163_T	170_V	0.857	0.98
88_A	92_D	0.856	0.98
154_P	157_Q	0.855	0.98
300_G	326_V	0.853	0.98
271_F	341_L	0.850	0.98
221_D	224_D	0.848	0.98
128_A	220_V	0.846	0.98
275_A	333_L	0.845	0.98
162_P	165_H	0.844	0.98
85_G	89_D	0.843	0.98
265_C	283_P	0.842	0.98
272_A	344_L	0.842	0.98
140_T	231_E	0.839	0.98
87_G	90_F	0.834	0.98
92_D	96_D	0.830	0.98
261_N	310_V	0.828	0.98
91_S	95_G	0.828	0.98
65_A	72_A	0.826	0.98
205_R	236_E	0.826	0.98
272_A	345_Q	0.825	0.98
349_G	352_T	0.824	0.98
305_M	321_L	0.824	0.98
312_S	315_G	0.824	0.98
47_F	51_K	0.823	0.98
152_A	158_P	0.822	0.98
155_G	158_P	0.821	0.98
153_K	156_T	0.819	0.98
333_L	337_Q	0.817	0.97
147_C	161_C	0.816	0.97
123_L	127_E	0.814	0.97
293_V	325_V	0.812	0.97
189_R	237_H	0.806	0.97
343_E	347_S	0.803	0.97
337_Q	341_L	0.801	0.97
93_I	96_D	0.800	0.97
119_Y	136_I	0.800	0.97
125_L	129_V	0.800	0.97
9_I	50_I	0.798	0.97
108_R	111_A	0.797	0.97
60_S	64_A	0.796	0.97
109_Q	237_H	0.796	0.97
173_R	177_F	0.794	0.97
161_C	164_C	0.794	0.97
295_G	338_K	0.791	0.97
59_D	62_K	0.790	0.97
235_G	240_P	0.790	0.97
140_T	233_E	0.781	0.97
212_L	231_E	0.778	0.97
218_A	311_K	0.776	0.97
102_F	105_G	0.776	0.97
189_R	192_L	0.770	0.96
214_V	246_V	0.770	0.96
159_Q	162_P	0.768	0.96
161_C	183_C	0.765	0.96
45_A	49_E	0.764	0.96
111_A	240_P	0.764	0.96
81_G	84_F	0.761	0.96
337_Q	347_S	0.760	0.96
267_V	325_V	0.757	0.96
159_Q	192_L	0.755	0.96
154_P	195_D	0.755	0.96
130_R	286_D	0.748	0.96
125_L	253_H	0.748	0.96
308_K	318_Q	0.745	0.96
164_C	190_G	0.743	0.96
335_E	338_K	0.743	0.96
198_N	201_H	0.741	0.96
337_Q	348_F	0.740	0.96
90_F	96_D	0.740	0.96
291_L	305_M	0.740	0.96
164_C	183_C	0.739	0.95
265_C	323_C	0.738	0.95
74_F	78_G	0.736	0.95
125_L	250_V	0.735	0.95
121_M	246_V	0.733	0.95
147_C	200_C	0.731	0.95
217_P	220_V	0.729	0.95
203_H	236_E	0.728	0.95
28_L	46_K	0.728	0.95
282_V	321_L	0.728	0.95
40_D	44_E	0.728	0.95
182_T	187_Q	0.727	0.95
54_Y	58_T	0.726	0.95
129_V	284_T	0.724	0.95
90_F	93_I	0.721	0.95
340_L	347_S	0.721	0.95
272_A	341_L	0.720	0.95
104_G	107_G	0.715	0.95
152_A	193_I	0.712	0.94
88_A	91_S	0.712	0.94
259_E	264_Y	0.711	0.94
147_C	164_C	0.711	0.94
12_V	63_R	0.711	0.94
150_S	155_G	0.710	0.94
86_G	91_S	0.705	0.94
164_C	186_C	0.704	0.94
110_R	237_H	0.702	0.94
88_A	95_G	0.702	0.94
100_D	103_G	0.700	0.94
31_K	46_K	0.699	0.94
90_F	95_G	0.699	0.94
144_C	164_C	0.698	0.94
65_A	68_Q	0.696	0.94
345_Q	349_G	0.696	0.94
214_V	228_L	0.692	0.94
6_Y	71_H	0.691	0.94
328_E	331_V	0.691	0.94
146_V	198_N	0.691	0.94
73_A	76_Q	0.689	0.93
56_V	74_F	0.689	0.93
140_T	208_R	0.688	0.93
121_M	134_K	0.685	0.93
93_I	97_V	0.684	0.93
170_V	173_R	0.682	0.93
147_C	183_C	0.681	0.93
222_T	252_Q	0.681	0.93
278_G	293_V	0.680	0.93
85_G	88_A	0.679	0.93
123_L	220_V	0.678	0.93
212_L	228_L	0.678	0.93
288_R	308_K	0.675	0.93
197_C	202_G	0.674	0.93
334_N	347_S	0.671	0.93
12_V	20_E	0.670	0.93
144_C	149_G	0.668	0.92
45_A	48_K	0.668	0.92
25_Y	55_E	0.665	0.92
226_I	248_V	0.665	0.92
166_G	190_G	0.664	0.92
236_E	239_A	0.663	0.92
125_L	130_R	0.662	0.92
32_Y	43_A	0.656	0.92
123_L	250_V	0.653	0.92
116_D	245_Y	0.652	0.91
43_A	46_K	0.652	0.91
264_Y	302_L	0.650	0.91
130_R	318_Q	0.650	0.91
147_C	197_C	0.648	0.91
71_H	75_E	0.646	0.91
286_D	308_K	0.646	0.91
184_P	187_Q	0.646	0.91
3_K	9_I	0.646	0.91
61_Q	68_Q	0.646	0.91
298_Q	329_T	0.645	0.91
274_A	277_G	0.644	0.91
345_Q	350_G	0.644	0.91
46_K	50_I	0.643	0.91
193_I	196_P	0.639	0.91
40_D	43_A	0.637	0.91
255_I	268_P	0.635	0.90
123_L	132_V	0.635	0.90
257_E	264_Y	0.635	0.90
168_G	190_G	0.634	0.90
158_P	195_D	0.634	0.90
8_E	13_S	0.633	0.90
117_L	233_E	0.632	0.90
297_T	301_K	0.632	0.90
305_M	308_K	0.630	0.90
147_C	202_G	0.629	0.90
29_A	36_R	0.626	0.90
172_M	179_V	0.625	0.90
75_E	78_G	0.625	0.90
3_K	49_E	0.620	0.89
18_E	58_T	0.618	0.89
166_G	183_C	0.617	0.89
72_A	76_Q	0.617	0.89
298_Q	331_V	0.617	0.89
205_R	234_A	0.616	0.89
141_L	203_H	0.615	0.89
79_M	82_G	0.614	0.89
63_R	66_Y	0.613	0.89
253_H	256_F	0.612	0.89
113_R	240_P	0.612	0.89
88_A	93_I	0.610	0.89
183_C	190_G	0.607	0.88
183_C	188_G	0.606	0.88
37_N	42_E	0.605	0.88
267_V	323_C	0.605	0.88
3_K	75_E	0.600	0.88
204_G	217_P	0.599	0.88
86_G	90_F	0.599	0.88
91_S	96_D	0.595	0.87
174_Q	177_F	0.595	0.87
23_K	27_R	0.594	0.87
173_R	178_A	0.592	0.87
119_Y	246_V	0.589	0.87
345_Q	352_T	0.588	0.87
40_D	46_K	0.587	0.87
167_S	181_Q	0.586	0.87
8_E	14_K	0.586	0.87
113_R	243_D	0.585	0.86
277_G	296_E	0.585	0.86
235_G	238_G	0.585	0.86
114_G	232_G	0.584	0.86
169_Q	173_R	0.584	0.86
298_Q	301_K	0.584	0.86
19_R	26_K	0.583	0.86
73_A	77_G	0.582	0.86
143_E	234_A	0.581	0.86
170_V	174_Q	0.578	0.86
117_L	140_T	0.577	0.86
52_E	55_E	0.577	0.86
230_G	243_D	0.576	0.86
138_I	244_L	0.571	0.85
37_N	41_K	0.571	0.85
275_A	296_E	0.570	0.85
141_L	233_E	0.570	0.85
284_T	310_V	0.570	0.85
107_G	110_R	0.567	0.85
89_D	92_D	0.565	0.84
168_G	186_C	0.565	0.84
274_A	327_V	0.564	0.84
164_C	188_G	0.564	0.84
333_L	341_L	0.564	0.84
91_S	98_F	0.563	0.84
272_A	348_F	0.563	0.84
168_G	183_C	0.563	0.84
151_G	202_G	0.562	0.84
144_C	166_G	0.561	0.84
195_D	198_N	0.561	0.84
253_H	265_C	0.559	0.84
78_G	82_G	0.559	0.84
140_T	234_A	0.559	0.84
158_P	193_I	0.559	0.84
186_C	200_C	0.558	0.84
329_T	341_L	0.557	0.84
86_G	96_D	0.555	0.83
256_F	285_L	0.555	0.83
232_G	239_A	0.554	0.83
161_C	168_G	0.553	0.83
257_E	324_R	0.553	0.83
32_Y	38_Q	0.552	0.83
147_C	151_G	0.551	0.83
265_C	268_P	0.550	0.83
144_C	186_C	0.550	0.83
299_T	327_V	0.550	0.83
145_D	148_H	0.549	0.83
87_G	93_I	0.547	0.83
161_C	186_C	0.547	0.83
161_C	188_G	0.546	0.82
144_C	202_G	0.545	0.82
116_D	242_G	0.545	0.82
174_Q	179_V	0.544	0.82
265_C	282_V	0.543	0.82
26_K	30_M	0.542	0.82
131_G	161_C	0.540	0.82
105_G	108_R	0.540	0.82
161_C	166_G	0.539	0.82
203_H	206_V	0.539	0.82
149_G	161_C	0.537	0.81
149_G	202_G	0.537	0.81
166_G	188_G	0.536	0.81
150_S	158_P	0.535	0.81
140_T	241_A	0.535	0.81
269_I	325_V	0.535	0.81
270_N	278_G	0.534	0.81
186_C	197_C	0.534	0.81
89_D	93_I	0.534	0.81
5_D	71_H	0.533	0.81
181_Q	184_P	0.533	0.81
114_G	235_G	0.533	0.81
152_A	196_P	0.533	0.81
268_P	272_A	0.532	0.81
78_G	81_G	0.532	0.81
274_A	298_Q	0.531	0.81
116_D	227_R	0.531	0.81
74_F	79_M	0.531	0.81
9_I	71_H	0.528	0.80
131_G	164_C	0.527	0.80
283_P	321_L	0.526	0.80
285_L	310_V	0.526	0.80
274_A	296_E	0.526	0.80
91_S	97_V	0.524	0.80
151_G	161_C	0.523	0.80
129_V	132_V	0.522	0.80
166_G	186_C	0.522	0.80
62_K	65_A	0.519	0.79
80_G	83_G	0.517	0.79
130_R	218_A	0.517	0.79
183_C	200_C	0.517	0.79
42_E	46_K	0.515	0.79
148_H	154_P	0.515	0.79
235_G	239_A	0.511	0.78
152_A	157_Q	0.511	0.78
144_C	190_G	0.509	0.78
149_G	200_C	0.506	0.77
171_Q	176_F	0.505	0.77
173_R	179_V	0.505	0.77
74_F	77_G	0.503	0.77
161_C	190_G	0.503	0.77
138_I	210_K	0.502	0.77
8_E	71_H	0.502	0.77
69_Y	72_A	0.501	0.77
227_R	243_D	0.501	0.77
272_A	276_L	0.501	0.77
144_C	161_C	0.501	0.77
154_P	158_P	0.501	0.77
147_C	166_G	0.500	0.77
127_E	130_R	0.500	0.77

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3lz8A	2	0.5027	100	0.312	Contact Map
4j80A	2	0.7101	100	0.346	Contact Map
1nltA	1	0.5824	100	0.455	Contact Map
2q2gA	3	0.4628	100	0.593	Contact Map
3agxA	2	0.4628	100	0.594	Contact Map
1c3gA	2	0.4468	100	0.609	Contact Map
1bq0A	1	0.2048	100	0.732	Contact Map
4j7zA	1	0.2739	100	0.736	Contact Map
2ctqA	1	0.2553	99.9	0.76	Contact Map
2yuaA	1	0.2287	99.9	0.764	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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