GREMLIN Database
DSDX - DsdX permease
UniProt: P08555 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10250
Length: 445 (418)
Sequences: 5865 (3979)
Seq/√Len: 194.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_T95_R3.6271.00
300_N303_G3.4771.00
290_S293_T3.4191.00
268_P272_M3.4041.00
234_T238_P2.8291.00
320_A324_S2.8091.00
14_S318_F2.8071.00
329_D333_V2.7421.00
201_L205_L2.7331.00
415_T418_E2.7151.00
268_P271_A2.7131.00
82_V297_H2.7101.00
17_L39_F2.6721.00
200_F204_R2.6661.00
14_S40_V2.6341.00
338_M341_H2.5861.00
228_L232_L2.5751.00
205_L209_P2.4761.00
237_L278_V2.4511.00
202_G205_L2.4441.00
53_N57_S2.3861.00
428_F432_V2.3721.00
238_P242_M2.3181.00
204_R208_K2.2871.00
231_T234_T2.2841.00
192_I433_V2.2601.00
82_V293_T2.2531.00
54_A324_S2.2531.00
347_W431_S2.2471.00
201_L204_R2.2461.00
333_V336_S2.2251.00
114_I117_F2.1901.00
16_V20_L2.1901.00
20_L24_K2.1871.00
92_T228_L2.1851.00
229_G233_F2.1791.00
436_A440_L2.1411.00
344_L435_L2.1251.00
50_D53_N2.1061.00
184_L188_M2.0831.00
47_G50_D2.0801.00
203_Q207_F2.0801.00
205_L208_K2.0791.00
208_K211_P2.0671.00
204_R207_F2.0141.00
350_A367_A1.9951.00
234_T242_M1.9951.00
197_F201_L1.9511.00
380_D383_P1.9481.00
87_E91_L1.9451.00
187_L191_L1.9091.00
201_L208_K1.9071.00
227_S230_A1.8911.00
235_I242_M1.8821.00
272_M276_V1.8611.00
198_L201_L1.8481.00
109_G112_C1.8451.00
432_V436_A1.8181.00
375_L386_I1.8091.00
57_S61_G1.7751.00
242_M246_T1.7171.00
171_L390_I1.7101.00
330_T334_I1.7081.00
204_R209_P1.7031.00
199_K203_Q1.6561.00
202_G206_P1.6471.00
271_A276_V1.6431.00
421_K425_T1.6401.00
238_P246_T1.6261.00
203_Q206_P1.6221.00
47_G51_M1.6211.00
201_L209_P1.6121.00
246_T250_L1.6001.00
206_P209_P1.5911.00
10_T43_M1.5781.00
103_V195_P1.5751.00
351_L396_G1.5641.00
196_L200_F1.5491.00
206_P210_V1.5451.00
174_D177_S1.5421.00
78_K82_V1.5321.00
186_G189_A1.5301.00
144_A412_C1.5231.00
97_R100_S1.5131.00
229_G234_T1.5081.00
346_A390_I1.5041.00
268_P273_F1.5001.00
200_F203_Q1.4931.00
178_V387_A1.4921.00
439_F442_S1.4861.00
241_L245_K1.4841.00
293_T296_T1.4801.00
120_V123_V1.4771.00
277_F281_Y1.4681.00
355_A397_C1.4661.00
235_I238_P1.4641.00
167_V364_M1.4571.00
197_F200_F1.4531.00
228_L231_T1.4431.00
54_A320_A1.4361.00
202_G209_P1.4281.00
74_T298_T1.4241.00
296_T300_N1.4241.00
17_L36_A1.4011.00
246_T249_E1.3991.00
59_I67_A1.3921.00
18_I36_A1.3911.00
199_K202_G1.3791.00
231_T238_P1.3731.00
108_V112_C1.3731.00
105_M108_V1.3711.00
203_Q209_P1.3631.00
425_T429_I1.3621.00
203_Q208_K1.3581.00
241_L274_I1.3551.00
88_R92_T1.3491.00
108_V111_I1.3441.00
198_L202_G1.3351.00
196_L199_K1.3321.00
194_G198_L1.3301.00
194_G197_F1.3301.00
27_F32_A1.3281.00
243_L246_T1.3191.00
114_I118_V1.3111.00
376_P383_P1.3081.00
230_A234_T1.3071.00
202_G208_K1.2851.00
239_I242_M1.2811.00
156_C395_I1.2811.00
245_K249_E1.2761.00
248_A252_M1.2741.00
204_R211_P1.2701.00
107_L111_I1.2671.00
55_I317_A1.2661.00
234_T250_L1.2601.00
226_P231_T1.2581.00
263_E266_G1.2571.00
275_A279_A1.2481.00
409_K419_T1.2441.00
78_K297_H1.2421.00
186_G190_S1.2391.00
118_V121_G1.2231.00
416_L420_F1.2151.00
319_N323_K1.2151.00
230_A233_F1.2141.00
185_V441_L1.2131.00
117_F120_V1.2131.00
409_K416_L1.2081.00
205_L210_V1.2041.00
197_F204_R1.2031.00
39_F43_M1.2031.00
231_T250_L1.2021.00
53_N56_E1.2001.00
198_L205_L1.1971.00
82_V300_N1.1871.00
134_K140_L1.1861.00
270_T274_I1.1851.00
183_L187_L1.1751.00
17_L21_T1.1731.00
271_A279_A1.1691.00
62_T316_G1.1621.00
181_Y185_V1.1591.00
200_F208_K1.1581.00
204_R210_V1.1551.00
106_V190_S1.1551.00
137_N208_K1.1531.00
98_W135_K1.1521.00
180_V183_L1.1491.00
245_K250_L1.1461.00
240_A244_V1.1461.00
426_A430_A1.1441.00
197_F205_L1.1421.00
180_V184_L1.1281.00
119_E403_S1.1221.00
266_G271_A1.1131.00
280_Y283_L1.1051.00
392_S438_T1.0931.00
207_F211_P1.0911.00
182_G185_V1.0911.00
270_T276_V1.0901.00
278_V282_V1.0901.00
181_Y388_I1.0871.00
195_P202_G1.0811.00
229_G232_L1.0791.00
249_E252_M1.0771.00
185_V188_M1.0771.00
389_A393_G1.0761.00
105_M111_I1.0761.00
97_R101_V1.0731.00
181_Y184_L1.0671.00
269_I273_F1.0651.00
359_S362_V1.0561.00
233_F237_L1.0511.00
396_G431_S1.0511.00
196_L204_R1.0501.00
213_E216_D1.0471.00
378_Y381_I1.0381.00
168_A172_G1.0351.00
192_I196_L1.0311.00
86_A90_G1.0311.00
195_P198_L1.0291.00
197_F202_G1.0271.00
87_E223_K1.0261.00
69_V312_I1.0251.00
85_A231_T1.0231.00
272_M275_A1.0201.00
347_W435_L1.0171.00
32_A36_A1.0141.00
269_I272_M1.0111.00
280_Y284_G1.0091.00
246_T251_N1.0051.00
105_M109_G1.0031.00
14_S39_F1.0031.00
119_E312_I1.0011.00
58_G320_A1.0011.00
382_S385_I1.0011.00
244_V248_A0.9971.00
222_E225_L0.9941.00
271_A282_V0.9921.00
326_S329_D0.9870.99
36_A39_F0.9870.99
437_G441_L0.9840.99
228_L234_T0.9820.99
417_N421_K0.9810.99
91_L135_K0.9800.99
192_I429_I0.9800.99
201_L211_P0.9780.99
214_F218_K0.9730.99
247_I251_N0.9720.99
197_F429_I0.9710.99
201_L206_P0.9680.99
214_F217_L0.9660.99
203_Q211_P0.9660.99
289_M294_M0.9660.99
398_T402_D0.9650.99
231_T235_I0.9560.99
292_G296_T0.9560.99
49_L53_N0.9450.99
149_T194_G0.9420.99
226_P230_A0.9370.99
76_L275_A0.9370.99
196_L203_Q0.9370.99
97_R104_I0.9360.99
396_G428_F0.9350.99
170_K368_T0.9340.99
392_S434_A0.9340.99
185_V437_G0.9330.99
276_V280_Y0.9330.99
272_M280_Y0.9300.99
191_L196_L0.9280.99
118_V404_L0.9280.99
227_S231_T0.9230.99
225_L229_G0.9200.99
170_K173_A0.9190.99
433_V437_G0.9170.99
268_P276_V0.9130.99
40_V43_M0.9090.99
201_L207_F0.9090.99
237_L240_A0.9050.99
83_S283_L0.9050.99
222_E227_S0.9050.99
145_I149_T0.9030.99
244_V250_L0.8990.99
320_A323_K0.8960.99
231_T242_M0.8950.99
238_P241_L0.8940.99
246_T252_M0.8930.99
245_K248_A0.8910.99
228_L242_M0.8900.99
424_T428_F0.8860.99
239_I243_L0.8840.99
107_L110_L0.8820.99
312_I403_S0.8790.99
220_R224_T0.8780.99
268_P279_A0.8760.99
355_A396_G0.8750.99
279_A283_L0.8750.99
266_G279_A0.8750.99
154_V161_H0.8660.99
200_F206_P0.8650.99
264_F267_N0.8630.99
122_V411_Y0.8630.99
271_A275_A0.8620.99
279_A282_V0.8620.99
169_N172_G0.8600.99
434_A438_T0.8600.99
372_A376_P0.8560.99
106_V110_L0.8530.99
247_I250_L0.8520.99
119_E123_V0.8470.98
418_E421_K0.8460.98
427_T430_A0.8460.98
263_E267_N0.8450.98
188_M192_I0.8450.98
106_V112_C0.8440.98
105_M110_L0.8420.98
205_L211_P0.8390.98
220_R223_K0.8380.98
199_K207_F0.8380.98
243_L247_I0.8370.98
229_G238_P0.8360.98
79_M279_A0.8360.98
238_P243_L0.8340.98
289_M293_T0.8330.98
37_S41_G0.8300.98
227_S233_F0.8290.98
113_G117_F0.8280.98
242_M250_L0.8270.98
228_L236_L0.8260.98
199_K205_L0.8250.98
233_F282_V0.8240.98
99_L103_V0.8230.98
106_V109_G0.8230.98
57_S324_S0.8230.98
224_T228_L0.8200.98
224_T227_S0.8200.98
364_M394_A0.8180.98
104_I110_L0.8180.98
188_M191_L0.8160.98
229_G251_N0.8150.98
242_M245_K0.8140.98
272_M279_A0.8140.98
198_L204_R0.8130.98
268_P275_A0.8120.98
222_E226_P0.8120.98
40_V318_F0.8090.98
244_V249_E0.8090.98
228_L235_I0.8080.98
344_L439_F0.8080.98
388_I438_T0.8050.98
225_L228_L0.8030.98
54_A57_S0.7970.98
398_T423_Y0.7900.98
397_C424_T0.7890.98
305_I309_L0.7870.98
91_L94_Q0.7870.98
145_I422_Y0.7860.97
354_H402_D0.7850.97
234_T282_V0.7840.97
178_V384_E0.7840.97
360_A398_T0.7840.97
30_F310_L0.7840.97
351_L431_S0.7790.97
435_L439_F0.7790.97
200_F205_L0.7780.97
290_S294_M0.7750.97
354_H360_A0.7720.97
40_V321_I0.7710.97
202_G207_F0.7680.97
293_T297_H0.7620.97
105_M112_C0.7610.97
76_L276_V0.7600.97
277_F282_V0.7590.97
57_S60_G0.7590.97
237_L241_L0.7580.97
89_I231_T0.7570.97
52_V56_E0.7560.97
404_L408_V0.7550.97
35_L39_F0.7530.97
73_G301_G0.7500.97
226_P238_P0.7480.97
194_G201_L0.7460.97
194_G200_F0.7450.97
181_Y384_E0.7440.96
133_A143_L0.7440.96
104_I111_I0.7430.96
338_M342_P0.7430.96
357_V366_G0.7410.96
119_E122_V0.7410.96
268_P274_I0.7390.96
11_L15_I0.7390.96
269_I279_A0.7390.96
232_L235_I0.7380.96
207_F210_V0.7380.96
299_E303_G0.7370.96
21_T32_A0.7370.96
152_M427_T0.7350.96
168_A171_L0.7350.96
120_V163_A0.7330.96
373_P378_Y0.7310.96
220_R227_S0.7310.96
78_K81_E0.7310.96
54_A58_G0.7290.96
31_L276_V0.7290.96
85_A88_R0.7280.96
277_F283_L0.7280.96
21_T27_F0.7260.96
276_V282_V0.7220.96
30_F34_L0.7220.96
10_T13_I0.7190.96
103_V107_L0.7190.96
269_I276_V0.7180.96
115_T118_V0.7170.96
234_T237_L0.7150.96
46_M50_D0.7150.96
102_D105_M0.7140.96
354_H363_A0.7140.96
237_L275_A0.7140.96
236_L242_M0.7130.96
17_L20_L0.7120.96
363_A402_D0.7070.95
138_T142_K0.7070.95
177_S180_V0.7060.95
189_A437_G0.7050.95
267_N271_A0.7010.95
184_L191_L0.7010.95
113_G118_V0.6990.95
148_C405_F0.6980.95
38_F270_T0.6960.95
202_G210_V0.6950.95
150_A154_V0.6940.95
248_A251_N0.6930.95
44_M47_G0.6930.95
226_P242_M0.6910.95
88_R228_L0.6900.95
28_H31_L0.6900.95
154_V158_V0.6880.95
346_A371_V0.6880.95
335_L349_V0.6860.95
225_L232_L0.6860.95
12_L16_V0.6840.94
68_A72_L0.6840.94
311_I365_M0.6830.94
215_A218_K0.6830.94
230_A238_P0.6810.94
350_A363_A0.6800.94
423_Y427_T0.6790.94
357_V362_V0.6770.94
188_M437_G0.6770.94
197_F425_T0.6750.94
97_R102_D0.6740.94
116_L119_E0.6740.94
380_D384_E0.6730.94
78_K300_N0.6720.94
133_A138_T0.6700.94
235_I246_T0.6680.94
177_S384_E0.6640.94
233_F250_L0.6630.93
360_A394_A0.6630.93
46_M54_A0.6620.93
249_E263_E0.6620.93
166_Y365_M0.6600.93
280_Y298_T0.6580.93
218_K221_D0.6560.93
214_F220_R0.6560.93
226_P234_T0.6560.93
228_L238_P0.6550.93
110_L114_I0.6550.93
213_E217_L0.6530.93
98_W101_V0.6520.93
121_G151_L0.6510.93
232_L238_P0.6500.93
97_R112_C0.6450.93
270_T273_F0.6440.92
267_N276_V0.6440.92
179_I182_G0.6440.92
373_P377_L0.6430.92
112_C125_L0.6430.92
354_H398_T0.6420.92
182_G186_G0.6380.92
343_I381_I0.6380.92
281_Y284_G0.6380.92
103_V110_L0.6370.92
245_K251_N0.6360.92
291_M294_M0.6340.92
185_V388_I0.6340.92
330_T333_V0.6340.92
179_I183_L0.6320.92
100_S104_I0.6310.92
271_A283_L0.6310.92
387_A430_A0.6310.92
363_A367_A0.6290.92
299_E302_F0.6280.92
13_I17_L0.6270.91
234_T241_L0.6260.91
271_A274_I0.6260.91
194_G204_R0.6250.91
114_I154_V0.6250.91
288_H294_M0.6220.91
114_I119_E0.6210.91
10_T14_S0.6200.91
224_T229_G0.6190.91
198_L209_P0.6190.91
354_H394_A0.6190.91
360_A403_S0.6160.91
153_A430_A0.6140.91
245_K252_M0.6140.91
44_M325_S0.6140.91
345_L375_L0.6120.90
399_I427_T0.6120.90
217_L220_R0.6120.90
9_S13_I0.6110.90
424_T431_S0.6100.90
374_M378_Y0.6080.90
231_T246_T0.6070.90
351_L397_C0.6060.90
350_A394_A0.6030.90
422_Y425_T0.6030.90
129_A133_A0.6030.90
419_T423_Y0.6020.90
195_P199_K0.6010.90
388_I392_S0.6010.90
41_G51_M0.6010.90
272_M283_L0.6000.90
341_H344_L0.6000.90
232_L236_L0.6000.90
195_P204_R0.5980.89
113_G119_E0.5970.89
231_T249_E0.5920.89
10_T36_A0.5890.89
170_K369_A0.5880.89
200_F211_P0.5870.89
68_A71_G0.5860.88
199_K204_R0.5850.88
269_I277_F0.5840.88
195_P200_F0.5840.88
115_T119_E0.5820.88
268_P283_L0.5810.88
99_L104_I0.5810.88
238_P250_L0.5780.88
113_G120_V0.5780.88
173_A178_V0.5770.88
142_K202_G0.5750.88
129_A147_L0.5730.87
194_G199_K0.5710.87
200_F207_F0.5690.87
181_Y188_M0.5690.87
10_T39_F0.5680.87
187_L190_S0.5680.87
340_M344_L0.5680.87
353_L357_V0.5670.87
155_H159_P0.5670.87
113_G154_V0.5650.87
362_V366_G0.5650.87
233_F236_L0.5650.87
283_L294_M0.5650.87
88_R227_S0.5640.87
21_T35_L0.5620.86
284_G288_H0.5620.86
152_M395_I0.5620.86
385_I438_T0.5620.86
14_S18_I0.5620.86
332_A366_G0.5610.86
225_L231_T0.5600.86
333_V337_N0.5600.86
104_I107_L0.5590.86
400_V420_F0.5590.86
273_F276_V0.5580.86
10_T44_M0.5580.86
265_I269_I0.5550.86
433_V436_A0.5540.86
236_L243_L0.5530.85
178_V181_Y0.5530.85
91_L225_L0.5520.85
438_T442_S0.5500.85
103_V111_I0.5460.85
238_P251_N0.5450.85
158_V161_H0.5420.84
17_L24_K0.5410.84
228_L233_F0.5410.84
131_S331_L0.5400.84
238_P249_E0.5390.84
270_T283_L0.5390.84
226_P240_A0.5390.84
347_W351_L0.5380.84
197_F208_K0.5370.84
60_G64_G0.5370.84
11_L14_S0.5370.84
221_D224_T0.5360.84
225_L238_P0.5350.84
113_G116_L0.5350.84
142_K146_P0.5350.84
277_F284_G0.5350.84
118_V122_V0.5340.83
198_L206_P0.5330.83
342_P378_Y0.5320.83
417_N420_F0.5310.83
88_R231_T0.5310.83
199_K209_P0.5290.83
15_I18_I0.5280.83
216_D221_D0.5280.83
148_C406_W0.5270.83
117_F163_A0.5270.83
11_L327_L0.5270.83
57_S320_A0.5260.83
182_G190_S0.5250.82
134_K137_N0.5250.82
217_L221_D0.5250.82
244_V251_N0.5240.82
437_G440_L0.5230.82
114_I120_V0.5230.82
157_V392_S0.5220.82
198_L208_K0.5210.82
175_I184_L0.5210.82
269_I283_L0.5200.82
267_N272_M0.5200.82
153_A186_G0.5190.82
264_F268_P0.5190.82
175_I179_I0.5180.82
234_T246_T0.5180.82
267_N270_T0.5160.81
314_A318_F0.5160.81
346_A350_A0.5160.81
242_M249_E0.5150.81
57_S329_D0.5130.81
51_M56_E0.5120.81
398_T401_T0.5120.81
397_C428_F0.5120.81
422_Y426_A0.5120.81
121_G161_H0.5110.81
106_V146_P0.5090.80
78_K304_S0.5080.80
242_M248_A0.5080.80
178_V182_G0.5080.80
184_L189_A0.5060.80
182_G188_M0.5060.80
346_A386_I0.5060.80
231_T251_N0.5040.80
397_C420_F0.5040.80
284_G294_M0.5040.80
13_I16_V0.5030.80
198_L203_Q0.5020.80
221_D337_N0.5010.79
280_Y294_M0.5010.79
139_S205_L0.5010.79
36_A128_L0.5000.79
328_A332_A0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r1iA 2 0.973 100 0.571 Contact Map
4r0cA 3 0.964 100 0.585 Contact Map
4f35D 2 0.8921 100 0.634 Contact Map
4pd6A 3 0.7573 63.3 0.949 Contact Map
4dx5A 3 0.3843 52.2 0.952 Contact Map
2nwlA 3 0.7326 52 0.952 Contact Map
3aqpA 1 0.3371 48 0.954 Contact Map
2cfqA 1 0.8157 46.5 0.954 Contact Map
3qe7A 2 0.4494 40.6 0.956 Contact Map
4k0jA 3 0.3236 37.8 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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