GREMLIN Database
CVPA - Colicin V production protein
UniProt: P08550 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10169
Length: 162 (152)
Sequences: 2076 (1626)
Seq/√Len: 131.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_S108_R4.9061.00
16_S102_V4.0591.00
40_V73_T4.0071.00
85_G97_D3.5671.00
33_T77_G3.5171.00
12_I106_A3.0561.00
40_V69_L2.9481.00
16_S106_A2.7471.00
24_F100_L2.7091.00
15_S105_G2.6811.00
48_L69_L2.5161.00
8_I137_L2.4811.00
15_S109_G2.4341.00
27_E104_F2.2711.00
29_L81_N2.2601.00
41_A66_I2.1531.00
22_R27_E2.0771.00
11_V116_I2.0391.00
48_L51_W1.9841.00
91_T97_D1.9811.00
39_F43_H1.9171.00
47_Y50_V1.8931.00
135_S138_I1.7711.00
6_Y10_A1.7681.00
3_W7_A1.7401.00
9_I13_A1.7361.00
18_V22_R1.6481.00
11_V15_S1.6261.00
69_L73_T1.5761.00
45_Y65_A1.5451.00
55_F64_I1.5451.00
132_W138_I1.5431.00
49_S62_N1.5281.00
11_V109_G1.5251.00
45_Y62_N1.5031.00
92_G95_G1.4911.00
45_Y66_I1.4671.00
37_A70_F1.4531.00
48_L65_A1.4371.00
130_E134_K1.4361.00
114_A141_F1.4211.00
36_C77_G1.3871.00
49_S65_A1.3831.00
17_L21_I1.3831.00
88_V91_T1.3821.00
99_V103_C1.3671.00
12_I109_G1.3661.00
8_I113_V1.3401.00
37_A73_T1.3111.00
4_I8_I1.3021.00
27_E108_R1.2281.00
41_A65_A1.2221.00
114_A144_I1.2061.00
137_L140_Q1.1910.99
11_V113_V1.1790.99
105_G109_G1.1780.99
52_F68_V1.1620.99
55_F61_R1.1570.99
18_V21_I1.1310.99
60_V64_I1.1110.99
29_L37_A1.0900.99
84_I87_L1.0690.99
26_R81_N1.0630.99
142_S145_I1.0620.99
110_V114_A1.0490.99
72_A139_P1.0250.98
72_A80_V1.0170.98
25_V88_V1.0150.98
140_Q144_I0.9860.98
26_R85_G0.9780.98
88_V93_L0.9700.98
52_F65_A0.9690.98
52_F61_R0.9490.97
34_W108_R0.9410.97
2_V6_Y0.9260.97
133_S139_P0.9250.97
70_F74_L0.9210.97
65_A69_L0.9190.97
29_L84_I0.9060.96
41_A117_L0.9060.96
118_F145_I0.9010.96
44_Y69_L0.8970.96
97_D131_D0.8790.96
78_A108_R0.8760.96
135_S141_F0.8650.95
34_W37_A0.8630.95
7_A10_A0.8590.95
44_Y47_Y0.8590.95
104_F108_R0.8590.95
124_T132_W0.8570.95
120_L123_F0.8570.95
114_A138_I0.8560.95
37_A41_A0.8510.95
53_T58_E0.8480.95
16_S20_L0.8430.95
5_D136_Q0.8340.94
20_L102_V0.8290.94
5_D37_A0.8170.94
66_I93_L0.8160.94
42_S45_Y0.8040.93
6_Y151_Y0.8030.93
83_V86_Q0.7770.92
70_F73_T0.7730.92
121_D142_S0.7710.92
26_R114_A0.7690.92
91_T142_S0.7660.91
10_A32_V0.7600.91
103_C107_L0.7500.91
5_D135_S0.7410.90
47_Y65_A0.7390.90
142_S146_R0.7390.90
67_A152_L0.7370.90
110_V144_I0.7280.89
11_V112_I0.7240.89
89_E130_E0.7200.89
83_V93_L0.7180.89
37_A74_L0.7170.88
24_F28_A0.7110.88
24_F104_F0.7090.88
34_W100_L0.7020.87
24_F81_N0.7000.87
13_A17_L0.6930.87
143_F146_R0.6910.87
6_Y33_T0.6820.86
29_L41_A0.6820.86
113_V137_L0.6810.86
12_I16_S0.6790.86
54_G60_V0.6760.85
25_V84_I0.6760.85
7_A141_F0.6740.85
45_Y69_L0.6610.84
38_F42_S0.6590.84
32_V77_G0.6560.84
80_V88_V0.6550.84
38_F41_A0.6550.84
109_G113_V0.6370.82
34_W74_L0.6360.82
74_L78_A0.6360.82
10_A149_F0.6340.82
124_T127_S0.6300.81
88_V97_D0.6290.81
148_F153_Q0.6270.81
50_V53_T0.6270.81
51_W54_G0.6260.81
113_V141_F0.6250.81
58_E130_E0.6250.81
20_L98_R0.6230.80
58_E148_F0.6190.80
125_G128_K0.6180.80
11_V60_V0.6180.80
40_V56_E0.6150.80
49_S53_T0.6130.79
59_L129_S0.6090.79
25_V97_D0.6030.78
48_L118_F0.6010.78
85_G94_S0.5990.78
60_V119_F0.5980.78
10_A151_Y0.5940.77
72_A151_Y0.5910.77
10_A52_F0.5900.77
42_S115_A0.5890.77
114_A146_R0.5890.77
79_I82_F0.5880.77
37_A92_G0.5850.76
60_V63_G0.5840.76
126_V132_W0.5830.76
32_V86_Q0.5810.76
118_F149_F0.5800.76
74_L108_R0.5800.76
29_L108_R0.5790.75
133_S136_Q0.5790.75
38_F50_V0.5760.75
81_N85_G0.5760.75
84_I88_V0.5750.75
43_H80_V0.5700.74
91_T94_S0.5690.74
41_A78_A0.5690.74
8_I117_L0.5680.74
116_I120_L0.5670.74
64_I78_A0.5660.74
107_L143_F0.5650.74
74_L81_N0.5650.74
22_R108_R0.5640.74
10_A14_F0.5620.73
44_Y73_T0.5610.73
148_F152_L0.5580.73
28_A136_Q0.5560.72
34_W70_F0.5550.72
102_V129_S0.5540.72
127_S153_Q0.5520.72
12_I110_V0.5510.72
33_T73_T0.5510.72
5_D137_L0.5510.72
13_A128_K0.5500.72
53_T61_R0.5470.71
50_V80_V0.5400.70
23_G101_G0.5360.70
22_R122_S0.5300.69
104_F112_I0.5300.69
27_E30_S0.5290.69
15_S34_W0.5280.69
94_S97_D0.5260.68
114_A145_I0.5210.68
4_I131_D0.5210.68
4_I138_I0.5210.68
39_F85_G0.5210.68
120_L124_T0.5210.68
43_H47_Y0.5200.67
31_L82_F0.5180.67
54_G79_I0.5180.67
40_V115_A0.5150.67
82_F99_V0.5140.67
9_I137_L0.5130.66
111_L114_A0.5110.66
26_R93_L0.5100.66
100_L141_F0.5090.66
19_S23_G0.5090.66
121_D132_W0.5080.66
117_L145_I0.5070.66
33_T123_F0.5070.66
85_G102_V0.5060.65
72_A107_L0.5060.65
18_V115_A0.5030.65
144_I148_F0.5030.65
18_V37_A0.5030.65
38_F140_Q0.5020.65
51_W130_E0.5010.65
76_V118_F0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j9pD 4 0.9938 32.9 0.907 Contact Map
3j5pB 3 0.9815 18 0.918 Contact Map
4aw6A 2 0.8272 15.1 0.92 Contact Map
4il3A 1 0.8827 9.3 0.928 Contact Map
2kluA 1 0.4074 7.4 0.931 Contact Map
3udcA 3 0.6605 6.8 0.932 Contact Map
2m20A 2 0.3704 4.8 0.937 Contact Map
3j01B 1 0.6173 4.7 0.937 Contact Map
3behA 3 0.784 4.5 0.938 Contact Map
3tuiA 2 0.7284 3.3 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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