GREMLIN Database
DACC - D-alanyl-D-alanine carboxypeptidase DacC
UniProt: P08506 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10203
Length: 400 (366)
Sequences: 4215 (3343)
Seq/√Len: 174.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_E58_A3.7431.00
59_D185_R3.7161.00
145_A154_L3.0391.00
90_M118_Q3.0171.00
121_V140_L2.9801.00
94_G142_D2.9141.00
353_T365_Q2.7841.00
76_V140_L2.7001.00
232_D256_R2.5971.00
57_N60_E2.5851.00
44_L281_G2.5671.00
191_G234_M2.5631.00
95_K115_P2.5191.00
89_D143_Y2.4661.00
126_K207_E2.4591.00
158_Y161_K2.4581.00
164_L190_L2.4321.00
257_L281_G2.4231.00
78_Q158_Y2.4201.00
350_V367_P2.4151.00
128_V140_L2.3671.00
61_K181_F2.3571.00
230_N252_Q2.3371.00
74_Y193_A2.3041.00
120_S123_D2.2231.00
70_I247_V2.2221.00
232_D249_S2.2091.00
127_G133_G2.2011.00
59_D166_N2.1441.00
345_L370_V2.1001.00
148_Q172_V2.0581.00
42_W54_A2.0571.00
47_Y258_I2.0411.00
128_V137_C2.0361.00
71_M167_T2.0351.00
289_T292_K2.0101.00
150_S153_G2.0071.00
92_T118_Q1.9931.00
307_K372_E1.9931.00
251_T254_D1.9881.00
185_R189_L1.9771.00
86_K89_D1.9471.00
313_G371_M1.9061.00
259_S274_S1.8971.00
147_S150_S1.8541.00
61_K166_N1.8441.00
357_Q362_S1.8211.00
250_A282_F1.8021.00
273_E276_K1.7841.00
153_G157_G1.7781.00
341_L351_V1.7511.00
71_M159_A1.7441.00
191_G247_V1.7381.00
95_K99_A1.7351.00
93_V139_A1.7341.00
91_V139_A1.7301.00
91_V143_Y1.7271.00
162_L193_A1.7251.00
145_A150_S1.7131.00
85_I121_V1.7041.00
350_V353_T1.6871.00
90_M120_S1.6781.00
333_S357_Q1.6541.00
44_L257_L1.6421.00
349_Q370_V1.6291.00
315_G367_P1.6271.00
67_L247_V1.6121.00
41_A184_A1.6031.00
96_D142_D1.6011.00
164_L189_L1.5891.00
88_T122_A1.5881.00
362_S365_Q1.5861.00
73_S129_I1.5811.00
299_T309_E1.5771.00
94_G97_A1.5741.00
200_E203_A1.5741.00
72_T137_C1.5721.00
41_A62_L1.5681.00
67_L187_M1.5661.00
228_N279_T1.5621.00
192_K258_I1.5571.00
79_A84_K1.5541.00
167_T182_S1.5541.00
239_T242_A1.5501.00
73_S128_V1.5421.00
130_I207_E1.5331.00
168_T181_F1.5281.00
193_A196_H1.5071.00
46_D255_M1.5041.00
351_V370_V1.4971.00
85_I143_Y1.4641.00
122_A126_K1.4641.00
170_Q179_G1.4571.00
209_E216_R1.4551.00
335_T355_D1.4531.00
157_G161_K1.4511.00
184_A262_L1.4431.00
40_R263_G1.4341.00
355_D365_Q1.4291.00
176_D241_G1.4171.00
310_V370_V1.4071.00
346_K373_N1.4041.00
122_A204_I1.3951.00
76_V121_V1.3941.00
64_P182_S1.3671.00
73_S125_N1.3641.00
43_I185_R1.3611.00
346_K349_Q1.3591.00
347_K373_N1.3531.00
122_A203_A1.3511.00
93_V113_L1.3391.00
127_G136_A1.3361.00
170_Q177_A1.3241.00
334_Y368_L1.3231.00
193_A197_D1.3181.00
87_L125_N1.3171.00
355_D362_S1.3121.00
333_S355_D1.3111.00
289_T319_S1.3081.00
67_L262_L1.2921.00
231_V248_A1.2911.00
43_I58_A1.2901.00
100_T138_I1.2831.00
68_T180_Q1.2791.00
81_K200_E1.2771.00
187_M247_V1.2761.00
192_K196_H1.2711.00
126_K210_F1.2681.00
251_T256_R1.2591.00
63_D176_D1.2511.00
126_K130_I1.2451.00
248_A274_S1.2421.00
154_L157_G1.2391.00
63_D241_G1.2301.00
74_Y158_Y1.2231.00
249_S256_R1.2221.00
87_L122_A1.2191.00
44_L259_S1.2141.00
211_T216_R1.2111.00
202_Y249_S1.2061.00
159_A164_L1.2041.00
208_K225_W1.2021.00
111_M127_G1.2001.00
74_Y197_D1.1931.00
97_A142_D1.1901.00
286_E324_R1.1891.00
335_T353_T1.1881.00
132_S235_K1.1841.00
85_I140_L1.1751.00
311_N371_M1.1731.00
42_W56_G1.1711.00
370_V373_N1.1611.00
150_S154_L1.1541.00
43_I52_V1.1491.00
41_A57_N1.1441.00
75_V79_A1.1421.00
70_I191_G1.1281.00
70_I234_M1.1161.00
289_T317_A1.1151.00
58_A185_R1.1111.00
59_D183_T1.1061.00
377_G381_G1.1061.00
45_M188_A1.0921.00
76_V128_V1.0891.00
242_A245_N1.0861.00
306_D375_E1.0861.00
300_Q312_L1.0851.00
80_L201_E1.0831.00
158_Y193_A1.0791.00
264_A273_E1.0791.00
170_Q180_Q1.0771.00
16_A19_F1.0761.00
228_N231_V1.0701.00
152_I172_V1.0601.00
292_K317_A1.0561.00
152_I156_N1.0541.00
292_K295_A1.0491.00
50_G192_K1.0471.00
275_E279_T1.0451.00
266_T269_I1.0390.99
76_V85_I1.0180.99
137_C172_V1.0120.99
96_D149_E1.0100.99
331_K357_Q1.0050.99
261_V274_S1.0040.99
312_L351_V1.0040.99
315_G369_I1.0000.99
98_W115_P0.9990.99
205_H234_M0.9980.99
326_Q329_N0.9960.99
231_V278_L0.9940.99
248_A278_L0.9890.99
40_R62_L0.9870.99
39_A264_A0.9850.99
93_V119_V0.9820.99
378_G381_G0.9780.99
287_T321_T0.9770.99
250_A278_L0.9770.99
168_T179_G0.9760.99
252_Q282_F0.9680.99
166_N183_T0.9620.99
96_D148_Q0.9580.99
64_P262_L0.9520.99
202_Y256_R0.9460.99
159_A190_L0.9440.99
75_V158_Y0.9430.99
61_K183_T0.9420.99
77_G201_E0.9420.99
133_G136_A0.9390.99
132_S236_T0.9370.99
195_I202_Y0.9350.99
188_A260_V0.9320.99
299_T311_N0.9300.99
203_A206_K0.9290.99
305_G343_A0.9290.99
138_I148_Q0.9270.99
88_T120_S0.9270.99
75_V144_V0.9210.99
114_K117_D0.9110.99
70_I194_L0.9100.99
357_Q360_G0.9070.99
332_A356_F0.9030.99
310_V374_V0.9020.99
251_T282_F0.9000.99
377_G385_D0.9000.99
144_V154_L0.8990.98
79_A82_A0.8930.98
310_V345_L0.8930.98
46_D287_T0.8920.98
91_V121_V0.8890.98
234_M249_S0.8880.98
291_I314_A0.8870.98
156_N168_T0.8870.98
311_N372_E0.8840.98
80_L85_I0.8830.98
124_L136_A0.8830.98
48_A319_S0.8820.98
93_V124_L0.8820.98
323_P326_Q0.8810.98
187_M262_L0.8720.98
212_F217_Q0.8720.98
287_T319_S0.8710.98
48_A256_R0.8680.98
113_L139_A0.8660.98
48_A287_T0.8660.98
189_L192_K0.8630.98
165_T185_R0.8610.98
157_G160_K0.8580.98
87_L204_I0.8570.98
293_P317_A0.8560.98
228_N250_A0.8530.98
80_L87_L0.8510.98
38_D273_E0.8480.98
318_G364_E0.8480.98
79_A144_V0.8460.98
344_P374_V0.8440.98
230_N279_T0.8410.98
129_I205_H0.8410.98
280_W285_F0.8390.98
252_Q279_T0.8370.98
78_Q197_D0.8360.98
92_T143_Y0.8350.98
376_E382_R0.8330.98
46_D321_T0.8330.98
119_V124_L0.8320.98
202_Y205_H0.8320.98
81_K197_D0.8310.97
36_S56_G0.8270.97
341_L345_L0.8250.97
302_V343_A0.8240.97
269_I273_E0.8220.97
119_V123_D0.8210.97
66_S235_K0.8210.97
265_K269_I0.8190.97
182_S187_M0.8180.97
40_R60_E0.8130.97
84_K154_L0.8120.97
25_A28_A0.8090.97
354_I366_R0.8070.97
280_W284_F0.8050.97
169_F187_M0.8030.97
246_L274_S0.8030.97
349_Q373_N0.8030.97
43_I260_V0.8030.97
43_I188_A0.8020.97
176_D239_T0.8020.97
123_D126_K0.8020.97
226_S275_E0.8010.97
318_G366_R0.7990.97
302_V305_G0.7980.97
160_K165_T0.7950.97
78_Q82_A0.7940.97
345_L351_V0.7930.97
71_M155_M0.7920.97
194_L234_M0.7920.97
45_M192_K0.7920.97
76_V144_V0.7910.97
65_A242_A0.7910.97
222_R271_F0.7810.96
70_I129_I0.7790.96
261_V264_A0.7790.96
117_D215_I0.7780.96
43_I55_E0.7760.96
79_A154_L0.7740.96
23_P26_F0.7720.96
228_N275_E0.7710.96
247_V260_V0.7700.96
125_N204_I0.7690.96
201_E205_H0.7610.96
238_T244_Y0.7590.96
187_M191_G0.7590.96
123_D213_N0.7540.96
305_G374_V0.7510.95
77_G125_N0.7490.95
149_E153_G0.7480.95
21_F24_T0.7480.95
109_S133_G0.7480.95
85_I89_D0.7390.95
195_I256_R0.7360.95
217_Q220_R0.7340.95
24_T28_A0.7310.95
85_I91_V0.7310.95
159_A169_F0.7300.95
110_V113_L0.7290.95
71_M75_V0.7290.95
210_F217_Q0.7250.95
209_E218_P0.7250.95
75_V78_Q0.7230.94
41_A262_L0.7220.94
67_L245_N0.7210.94
83_D86_K0.7200.94
195_I232_D0.7190.94
228_N278_L0.7150.94
111_M119_V0.7150.94
383_V387_V0.7140.94
330_L358_L0.7130.94
71_M169_F0.7130.94
126_K204_I0.7090.94
94_G139_A0.7080.94
194_L201_E0.7060.94
70_I190_L0.7030.94
239_T245_N0.7010.93
191_G233_G0.7000.93
221_N246_L0.7000.93
73_S77_G0.6990.93
332_A354_I0.6990.93
155_M159_A0.6990.93
17_F20_L0.6980.93
91_V124_L0.6970.93
296_T311_N0.6970.93
166_N186_D0.6960.93
159_A162_L0.6960.93
221_N248_A0.6930.93
329_N359_N0.6910.93
259_S277_L0.6900.93
259_S278_L0.6900.93
288_V327_L0.6850.93
73_S205_H0.6850.93
156_N169_F0.6850.93
131_Q220_R0.6850.93
71_M164_L0.6810.92
276_K279_T0.6800.92
162_L190_L0.6780.92
66_S69_K0.6780.92
330_L363_I0.6780.92
348_G370_V0.6690.92
66_S237_G0.6690.92
100_T175_L0.6680.92
314_A368_L0.6650.92
108_S112_F0.6620.91
211_T214_K0.6610.91
78_Q161_K0.6590.91
87_L90_M0.6590.91
248_A259_S0.6590.91
62_L262_L0.6590.91
255_M287_T0.6550.91
45_M258_I0.6550.91
63_D177_A0.6550.91
111_M131_Q0.6540.91
53_L285_F0.6510.91
154_L158_Y0.6490.91
75_V155_M0.6470.90
255_M285_F0.6470.90
66_S132_S0.6460.90
55_E185_R0.6440.90
244_Y267_D0.6430.90
230_N250_A0.6400.90
131_Q217_Q0.6350.90
45_M189_L0.6320.89
119_V212_F0.6310.89
130_I210_F0.6310.89
312_L368_L0.6290.89
67_L70_I0.6260.89
51_K321_T0.6250.89
358_L363_I0.6230.89
55_E59_D0.6220.89
44_L277_L0.6220.89
96_D100_T0.6210.89
304_F342_T0.6200.89
306_D381_G0.6200.89
71_M190_L0.6190.88
75_V154_L0.6180.88
379_F383_V0.6160.88
187_M245_N0.6140.88
13_A19_F0.6140.88
100_T110_V0.6130.88
51_K361_K0.6100.88
294_D313_G0.6100.88
294_D314_A0.6050.87
167_T186_D0.6050.87
168_T180_Q0.6050.87
201_E204_I0.6010.87
194_L205_H0.6010.87
107_G110_V0.6010.87
123_D210_F0.6000.87
205_H233_G0.5970.87
13_A16_A0.5970.87
201_E234_M0.5940.86
228_N252_Q0.5930.86
182_S186_D0.5930.86
314_A318_G0.5930.86
35_P280_W0.5890.86
205_H249_S0.5870.86
222_R226_S0.5860.86
277_L281_G0.5850.85
85_I144_V0.5830.85
77_G200_E0.5820.85
65_A68_T0.5810.85
124_L140_L0.5800.85
139_A143_Y0.5790.85
232_D251_T0.5790.85
165_T189_L0.5770.85
158_Y162_L0.5760.85
331_K360_G0.5760.85
129_I201_E0.5760.85
381_G384_W0.5750.85
156_N160_K0.5750.85
68_T182_S0.5740.84
37_V42_W0.5730.84
144_V152_I0.5730.84
108_S135_D0.5730.84
343_A374_V0.5720.84
79_A85_I0.5720.84
46_D49_S0.5710.84
304_F386_F0.5680.84
284_F323_P0.5670.84
100_T107_G0.5670.84
69_K134_N0.5660.84
221_N224_L0.5650.83
23_P27_A0.5600.83
288_V322_I0.5600.83
117_D213_N0.5590.83
278_L281_G0.5570.83
348_G369_I0.5570.83
264_A269_I0.5570.83
220_R238_T0.5560.83
301_R309_E0.5560.83
334_Y354_I0.5540.82
57_N62_L0.5540.82
152_I167_T0.5540.82
28_A31_T0.5530.82
61_K182_S0.5530.82
51_K326_Q0.5510.82
15_S19_F0.5500.82
358_L361_K0.5500.82
353_T367_P0.5500.82
45_M50_G0.5490.82
197_D200_E0.5480.82
236_T270_R0.5470.81
173_H176_D0.5470.81
195_I234_M0.5470.81
381_G385_D0.5470.81
228_N282_F0.5460.81
65_A237_G0.5450.81
286_E325_G0.5440.81
336_L352_G0.5430.81
141_A148_Q0.5430.81
87_L200_E0.5430.81
52_V58_A0.5430.81
231_V250_A0.5420.81
261_V277_L0.5410.81
176_D242_A0.5400.81
109_S236_T0.5400.81
66_S236_T0.5400.81
65_A236_T0.5390.81
96_D138_I0.5380.80
53_L257_L0.5370.80
78_Q81_K0.5360.80
74_Y162_L0.5360.80
122_A200_E0.5360.80
19_F22_A0.5350.80
266_T272_N0.5350.80
322_I330_L0.5350.80
52_V55_E0.5340.80
39_A273_E0.5320.80
22_A26_F0.5320.80
302_V341_L0.5310.80
22_A27_A0.5300.79
226_S271_F0.5300.79
77_G205_H0.5300.79
291_I294_D0.5290.79
291_I356_F0.5290.79
47_Y192_K0.5280.79
164_L186_D0.5280.79
77_G204_I0.5270.79
56_G273_E0.5260.79
246_L271_F0.5260.79
246_L261_V0.5250.79
64_P187_M0.5240.79
202_Y206_K0.5210.78
64_P68_T0.5210.78
111_M133_G0.5210.78
187_M190_L0.5210.78
288_V291_I0.5210.78
74_Y190_L0.5200.78
37_V273_E0.5190.78
222_R267_D0.5190.78
25_A29_E0.5180.78
130_I204_I0.5170.78
180_Q245_N0.5160.78
113_L119_V0.5160.78
13_A20_L0.5160.78
337_T340_Q0.5150.77
38_D269_I0.5150.77
302_V310_V0.5150.77
100_T108_S0.5140.77
238_T267_D0.5140.77
75_V167_T0.5130.77
71_M162_L0.5120.77
303_W340_Q0.5120.77
296_T299_T0.5120.77
350_V369_I0.5110.77
202_Y232_D0.5100.77
27_A30_Q0.5100.77
176_D179_G0.5090.77
169_F190_L0.5090.77
70_I201_E0.5080.77
302_V344_P0.5080.77
65_A132_S0.5080.77
119_V127_G0.5070.76
199_P202_Y0.5070.76
110_V135_D0.5040.76
378_G382_R0.5030.76
266_T271_F0.5030.76
23_P28_A0.5010.76
246_L259_S0.5010.76
96_D99_A0.5000.75
45_M52_V0.5000.75
305_G344_P0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mzfA 1 0.88 100 0.253 Contact Map
4k91A 1 0.8575 100 0.267 Contact Map
3itaA 1 0.8725 100 0.268 Contact Map
3a3jA 1 0.8525 100 0.28 Contact Map
1xp4A 3 0.8425 100 0.286 Contact Map
3mfdA 1 0.7975 100 0.3 Contact Map
3hunA 1 0.7975 100 0.38 Contact Map
1tvfA 1 0.825 100 0.411 Contact Map
4pprA 1 0.715 100 0.491 Contact Map
4ryeA 1 0.6375 100 0.498 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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