GREMLIN Database
CREC - Sensor protein CreC
UniProt: P08401 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10730
Length: 474 (438)
Sequences: 50388 (43896)
Seq/√Len: 2097.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
406_D410_G3.9511.00
405_L464_L3.8961.00
443_S447_R3.6451.00
278_A297_I3.6381.00
328_V363_A3.5341.00
454_T466_S3.4721.00
399_H468_R3.4221.00
383_T407_T2.9581.00
403_K464_L2.9331.00
392_S403_K2.8611.00
458_V461_G2.8161.00
412_P415_A2.7631.00
401_T468_R2.7521.00
363_A449_F2.7411.00
416_L457_N2.7311.00
401_T466_S2.7011.00
403_K466_S2.6561.00
394_E401_T2.6381.00
390_T405_L2.6341.00
353_H390_T2.6181.00
282_R298_L2.6121.00
455_L465_A2.6071.00
327_A362_A2.6051.00
442_V453_V2.5961.00
282_R295_D2.5831.00
416_L455_L2.4871.00
353_H388_C2.4521.00
275_R302_A2.4371.00
371_A446_A2.4321.00
388_C407_T2.4151.00
446_A451_G2.4021.00
392_S405_L2.3831.00
234_S237_R2.3721.00
355_T392_S2.3691.00
456_R464_L2.3631.00
394_E403_K2.3471.00
457_N463_V2.3011.00
329_D332_A2.2811.00
275_R301_N2.2761.00
420_F453_V2.2621.00
326_T365_P2.2591.00
456_R466_S2.2351.00
336_R369_E2.1811.00
411_I419_I2.1231.00
247_R250_L2.1121.00
327_A360_N2.1011.00
446_A467_L2.0931.00
415_A418_R2.0861.00
287_P290_V2.0801.00
355_T390_T2.0511.00
351_T388_C2.0511.00
452_E468_R2.0351.00
341_R373_G2.0151.00
219_S224_K2.0041.00
411_I415_A1.9991.00
383_T387_G1.9921.00
371_A445_V1.9861.00
99_D103_K1.9791.00
413_D416_L1.9531.00
246_M250_L1.8731.00
371_A442_V1.8651.00
345_L380_I1.8641.00
286_P290_V1.8601.00
236_L240_A1.8381.00
387_G407_T1.8131.00
372_L402_L1.8111.00
279_E298_L1.8021.00
305_Q309_E1.7901.00
447_R452_E1.7901.00
363_A368_L1.7891.00
331_A393_A1.7691.00
445_V449_F1.7691.00
418_R424_Y1.7561.00
396_D401_T1.7491.00
244_E247_R1.7331.00
254_N258_Q1.7221.00
233_S237_R1.7171.00
325_L362_A1.7141.00
418_R421_E1.7091.00
232_G237_R1.7051.00
454_T468_R1.6911.00
402_L467_L1.6811.00
282_R291_A1.6681.00
258_Q262_A1.6541.00
278_A298_L1.6501.00
415_A424_Y1.6481.00
256_I260_V1.6331.00
457_N461_G1.6221.00
275_R305_Q1.6191.00
247_R251_E1.6191.00
277_A293_F1.6091.00
383_T389_I1.5991.00
281_L294_T1.5891.00
377_D381_D1.5681.00
364_E367_L1.5651.00
412_P459_Q1.5401.00
411_I463_V1.5311.00
286_P289_V1.5221.00
390_T407_T1.4951.00
96_Y165_S1.4921.00
382_F425_S1.4901.00
367_L370_Q1.4811.00
371_A467_L1.4611.00
329_D358_E1.4541.00
24_A28_K1.4531.00
406_D462_G1.4531.00
331_A335_R1.4361.00
374_N442_V1.4301.00
342_T346_A1.4241.00
274_I301_N1.4211.00
233_S236_L1.4131.00
240_A244_E1.4121.00
415_A426_L1.4051.00
298_L302_A1.3941.00
421_E424_Y1.3911.00
457_N460_E1.3911.00
446_A453_V1.3791.00
329_D360_N1.3671.00
336_R365_P1.3571.00
281_L290_V1.3561.00
275_R298_L1.3541.00
229_P232_G1.3381.00
236_L239_L1.3331.00
237_R240_A1.3311.00
416_L420_F1.3271.00
214_T218_D1.3171.00
211_A214_T1.3071.00
399_H452_E1.3041.00
323_V364_E1.2791.00
243_L246_M1.2701.00
273_A300_Q1.2681.00
419_I455_L1.2661.00
274_I297_I1.2591.00
278_A282_R1.2501.00
94_H167_G1.2441.00
420_F455_L1.2401.00
344_Q347_E1.2341.00
93_Y168_K1.2311.00
365_P369_E1.2271.00
273_A277_A1.2201.00
98_T104_V1.2181.00
451_G469_L1.2171.00
220_V247_R1.2141.00
199_G203_V1.2121.00
367_L448_L1.2101.00
340_A369_E1.2081.00
284_G290_V1.1871.00
444_E447_R1.1761.00
334_F393_A1.1721.00
277_A296_N1.1711.00
295_D299_T1.1651.00
420_F465_A1.1631.00
338_S354_V1.1561.00
259_Y263_L1.1531.00
252_G255_Y1.1471.00
367_L445_V1.1361.00
233_S240_A1.1301.00
333_L337_V1.1291.00
455_L463_V1.1261.00
177_I181_E1.1211.00
411_I416_L1.1171.00
178_K182_R1.1161.00
217_A221_T1.1151.00
325_L449_F1.1131.00
262_A422_R1.1121.00
80_R84_G1.1031.00
155_M160_L1.1031.00
306_A366_A1.1031.00
278_A294_T1.1011.00
278_A301_N1.0971.00
359_V395_V1.0961.00
214_T238_K1.0911.00
227_P248_V1.0901.00
94_H107_D1.0871.00
359_V400_V1.0761.00
266_E370_Q1.0751.00
240_A243_L1.0741.00
287_P291_A1.0711.00
337_V376_L1.0691.00
368_L449_F1.0651.00
427_P432_Q1.0581.00
406_D463_V1.0581.00
335_R354_V1.0551.00
300_Q303_R1.0511.00
213_L217_A1.0491.00
312_L315_A1.0461.00
411_I455_L1.0411.00
219_S226_V1.0401.00
203_V207_N1.0361.00
285_P290_V1.0321.00
25_I29_E1.0281.00
184_I188_S1.0261.00
292_R296_N1.0251.00
237_R241_Q1.0191.00
276_G280_I1.0181.00
375_L465_A1.0181.00
379_A389_I1.0021.00
217_A220_V1.0001.00
245_S249_K0.9941.00
239_L243_L0.9901.00
323_V367_L0.9871.00
96_Y104_V0.9831.00
266_E374_N0.9801.00
174_A177_I0.9791.00
291_A295_D0.9761.00
341_R376_L0.9761.00
372_L404_V0.9761.00
242_A245_S0.9731.00
372_L376_L0.9691.00
375_L453_V0.9691.00
225_P251_E0.9681.00
332_A336_R0.9671.00
309_E313_R0.9671.00
173_M177_I0.9641.00
422_R444_E0.9571.00
296_N300_Q0.9571.00
396_D399_H0.9561.00
197_V201_G0.9511.00
337_V369_E0.9481.00
170_N174_A0.9471.00
151_A163_V0.9461.00
340_A373_G0.9451.00
374_N377_D0.9421.00
446_A469_L0.9391.00
246_M249_K0.9381.00
46_A49_L0.9371.00
328_V333_L0.9361.00
341_R377_D0.9351.00
411_I417_S0.9331.00
331_A358_E0.9321.00
337_V373_G0.9311.00
243_L247_R0.9291.00
46_A50_A0.9291.00
338_S342_T0.9261.00
39_E43_I0.9251.00
244_E248_V0.9241.00
275_R279_E0.9231.00
429_A432_Q0.9191.00
369_E373_G0.9181.00
330_V402_L0.9151.00
221_T224_K0.9141.00
43_I47_T0.9101.00
227_P251_E0.9091.00
98_T165_S0.9081.00
345_L389_I0.9071.00
238_K242_A0.9031.00
149_Y167_G0.9021.00
107_D111_K0.8981.00
310_T367_L0.8981.00
370_Q445_V0.8971.00
437_L441_F0.8971.00
210_I214_T0.8951.00
288_E291_A0.8941.00
333_L363_A0.8941.00
196_L200_A0.8931.00
31_K35_R0.8921.00
330_V400_V0.8921.00
178_K181_E0.8881.00
123_V127_L0.8871.00
337_V341_R0.8871.00
419_I465_A0.8851.00
299_T336_R0.8851.00
375_L442_V0.8851.00
376_L391_L0.8811.00
204_W208_R0.8801.00
258_Q422_R0.8771.00
396_D468_R0.8771.00
297_I301_N0.8751.00
254_N257_E0.8751.00
350_I383_T0.8731.00
79_F83_I0.8701.00
382_F409_S0.8691.00
214_T217_A0.8691.00
124_W128_R0.8691.00
411_I457_N0.8691.00
420_F443_S0.8681.00
273_A276_G0.8681.00
153_P160_L0.8641.00
306_A310_T0.8601.00
56_D60_G0.8581.00
412_P426_L0.8541.00
334_F391_L0.8541.00
266_E270_P0.8531.00
42_L46_A0.8521.00
323_V448_L0.8511.00
121_N125_L0.8511.00
325_L363_A0.8501.00
301_N305_Q0.8481.00
183_R186_W0.8481.00
232_G240_A0.8461.00
442_V446_A0.8451.00
206_I209_S0.8451.00
344_Q377_D0.8441.00
267_L304_M0.8431.00
144_E148_M0.8401.00
265_H374_N0.8391.00
125_L129_G0.8381.00
227_P247_R0.8351.00
210_I213_L0.8341.00
217_A243_L0.8341.00
413_D458_V0.8291.00
410_G463_V0.8251.00
329_D359_V0.8251.00
314_Q440_A0.8221.00
268_K305_Q0.8191.00
335_R339_E0.8181.00
201_G205_W0.8171.00
334_F372_L0.8141.00
277_A297_I0.8121.00
241_Q244_E0.8121.00
253_K256_I0.8121.00
184_I187_A0.8101.00
220_V246_M0.8101.00
292_R295_D0.8081.00
203_V206_I0.8051.00
376_L389_I0.8041.00
28_K31_K0.8031.00
182_R186_W0.8031.00
405_L458_V0.8021.00
216_Y228_L0.7991.00
371_A449_F0.7961.00
375_L467_L0.7941.00
39_E42_L0.7921.00
239_L242_A0.7921.00
104_V107_D0.7911.00
413_D457_N0.7901.00
413_D417_S0.7901.00
179_R182_R0.7891.00
269_S273_A0.7861.00
139_N143_P0.7851.00
454_T467_L0.7851.00
263_L311_L0.7791.00
268_K309_E0.7771.00
79_F82_N0.7751.00
209_S214_T0.7741.00
227_P244_E0.7731.00
325_L450_N0.7721.00
217_A242_A0.7711.00
147_V151_A0.7711.00
339_E342_T0.7691.00
271_L308_V0.7671.00
373_G377_D0.7631.00
238_K241_Q0.7621.00
108_S111_K0.7581.00
140_P143_P0.7561.00
391_L404_V0.7541.00
142_D145_S0.7531.00
174_A178_K0.7521.00
259_Y266_E0.7471.00
406_D409_S0.7451.00
335_R338_S0.7451.00
350_I354_V0.7451.00
366_A369_E0.7441.00
83_I87_N0.7441.00
356_P359_V0.7421.00
99_D105_L0.7421.00
195_A199_G0.7411.00
107_D110_N0.7411.00
345_L352_L0.7401.00
282_R294_T0.7351.00
350_I380_I0.7351.00
383_T386_S0.7351.00
313_R367_L0.7341.00
338_S352_L0.7341.00
57_L61_D0.7341.00
50_A54_R0.7341.00
219_S223_N0.7331.00
346_A349_K0.7331.00
401_T454_T0.7321.00
87_N106_F0.7321.00
425_S434_S0.7321.00
77_R81_A0.7311.00
23_L27_V0.7291.00
141_A145_S0.7281.00
153_P163_V0.7271.00
343_V347_E0.7271.00
313_R370_Q0.7251.00
77_R80_R0.7251.00
357_T395_V0.7241.00
257_E318_E0.7231.00
251_E254_N0.7231.00
393_A402_L0.7231.00
273_A296_N0.7221.00
451_G467_L0.7221.00
293_F297_I0.7211.00
289_V293_F0.7211.00
295_D298_L0.7201.00
183_R187_A0.7161.00
444_E448_L0.7161.00
215_R219_S0.7161.00
416_L456_R0.7141.00
379_A404_V0.7071.00
296_N299_T0.7061.00
341_R380_I0.7061.00
60_G64_H0.7061.00
266_E269_S0.7051.00
345_L348_K0.7051.00
211_A215_R0.7051.00
116_D119_R0.7041.00
150_V153_P0.7041.00
233_S239_L0.7031.00
45_T48_L0.7011.00
37_A41_T0.7011.00
229_P244_E0.6991.00
209_S213_L0.6991.00
324_V364_E0.6931.00
173_M176_V0.6921.00
235_E238_K0.6881.00
359_V393_A0.6871.00
93_Y96_Y0.6861.00
451_G470_H0.6861.00
355_T394_E0.6851.00
265_H269_S0.6851.00
367_L449_F0.6851.00
153_P162_G0.6831.00
28_K32_P0.6831.00
54_R58_L0.6831.00
223_N226_V0.6811.00
403_K456_R0.6801.00
303_R369_E0.6801.00
208_R212_R0.6781.00
272_A276_G0.6771.00
39_E148_M0.6761.00
234_S238_K0.6741.00
151_A165_S0.6741.00
122_D125_L0.6731.00
57_L60_G0.6731.00
280_I293_F0.6721.00
310_T370_Q0.6721.00
277_A300_Q0.6701.00
381_D425_S0.6701.00
147_V167_G0.6681.00
349_K386_S0.6671.00
56_D59_S0.6661.00
214_T242_A0.6641.00
188_S192_L0.6641.00
212_R215_R0.6631.00
349_K385_E0.6611.00
230_D234_S0.6601.00
219_S222_D0.6571.00
20_W24_A0.6561.00
40_G43_I0.6551.00
35_R39_E0.6531.00
359_V362_A0.6531.00
262_A266_E0.6531.00
419_I440_A0.6531.00
228_L240_A0.6521.00
345_L350_I0.6511.00
218_D238_K0.6501.00
367_L371_A0.6491.00
27_V181_E0.6491.00
241_Q245_S0.6481.00
172_A175_P0.6481.00
200_A204_W0.6481.00
149_Y152_A0.6471.00
290_V293_F0.6461.00
260_V264_T0.6451.00
416_L465_A0.6451.00
266_E307_L0.6451.00
234_S240_A0.6441.00
393_A400_V0.6431.00
130_Q134_R0.6421.00
38_T41_T0.6411.00
58_L61_D0.6401.00
269_S276_G0.6391.00
205_W208_R0.6391.00
119_R122_D0.6381.00
218_D222_D0.6381.00
230_D241_Q0.6381.00
229_P233_S0.6371.00
156_D161_I0.6361.00
304_M308_V0.6351.00
37_A40_G0.6331.00
185_L189_A0.6331.00
331_A359_V0.6331.00
175_P179_R0.6331.00
81_A85_G0.6331.00
260_V263_L0.6331.00
94_H108_S0.6321.00
216_Y226_V0.6311.00
395_V400_V0.6311.00
425_S433_K0.6281.00
117_Y123_V0.6281.00
81_A84_G0.6261.00
145_S148_M0.6261.00
221_T245_S0.6261.00
348_K380_I0.6251.00
328_V362_A0.6231.00
429_A433_K0.6231.00
302_A305_Q0.6221.00
328_V368_L0.6211.00
146_S149_Y0.6201.00
409_S463_V0.6201.00
14_L18_A0.6191.00
139_N142_D0.6191.00
186_W190_I0.6181.00
441_F445_V0.6171.00
96_Y167_G0.6171.00
267_L270_P0.6161.00
312_L316_R0.6151.00
281_L293_F0.6141.00
338_S391_L0.6131.00
232_G236_L0.6131.00
443_S452_E0.6131.00
281_L297_I0.6131.00
91_N94_H0.6121.00
351_T354_V0.6111.00
332_A335_R0.6101.00
97_M105_L0.6091.00
230_D240_A0.6081.00
97_M162_G0.6071.00
328_V365_P0.6051.00
129_G132_G0.6051.00
126_T129_G0.6041.00
38_T42_L0.6041.00
249_K252_G0.6041.00
358_E361_V0.6021.00
323_V449_F0.6021.00
244_E250_L0.5991.00
163_V167_G0.5991.00
399_H470_H0.5981.00
84_G87_N0.5971.00
148_M168_K0.5951.00
304_M312_L0.5951.00
120_W123_V0.5941.00
333_L368_L0.5931.00
255_Y258_Q0.5931.00
125_L128_R0.5921.00
410_G462_G0.5901.00
370_Q373_G0.5881.00
389_I404_V0.5881.00
311_L423_F0.5871.00
162_G166_V0.5851.00
361_V400_V0.5841.00
83_I86_I0.5831.00
280_I284_G0.5831.00
415_A428_R0.5831.00
100_A160_L0.5821.00
344_Q348_K0.5811.00
381_D433_K0.5801.00
141_A144_E0.5801.00
139_N145_S0.5791.00
82_N87_N0.5781.00
384_P387_G0.5771.00
36_R39_E0.5771.00
266_E441_F0.5761.00
343_V346_A0.5751.00
90_R93_Y0.5741.00
375_L446_A0.5741.00
331_A357_T0.5731.00
140_P144_E0.5731.00
284_G293_F0.5731.00
189_A193_G0.5721.00
60_G63_T0.5721.00
105_L162_G0.5701.00
279_E282_R0.5701.00
35_R38_T0.5701.00
27_V31_K0.5681.00
218_D221_T0.5661.00
140_P147_V0.5641.00
332_A365_P0.5631.00
99_D102_G0.5631.00
130_Q133_A0.5621.00
314_Q444_E0.5621.00
333_L369_E0.5611.00
259_Y264_T0.5611.00
208_R211_A0.5601.00
131_Y135_S0.5581.00
120_W124_W0.5581.00
381_D434_S0.5571.00
41_T44_D0.5571.00
213_L216_Y0.5561.00
96_Y111_K0.5551.00
294_T298_L0.5551.00
91_N95_V0.5541.00
148_M151_A0.5541.00
116_D120_W0.5541.00
155_M158_S0.5541.00
155_M162_G0.5531.00
330_V361_V0.5521.00
104_V108_S0.5521.00
428_R432_Q0.5511.00
82_N85_G0.5511.00
417_S421_E0.5501.00
305_Q308_V0.5491.00
272_A275_R0.5491.00
440_A444_E0.5491.00
212_R216_Y0.5471.00
334_F354_V0.5471.00
142_D146_S0.5471.00
348_K383_T0.5471.00
15_V18_A0.5471.00
41_T45_T0.5461.00
412_P416_L0.5461.00
245_S248_V0.5461.00
314_Q318_E0.5451.00
388_C405_L0.5431.00
405_L460_E0.5421.00
148_M173_M0.5421.00
300_Q340_A0.5421.00
300_Q304_M0.5401.00
411_I465_A0.5401.00
216_Y219_S0.5391.00
162_G165_S0.5381.00
98_T151_A0.5371.00
274_I278_A0.5361.00
40_G44_D0.5351.00
149_Y165_S0.5351.00
82_N86_I0.5341.00
11_Y199_G0.5341.00
230_D233_S0.5331.00
228_L244_E0.5331.00
117_Y120_W0.5331.00
59_S62_P0.5311.00
266_E300_Q0.5311.00
292_R339_E0.5301.00
151_A154_I0.5301.00
147_V150_V0.5291.00
202_M206_I0.5291.00
264_T270_P0.5281.00
345_L349_K0.5281.00
302_A306_A0.5281.00
161_I165_S0.5271.00
181_E185_L0.5241.00
261_Y264_T0.5241.00
97_M164_L0.5241.00
51_E55_P0.5241.00
446_A452_E0.5221.00
24_A27_V0.5221.00
126_T130_Q0.5211.00
259_Y312_L0.5201.00
368_L372_L0.5171.00
36_R40_G0.5161.00
264_T268_K0.5141.00
215_R218_D0.5131.00
121_N124_W0.5121.00
177_I180_S0.5121.00
230_D237_R0.5111.00
395_V399_H0.5101.00
390_T393_A0.5101.00
49_L52_L0.5091.00
331_A354_V0.5091.00
384_P407_T0.5071.00
94_H111_K0.5071.00
268_K312_L0.5071.00
381_D427_P0.5061.00
453_V465_A0.5051.00
267_L308_V0.5051.00
299_T302_A0.5051.00
78_P82_N0.5031.00
376_L380_I0.5031.00
112_A116_D0.5011.00
179_R183_R0.5011.00
33_G37_A0.5011.00
268_K304_M0.5001.00
210_I236_L0.5001.00
259_Y423_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.5654 100 0.382 Contact Map
4bixA 2 0.4768 100 0.419 Contact Map
4ctiA 2 0.4768 100 0.435 Contact Map
4gczA 2 0.7384 100 0.461 Contact Map
3a0rA 2 0.692 100 0.464 Contact Map
4q20A 2 0.4789 100 0.485 Contact Map
4mpcA 2 0.616 100 0.487 Contact Map
3d36A 2 0.4641 100 0.491 Contact Map
3jz3A 2 0.3333 100 0.492 Contact Map
2q8gA 2 0.6245 100 0.495 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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