GREMLIN Database
PHOR - Phosphate regulon sensor protein PhoR
UniProt: P08400 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10733
Length: 431 (341)
Sequences: 37796 (31968)
Seq/√Len: 1731.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
226_L246_M3.2931.00
278_V313_G3.2741.00
406_N418_S3.2201.00
198_H201_E2.9941.00
355_E416_R2.9841.00
395_K399_N2.7361.00
366_I407_I2.6701.00
356_D360_G2.6561.00
410_T413_K2.5991.00
362_A365_H2.5791.00
333_T357_N2.5511.00
109_D192_R2.5351.00
351_E420_V2.5071.00
230_N247_R2.4951.00
353_S416_R2.4461.00
346_V351_E2.4411.00
313_G401_H2.4261.00
351_E418_S2.3821.00
277_K312_S2.3561.00
304_E342_R2.3551.00
230_N244_H2.3531.00
342_R353_S2.3421.00
353_S418_S2.3281.00
344_Q351_E2.2661.00
276_E315_E2.2611.00
394_V405_L2.2491.00
302_T340_T2.2451.00
223_Q250_T2.2421.00
112_V189_M2.2311.00
286_V319_R2.1561.00
340_T355_E2.1531.00
302_T338_H2.0521.00
321_A398_V2.0331.00
342_R355_E2.0191.00
126_L129_Q2.0141.00
304_E340_T2.0111.00
407_I417_F2.0061.00
236_G239_R1.9841.00
279_D282_M1.9831.00
361_I365_H1.9791.00
344_Q353_S1.9321.00
86_N90_R1.9161.00
398_V419_F1.8871.00
408_E416_R1.8731.00
366_I409_S1.8451.00
363_P366_I1.8411.00
321_A394_V1.8311.00
361_I369_L1.8291.00
300_T338_H1.8261.00
223_Q251_Q1.8241.00
398_V403_S1.8201.00
370_T405_L1.7921.00
110_A191_A1.7871.00
345_R423_E1.7871.00
104_A122_W1.7821.00
110_A130_I1.7451.00
404_R420_V1.7411.00
115_T119_G1.7301.00
352_F419_F1.7041.00
291_A323_S1.7031.00
409_S415_T1.6821.00
225_Y242_A1.6791.00
349_G420_V1.6791.00
97_I101_R1.6551.00
408_E418_S1.6541.00
365_H368_R1.6341.00
368_R374_Y1.6251.00
86_N89_R1.6061.00
313_G318_L1.5891.00
399_N404_R1.5891.00
281_P343_W1.5881.00
321_A397_A1.5681.00
397_A401_H1.5681.00
230_N240_E1.5561.00
322_I352_F1.5401.00
362_A411_V1.5381.00
133_L170_N1.5141.00
125_G129_Q1.5071.00
198_H202_G1.4991.00
275_N312_S1.4911.00
101_R105_E1.4711.00
254_E258_K1.4411.00
229_M243_L1.4381.00
222_L250_T1.4361.00
227_E247_R1.4321.00
409_S413_K1.4291.00
314_N317_Q1.4241.00
226_L247_R1.4131.00
338_H357_N1.4121.00
96_L99_R1.4001.00
406_N420_V1.3931.00
176_E197_M1.3861.00
176_E192_R1.3741.00
154_Q158_T1.3741.00
112_V120_I1.3701.00
371_E374_Y1.3621.00
105_E125_G1.3561.00
305_I343_W1.3551.00
169_L173_R1.3521.00
225_Y245_T1.3461.00
317_Q320_S1.3411.00
229_M239_R1.3401.00
197_M201_E1.3391.00
141_Q145_N1.3301.00
346_V420_V1.3281.00
128_Q135_W1.3201.00
194_V197_M1.3091.00
332_H375_R1.3081.00
292_Q295_S1.2961.00
368_R371_E1.2941.00
107_L111_V1.2901.00
82_M86_N1.2831.00
247_R251_Q1.2791.00
162_S176_E1.2681.00
148_R151_E1.2611.00
286_V315_E1.2571.00
164_P198_H1.2481.00
123_C127_A1.2271.00
337_T357_N1.2221.00
189_M193_D1.2221.00
112_V127_A1.2191.00
232_Q239_R1.2161.00
294_L330_V1.2071.00
177_I191_A1.2061.00
350_A423_E1.2021.00
90_R94_G1.1891.00
226_L250_T1.1841.00
321_A419_F1.1801.00
193_D197_M1.1701.00
153_T157_K1.1641.00
333_T339_I1.1631.00
87_K90_R1.1621.00
196_Q199_Q1.1611.00
317_Q400_H1.1511.00
134_R137_E1.1511.00
409_S412_G1.1471.00
365_H374_Y1.1431.00
375_R384_T1.1411.00
222_L246_M1.1341.00
291_A326_V1.1331.00
221_V249_Q1.1281.00
244_H248_E1.1261.00
310_K345_R1.1201.00
369_L407_I1.1091.00
333_T337_T1.1061.00
100_F104_A1.1021.00
359_P384_T1.1021.00
83_Q86_N1.1011.00
288_E303_F1.0931.00
114_T189_M1.0921.00
275_N401_H1.0921.00
123_C128_Q1.0901.00
365_H376_V1.0861.00
361_I407_I1.0841.00
127_A131_L1.0821.00
278_V283_M1.0811.00
281_P305_I1.0611.00
241_K245_T1.0611.00
165_L177_I1.0601.00
240_E244_H1.0551.00
281_P285_R1.0531.00
255_G316_D1.0491.00
245_T249_Q1.0481.00
370_T407_I1.0441.00
166_N174_H1.0371.00
199_Q202_G1.0271.00
356_D414_G1.0271.00
226_L243_L1.0211.00
327_Y331_N1.0151.00
361_I415_T1.0131.00
128_Q134_R1.0111.00
340_T357_N1.0081.00
99_R113_L1.0061.00
226_L230_N1.0011.00
285_R303_F0.9931.00
290_E323_S0.9901.00
113_L188_L0.9891.00
221_V225_Y0.9871.00
275_N313_G0.9801.00
315_E319_R0.9791.00
98_K102_S0.9691.00
320_S397_A0.9681.00
223_Q254_E0.9671.00
223_Q247_R0.9671.00
142_N145_N0.9601.00
317_Q397_A0.9581.00
398_V405_L0.9571.00
119_G142_N0.9411.00
89_R93_L0.9401.00
94_G98_K0.9401.00
125_G128_Q0.9361.00
361_I366_I0.9311.00
113_L122_W0.9271.00
361_I367_P0.9211.00
233_P239_R0.9181.00
319_R323_S0.9161.00
287_V319_R0.9121.00
306_D344_Q0.9121.00
216_R254_E0.9111.00
372_R396_H0.9091.00
283_M287_V0.9071.00
94_G97_I0.9051.00
211_V260_L0.9041.00
322_I326_V0.9021.00
288_E292_Q0.8971.00
398_V421_I0.8911.00
188_L193_D0.8901.00
331_N377_D0.8871.00
284_L343_W0.8861.00
248_E286_V0.8801.00
249_Q252_R0.8761.00
234_L239_R0.8751.00
113_L121_F0.8751.00
241_K244_H0.8681.00
287_V291_A0.8661.00
299_Q330_V0.8661.00
326_V339_I0.8661.00
204_R208_F0.8641.00
351_E406_N0.8631.00
91_R95_N0.8621.00
88_K92_E0.8611.00
131_L167_L0.8561.00
151_E166_N0.8551.00
263_L392_A0.8551.00
369_L417_F0.8551.00
403_S421_I0.8541.00
89_R92_E0.8541.00
280_V352_F0.8521.00
215_L253_M0.8511.00
250_T254_E0.8451.00
235_E239_R0.8441.00
123_C138_D0.8441.00
318_L401_H0.8401.00
237_A240_E0.8391.00
306_D343_W0.8381.00
162_S178_R0.8361.00
115_T121_F0.8321.00
114_T120_I0.8211.00
329_A339_I0.8201.00
194_V198_H0.8191.00
363_P410_T0.8191.00
312_S424_R0.8141.00
90_R93_L0.8111.00
282_M286_V0.8081.00
224_G228_M0.8081.00
215_L218_P0.8071.00
114_T143_I0.8001.00
287_V323_S0.7981.00
225_Y246_M0.7971.00
245_T248_E0.7961.00
322_I354_V0.7961.00
187_L190_V0.7951.00
233_P236_G0.7941.00
349_G404_R0.7931.00
190_V193_D0.7921.00
93_L96_L0.7891.00
214_E217_T0.7871.00
325_L405_L0.7871.00
288_E301_F0.7851.00
173_R193_D0.7841.00
282_M315_E0.7811.00
325_L394_V0.7801.00
174_H195_T0.7791.00
259_Q317_Q0.7781.00
93_L97_I0.7771.00
290_E319_R0.7771.00
284_L341_V0.7731.00
325_L417_F0.7731.00
95_N99_R0.7721.00
333_T336_G0.7721.00
394_V398_V0.7711.00
289_R292_Q0.7711.00
370_T417_F0.7691.00
252_R319_R0.7671.00
133_L137_E0.7661.00
110_A127_A0.7571.00
406_N419_F0.7571.00
107_L190_V0.7571.00
356_D415_T0.7561.00
396_H399_N0.7531.00
325_L419_F0.7511.00
213_H324_N0.7511.00
179_V187_L0.7501.00
306_D309_L0.7471.00
236_G240_E0.7451.00
283_M313_G0.7411.00
92_E96_L0.7411.00
112_V191_A0.7391.00
297_K330_V0.7381.00
258_K262_T0.7381.00
217_T221_V0.7361.00
114_T179_V0.7351.00
210_N372_R0.7341.00
285_R289_R0.7321.00
324_N394_V0.7311.00
83_Q87_K0.7291.00
102_S106_S0.7271.00
255_G259_Q0.7261.00
97_I100_F0.7261.00
228_M242_A0.7251.00
87_K91_R0.7241.00
91_R94_G0.7221.00
361_I391_L0.7211.00
346_V349_G0.7211.00
122_W135_W0.7211.00
217_T224_G0.7201.00
219_L257_V0.7201.00
317_Q401_H0.7191.00
191_A195_T0.7181.00
360_G415_T0.7171.00
99_R122_W0.7171.00
216_R261_L0.7171.00
180_M188_L0.7161.00
331_N375_R0.7151.00
225_Y249_Q0.7141.00
111_V124_N0.7111.00
206_N372_R0.7101.00
125_G135_W0.7101.00
366_I370_T0.7081.00
294_L299_Q0.7041.00
84_L87_K0.7021.00
273_L400_H0.7011.00
214_E320_S0.6991.00
110_A126_L0.6991.00
291_A330_V0.6981.00
275_N424_R0.6961.00
206_N210_N0.6961.00
284_L303_F0.6961.00
279_D310_K0.6951.00
174_H198_H0.6951.00
223_Q227_E0.6931.00
84_L88_K0.6921.00
100_F103_G0.6891.00
82_M87_K0.6871.00
216_R258_K0.6841.00
148_R166_N0.6801.00
273_L401_H0.6801.00
232_Q236_G0.6791.00
326_V341_V0.6781.00
246_M250_T0.6771.00
179_V189_M0.6761.00
164_P176_E0.6741.00
280_V350_A0.6741.00
251_Q255_G0.6721.00
221_V224_G0.6721.00
361_I409_S0.6711.00
109_D126_L0.6701.00
104_A111_V0.6691.00
169_L172_G0.6681.00
85_R89_R0.6651.00
287_V326_V0.6641.00
273_L314_N0.6641.00
407_I415_T0.6621.00
137_E170_N0.6621.00
85_R88_K0.6611.00
278_V315_E0.6611.00
291_A327_Y0.6591.00
262_T317_Q0.6591.00
304_E344_Q0.6581.00
214_E218_P0.6571.00
114_T152_F0.6561.00
104_A124_N0.6551.00
229_M246_M0.6541.00
201_E205_R0.6531.00
396_H400_H0.6531.00
147_L151_E0.6521.00
189_M195_T0.6491.00
363_P367_P0.6491.00
375_R385_G0.6491.00
221_V245_T0.6491.00
310_K423_E0.6481.00
128_Q138_D0.6481.00
273_L317_Q0.6481.00
96_L100_F0.6471.00
334_P337_T0.6471.00
403_S422_P0.6451.00
294_L301_F0.6451.00
337_T340_T0.6391.00
114_T187_L0.6371.00
299_Q357_N0.6371.00
285_R305_I0.6361.00
403_S419_F0.6351.00
328_N390_G0.6341.00
214_E256_L0.6341.00
251_Q254_E0.6331.00
238_V242_A0.6311.00
283_M318_L0.6301.00
284_L322_I0.6291.00
271_T317_Q0.6271.00
229_M242_A0.6251.00
294_L339_I0.6251.00
379_A384_T0.6251.00
183_T186_Q0.6231.00
220_T224_G0.6221.00
92_E95_N0.6201.00
187_L193_D0.6191.00
332_H359_P0.6181.00
131_L191_A0.6181.00
389_L393_I0.6151.00
155_Y158_T0.6141.00
285_R288_E0.6121.00
362_A376_V0.6121.00
341_V354_V0.6111.00
366_I408_E0.6101.00
391_L417_F0.6091.00
133_L138_D0.6091.00
244_H247_R0.6081.00
309_L343_W0.6071.00
232_Q235_E0.6071.00
178_R192_R0.6011.00
241_K289_R0.6011.00
324_N327_Y0.6001.00
369_L392_A0.6001.00
372_R392_A0.5981.00
275_N402_E0.5981.00
109_D190_V0.5981.00
379_A385_G0.5971.00
321_A401_H0.5971.00
114_T118_G0.5971.00
299_Q303_F0.5951.00
375_R386_G0.5951.00
298_K335_E0.5941.00
242_A246_M0.5911.00
214_E253_M0.5911.00
175_L191_A0.5911.00
135_W139_N0.5901.00
331_N385_G0.5881.00
214_E324_N0.5871.00
205_R267_E0.5841.00
278_V312_S0.5841.00
167_L173_R0.5811.00
230_N243_L0.5801.00
293_T296_Q0.5791.00
213_H217_T0.5791.00
316_D319_R0.5771.00
110_A124_N0.5741.00
360_G414_G0.5741.00
152_F156_L0.5731.00
242_A245_T0.5701.00
207_F211_V0.5691.00
83_Q90_R0.5681.00
353_S408_E0.5661.00
80_H84_L0.5651.00
195_T199_Q0.5651.00
103_G106_S0.5651.00
265_K387_S0.5641.00
325_L354_V0.5641.00
111_V188_L0.5641.00
227_E230_N0.5641.00
119_G140_G0.5631.00
124_N127_A0.5621.00
187_L191_A0.5591.00
279_D308_G0.5591.00
147_L165_L0.5591.00
366_I417_F0.5581.00
300_T303_F0.5571.00
359_P415_T0.5571.00
123_C131_L0.5551.00
103_G188_L0.5551.00
227_E231_E0.5541.00
214_E393_I0.5511.00
405_L417_F0.5501.00
243_L247_R0.5481.00
165_L168_V0.5481.00
288_E326_V0.5431.00
130_I175_L0.5411.00
133_L169_L0.5411.00
112_V177_I0.5411.00
348_H423_E0.5401.00
267_E372_R0.5391.00
306_D310_K0.5341.00
201_E204_R0.5341.00
299_Q339_I0.5331.00
203_A206_N0.5321.00
104_A107_L0.5311.00
228_M232_Q0.5311.00
118_G143_I0.5301.00
202_G206_N0.5291.00
261_L265_K0.5291.00
103_G107_L0.5281.00
80_H83_Q0.5281.00
232_Q242_A0.5281.00
398_V404_R0.5281.00
306_D345_R0.5261.00
80_H86_N0.5251.00
337_T355_E0.5251.00
332_H377_D0.5241.00
111_V122_W0.5231.00
419_F422_P0.5211.00
343_W352_F0.5161.00
305_I309_L0.5161.00
218_P253_M0.5151.00
188_L195_T0.5151.00
181_P187_L0.5131.00
153_T156_L0.5111.00
329_A354_V0.5101.00
167_L191_A0.5101.00
359_P409_S0.5081.00
214_E249_Q0.5081.00
253_M256_L0.5071.00
98_K101_R0.5061.00
82_M90_R0.5061.00
299_Q333_T0.5061.00
378_K385_G0.5051.00
297_K333_T0.5041.00
245_T289_R0.5041.00
255_G258_K0.5021.00
298_K336_G0.5011.00
274_L314_N0.5011.00
100_F122_W0.5011.00
217_T261_L0.5001.00
110_A177_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.8817 100 0.246 Contact Map
3a0rA 2 0.7262 100 0.333 Contact Map
4gczA 2 0.7796 100 0.343 Contact Map
4q20A 2 0.5313 100 0.465 Contact Map
4r3aA 1 0.6891 100 0.467 Contact Map
3jz3A 2 0.3712 100 0.469 Contact Map
3d36A 2 0.5104 100 0.477 Contact Map
4mpcA 2 0.7053 100 0.477 Contact Map
2c2aA 2 0.5383 100 0.477 Contact Map
4e01A 3 0.652 100 0.484 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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