PHOR - ECOLI - GREMLIN Contacts

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PHOR - Phosphate regulon sensor protein PhoR

UniProt:	P08400	Sequences: MLERLSWKRLVLELLLCCLPAFILGAFFGYLPWFLLASVTGLLIWHFWNLLRLSWWLWVDRSMTPPPGRGSWEPLLYGLHQMQLRNKKRRRELGNLIKRFRSGAESLPDAVVLTTEEGGIFWCNGLAQQILGLRWPEDNGQNILNLLRYPEFTQYLKTRDFSRPLNLVLNTGRHLEIRVMPYTHKQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMNEQPLEGAVREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTHLLNEKVDVPMMLRVVEREAQTLSQKKQTFTFEIDNGLKVSGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPHGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVNHHESRLNIESTVGKGTRFSFVIPERLIAKNSD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10733
Length:	431 (341)
Sequences:	37796 (31968)
Seq/√Len:	1731.2

ECOLI - PHOR ARCB RCSC RCSD ATOS EVGS BARA TORS DPIB ZRAS DCUS NTRB NARX NARQ BAES GLRK KDPD CREC CUSS PHOQ CPXA RSTB ENVZ QSEC YEDV BASS YPDA
BACSU - YYCG RESE PHOR KINE KINA KINC MALK CITS DCTS KIND YCLK YVRG YKOH DEGS CSSS KINB YVCQ GLNK LYTS YCBM BCES YHCY YXDK COMP YRKQ LIAS
HALSA - Q9HQ16 O51970 Q9HRE4 Q9HR10 Q9HQG5 Q9HRG1 Q9HNA6 Q9HQB9 Q9HNM2 BAT Q9HQE9 Q9HQ15

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
226_L	246_M	3.293	1.00
278_V	313_G	3.274	1.00
406_N	418_S	3.220	1.00
198_H	201_E	2.994	1.00
355_E	416_R	2.984	1.00
395_K	399_N	2.736	1.00
366_I	407_I	2.670	1.00
356_D	360_G	2.656	1.00
410_T	413_K	2.599	1.00
362_A	365_H	2.579	1.00
333_T	357_N	2.551	1.00
109_D	192_R	2.535	1.00
351_E	420_V	2.507	1.00
230_N	247_R	2.495	1.00
353_S	416_R	2.446	1.00
346_V	351_E	2.441	1.00
313_G	401_H	2.426	1.00
351_E	418_S	2.382	1.00
277_K	312_S	2.356	1.00
304_E	342_R	2.355	1.00
230_N	244_H	2.353	1.00
342_R	353_S	2.342	1.00
353_S	418_S	2.328	1.00
344_Q	351_E	2.266	1.00
276_E	315_E	2.261	1.00
394_V	405_L	2.249	1.00
302_T	340_T	2.245	1.00
223_Q	250_T	2.242	1.00
112_V	189_M	2.231	1.00
286_V	319_R	2.156	1.00
340_T	355_E	2.153	1.00
302_T	338_H	2.052	1.00
321_A	398_V	2.033	1.00
342_R	355_E	2.019	1.00
126_L	129_Q	2.014	1.00
304_E	340_T	2.011	1.00
407_I	417_F	2.006	1.00
236_G	239_R	1.984	1.00
279_D	282_M	1.983	1.00
361_I	365_H	1.979	1.00
344_Q	353_S	1.932	1.00
86_N	90_R	1.916	1.00
398_V	419_F	1.887	1.00
408_E	416_R	1.873	1.00
366_I	409_S	1.845	1.00
363_P	366_I	1.841	1.00
321_A	394_V	1.831	1.00
361_I	369_L	1.829	1.00
300_T	338_H	1.826	1.00
223_Q	251_Q	1.824	1.00
398_V	403_S	1.820	1.00
370_T	405_L	1.792	1.00
110_A	191_A	1.787	1.00
345_R	423_E	1.787	1.00
104_A	122_W	1.782	1.00
110_A	130_I	1.745	1.00
404_R	420_V	1.741	1.00
115_T	119_G	1.730	1.00
352_F	419_F	1.704	1.00
291_A	323_S	1.703	1.00
409_S	415_T	1.682	1.00
225_Y	242_A	1.679	1.00
349_G	420_V	1.679	1.00
97_I	101_R	1.655	1.00
408_E	418_S	1.654	1.00
365_H	368_R	1.634	1.00
368_R	374_Y	1.625	1.00
86_N	89_R	1.606	1.00
313_G	318_L	1.589	1.00
399_N	404_R	1.589	1.00
281_P	343_W	1.588	1.00
321_A	397_A	1.568	1.00
397_A	401_H	1.568	1.00
230_N	240_E	1.556	1.00
322_I	352_F	1.540	1.00
362_A	411_V	1.538	1.00
133_L	170_N	1.514	1.00
125_G	129_Q	1.507	1.00
198_H	202_G	1.499	1.00
275_N	312_S	1.491	1.00
101_R	105_E	1.471	1.00
254_E	258_K	1.441	1.00
229_M	243_L	1.438	1.00
222_L	250_T	1.436	1.00
227_E	247_R	1.432	1.00
409_S	413_K	1.429	1.00
314_N	317_Q	1.424	1.00
226_L	247_R	1.413	1.00
338_H	357_N	1.412	1.00
96_L	99_R	1.400	1.00
406_N	420_V	1.393	1.00
176_E	197_M	1.386	1.00
176_E	192_R	1.374	1.00
154_Q	158_T	1.374	1.00
112_V	120_I	1.370	1.00
371_E	374_Y	1.362	1.00
105_E	125_G	1.356	1.00
305_I	343_W	1.355	1.00
169_L	173_R	1.352	1.00
225_Y	245_T	1.346	1.00
317_Q	320_S	1.341	1.00
229_M	239_R	1.340	1.00
197_M	201_E	1.339	1.00
141_Q	145_N	1.330	1.00
346_V	420_V	1.328	1.00
128_Q	135_W	1.320	1.00
194_V	197_M	1.309	1.00
332_H	375_R	1.308	1.00
292_Q	295_S	1.296	1.00
368_R	371_E	1.294	1.00
107_L	111_V	1.290	1.00
82_M	86_N	1.283	1.00
247_R	251_Q	1.279	1.00
162_S	176_E	1.268	1.00
148_R	151_E	1.261	1.00
286_V	315_E	1.257	1.00
164_P	198_H	1.248	1.00
123_C	127_A	1.227	1.00
337_T	357_N	1.222	1.00
189_M	193_D	1.222	1.00
112_V	127_A	1.219	1.00
232_Q	239_R	1.216	1.00
294_L	330_V	1.207	1.00
177_I	191_A	1.206	1.00
350_A	423_E	1.202	1.00
90_R	94_G	1.189	1.00
226_L	250_T	1.184	1.00
321_A	419_F	1.180	1.00
193_D	197_M	1.170	1.00
153_T	157_K	1.164	1.00
333_T	339_I	1.163	1.00
87_K	90_R	1.162	1.00
196_Q	199_Q	1.161	1.00
317_Q	400_H	1.151	1.00
134_R	137_E	1.151	1.00
409_S	412_G	1.147	1.00
365_H	374_Y	1.143	1.00
375_R	384_T	1.141	1.00
222_L	246_M	1.134	1.00
291_A	326_V	1.133	1.00
221_V	249_Q	1.128	1.00
244_H	248_E	1.126	1.00
310_K	345_R	1.120	1.00
369_L	407_I	1.109	1.00
333_T	337_T	1.106	1.00
100_F	104_A	1.102	1.00
359_P	384_T	1.102	1.00
83_Q	86_N	1.101	1.00
288_E	303_F	1.093	1.00
114_T	189_M	1.092	1.00
275_N	401_H	1.092	1.00
123_C	128_Q	1.090	1.00
365_H	376_V	1.086	1.00
361_I	407_I	1.084	1.00
127_A	131_L	1.082	1.00
278_V	283_M	1.081	1.00
281_P	305_I	1.061	1.00
241_K	245_T	1.061	1.00
165_L	177_I	1.060	1.00
240_E	244_H	1.055	1.00
281_P	285_R	1.053	1.00
255_G	316_D	1.049	1.00
245_T	249_Q	1.048	1.00
370_T	407_I	1.044	1.00
166_N	174_H	1.037	1.00
199_Q	202_G	1.027	1.00
356_D	414_G	1.027	1.00
226_L	243_L	1.021	1.00
327_Y	331_N	1.015	1.00
361_I	415_T	1.013	1.00
128_Q	134_R	1.011	1.00
340_T	357_N	1.008	1.00
99_R	113_L	1.006	1.00
226_L	230_N	1.001	1.00
285_R	303_F	0.993	1.00
290_E	323_S	0.990	1.00
113_L	188_L	0.989	1.00
221_V	225_Y	0.987	1.00
275_N	313_G	0.980	1.00
315_E	319_R	0.979	1.00
98_K	102_S	0.969	1.00
320_S	397_A	0.968	1.00
223_Q	254_E	0.967	1.00
223_Q	247_R	0.967	1.00
142_N	145_N	0.960	1.00
317_Q	397_A	0.958	1.00
398_V	405_L	0.957	1.00
119_G	142_N	0.941	1.00
89_R	93_L	0.940	1.00
94_G	98_K	0.940	1.00
125_G	128_Q	0.936	1.00
361_I	366_I	0.931	1.00
113_L	122_W	0.927	1.00
361_I	367_P	0.921	1.00
233_P	239_R	0.918	1.00
319_R	323_S	0.916	1.00
287_V	319_R	0.912	1.00
306_D	344_Q	0.912	1.00
216_R	254_E	0.911	1.00
372_R	396_H	0.909	1.00
283_M	287_V	0.907	1.00
94_G	97_I	0.905	1.00
211_V	260_L	0.904	1.00
322_I	326_V	0.902	1.00
288_E	292_Q	0.897	1.00
398_V	421_I	0.891	1.00
188_L	193_D	0.890	1.00
331_N	377_D	0.887	1.00
284_L	343_W	0.886	1.00
248_E	286_V	0.880	1.00
249_Q	252_R	0.876	1.00
234_L	239_R	0.875	1.00
113_L	121_F	0.875	1.00
241_K	244_H	0.868	1.00
287_V	291_A	0.866	1.00
299_Q	330_V	0.866	1.00
326_V	339_I	0.866	1.00
204_R	208_F	0.864	1.00
351_E	406_N	0.863	1.00
91_R	95_N	0.862	1.00
88_K	92_E	0.861	1.00
131_L	167_L	0.856	1.00
151_E	166_N	0.855	1.00
263_L	392_A	0.855	1.00
369_L	417_F	0.855	1.00
403_S	421_I	0.854	1.00
89_R	92_E	0.854	1.00
280_V	352_F	0.852	1.00
215_L	253_M	0.851	1.00
250_T	254_E	0.845	1.00
235_E	239_R	0.844	1.00
123_C	138_D	0.844	1.00
318_L	401_H	0.840	1.00
237_A	240_E	0.839	1.00
306_D	343_W	0.838	1.00
162_S	178_R	0.836	1.00
115_T	121_F	0.832	1.00
114_T	120_I	0.821	1.00
329_A	339_I	0.820	1.00
194_V	198_H	0.819	1.00
363_P	410_T	0.819	1.00
312_S	424_R	0.814	1.00
90_R	93_L	0.811	1.00
282_M	286_V	0.808	1.00
224_G	228_M	0.808	1.00
215_L	218_P	0.807	1.00
114_T	143_I	0.800	1.00
287_V	323_S	0.798	1.00
225_Y	246_M	0.797	1.00
245_T	248_E	0.796	1.00
322_I	354_V	0.796	1.00
187_L	190_V	0.795	1.00
233_P	236_G	0.794	1.00
349_G	404_R	0.793	1.00
190_V	193_D	0.792	1.00
93_L	96_L	0.789	1.00
214_E	217_T	0.787	1.00
325_L	405_L	0.787	1.00
288_E	301_F	0.785	1.00
173_R	193_D	0.784	1.00
282_M	315_E	0.781	1.00
325_L	394_V	0.780	1.00
174_H	195_T	0.779	1.00
259_Q	317_Q	0.778	1.00
93_L	97_I	0.777	1.00
290_E	319_R	0.777	1.00
284_L	341_V	0.773	1.00
325_L	417_F	0.773	1.00
95_N	99_R	0.772	1.00
333_T	336_G	0.772	1.00
394_V	398_V	0.771	1.00
289_R	292_Q	0.771	1.00
370_T	417_F	0.769	1.00
252_R	319_R	0.767	1.00
133_L	137_E	0.766	1.00
110_A	127_A	0.757	1.00
406_N	419_F	0.757	1.00
107_L	190_V	0.757	1.00
356_D	415_T	0.756	1.00
396_H	399_N	0.753	1.00
325_L	419_F	0.751	1.00
213_H	324_N	0.751	1.00
179_V	187_L	0.750	1.00
306_D	309_L	0.747	1.00
236_G	240_E	0.745	1.00
283_M	313_G	0.741	1.00
92_E	96_L	0.741	1.00
112_V	191_A	0.739	1.00
297_K	330_V	0.738	1.00
258_K	262_T	0.738	1.00
217_T	221_V	0.736	1.00
114_T	179_V	0.735	1.00
210_N	372_R	0.734	1.00
285_R	289_R	0.732	1.00
324_N	394_V	0.731	1.00
83_Q	87_K	0.729	1.00
102_S	106_S	0.727	1.00
255_G	259_Q	0.726	1.00
97_I	100_F	0.726	1.00
228_M	242_A	0.725	1.00
87_K	91_R	0.724	1.00
91_R	94_G	0.722	1.00
361_I	391_L	0.721	1.00
346_V	349_G	0.721	1.00
122_W	135_W	0.721	1.00
217_T	224_G	0.720	1.00
219_L	257_V	0.720	1.00
317_Q	401_H	0.719	1.00
191_A	195_T	0.718	1.00
360_G	415_T	0.717	1.00
99_R	122_W	0.717	1.00
216_R	261_L	0.717	1.00
180_M	188_L	0.716	1.00
331_N	375_R	0.715	1.00
225_Y	249_Q	0.714	1.00
111_V	124_N	0.711	1.00
206_N	372_R	0.710	1.00
125_G	135_W	0.710	1.00
366_I	370_T	0.708	1.00
294_L	299_Q	0.704	1.00
84_L	87_K	0.702	1.00
273_L	400_H	0.701	1.00
214_E	320_S	0.699	1.00
110_A	126_L	0.699	1.00
291_A	330_V	0.698	1.00
275_N	424_R	0.696	1.00
206_N	210_N	0.696	1.00
284_L	303_F	0.696	1.00
279_D	310_K	0.695	1.00
174_H	198_H	0.695	1.00
223_Q	227_E	0.693	1.00
84_L	88_K	0.692	1.00
100_F	103_G	0.689	1.00
82_M	87_K	0.687	1.00
216_R	258_K	0.684	1.00
148_R	166_N	0.680	1.00
273_L	401_H	0.680	1.00
232_Q	236_G	0.679	1.00
326_V	341_V	0.678	1.00
246_M	250_T	0.677	1.00
179_V	189_M	0.676	1.00
164_P	176_E	0.674	1.00
280_V	350_A	0.674	1.00
251_Q	255_G	0.672	1.00
221_V	224_G	0.672	1.00
361_I	409_S	0.671	1.00
109_D	126_L	0.670	1.00
104_A	111_V	0.669	1.00
169_L	172_G	0.668	1.00
85_R	89_R	0.665	1.00
287_V	326_V	0.664	1.00
273_L	314_N	0.664	1.00
407_I	415_T	0.662	1.00
137_E	170_N	0.662	1.00
85_R	88_K	0.661	1.00
278_V	315_E	0.661	1.00
291_A	327_Y	0.659	1.00
262_T	317_Q	0.659	1.00
304_E	344_Q	0.658	1.00
214_E	218_P	0.657	1.00
114_T	152_F	0.656	1.00
104_A	124_N	0.655	1.00
229_M	246_M	0.654	1.00
201_E	205_R	0.653	1.00
396_H	400_H	0.653	1.00
147_L	151_E	0.652	1.00
189_M	195_T	0.649	1.00
363_P	367_P	0.649	1.00
375_R	385_G	0.649	1.00
221_V	245_T	0.649	1.00
310_K	423_E	0.648	1.00
128_Q	138_D	0.648	1.00
273_L	317_Q	0.648	1.00
96_L	100_F	0.647	1.00
334_P	337_T	0.647	1.00
403_S	422_P	0.645	1.00
294_L	301_F	0.645	1.00
337_T	340_T	0.639	1.00
114_T	187_L	0.637	1.00
299_Q	357_N	0.637	1.00
285_R	305_I	0.636	1.00
403_S	419_F	0.635	1.00
328_N	390_G	0.634	1.00
214_E	256_L	0.634	1.00
251_Q	254_E	0.633	1.00
238_V	242_A	0.631	1.00
283_M	318_L	0.630	1.00
284_L	322_I	0.629	1.00
271_T	317_Q	0.627	1.00
229_M	242_A	0.625	1.00
294_L	339_I	0.625	1.00
379_A	384_T	0.625	1.00
183_T	186_Q	0.623	1.00
220_T	224_G	0.622	1.00
92_E	95_N	0.620	1.00
187_L	193_D	0.619	1.00
332_H	359_P	0.618	1.00
131_L	191_A	0.618	1.00
389_L	393_I	0.615	1.00
155_Y	158_T	0.614	1.00
285_R	288_E	0.612	1.00
362_A	376_V	0.612	1.00
341_V	354_V	0.611	1.00
366_I	408_E	0.610	1.00
391_L	417_F	0.609	1.00
133_L	138_D	0.609	1.00
244_H	247_R	0.608	1.00
309_L	343_W	0.607	1.00
232_Q	235_E	0.607	1.00
178_R	192_R	0.601	1.00
241_K	289_R	0.601	1.00
324_N	327_Y	0.600	1.00
369_L	392_A	0.600	1.00
372_R	392_A	0.598	1.00
275_N	402_E	0.598	1.00
109_D	190_V	0.598	1.00
379_A	385_G	0.597	1.00
321_A	401_H	0.597	1.00
114_T	118_G	0.597	1.00
299_Q	303_F	0.595	1.00
375_R	386_G	0.595	1.00
298_K	335_E	0.594	1.00
242_A	246_M	0.591	1.00
214_E	253_M	0.591	1.00
175_L	191_A	0.591	1.00
135_W	139_N	0.590	1.00
331_N	385_G	0.588	1.00
214_E	324_N	0.587	1.00
205_R	267_E	0.584	1.00
278_V	312_S	0.584	1.00
167_L	173_R	0.581	1.00
230_N	243_L	0.580	1.00
293_T	296_Q	0.579	1.00
213_H	217_T	0.579	1.00
316_D	319_R	0.577	1.00
110_A	124_N	0.574	1.00
360_G	414_G	0.574	1.00
152_F	156_L	0.573	1.00
242_A	245_T	0.570	1.00
207_F	211_V	0.569	1.00
83_Q	90_R	0.568	1.00
353_S	408_E	0.566	1.00
80_H	84_L	0.565	1.00
195_T	199_Q	0.565	1.00
103_G	106_S	0.565	1.00
265_K	387_S	0.564	1.00
325_L	354_V	0.564	1.00
111_V	188_L	0.564	1.00
227_E	230_N	0.564	1.00
119_G	140_G	0.563	1.00
124_N	127_A	0.562	1.00
187_L	191_A	0.559	1.00
279_D	308_G	0.559	1.00
147_L	165_L	0.559	1.00
366_I	417_F	0.558	1.00
300_T	303_F	0.557	1.00
359_P	415_T	0.557	1.00
123_C	131_L	0.555	1.00
103_G	188_L	0.555	1.00
227_E	231_E	0.554	1.00
214_E	393_I	0.551	1.00
405_L	417_F	0.550	1.00
243_L	247_R	0.548	1.00
165_L	168_V	0.548	1.00
288_E	326_V	0.543	1.00
130_I	175_L	0.541	1.00
133_L	169_L	0.541	1.00
112_V	177_I	0.541	1.00
348_H	423_E	0.540	1.00
267_E	372_R	0.539	1.00
306_D	310_K	0.534	1.00
201_E	204_R	0.534	1.00
299_Q	339_I	0.533	1.00
203_A	206_N	0.532	1.00
104_A	107_L	0.531	1.00
228_M	232_Q	0.531	1.00
118_G	143_I	0.530	1.00
202_G	206_N	0.529	1.00
261_L	265_K	0.529	1.00
103_G	107_L	0.528	1.00
80_H	83_Q	0.528	1.00
232_Q	242_A	0.528	1.00
398_V	404_R	0.528	1.00
306_D	345_R	0.526	1.00
80_H	86_N	0.525	1.00
337_T	355_E	0.525	1.00
332_H	377_D	0.524	1.00
111_V	122_W	0.523	1.00
419_F	422_P	0.521	1.00
343_W	352_F	0.516	1.00
305_I	309_L	0.516	1.00
218_P	253_M	0.515	1.00
188_L	195_T	0.515	1.00
181_P	187_L	0.513	1.00
153_T	156_L	0.511	1.00
329_A	354_V	0.510	1.00
167_L	191_A	0.510	1.00
359_P	409_S	0.508	1.00
214_E	249_Q	0.508	1.00
253_M	256_L	0.507	1.00
98_K	101_R	0.506	1.00
82_M	90_R	0.506	1.00
299_Q	333_T	0.506	1.00
378_K	385_G	0.505	1.00
297_K	333_T	0.504	1.00
245_T	289_R	0.504	1.00
255_G	258_K	0.502	1.00
298_K	336_G	0.501	1.00
274_L	314_N	0.501	1.00
100_F	122_W	0.501	1.00
217_T	261_L	0.500	1.00
110_A	177_I	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i5sA	2	0.8817	100	0.246	Contact Map
3a0rA	2	0.7262	100	0.333	Contact Map
4gczA	2	0.7796	100	0.343	Contact Map
4q20A	2	0.5313	100	0.465	Contact Map
4r3aA	1	0.6891	100	0.467	Contact Map
3jz3A	2	0.3712	100	0.469	Contact Map
3d36A	2	0.5104	100	0.477	Contact Map
4mpcA	2	0.7053	100	0.477	Contact Map
2c2aA	2	0.5383	100	0.477	Contact Map
4e01A	3	0.652	100	0.484	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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