GREMLIN Database
SPPA - Protease 4
UniProt: P08395 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10968
Length: 618 (541)
Sequences: 1291 (972)
Seq/√Len: 41.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
368_I392_A6.5181.00
434_I484_G6.2501.00
372_V415_S5.5621.00
191_S218_D4.7861.00
498_S503_I4.7091.00
400_V539_L4.5851.00
105_R140_E3.6471.00
104_I116_I3.5051.00
357_R388_E3.4821.00
422_V535_K3.3501.00
138_L148_V3.2771.00
420_Y535_K3.2031.00
289_A387_A3.1821.00
492_V503_I2.9331.00
108_K140_E2.9011.00
367_A536_A2.9001.00
425_P526_L2.8881.00
127_D405_G2.8461.00
190_K194_D2.8451.00
331_V359_A2.8181.00
489_I500_P2.7821.00
401_V418_A2.7671.00
356_I389_L2.7451.00
100_I134_I2.6731.00
420_Y525_S2.6601.00
504_D508_Q2.6171.00
385_I414_I2.5761.00
116_I141_F2.5691.00
356_I392_A2.5421.00
229_S233_G2.5371.00
340_G348_G2.5291.00
416_T495_A2.5161.00
234_E513_T2.5131.00
230_R516_D2.5041.00
499_T502_Q2.4981.00
208_Y226_E2.4841.00
349_G353_A2.4781.00
207_T508_Q2.4541.00
486_K500_P2.4361.00
282_V285_L2.4061.00
339_D349_G2.3711.00
168_K284_A2.3521.00
536_A540_A2.3171.00
191_S451_H2.2501.00
360_R388_E2.2301.00
370_L389_L2.2091.00
336_A375_P2.1861.00
110_D316_Y2.1841.00
202_V216_I2.1741.00
334_N373_N2.1681.00
502_Q505_K2.1270.99
333_A347_V2.1190.99
360_R391_A2.1170.99
489_I504_D2.1090.99
389_L399_V2.0770.99
200_T439_T2.0760.99
535_K539_L2.0750.99
506_I520_N2.0680.99
329_G365_V2.0240.99
333_A414_I1.9930.99
467_R473_A1.9890.99
67_I134_I1.9850.99
504_D507_A1.9580.99
115_G147_P1.9460.99
406_M428_L1.9410.99
213_E221_S1.9370.99
356_I368_I1.9280.99
333_A352_T1.8860.99
388_E391_A1.8810.99
434_I481_I1.8750.99
23_R28_N1.8500.98
16_W20_N1.8370.98
456_S462_D1.8270.98
17_R20_N1.8200.98
419_N539_L1.8170.98
170_W286_A1.8010.98
58_A117_V1.7800.98
197_K447_S1.7750.98
135_G165_F1.7710.98
170_W284_A1.7590.98
326_D366_K1.7470.98
219_D222_P1.7450.98
234_E516_D1.7450.98
535_K538_E1.7440.98
25_M28_N1.7420.98
212_V435_F1.7370.98
188_Y220_M1.7340.98
54_A57_G1.7320.98
386_R413_W1.7040.97
117_V291_I1.7010.97
528_D531_D1.6850.97
116_I138_L1.6840.97
422_V531_D1.6830.97
360_R392_A1.6820.97
513_T516_D1.6790.97
515_Q518_K1.6720.97
489_I493_A1.6650.97
150_A166_A1.6580.97
371_R402_S1.6500.97
490_T494_D1.6250.96
523_V526_L1.6120.96
487_R491_L1.6100.96
516_D519_A1.6080.96
416_T492_V1.6040.96
274_K278_E1.6020.96
369_V536_A1.6020.96
203_F474_Q1.5810.96
387_A391_A1.5810.96
459_P472_E1.5720.96
171_L285_L1.5690.95
525_S531_D1.5600.95
201_H474_Q1.5530.95
18_L23_R1.5480.95
130_S373_N1.5370.95
14_W20_N1.5360.95
135_G246_N1.5360.95
331_V356_I1.5230.95
368_I397_K1.5220.95
369_V529_F1.5150.95
164_S246_N1.5050.94
481_I484_G1.4980.94
182_F232_I1.4880.94
21_F25_M1.4840.94
108_K144_S1.4810.94
153_E288_S1.4690.94
210_S220_M1.4400.93
525_S535_K1.4130.92
348_G351_T1.4070.92
347_V352_T1.3840.91
53_T311_I1.3800.91
537_A545_W1.3690.91
244_A249_I1.3640.91
138_L165_F1.3590.91
555_T558_D1.3550.90
353_A388_E1.3540.90
493_A498_S1.3530.90
20_N24_E1.3310.90
152_G155_Y1.3300.90
359_A368_I1.3280.90
130_S405_G1.3230.89
132_Q238_N1.3210.89
139_K165_F1.3080.89
367_A540_A1.3070.89
416_T489_I1.3070.89
400_V536_A1.3030.89
253_Q256_P1.2990.88
490_T500_P1.2970.88
32_I36_L1.2960.88
56_R114_T1.2950.88
255_F458_S1.2930.88
391_A394_A1.2820.88
16_W19_L1.2800.88
342_E351_T1.2690.87
161_Y242_T1.2680.87
277_L282_V1.2660.87
28_N31_F1.2640.87
400_V532_A1.2600.87
189_Y214_P1.2530.87
28_N32_I1.2530.87
67_I100_I1.2440.86
353_A384_V1.2420.86
187_L452_T1.2420.86
518_K525_S1.2410.86
199_S443_N1.2400.86
57_G113_I1.2390.86
355_Q359_A1.2360.86
347_V414_I1.2240.85
294_A298_E1.2240.85
65_G123_F1.2220.85
443_N447_S1.2200.85
486_K504_D1.2200.85
383_E491_L1.2130.85
218_D451_H1.2080.85
286_A294_A1.2060.84
131_M162_L1.2030.84
498_S502_Q1.2030.84
231_W511_V1.2020.84
222_P229_S1.1950.84
356_I399_V1.1940.84
205_V482_E1.1920.84
53_T57_G1.1920.84
365_V397_K1.1900.84
327_S362_D1.1820.83
441_V465_I1.1760.83
55_S112_N1.1750.83
359_A392_A1.1730.83
60_L310_A1.1720.83
111_R363_P1.1700.83
236_W458_S1.1670.82
471_P474_Q1.1670.82
339_D378_S1.1650.82
220_M453_D1.1650.82
199_S440_T1.1640.82
168_K294_A1.1630.82
250_P253_Q1.1610.82
202_V212_V1.1610.82
373_N405_G1.1590.82
173_P285_L1.1570.82
372_V385_I1.1550.82
267_K459_P1.1540.82
400_V535_K1.1530.82
34_L38_G1.1470.81
286_A290_E1.1420.81
420_Y539_L1.1400.81
220_M225_R1.1400.81
499_T504_D1.1380.81
228_D231_W1.1300.80
182_F239_Y1.1240.80
461_A468_A1.1230.80
403_M427_T1.1130.79
329_G551_V1.1120.79
169_I283_D1.1090.79
500_P504_D1.1090.79
369_V537_A1.1050.79
198_V444_S1.1040.79
217_R221_S1.1020.79
372_V406_M1.0900.78
531_D534_A1.0870.78
240_L254_V1.0820.77
224_A227_A1.0810.77
157_Q180_H1.0780.77
13_K16_W1.0760.77
506_I512_W1.0680.76
20_N23_R1.0680.76
141_F144_S1.0670.76
501_E505_K1.0610.76
370_L401_V1.0540.75
501_E504_D1.0540.75
393_R495_A1.0480.75
400_V540_A1.0430.75
75_Q78_S1.0410.75
423_A523_V1.0390.74
352_T370_L1.0390.74
445_L452_T1.0370.74
416_T503_I1.0370.74
20_N28_N1.0350.74
137_A140_E1.0330.74
286_A291_I1.0290.74
139_K245_A1.0230.73
330_V529_F1.0200.73
205_V434_I1.0160.73
390_A394_A1.0110.72
393_R419_N1.0080.72
147_P167_N1.0060.72
529_F533_V1.0060.72
295_L299_F1.0060.72
443_N446_D1.0050.72
217_R223_A1.0040.72
556_F560_V1.0020.72
289_A391_A1.0000.71
165_F246_N0.9990.71
554_P558_D0.9950.71
183_A456_S0.9930.71
290_E387_A0.9920.71
240_L255_F0.9830.70
284_A290_E0.9810.70
212_V216_I0.9790.70
104_I138_L0.9780.70
196_L444_S0.9720.69
227_A510_H0.9710.69
192_L196_L0.9700.69
532_A536_A0.9670.69
182_F235_L0.9660.69
357_R361_L0.9650.69
205_V478_Q0.9640.69
332_F549_Y0.9580.68
132_Q242_T0.9560.68
193_L200_T0.9550.68
33_F37_V0.9510.68
552_D558_D0.9490.67
390_A417_P0.9490.67
478_Q482_E0.9480.67
133_Y424_N0.9470.67
338_M346_N0.9470.67
194_D218_D0.9400.67
357_R391_A0.9390.67
142_R167_N0.9390.67
197_K444_S0.9380.67
368_I399_V0.9370.66
342_E348_G0.9370.66
206_G213_E0.9360.66
172_S384_V0.9320.66
190_K218_D0.9320.66
105_R137_A0.9280.66
240_L251_A0.9280.66
530_D534_A0.9200.65
104_I141_F0.9190.65
403_M423_A0.9190.65
370_L414_I0.9190.65
489_I492_V0.9190.65
331_V389_L0.9180.65
62_D119_D0.9170.65
67_I97_L0.9170.65
149_Y291_I0.9170.65
379_V413_W0.9160.65
244_A254_V0.9160.65
337_I382_S0.9150.65
206_G508_Q0.9140.64
207_T223_A0.9130.64
202_V437_V0.9120.64
225_R229_S0.9110.64
533_V547_L0.9080.64
383_E487_R0.9080.64
460_L473_A0.9070.64
422_V526_L0.9050.64
436_G477_M0.9040.64
331_V355_Q0.9010.63
118_M166_A0.9010.63
275_Y279_N0.9000.63
215_F437_V0.8980.63
379_V484_G0.8930.63
148_V166_A0.8920.63
441_V444_S0.8910.62
276_A348_G0.8910.62
518_K526_L0.8900.62
102_N106_Q0.8880.62
386_R491_L0.8830.62
489_I503_I0.8810.62
59_L107_A0.8780.61
372_V375_P0.8750.61
352_T355_Q0.8690.61
58_A115_G0.8690.61
28_N36_L0.8680.60
277_L284_A0.8670.60
554_P562_D0.8670.60
225_R453_D0.8660.60
293_K303_K0.8660.60
59_L316_Y0.8650.60
240_L244_A0.8650.60
97_L101_V0.8650.60
171_L175_G0.8620.60
502_Q506_I0.8610.60
253_Q280_K0.8610.60
333_A370_L0.8590.60
413_W491_L0.8580.60
338_M381_A0.8580.60
13_K17_R0.8580.60
127_D182_F0.8570.59
388_E392_A0.8560.59
136_K424_N0.8550.59
518_K523_V0.8550.59
98_F549_Y0.8540.59
280_K541_K0.8510.59
231_W428_L0.8490.59
60_L308_Y0.8490.59
140_E143_D0.8490.59
212_V482_E0.8420.58
224_A228_D0.8380.58
21_F24_E0.8350.57
188_Y224_A0.8350.57
136_K531_D0.8340.57
489_I508_Q0.8330.57
19_L28_N0.8310.57
372_V404_G0.8300.57
445_L466_T0.8290.57
211_A375_P0.8270.57
393_R418_A0.8270.57
497_H541_K0.8250.57
328_I547_L0.8250.57
130_S404_G0.8250.57
30_F35_V0.8240.56
139_K143_D0.8210.56
110_D359_A0.8210.56
177_V282_V0.8200.56
148_V167_N0.8200.56
390_A494_D0.8190.56
118_M162_L0.8190.56
340_G351_T0.8180.56
197_K200_T0.8170.56
211_A435_F0.8160.56
372_V414_I0.8160.56
22_V26_V0.8150.56
244_A252_E0.8150.56
297_K541_K0.8080.55
171_L282_V0.8080.55
386_R495_A0.8080.55
331_V368_I0.8070.55
275_Y278_E0.8070.55
210_S224_A0.8070.55
325_G546_H0.7980.54
249_I254_V0.7980.54
248_Q497_H0.7960.54
422_V525_S0.7960.54
384_V388_E0.7950.54
198_V331_V0.7950.54
331_V392_A0.7950.54
417_P495_A0.7890.53
135_G161_Y0.7880.53
198_V542_V0.7880.53
211_A215_F0.7880.53
16_W21_F0.7870.53
155_Y175_G0.7860.53
149_Y298_E0.7850.53
237_Q515_Q0.7830.53
77_F81_S0.7820.53
392_A396_G0.7810.52
249_I552_D0.7790.52
149_Y446_D0.7790.52
103_T317_A0.7780.52
529_F547_L0.7780.52
205_V484_G0.7780.52
470_P473_A0.7760.52
341_E354_A0.7760.52
279_N477_M0.7740.52
204_R212_V0.7740.52
498_S521_G0.7740.52
327_S546_H0.7700.51
213_E217_R0.7690.51
289_A388_E0.7670.51
359_A397_K0.7640.51
503_I506_I0.7640.51
17_R24_E0.7640.51
492_V506_I0.7630.51
534_A538_E0.7620.51
185_N456_S0.7590.50
100_I313_Y0.7580.50
191_S194_D0.7570.50
213_E224_A0.7560.50
101_V137_A0.7560.50
37_V144_S0.7560.50
446_D451_H0.7540.50
285_L291_I0.7520.50
189_Y192_L0.7510.50
22_V27_L0.7510.50
416_T491_L0.7500.50
560_V574_D0.7490.49
53_T113_I0.7490.49
36_L243_V0.7490.49
503_I508_Q0.7480.49
196_L448_I0.7480.49
138_L166_A0.7480.49
311_I316_Y0.7470.49
400_V547_L0.7440.49
244_A470_P0.7420.49
406_M415_S0.7420.49
68_V345_G0.7390.48
59_L110_D0.7380.48
34_L37_V0.7350.48
312_S400_V0.7350.48
16_W32_I0.7330.48
25_M29_L0.7300.48
270_G275_Y0.7300.48
356_I361_L0.7300.48
234_E515_Q0.7290.48
153_E384_V0.7280.47
35_V38_G0.7280.47
131_M243_V0.7270.47
174_Q487_R0.7260.47
172_S379_V0.7260.47
362_D397_K0.7240.47
23_R31_F0.7240.47
532_A540_A0.7220.47
294_A297_K0.7200.47
19_L25_M0.7180.47
341_E348_G0.7160.46
378_S411_G0.7150.46
18_L28_N0.7150.46
32_I35_V0.7150.46
330_V549_Y0.7130.46
230_R513_T0.7120.46
486_K489_I0.7110.46
208_Y385_I0.7100.46
274_K277_L0.7060.45
489_I499_T0.7000.45
486_K490_T0.7000.45
108_K143_D0.6990.45
245_A297_K0.6980.45
244_A472_E0.6980.45
352_T414_I0.6970.45
58_A299_F0.6970.45
100_I328_I0.6960.44
203_F469_L0.6960.44
357_R360_R0.6940.44
61_L104_I0.6930.44
75_Q81_S0.6930.44
380_T384_V0.6930.44
353_A357_R0.6920.44
163_A169_I0.6910.44
16_W29_L0.6910.44
151_V172_S0.6900.44
18_L22_V0.6890.44
353_A356_I0.6880.44
564_M567_S0.6870.44
438_I469_L0.6870.44
18_L24_E0.6870.44
14_W18_L0.6860.44
219_D453_D0.6860.44
171_L284_A0.6840.43
199_S442_E0.6840.43
378_S381_A0.6840.43
14_W17_R0.6820.43
16_W28_N0.6810.43
271_D274_K0.6800.43
287_S387_A0.6800.43
369_V547_L0.6790.43
220_M228_D0.6780.43
127_D158_G0.6750.43
174_Q413_W0.6740.42
233_G280_K0.6740.42
203_F478_Q0.6730.42
515_Q519_A0.6730.42
338_M348_G0.6710.42
236_W457_T0.6710.42
215_F336_A0.6700.42
132_Q425_P0.6700.42
241_N251_A0.6690.42
128_Q235_L0.6690.42
69_D371_R0.6690.42
348_G381_A0.6680.42
327_S548_E0.6680.42
19_L31_F0.6670.42
559_K563_N0.6670.42
211_A216_I0.6640.42
333_A411_G0.6630.41
188_Y251_A0.6630.41
220_M224_A0.6620.41
168_K283_D0.6620.41
413_W487_R0.6620.41
67_I130_S0.6620.41
386_R417_P0.6590.41
435_F457_T0.6570.41
444_S448_I0.6560.41
141_F161_Y0.6540.41
268_T275_Y0.6540.41
148_V359_A0.6540.41
20_N32_I0.6540.41
300_G544_Q0.6540.41
280_K497_H0.6530.41
333_A389_L0.6520.40
349_G381_A0.6510.40
123_F510_H0.6510.40
161_Y239_Y0.6500.40
403_M526_L0.6460.40
13_K21_F0.6460.40
558_D561_M0.6440.40
244_A250_P0.6440.40
557_F560_V0.6440.40
311_I314_Y0.6430.40
143_D248_Q0.6420.40
125_G130_S0.6400.39
331_V348_G0.6400.39
347_V375_P0.6390.39
380_T383_E0.6390.39
203_F482_E0.6370.39
275_Y476_M0.6360.39
239_Y243_V0.6350.39
557_F561_M0.6350.39
98_F134_I0.6350.39
242_T246_N0.6340.39
347_V351_T0.6340.39
361_L513_T0.6330.39
242_T393_R0.6320.39
142_R165_F0.6320.39
454_G462_D0.6310.39
233_G457_T0.6310.39
379_V417_P0.6310.39
367_A400_V0.6300.38
62_D404_G0.6300.38
14_W23_R0.6280.38
16_W23_R0.6280.38
129_P133_Y0.6270.38
243_V352_T0.6270.38
238_N242_T0.6270.38
80_L365_V0.6270.38
441_V445_L0.6260.38
121_K439_T0.6260.38
370_L385_I0.6260.38
232_I457_T0.6260.38
360_R396_G0.6250.38
143_D541_K0.6250.38
115_G149_Y0.6250.38
372_V401_V0.6240.38
328_I506_I0.6220.38
241_N245_A0.6220.38
151_V197_K0.6220.38
284_A294_A0.6210.38
192_L328_I0.6200.38
352_T356_I0.6190.38
338_M342_E0.6190.38
134_I138_L0.6180.37
133_Y528_D0.6170.37
37_V250_P0.6140.37
493_A499_T0.6130.37
76_R226_E0.6130.37
15_T20_N0.6130.37
104_I161_Y0.6120.37
265_L268_T0.6120.37
403_M429_T0.6110.37
355_Q392_A0.6110.37
17_R28_N0.6110.37
201_H440_T0.6110.37
171_L215_F0.6100.37
207_T504_D0.6100.37
135_G460_L0.6090.37
36_L245_A0.6090.37
17_R21_F0.6080.37
277_L285_L0.6080.37
192_L450_V0.6080.37
289_A392_A0.6070.36
493_A503_I0.6060.36
184_T228_D0.6050.36
61_L118_M0.6050.36
187_L244_A0.6040.36
42_W45_V0.6040.36
14_W19_L0.6030.36
157_Q457_T0.6010.36
16_W25_M0.6010.36
160_Y247_R0.6010.36
27_L103_T0.6000.36
356_I370_L0.6000.36
434_I480_S0.5980.36
386_R416_T0.5980.36
17_R23_R0.5980.36
58_A308_Y0.5980.36
187_L192_L0.5980.36
237_Q372_V0.5980.36
330_V533_V0.5980.36
327_S533_V0.5970.36
175_G453_D0.5970.36
29_L32_I0.5960.36
340_G350_D0.5950.35
168_K298_E0.5950.35
375_P411_G0.5950.35
197_K443_N0.5940.35
383_E413_W0.5920.35
26_V30_F0.5920.35
386_R390_A0.5920.35
572_L575_A0.5920.35
330_V547_L0.5920.35
191_S198_V0.5910.35
132_Q424_N0.5900.35
133_Y479_L0.5900.35
206_G221_S0.5900.35
349_G384_V0.5890.35
77_F80_L0.5880.35
206_G478_Q0.5870.35
32_I39_V0.5860.35
427_T523_V0.5850.35
14_W24_E0.5850.35
47_G75_Q0.5830.34
113_I321_P0.5830.34
197_K446_D0.5810.34
157_Q236_W0.5800.34
307_N502_Q0.5790.34
189_Y215_F0.5790.34
413_W416_T0.5780.34
62_D65_G0.5780.34
235_L239_Y0.5770.34
158_G192_L0.5770.34
378_S382_S0.5770.34
204_R216_I0.5770.34
132_Q161_Y0.5750.34
254_V281_L0.5750.34
375_P406_M0.5740.34
172_S206_G0.5740.34
22_V34_L0.5730.34
389_L495_A0.5730.34
299_F308_Y0.5730.34
497_H543_K0.5730.34
559_K566_G0.5730.34
170_W294_A0.5720.33
471_P525_S0.5710.33
353_A389_L0.5710.33
227_A373_N0.5700.33
68_V94_E0.5690.33
516_D520_N0.5680.33
570_A573_P0.5680.33
383_E492_V0.5670.33
186_G224_A0.5670.33
214_P478_Q0.5660.33
103_T313_Y0.5660.33
347_V379_V0.5660.33
127_D406_M0.5660.33
143_D225_R0.5660.33
230_R233_G0.5650.33
464_S516_D0.5650.33
363_P394_A0.5650.33
291_I295_L0.5640.33
292_E357_R0.5640.33
436_G481_I0.5630.33
350_D353_A0.5620.33
325_G364_K0.5620.33
276_A340_G0.5610.33
200_T507_A0.5600.32
210_S454_G0.5600.32
143_D519_A0.5600.32
327_S364_K0.5590.32
375_P401_V0.5590.32
95_N100_I0.5580.32
29_L33_F0.5570.32
133_Y371_R0.5570.32
172_S205_V0.5570.32
193_L196_L0.5560.32
213_E457_T0.5560.32
214_P435_F0.5560.32
44_Q441_V0.5540.32
400_V419_N0.5540.32
532_A539_L0.5540.32
139_K382_S0.5540.32
22_V25_M0.5530.32
396_G399_V0.5530.32
249_I256_P0.5530.32
313_Y404_G0.5520.32
463_V477_M0.5520.32
133_Y530_D0.5520.32
240_L458_S0.5510.32
136_K139_K0.5510.32
323_D450_V0.5510.32
79_K100_I0.5500.32
174_Q383_E0.5500.32
271_D386_R0.5500.32
322_A533_V0.5480.32
280_K461_A0.5480.32
128_Q405_G0.5480.32
139_K142_R0.5470.31
400_V463_V0.5470.31
27_L36_L0.5470.31
18_L27_L0.5460.31
278_E538_E0.5460.31
21_F28_N0.5450.31
177_V276_A0.5450.31
163_A386_R0.5440.31
501_E519_A0.5440.31
352_T385_I0.5440.31
35_V148_V0.5440.31
301_W306_K0.5440.31
300_G543_K0.5430.31
222_P448_I0.5430.31
307_N310_A0.5420.31
341_E350_D0.5420.31
196_L445_L0.5420.31
277_L406_M0.5420.31
135_G242_T0.5410.31
220_M454_G0.5410.31
216_I482_E0.5380.31
26_V282_V0.5380.31
129_P491_L0.5380.31
179_L269_G0.5370.31
254_V545_W0.5360.31
185_N428_L0.5360.31
213_E537_A0.5350.30
212_V457_T0.5350.30
71_P96_S0.5340.30
252_E560_V0.5330.30
147_P413_W0.5320.30
462_D467_R0.5310.30
13_K24_E0.5310.30
248_Q538_E0.5310.30
445_L465_I0.5300.30
230_R510_H0.5290.30
242_T245_A0.5290.30
287_S456_S0.5290.30
22_V290_E0.5280.30
217_R224_A0.5280.30
226_E230_R0.5280.30
153_E380_T0.5270.30
160_Y403_M0.5250.30
53_T112_N0.5250.30
16_W24_E0.5250.30
287_S413_W0.5250.30
30_F572_L0.5250.30
132_Q136_K0.5240.30
359_A365_V0.5240.30
26_V31_F0.5230.30
517_A522_L0.5230.30
534_A541_K0.5230.30
149_Y284_A0.5220.29
191_S195_K0.5220.29
413_W435_F0.5200.29
203_F477_M0.5190.29
69_D404_G0.5190.29
136_K528_D0.5180.29
241_N544_Q0.5180.29
421_I495_A0.5180.29
13_K20_N0.5170.29
223_A226_E0.5170.29
22_V31_F0.5160.29
92_L232_I0.5160.29
20_N39_V0.5150.29
248_Q542_V0.5150.29
568_V571_M0.5150.29
527_G532_A0.5140.29
178_D375_P0.5140.29
156_S241_N0.5140.29
554_P561_M0.5130.29
397_K418_A0.5130.29
436_G483_N0.5130.29
131_M158_G0.5120.29
469_L474_Q0.5110.29
252_E256_P0.5110.29
393_R436_G0.5110.29
373_N401_V0.5100.29
45_V55_S0.5100.29
169_I179_L0.5090.28
174_Q379_V0.5090.28
202_V205_V0.5080.28
361_L481_I0.5060.28
187_L464_S0.5060.28
201_H442_E0.5060.28
313_Y316_Y0.5050.28
219_D451_H0.5050.28
196_L208_Y0.5050.28
203_F231_W0.5050.28
484_G489_I0.5040.28
25_M507_A0.5040.28
182_F405_G0.5030.28
306_K361_L0.5020.28
340_G349_G0.5020.28
501_E508_Q0.5010.28
297_K543_K0.5010.28
27_L33_F0.5010.28
325_G544_Q0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bf0A 3 0.7735 100 0.386 Contact Map
4kwbA 5 0.3851 100 0.773 Contact Map
3rstA 3 0.3625 100 0.784 Contact Map
3vivA 2 0.3269 100 0.84 Contact Map
4gm2A 3 0.2751 100 0.843 Contact Map
2f6iA 5 0.2913 100 0.854 Contact Map
4u0gA 4 0.3155 100 0.858 Contact Map
3p2lA 4 0.3042 100 0.859 Contact Map
2cbyA 3 0.2702 100 0.859 Contact Map
1yg6A 4 0.3074 100 0.863 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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