GREMLIN Database
USG - USG-1 protein
UniProt: P08390 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11059
Length: 337 (298)
Sequences: 7297 (3734)
Seq/√Len: 216.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_K146_D3.8051.00
6_N33_E3.7641.00
261_A307_V3.4861.00
8_A67_A3.3801.00
133_L159_I3.2161.00
151_S253_L2.9481.00
272_V291_H2.9131.00
129_V327_I2.8811.00
272_V293_S2.7971.00
92_L331_L2.7431.00
46_Q53_T2.6521.00
257_A260_E2.5651.00
152_R251_E2.4401.00
32_G328_A2.4271.00
199_M238_A2.4121.00
69_L328_A2.4081.00
137_L155_V2.3611.00
263_D267_Q2.2941.00
161_A195_L2.2841.00
27_R329_E2.2771.00
117_V225_Q2.2401.00
140_A248_V2.2311.00
136_Q246_Q2.1811.00
23_T325_V2.0491.00
71_F328_A2.0171.00
19_A22_E2.0101.00
318_F326_K2.0021.00
48_R53_T1.9691.00
137_L246_Q1.9611.00
140_A309_F1.9601.00
127_I331_L1.9351.00
20_L71_F1.9271.00
46_Q55_T1.9221.00
136_Q313_A1.9201.00
262_R266_V1.9021.00
260_E263_D1.8971.00
5_W332_V1.8841.00
156_T247_M1.8761.00
133_L157_S1.8571.00
147_Q264_A1.8181.00
138_L219_E1.8151.00
151_S251_E1.7971.00
40_N58_D1.7651.00
280_P295_G1.7641.00
141_L153_I1.7551.00
80_A99_L1.7511.00
6_N35_Y1.7411.00
144_L252_A1.7391.00
258_A262_R1.7211.00
19_A242_Y1.6911.00
59_A82_W1.6811.00
24_L32_G1.6621.00
7_I69_L1.6371.00
166_K170_D1.6321.00
240_V282_Q1.6291.00
105_D125_N1.6151.00
157_S246_Q1.5851.00
111_P330_K1.5851.00
140_A311_S1.5821.00
116_F119_T1.5741.00
21_L34_I1.5611.00
12_A37_L1.5591.00
204_P211_R1.5441.00
154_S249_N1.5221.00
144_L307_V1.5141.00
317_R322_L1.5081.00
16_V321_A1.4821.00
114_N117_V1.4571.00
81_A85_E1.4541.00
170_D173_A1.4511.00
248_V311_S1.4501.00
85_E88_N1.4441.00
146_D268_G1.4391.00
7_I32_G1.4371.00
265_F309_F1.4341.00
6_N68_Q1.4271.00
65_T89_S1.4131.00
263_D266_V1.4031.00
87_T126_V1.4011.00
258_A299_N1.3721.00
45_E49_F1.3641.00
10_L72_F1.3591.00
252_A307_V1.3541.00
262_R276_E1.3461.00
77_E99_L1.3421.00
255_P299_N1.3321.00
92_L125_N1.3301.00
113_V142_K1.3271.00
290_P317_R1.3161.00
72_F83_V1.3111.00
137_L248_V1.3041.00
248_V309_F1.2851.00
69_L332_V1.2831.00
70_A91_C1.2701.00
142_K223_I1.2581.00
258_A297_V1.2571.00
82_W85_E1.2551.00
196_A241_F1.2511.00
251_E306_Q1.2511.00
115_P330_K1.2341.00
8_A70_A1.2281.00
110_V138_L1.2191.00
147_Q260_E1.2101.00
46_Q49_F1.2061.00
144_L265_F1.1981.00
116_F225_Q1.1921.00
290_P322_L1.1881.00
137_L216_I1.1861.00
292_L313_A1.1821.00
155_V248_V1.1811.00
152_R306_Q1.1711.00
259_E263_D1.1701.00
217_V302_G1.1631.00
84_E88_N1.1601.00
202_L277_N1.1501.00
115_P118_L1.1441.00
164_Q168_A1.1391.00
245_A312_V1.1391.00
162_S241_F1.1351.00
250_F307_V1.1301.00
292_L311_S1.1211.00
92_L127_I1.1161.00
64_W86_A1.1141.00
238_A282_Q1.1141.00
156_T249_N1.1091.00
158_L238_A1.0941.00
21_L47_L1.0801.00
35_Y67_A1.0781.00
250_F309_F1.0771.00
112_E326_K1.0761.00
103_E222_K1.0751.00
141_L250_F1.0741.00
136_Q157_S1.0731.00
153_I250_F1.0711.00
102_L218_D1.0541.00
13_T39_R1.0471.00
265_F273_L1.0461.00
83_V93_V1.0391.00
112_E318_F1.0381.00
169_V173_A1.0351.00
212_E215_R1.0341.00
317_R325_V1.0271.00
203_L211_R1.0251.00
140_A143_P1.0241.00
107_P124_R1.0201.00
61_E85_E1.0091.00
252_A299_N1.0071.00
274_S293_S1.0051.00
273_L297_V1.0031.00
85_E89_S1.0021.00
262_R273_L1.0021.00
267_Q270_D1.0011.00
148_G256_L0.9991.00
60_A63_D0.9981.00
281_T285_D0.9951.00
144_L261_A0.9931.00
67_A70_A0.9901.00
285_D293_S0.9891.00
139_A292_L0.9871.00
32_G332_V0.9841.00
5_W69_L0.9831.00
158_L249_N0.9761.00
71_F324_A0.9761.00
259_E262_R0.9721.00
58_D61_E0.9711.00
16_V320_G0.9651.00
23_T322_L0.9641.00
8_A36_A0.9591.00
62_F65_T0.9581.00
245_A310_W0.9561.00
266_V275_E0.9551.00
149_G253_L0.9511.00
243_G315_N0.9461.00
198_N281_T0.9360.99
219_E222_K0.9340.99
245_A282_Q0.9330.99
13_T56_V0.9330.99
147_Q267_Q0.9310.99
140_A265_F0.9310.99
168_A172_L0.9290.99
221_R229_L0.9280.99
230_M304_P0.9260.99
168_A173_A0.9240.99
279_F310_W0.9220.99
114_N219_E0.9200.99
262_R275_E0.9200.99
25_A50_G0.9170.99
6_N32_G0.9150.99
56_V59_A0.9120.99
94_I328_A0.9110.99
106_V126_V0.9090.99
236_V247_M0.9030.99
38_A42_S0.9010.99
214_R218_D0.9000.99
136_Q311_S0.8970.99
69_L92_L0.8970.99
215_R219_E0.8920.99
35_Y57_Q0.8910.99
193_R281_T0.8890.99
232_S249_N0.8790.99
74_A97_S0.8780.99
70_A86_A0.8770.99
133_L216_I0.8750.99
274_S285_D0.8720.99
254_R260_E0.8720.99
42_S45_E0.8630.99
145_I150_L0.8440.99
78_A81_A0.8430.99
328_A332_V0.8420.99
173_A241_F0.8410.99
289_T293_S0.8400.99
27_R31_V0.8400.99
39_R42_S0.8360.99
255_P305_E0.8350.99
74_A79_T0.8320.99
141_L248_V0.8310.99
264_A269_E0.8290.99
105_D124_R0.8270.99
129_V320_G0.8250.99
83_V126_V0.8230.99
61_E81_A0.8220.99
256_L264_A0.8190.99
249_N308_Q0.8180.99
264_A270_D0.8160.99
47_L56_V0.8130.99
86_A93_V0.8120.99
118_L330_K0.8100.99
147_Q254_R0.8090.99
200_L281_T0.8080.99
57_Q63_D0.8020.98
199_M236_V0.8010.98
102_L128_A0.7950.98
155_V216_I0.7940.98
119_T123_N0.7940.98
262_R297_V0.7870.98
10_L59_A0.7840.98
294_V309_F0.7830.98
43_A58_D0.7790.98
158_L236_V0.7780.98
74_A78_A0.7780.98
274_S278_E0.7750.98
210_V215_R0.7710.98
77_E80_A0.7700.98
201_P245_A0.7690.98
247_M308_Q0.7630.98
242_Y316_V0.7590.98
213_E217_V0.7540.98
136_Q312_V0.7510.98
134_T203_L0.7490.98
156_T236_V0.7470.98
55_T58_D0.7430.97
286_A293_S0.7410.97
84_E87_T0.7400.97
23_T317_R0.7380.97
247_M310_W0.7380.97
12_A17_G0.7340.97
199_M282_Q0.7330.97
255_P264_A0.7300.97
141_L155_V0.7280.97
252_A255_P0.7260.97
35_Y66_Q0.7250.97
113_V139_A0.7230.97
252_A256_L0.7220.97
221_R228_G0.7220.97
132_S163_A0.7190.97
279_F295_G0.7190.97
98_G211_R0.7140.97
62_F89_S0.7130.97
155_V246_Q0.7080.97
169_V172_L0.7070.97
135_S323_M0.7040.96
252_A261_A0.7040.96
148_G257_A0.7030.96
201_P236_V0.7030.96
214_R217_V0.7020.96
96_S129_V0.6980.96
27_R290_P0.6970.96
34_I54_I0.6960.96
164_Q200_L0.6950.96
86_A97_S0.6910.96
115_P119_T0.6910.96
96_S323_M0.6880.96
42_S50_G0.6870.96
131_D215_R0.6850.96
76_K211_R0.6840.96
140_A292_L0.6820.96
134_T138_L0.6800.96
108_L134_T0.6790.96
48_R52_K0.6790.96
84_E100_F0.6780.96
65_T88_N0.6770.96
22_E25_A0.6770.96
9_V20_L0.6760.96
149_G264_A0.6730.95
69_L94_I0.6690.95
22_E26_E0.6680.95
9_V24_L0.6660.95
297_V307_V0.6630.95
5_W68_Q0.6620.95
279_F298_R0.6590.95
243_G287_S0.6590.95
230_M302_G0.6590.95
221_R227_E0.6580.95
36_A47_L0.6570.95
261_A297_V0.6570.95
142_K145_I0.6550.95
301_Y305_E0.6550.95
203_L209_S0.6550.95
57_Q66_Q0.6540.95
114_N222_K0.6480.94
144_L250_F0.6470.94
34_I52_K0.6470.94
94_I331_L0.6440.94
110_V139_A0.6420.94
158_L199_M0.6420.94
27_R30_P0.6420.94
18_E51_G0.6420.94
301_Y304_P0.6400.94
212_E216_I0.6360.94
148_G264_A0.6340.94
138_L220_V0.6310.94
72_F93_V0.6310.94
217_V231_I0.6300.94
25_A52_K0.6240.93
211_R214_R0.6240.93
241_F287_S0.6230.93
117_V222_K0.6220.93
24_L325_V0.6220.93
43_A55_T0.6200.93
194_Q283_V0.6190.93
217_V221_R0.6190.93
109_V327_I0.6170.93
261_A299_N0.6160.93
87_T90_G0.6130.93
148_G253_L0.6130.93
173_A193_R0.6120.93
204_P210_V0.6110.93
26_E317_R0.6110.93
9_V21_L0.6090.92
72_F79_T0.6030.92
216_I220_V0.6030.92
256_L261_A0.6020.92
59_A62_F0.6010.92
171_A200_L0.6010.92
84_E93_V0.5990.92
31_V49_F0.5980.92
201_P310_W0.5980.92
300_D306_Q0.5970.92
103_E218_D0.5950.92
258_A261_A0.5940.91
259_E276_E0.5940.91
7_I71_F0.5930.91
150_L250_F0.5930.91
142_K224_L0.5920.91
149_G256_L0.5910.91
136_Q292_L0.5900.91
155_V231_I0.5900.91
232_S306_Q0.5900.91
154_S251_E0.5880.91
136_Q244_H0.5880.91
67_A91_C0.5860.91
61_E89_S0.5830.91
154_S247_M0.5810.91
266_V270_D0.5810.91
148_G260_E0.5800.90
21_L36_A0.5790.90
58_D63_D0.5790.90
246_Q311_S0.5780.90
195_L237_Q0.5740.90
145_I153_I0.5740.90
15_A169_V0.5740.90
63_D66_Q0.5720.90
102_L214_R0.5720.90
80_A84_E0.5720.90
242_Y287_S0.5720.90
220_V225_Q0.5710.90
76_K98_G0.5700.90
137_L157_S0.5690.90
103_E106_V0.5670.89
197_F241_F0.5670.89
114_N118_L0.5660.89
77_E97_S0.5630.89
278_E281_T0.5620.89
257_A299_N0.5620.89
211_R215_R0.5600.89
268_G271_I0.5600.89
193_R285_D0.5580.89
71_F325_V0.5580.89
139_A268_G0.5560.89
47_L50_G0.5550.88
307_V310_W0.5530.88
151_S305_E0.5530.88
302_G305_E0.5520.88
7_I328_A0.5520.88
72_F86_A0.5510.88
160_S242_Y0.5500.88
137_L311_S0.5480.88
13_T42_S0.5480.88
242_Y315_N0.5470.88
254_R305_E0.5470.88
130_P135_S0.5460.88
265_F269_E0.5440.87
293_S312_V0.5440.87
24_L328_A0.5440.87
197_F287_S0.5420.87
33_E52_K0.5420.87
195_L198_N0.5410.87
79_T100_F0.5410.87
243_G286_A0.5390.87
110_V323_M0.5390.87
161_A193_R0.5380.87
232_S308_Q0.5380.87
12_A56_V0.5360.87
136_Q315_N0.5350.87
13_T38_A0.5330.86
211_R218_D0.5320.86
48_R51_G0.5300.86
155_V233_A0.5290.86
10_L74_A0.5290.86
101_A132_S0.5290.86
20_L325_V0.5260.86
300_D304_P0.5250.86
149_G252_A0.5250.86
78_A97_S0.5240.86
323_M327_I0.5240.86
10_L37_L0.5220.85
135_S313_A0.5210.85
257_A261_A0.5210.85
290_P326_K0.5200.85
12_A36_A0.5190.85
221_R224_L0.5180.85
94_I324_A0.5180.85
134_T246_Q0.5170.85
6_N67_A0.5140.84
21_L25_A0.5140.84
113_V138_L0.5110.84
168_A171_A0.5110.84
295_G298_R0.5110.84
217_V301_Y0.5080.84
100_F106_V0.5080.84
192_G195_L0.5060.83
83_V86_A0.5060.83
101_A163_A0.5040.83
132_S215_R0.5010.83
31_V34_I0.5010.83
262_R277_N0.5000.83
80_A103_E0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r00A 2 0.9911 100 0.198 Contact Map
2yv3A 2 0.9555 100 0.202 Contact Map
3uw3A 2 0.9763 100 0.204 Contact Map
3pzrA 2 0.9733 100 0.206 Contact Map
1t4bA 2 0.9674 100 0.214 Contact Map
3tz6A 2 0.9644 100 0.221 Contact Map
2hjsA 2 0.9852 100 0.228 Contact Map
1vknA 4 0.8932 100 0.237 Contact Map
4r3nA 2 0.9792 100 0.239 Contact Map
2nqtA 4 0.905 100 0.262 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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