USG - ECOLI - GREMLIN Contacts

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USG - USG-1 protein

UniProt:	P08390	Sequences: MSEGWNIAVLGATGAVGEALLETLAERQFPVGEIYALARNESAGEQLRFGGKTITVQDAAEFDWTQAQLAFFVAGKEATAAWVEEATNSGCLVIDSSGLFALEPDVPLVVPEVNPFVLTDYRNRNVIAVPDSLTSQLLAALKPLIDQGGLSRISVTSLISASAQGKKAVDALAGQSAKLLNGIPIDEEDFFGRQLAFNMLPLLPDSEGSVREERRIVDEVRKILQDEGLMISASVVQAPVFYGHAQMVNFEALRPLAAEEARDAFVQGEDIVLSEENEFPTQVGDASGTPHLSVGCVRNDYGMPEQVQFWSVADNVRFGGALMAVKIAEKLVQEYLY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11059
Length:	337 (298)
Sequences:	7297 (3734)
Seq/√Len:	216.3

ECOLI - USG DHAS ARGC
BACSU - DHAS ARGC
HALSA - Q9HPX0
SULSO - ARGC Q97ZL8 Q97WN3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
142_K	146_D	3.805	1.00
6_N	33_E	3.764	1.00
261_A	307_V	3.486	1.00
8_A	67_A	3.380	1.00
133_L	159_I	3.216	1.00
151_S	253_L	2.948	1.00
272_V	291_H	2.913	1.00
129_V	327_I	2.881	1.00
272_V	293_S	2.797	1.00
92_L	331_L	2.743	1.00
46_Q	53_T	2.652	1.00
257_A	260_E	2.565	1.00
152_R	251_E	2.440	1.00
32_G	328_A	2.427	1.00
199_M	238_A	2.412	1.00
69_L	328_A	2.408	1.00
137_L	155_V	2.361	1.00
263_D	267_Q	2.294	1.00
161_A	195_L	2.284	1.00
27_R	329_E	2.277	1.00
117_V	225_Q	2.240	1.00
140_A	248_V	2.231	1.00
136_Q	246_Q	2.181	1.00
23_T	325_V	2.049	1.00
71_F	328_A	2.017	1.00
19_A	22_E	2.010	1.00
318_F	326_K	2.002	1.00
48_R	53_T	1.969	1.00
137_L	246_Q	1.961	1.00
140_A	309_F	1.960	1.00
127_I	331_L	1.935	1.00
20_L	71_F	1.927	1.00
46_Q	55_T	1.922	1.00
136_Q	313_A	1.920	1.00
262_R	266_V	1.902	1.00
260_E	263_D	1.897	1.00
5_W	332_V	1.884	1.00
156_T	247_M	1.876	1.00
133_L	157_S	1.857	1.00
147_Q	264_A	1.818	1.00
138_L	219_E	1.815	1.00
151_S	251_E	1.797	1.00
40_N	58_D	1.765	1.00
280_P	295_G	1.764	1.00
141_L	153_I	1.755	1.00
80_A	99_L	1.751	1.00
6_N	35_Y	1.741	1.00
144_L	252_A	1.739	1.00
258_A	262_R	1.721	1.00
19_A	242_Y	1.691	1.00
59_A	82_W	1.681	1.00
24_L	32_G	1.662	1.00
7_I	69_L	1.637	1.00
166_K	170_D	1.632	1.00
240_V	282_Q	1.629	1.00
105_D	125_N	1.615	1.00
157_S	246_Q	1.585	1.00
111_P	330_K	1.585	1.00
140_A	311_S	1.582	1.00
116_F	119_T	1.574	1.00
21_L	34_I	1.561	1.00
12_A	37_L	1.559	1.00
204_P	211_R	1.544	1.00
154_S	249_N	1.522	1.00
144_L	307_V	1.514	1.00
317_R	322_L	1.508	1.00
16_V	321_A	1.482	1.00
114_N	117_V	1.457	1.00
81_A	85_E	1.454	1.00
170_D	173_A	1.451	1.00
248_V	311_S	1.450	1.00
85_E	88_N	1.444	1.00
146_D	268_G	1.439	1.00
7_I	32_G	1.437	1.00
265_F	309_F	1.434	1.00
6_N	68_Q	1.427	1.00
65_T	89_S	1.413	1.00
263_D	266_V	1.403	1.00
87_T	126_V	1.401	1.00
258_A	299_N	1.372	1.00
45_E	49_F	1.364	1.00
10_L	72_F	1.359	1.00
252_A	307_V	1.354	1.00
262_R	276_E	1.346	1.00
77_E	99_L	1.342	1.00
255_P	299_N	1.332	1.00
92_L	125_N	1.330	1.00
113_V	142_K	1.327	1.00
290_P	317_R	1.316	1.00
72_F	83_V	1.311	1.00
137_L	248_V	1.304	1.00
248_V	309_F	1.285	1.00
69_L	332_V	1.283	1.00
70_A	91_C	1.270	1.00
142_K	223_I	1.258	1.00
258_A	297_V	1.257	1.00
82_W	85_E	1.255	1.00
196_A	241_F	1.251	1.00
251_E	306_Q	1.251	1.00
115_P	330_K	1.234	1.00
8_A	70_A	1.228	1.00
110_V	138_L	1.219	1.00
147_Q	260_E	1.210	1.00
46_Q	49_F	1.206	1.00
144_L	265_F	1.198	1.00
116_F	225_Q	1.192	1.00
290_P	322_L	1.188	1.00
137_L	216_I	1.186	1.00
292_L	313_A	1.182	1.00
155_V	248_V	1.181	1.00
152_R	306_Q	1.171	1.00
259_E	263_D	1.170	1.00
217_V	302_G	1.163	1.00
84_E	88_N	1.160	1.00
202_L	277_N	1.150	1.00
115_P	118_L	1.144	1.00
164_Q	168_A	1.139	1.00
245_A	312_V	1.139	1.00
162_S	241_F	1.135	1.00
250_F	307_V	1.130	1.00
292_L	311_S	1.121	1.00
92_L	127_I	1.116	1.00
64_W	86_A	1.114	1.00
238_A	282_Q	1.114	1.00
156_T	249_N	1.109	1.00
158_L	238_A	1.094	1.00
21_L	47_L	1.080	1.00
35_Y	67_A	1.078	1.00
250_F	309_F	1.077	1.00
112_E	326_K	1.076	1.00
103_E	222_K	1.075	1.00
141_L	250_F	1.074	1.00
136_Q	157_S	1.073	1.00
153_I	250_F	1.071	1.00
102_L	218_D	1.054	1.00
13_T	39_R	1.047	1.00
265_F	273_L	1.046	1.00
83_V	93_V	1.039	1.00
112_E	318_F	1.038	1.00
169_V	173_A	1.035	1.00
212_E	215_R	1.034	1.00
317_R	325_V	1.027	1.00
203_L	211_R	1.025	1.00
140_A	143_P	1.024	1.00
107_P	124_R	1.020	1.00
61_E	85_E	1.009	1.00
252_A	299_N	1.007	1.00
274_S	293_S	1.005	1.00
273_L	297_V	1.003	1.00
85_E	89_S	1.002	1.00
262_R	273_L	1.002	1.00
267_Q	270_D	1.001	1.00
148_G	256_L	0.999	1.00
60_A	63_D	0.998	1.00
281_T	285_D	0.995	1.00
144_L	261_A	0.993	1.00
67_A	70_A	0.990	1.00
285_D	293_S	0.989	1.00
139_A	292_L	0.987	1.00
32_G	332_V	0.984	1.00
5_W	69_L	0.983	1.00
158_L	249_N	0.976	1.00
71_F	324_A	0.976	1.00
259_E	262_R	0.972	1.00
58_D	61_E	0.971	1.00
16_V	320_G	0.965	1.00
23_T	322_L	0.964	1.00
8_A	36_A	0.959	1.00
62_F	65_T	0.958	1.00
245_A	310_W	0.956	1.00
266_V	275_E	0.955	1.00
149_G	253_L	0.951	1.00
243_G	315_N	0.946	1.00
198_N	281_T	0.936	0.99
219_E	222_K	0.934	0.99
245_A	282_Q	0.933	0.99
13_T	56_V	0.933	0.99
147_Q	267_Q	0.931	0.99
140_A	265_F	0.931	0.99
168_A	172_L	0.929	0.99
221_R	229_L	0.928	0.99
230_M	304_P	0.926	0.99
168_A	173_A	0.924	0.99
279_F	310_W	0.922	0.99
114_N	219_E	0.920	0.99
262_R	275_E	0.920	0.99
25_A	50_G	0.917	0.99
6_N	32_G	0.915	0.99
56_V	59_A	0.912	0.99
94_I	328_A	0.911	0.99
106_V	126_V	0.909	0.99
236_V	247_M	0.903	0.99
38_A	42_S	0.901	0.99
214_R	218_D	0.900	0.99
136_Q	311_S	0.897	0.99
69_L	92_L	0.897	0.99
215_R	219_E	0.892	0.99
35_Y	57_Q	0.891	0.99
193_R	281_T	0.889	0.99
232_S	249_N	0.879	0.99
74_A	97_S	0.878	0.99
70_A	86_A	0.877	0.99
133_L	216_I	0.875	0.99
274_S	285_D	0.872	0.99
254_R	260_E	0.872	0.99
42_S	45_E	0.863	0.99
145_I	150_L	0.844	0.99
78_A	81_A	0.843	0.99
328_A	332_V	0.842	0.99
173_A	241_F	0.841	0.99
289_T	293_S	0.840	0.99
27_R	31_V	0.840	0.99
39_R	42_S	0.836	0.99
255_P	305_E	0.835	0.99
74_A	79_T	0.832	0.99
141_L	248_V	0.831	0.99
264_A	269_E	0.829	0.99
105_D	124_R	0.827	0.99
129_V	320_G	0.825	0.99
83_V	126_V	0.823	0.99
61_E	81_A	0.822	0.99
256_L	264_A	0.819	0.99
249_N	308_Q	0.818	0.99
264_A	270_D	0.816	0.99
47_L	56_V	0.813	0.99
86_A	93_V	0.812	0.99
118_L	330_K	0.810	0.99
147_Q	254_R	0.809	0.99
200_L	281_T	0.808	0.99
57_Q	63_D	0.802	0.98
199_M	236_V	0.801	0.98
102_L	128_A	0.795	0.98
155_V	216_I	0.794	0.98
119_T	123_N	0.794	0.98
262_R	297_V	0.787	0.98
10_L	59_A	0.784	0.98
294_V	309_F	0.783	0.98
43_A	58_D	0.779	0.98
158_L	236_V	0.778	0.98
74_A	78_A	0.778	0.98
274_S	278_E	0.775	0.98
210_V	215_R	0.771	0.98
77_E	80_A	0.770	0.98
201_P	245_A	0.769	0.98
247_M	308_Q	0.763	0.98
242_Y	316_V	0.759	0.98
213_E	217_V	0.754	0.98
136_Q	312_V	0.751	0.98
134_T	203_L	0.749	0.98
156_T	236_V	0.747	0.98
55_T	58_D	0.743	0.97
286_A	293_S	0.741	0.97
84_E	87_T	0.740	0.97
23_T	317_R	0.738	0.97
247_M	310_W	0.738	0.97
12_A	17_G	0.734	0.97
199_M	282_Q	0.733	0.97
255_P	264_A	0.730	0.97
141_L	155_V	0.728	0.97
252_A	255_P	0.726	0.97
35_Y	66_Q	0.725	0.97
113_V	139_A	0.723	0.97
252_A	256_L	0.722	0.97
221_R	228_G	0.722	0.97
132_S	163_A	0.719	0.97
279_F	295_G	0.719	0.97
98_G	211_R	0.714	0.97
62_F	89_S	0.713	0.97
155_V	246_Q	0.708	0.97
169_V	172_L	0.707	0.97
135_S	323_M	0.704	0.96
252_A	261_A	0.704	0.96
148_G	257_A	0.703	0.96
201_P	236_V	0.703	0.96
214_R	217_V	0.702	0.96
96_S	129_V	0.698	0.96
27_R	290_P	0.697	0.96
34_I	54_I	0.696	0.96
164_Q	200_L	0.695	0.96
86_A	97_S	0.691	0.96
115_P	119_T	0.691	0.96
96_S	323_M	0.688	0.96
42_S	50_G	0.687	0.96
131_D	215_R	0.685	0.96
76_K	211_R	0.684	0.96
140_A	292_L	0.682	0.96
134_T	138_L	0.680	0.96
108_L	134_T	0.679	0.96
48_R	52_K	0.679	0.96
84_E	100_F	0.678	0.96
65_T	88_N	0.677	0.96
22_E	25_A	0.677	0.96
9_V	20_L	0.676	0.96
149_G	264_A	0.673	0.95
69_L	94_I	0.669	0.95
22_E	26_E	0.668	0.95
9_V	24_L	0.666	0.95
297_V	307_V	0.663	0.95
5_W	68_Q	0.662	0.95
279_F	298_R	0.659	0.95
243_G	287_S	0.659	0.95
230_M	302_G	0.659	0.95
221_R	227_E	0.658	0.95
36_A	47_L	0.657	0.95
261_A	297_V	0.657	0.95
142_K	145_I	0.655	0.95
301_Y	305_E	0.655	0.95
203_L	209_S	0.655	0.95
57_Q	66_Q	0.654	0.95
114_N	222_K	0.648	0.94
144_L	250_F	0.647	0.94
34_I	52_K	0.647	0.94
94_I	331_L	0.644	0.94
110_V	139_A	0.642	0.94
158_L	199_M	0.642	0.94
27_R	30_P	0.642	0.94
18_E	51_G	0.642	0.94
301_Y	304_P	0.640	0.94
212_E	216_I	0.636	0.94
148_G	264_A	0.634	0.94
138_L	220_V	0.631	0.94
72_F	93_V	0.631	0.94
217_V	231_I	0.630	0.94
25_A	52_K	0.624	0.93
211_R	214_R	0.624	0.93
241_F	287_S	0.623	0.93
117_V	222_K	0.622	0.93
24_L	325_V	0.622	0.93
43_A	55_T	0.620	0.93
194_Q	283_V	0.619	0.93
217_V	221_R	0.619	0.93
109_V	327_I	0.617	0.93
261_A	299_N	0.616	0.93
87_T	90_G	0.613	0.93
148_G	253_L	0.613	0.93
173_A	193_R	0.612	0.93
204_P	210_V	0.611	0.93
26_E	317_R	0.611	0.93
9_V	21_L	0.609	0.92
72_F	79_T	0.603	0.92
216_I	220_V	0.603	0.92
256_L	261_A	0.602	0.92
59_A	62_F	0.601	0.92
171_A	200_L	0.601	0.92
84_E	93_V	0.599	0.92
31_V	49_F	0.598	0.92
201_P	310_W	0.598	0.92
300_D	306_Q	0.597	0.92
103_E	218_D	0.595	0.92
258_A	261_A	0.594	0.91
259_E	276_E	0.594	0.91
7_I	71_F	0.593	0.91
150_L	250_F	0.593	0.91
142_K	224_L	0.592	0.91
149_G	256_L	0.591	0.91
136_Q	292_L	0.590	0.91
155_V	231_I	0.590	0.91
232_S	306_Q	0.590	0.91
154_S	251_E	0.588	0.91
136_Q	244_H	0.588	0.91
67_A	91_C	0.586	0.91
61_E	89_S	0.583	0.91
154_S	247_M	0.581	0.91
266_V	270_D	0.581	0.91
148_G	260_E	0.580	0.90
21_L	36_A	0.579	0.90
58_D	63_D	0.579	0.90
246_Q	311_S	0.578	0.90
195_L	237_Q	0.574	0.90
145_I	153_I	0.574	0.90
15_A	169_V	0.574	0.90
63_D	66_Q	0.572	0.90
102_L	214_R	0.572	0.90
80_A	84_E	0.572	0.90
242_Y	287_S	0.572	0.90
220_V	225_Q	0.571	0.90
76_K	98_G	0.570	0.90
137_L	157_S	0.569	0.90
103_E	106_V	0.567	0.89
197_F	241_F	0.567	0.89
114_N	118_L	0.566	0.89
77_E	97_S	0.563	0.89
278_E	281_T	0.562	0.89
257_A	299_N	0.562	0.89
211_R	215_R	0.560	0.89
268_G	271_I	0.560	0.89
193_R	285_D	0.558	0.89
71_F	325_V	0.558	0.89
139_A	268_G	0.556	0.89
47_L	50_G	0.555	0.88
307_V	310_W	0.553	0.88
151_S	305_E	0.553	0.88
302_G	305_E	0.552	0.88
7_I	328_A	0.552	0.88
72_F	86_A	0.551	0.88
160_S	242_Y	0.550	0.88
137_L	311_S	0.548	0.88
13_T	42_S	0.548	0.88
242_Y	315_N	0.547	0.88
254_R	305_E	0.547	0.88
130_P	135_S	0.546	0.88
265_F	269_E	0.544	0.87
293_S	312_V	0.544	0.87
24_L	328_A	0.544	0.87
197_F	287_S	0.542	0.87
33_E	52_K	0.542	0.87
195_L	198_N	0.541	0.87
79_T	100_F	0.541	0.87
243_G	286_A	0.539	0.87
110_V	323_M	0.539	0.87
161_A	193_R	0.538	0.87
232_S	308_Q	0.538	0.87
12_A	56_V	0.536	0.87
136_Q	315_N	0.535	0.87
13_T	38_A	0.533	0.86
211_R	218_D	0.532	0.86
48_R	51_G	0.530	0.86
155_V	233_A	0.529	0.86
10_L	74_A	0.529	0.86
101_A	132_S	0.529	0.86
20_L	325_V	0.526	0.86
300_D	304_P	0.525	0.86
149_G	252_A	0.525	0.86
78_A	97_S	0.524	0.86
323_M	327_I	0.524	0.86
10_L	37_L	0.522	0.85
135_S	313_A	0.521	0.85
257_A	261_A	0.521	0.85
290_P	326_K	0.520	0.85
12_A	36_A	0.519	0.85
221_R	224_L	0.518	0.85
94_I	324_A	0.518	0.85
134_T	246_Q	0.517	0.85
6_N	67_A	0.514	0.84
21_L	25_A	0.514	0.84
113_V	138_L	0.511	0.84
168_A	171_A	0.511	0.84
295_G	298_R	0.511	0.84
217_V	301_Y	0.508	0.84
100_F	106_V	0.508	0.84
192_G	195_L	0.506	0.83
83_V	86_A	0.506	0.83
101_A	163_A	0.504	0.83
132_S	215_R	0.501	0.83
31_V	34_I	0.501	0.83
262_R	277_N	0.500	0.83
80_A	103_E	0.500	0.83

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2r00A	2	0.9911	100	0.198	Contact Map
2yv3A	2	0.9555	100	0.202	Contact Map
3uw3A	2	0.9763	100	0.204	Contact Map
3pzrA	2	0.9733	100	0.206	Contact Map
1t4bA	2	0.9674	100	0.214	Contact Map
3tz6A	2	0.9644	100	0.221	Contact Map
2hjsA	2	0.9852	100	0.228	Contact Map
1vknA	4	0.8932	100	0.237	Contact Map
4r3nA	2	0.9792	100	0.239	Contact Map
2nqtA	4	0.905	100	0.262	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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