GREMLIN Database
MURB - UDP-N-acetylenolpyruvoylglucosamine reductase
UniProt: P08373 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11205
Length: 342 (325)
Sequences: 2032 (1455)
Seq/√Len: 80.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_I84_G3.5541.00
274_L313_K3.4201.00
88_N91_R2.9661.00
108_A207_F2.9651.00
315_G321_W2.8931.00
129_L133_C2.6631.00
133_C136_V2.6621.00
69_G87_E2.6501.00
236_V263_L2.5531.00
150_T153_E2.4921.00
263_L320_V2.4641.00
82_H177_G2.4641.00
18_Q59_R2.4251.00
114_V176_V2.2701.00
282_A298_A2.2411.00
12_G225_G2.1911.00
236_V240_T2.1651.00
138_S147_V2.1421.00
92_L178_L2.1071.00
133_C156_F2.0931.00
22_C66_R2.0871.00
278_Q295_E2.0821.00
250_T271_Q2.0571.00
71_E82_H2.0501.00
135_Y177_G2.0351.00
218_L222_K2.0011.00
218_L221_P1.9801.00
92_L114_V1.9751.00
193_L210_V1.9671.00
46_L52_V1.9661.00
95_Y99_E1.9441.00
68_K87_E1.9101.00
241_A253_N1.9061.00
266_G289_A1.9061.00
20_I64_I1.9061.00
245_L253_N1.9011.00
129_L178_L1.8981.00
140_E170_R1.8791.00
96_T104_L1.8771.00
11_F227_A1.8641.00
138_S171_F1.8441.00
137_D175_A1.8281.00
154_C163_F1.8231.00
104_L132_V1.7801.00
274_L309_H1.7721.00
70_I95_Y1.7671.00
138_S149_L1.7381.00
90_H108_A1.7341.00
204_Q208_N1.7251.00
114_V178_L1.7201.00
279_I309_H1.7201.00
94_K207_F1.7201.00
41_Q61_T1.7141.00
160_D165_H1.7121.00
284_V306_L1.7011.00
22_C64_I1.6941.00
281_G302_D1.6841.00
147_V153_E1.6451.00
84_G87_E1.6401.00
90_H207_F1.6271.00
75_E182_K1.6211.00
146_Q174_V1.6171.00
192_D195_R1.6121.00
277_M309_H1.6071.00
157_G160_D1.6031.00
278_Q283_A1.5971.00
117_S178_L1.5901.00
238_A242_K1.5811.00
135_Y148_R1.5801.00
4_S14_D1.5791.00
137_D148_R1.5761.00
232_K323_E1.5701.00
16_N57_D1.5460.99
283_A295_E1.5450.99
272_C314_V1.5440.99
155_R166_E1.5400.99
256_Q259_G1.5310.99
274_L277_M1.5300.99
252_P264_A1.5280.99
6_K14_D1.5190.99
13_I300_S1.5180.99
281_G297_N1.5000.99
82_H175_A1.4940.99
98_Q204_Q1.4880.99
219_P222_K1.4880.99
29_L172_A1.4740.99
139_V144_G1.4700.99
97_L203_P1.4590.99
257_A260_S1.4580.99
78_A179_R1.4530.99
237_S240_T1.4480.99
10_T50_S1.4450.99
26_E137_D1.4370.99
134_A179_R1.4350.99
113_C116_S1.4060.99
13_I303_V1.3990.99
27_Q31_N1.3990.99
198_P201_V1.3980.99
241_A245_L1.3950.99
205_Q208_N1.3940.99
80_Y134_A1.3830.99
24_E28_Q1.3760.99
140_E147_V1.3760.99
13_I53_L1.3660.99
21_V61_T1.3640.99
117_S122_I1.3580.99
282_A306_L1.3550.99
140_E143_T1.3470.99
19_H41_Q1.3340.98
80_Y179_R1.3320.98
224_N293_I1.3270.98
19_H61_T1.3180.98
304_V328_F1.3140.98
9_N54_F1.3080.98
309_H313_K1.2990.98
81_L92_L1.2970.98
244_L251_A1.2890.98
240_T243_A1.2820.98
207_F211_C1.2690.98
47_G113_C1.2670.98
82_H137_D1.2500.98
283_A293_I1.2480.98
133_C178_L1.2310.97
274_L310_V1.2230.97
140_E145_K1.2220.97
83_V92_L1.2200.97
285_H288_Q1.2170.97
44_L58_Y1.2100.97
79_W101_M1.2040.97
21_V32_A1.2020.97
253_N261_V1.2000.97
141_L172_A1.1960.97
298_A303_V1.1720.97
264_A288_Q1.1620.96
92_L104_L1.1540.96
139_V146_Q1.1510.96
278_Q281_G1.1510.96
311_R321_W1.1450.96
196_L216_T1.1400.96
104_L178_L1.1210.96
242_K245_L1.1140.95
13_I282_A1.1140.95
8_W20_I1.1130.95
45_I172_A1.1110.95
308_H311_R1.1100.95
299_K302_D1.1090.95
42_P59_R1.1080.95
148_R177_G1.1040.95
139_V143_T1.1030.95
53_L326_V1.1000.95
43_V63_I1.0990.95
241_A251_A1.0950.95
241_A261_V1.0930.95
282_A303_V1.0900.95
97_L204_Q1.0840.95
272_C317_K1.0820.95
19_H35_Y1.0810.95
196_L212_H1.0800.95
11_F53_L1.0800.95
215_T220_D1.0750.94
189_T194_T1.0740.94
90_H94_K1.0670.94
292_L306_L1.0650.94
133_C176_V1.0620.94
36_A43_V1.0620.94
201_V205_Q1.0610.94
304_V324_P1.0600.94
55_L300_S1.0540.94
294_N298_A1.0490.94
137_D146_Q1.0470.94
32_A36_A1.0420.93
211_C215_T1.0340.93
266_G288_Q1.0340.93
238_A259_G1.0310.93
277_M313_K1.0310.93
283_A286_R1.0290.93
202_T205_Q1.0270.93
53_L282_A1.0250.93
26_E67_I1.0240.93
238_A258_D1.0160.93
95_Y101_M1.0140.92
104_L203_P1.0130.92
155_R165_H1.0100.92
208_N212_H1.0060.92
118_P156_F1.0050.92
54_F58_Y1.0020.92
137_D177_G0.9990.92
117_S129_L0.9910.92
301_E305_Q0.9890.92
9_N14_D0.9860.91
65_N85_A0.9850.91
220_D223_V0.9820.91
11_F225_G0.9770.91
44_L60_G0.9770.91
69_G84_G0.9740.91
256_Q260_S0.9730.91
201_V206_V0.9730.91
25_D28_Q0.9680.91
245_L251_A0.9670.91
57_D300_S0.9620.90
13_I298_A0.9550.90
65_N172_A0.9530.90
197_D201_V0.9410.89
286_R295_E0.9410.89
302_D305_Q0.9350.89
307_A324_P0.9340.89
96_T101_M0.9300.89
243_A247_Q0.9280.89
15_H57_D0.9210.88
23_A36_A0.9150.88
198_P205_Q0.9100.88
285_H291_V0.9090.88
67_I87_E0.9000.87
313_K316_E0.8940.87
155_R160_D0.8860.86
83_V178_L0.8860.86
6_K9_N0.8840.86
70_I87_E0.8800.86
274_L284_V0.8780.86
26_E146_Q0.8740.86
23_A65_N0.8710.85
74_D80_Y0.8690.85
5_L17_A0.8620.85
215_T223_V0.8560.84
240_T319_N0.8530.84
102_P203_P0.8500.84
109_L211_C0.8430.83
94_K97_L0.8430.83
92_L96_T0.8400.83
30_L34_Q0.8330.83
97_L207_F0.8300.82
157_G235_V0.8280.82
284_V310_V0.8270.82
72_I101_M0.8270.82
83_V114_V0.8240.82
33_W139_V0.8160.81
209_A212_H0.8150.81
20_I66_R0.8120.81
113_C117_S0.8100.81
192_D213_M0.8090.81
255_P261_V0.8060.81
239_E242_K0.8040.80
24_E66_R0.8040.80
109_L215_T0.8030.80
73_H82_H0.8010.80
119_I163_F0.7970.80
80_Y177_G0.7960.80
141_L169_D0.7950.80
280_G302_D0.7870.79
234_P265_A0.7850.79
94_K98_Q0.7830.79
104_L180_L0.7830.79
133_C151_A0.7800.78
248_F251_A0.7790.78
55_L326_V0.7780.78
25_D67_I0.7730.78
23_A63_I0.7720.78
142_A170_R0.7640.77
149_L171_F0.7620.77
237_S260_S0.7600.77
43_V141_L0.7590.76
186_P203_P0.7590.76
227_A292_L0.7590.76
184_W206_V0.7580.76
129_L136_V0.7540.76
270_D318_F0.7520.76
127_V132_V0.7510.76
127_V187_V0.7500.76
81_L101_M0.7480.75
191_G266_G0.7470.75
281_G296_D0.7470.75
311_R324_P0.7450.75
53_L298_A0.7430.75
32_A38_A0.7430.75
139_V174_V0.7420.75
140_E144_G0.7400.75
47_G54_F0.7390.75
90_H109_L0.7390.75
184_W203_P0.7350.74
82_H135_Y0.7340.74
270_D289_A0.7320.74
33_W141_L0.7260.73
129_L132_V0.7260.73
23_A172_A0.7240.73
23_A29_L0.7220.73
11_F284_V0.7170.72
252_P326_V0.7160.72
196_L209_A0.7120.72
52_V227_A0.7100.72
104_L127_V0.7080.71
271_Q318_F0.7050.71
102_P184_W0.7040.71
205_Q209_A0.7030.71
79_W182_K0.7030.71
90_H211_C0.7010.71
87_E92_L0.7010.71
89_W122_I0.6970.70
224_N285_H0.6970.70
284_V292_L0.6960.70
75_E80_Y0.6960.70
97_L104_L0.6940.70
54_F326_V0.6920.70
26_E30_L0.6910.70
72_I79_W0.6880.69
81_L95_Y0.6870.69
79_W184_W0.6870.69
81_L96_T0.6850.69
53_L324_P0.6840.69
188_L193_L0.6820.69
23_A32_A0.6810.68
94_K108_A0.6790.68
84_G175_A0.6780.68
72_I99_E0.6780.68
18_Q41_Q0.6770.68
168_Q171_F0.6740.68
245_L249_P0.6730.67
72_I75_E0.6710.67
65_N87_E0.6700.67
225_G284_V0.6690.67
155_R162_I0.6670.67
48_E88_N0.6660.67
186_P206_V0.6660.67
65_N113_C0.6660.67
193_L207_F0.6650.67
181_P184_W0.6570.66
54_F62_V0.6520.65
68_K84_G0.6520.65
315_G319_N0.6520.65
29_L67_I0.6510.65
78_A182_K0.6500.65
238_A261_V0.6490.65
225_G296_D0.6490.65
55_L329_I0.6470.64
238_A257_A0.6450.64
11_F55_L0.6420.64
91_R94_K0.6420.64
273_Q319_N0.6410.64
162_I166_E0.6390.63
46_L62_V0.6390.63
281_G295_E0.6390.63
11_F310_V0.6390.63
36_A61_T0.6380.63
312_Q316_E0.6370.63
236_V244_L0.6350.63
15_H300_S0.6330.63
264_A285_H0.6330.63
11_F294_N0.6320.63
20_I61_T0.6300.62
35_Y39_E0.6250.62
102_P183_E0.6240.62
127_V266_G0.6230.62
130_Q151_A0.6220.61
206_V210_V0.6210.61
35_Y41_Q0.6210.61
253_N264_A0.6210.61
271_Q317_K0.6200.61
108_A211_C0.6190.61
156_F232_K0.6170.61
92_L129_L0.6160.61
107_L127_V0.6140.60
193_L196_L0.6140.60
78_A206_V0.6130.60
186_P205_Q0.6130.60
122_I129_L0.6120.60
304_V308_H0.6110.60
43_V61_T0.6100.60
79_W181_P0.6100.60
87_E95_Y0.6090.60
244_L263_L0.6050.59
37_T43_V0.6040.59
245_L250_T0.6020.59
13_I292_L0.5990.59
35_Y38_A0.5990.59
243_A246_S0.5990.59
25_D30_L0.5980.58
298_A302_D0.5980.58
33_W43_V0.5960.58
324_P328_F0.5940.58
294_N303_V0.5930.58
293_I296_D0.5930.58
89_W93_V0.5920.58
273_Q293_I0.5920.58
160_D270_D0.5910.58
270_D275_K0.5910.58
122_I218_L0.5900.57
71_E84_G0.5890.57
191_G288_Q0.5820.56
44_L329_I0.5810.56
224_N295_E0.5800.56
300_S303_V0.5800.56
38_A43_V0.5800.56
192_D217_K0.5800.56
11_F326_V0.5790.56
235_V260_S0.5780.56
17_A54_F0.5780.56
106_N127_V0.5770.56
138_S173_I0.5760.56
149_L162_I0.5760.56
136_V175_A0.5750.55
80_Y182_K0.5730.55
166_E170_R0.5720.55
310_V316_E0.5710.55
282_A285_H0.5700.55
282_A307_A0.5670.54
83_V108_A0.5640.54
32_A63_I0.5640.54
9_N48_E0.5640.54
282_A294_N0.5630.54
61_T173_I0.5620.54
75_E101_M0.5610.54
288_Q291_V0.5610.54
192_D216_T0.5610.54
248_F266_G0.5600.54
109_L288_Q0.5570.53
199_T205_Q0.5570.53
44_L52_V0.5570.53
134_A177_G0.5570.53
92_L119_I0.5560.53
129_L176_V0.5540.53
106_N219_P0.5530.53
272_C313_K0.5500.52
138_S146_Q0.5500.52
30_L146_Q0.5490.52
248_F318_F0.5490.52
36_A41_Q0.5490.52
162_I171_F0.5470.52
305_Q309_H0.5470.52
9_N15_H0.5440.51
192_D196_L0.5430.51
223_V287_Q0.5430.51
264_A320_V0.5420.51
70_I99_E0.5420.51
81_L136_V0.5410.51
73_H177_G0.5410.51
312_Q315_G0.5400.51
267_W271_Q0.5390.51
292_L303_V0.5390.51
31_N34_Q0.5380.51
77_D182_K0.5370.51
134_A151_A0.5370.51
77_D183_E0.5360.50
307_A328_F0.5330.50
18_Q58_Y0.5320.50
248_F271_Q0.5310.50
15_H55_L0.5300.50
264_A289_A0.5290.50
18_Q60_G0.5280.49
131_R139_V0.5270.49
104_L176_V0.5250.49
31_N35_Y0.5250.49
109_L291_V0.5240.49
217_K275_K0.5230.49
92_L95_Y0.5220.49
23_A119_I0.5210.48
282_A300_S0.5200.48
282_A295_E0.5190.48
313_K317_K0.5190.48
238_A256_Q0.5190.48
252_P318_F0.5180.48
37_T40_G0.5180.48
279_I283_A0.5180.48
29_L65_N0.5170.48
30_L139_V0.5150.48
34_Q242_K0.5140.48
186_P201_V0.5130.47
236_V261_V0.5130.47
106_N218_L0.5130.47
72_I95_Y0.5120.47
27_Q30_L0.5120.47
134_A203_P0.5120.47
116_S119_I0.5110.47
93_V96_T0.5100.47
45_I63_I0.5080.47
42_P60_G0.5070.47
162_I165_H0.5070.47
221_P226_N0.5060.47
70_I96_T0.5050.46
34_Q144_G0.5050.46
308_H312_Q0.5040.46
116_S136_V0.5040.46
68_K323_E0.5030.46
268_L322_L0.5030.46
37_T63_I0.5030.46
44_L62_V0.5020.46
265_A322_L0.5020.46
201_V213_M0.5010.46
75_E79_W0.5010.46
102_P186_P0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i99A 1 0.9766 100 0.323 Contact Map
4jb1A 1 0.9591 100 0.355 Contact Map
1uxyA 1 0.9942 100 0.384 Contact Map
2gqtA 1 0.7573 100 0.466 Contact Map
1hskA 1 0.8275 100 0.474 Contact Map
4pytA 1 0.8246 100 0.475 Contact Map
3tx1A 1 0.8158 100 0.533 Contact Map
1wvfA 2 0.883 99.9 0.814 Contact Map
1zr6A 1 0.9269 99.9 0.816 Contact Map
3rjaA 1 0.9386 99.9 0.818 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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