GREMLIN Database
CRED - Inner membrane protein CreD
UniProt: P08369 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10145
Length: 450 (425)
Sequences: 451 (340)
Seq/√Len: 16.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_A197_L9.2671.00
98_Q282_V7.2351.00
45_I110_G6.1961.00
292_T341_L4.8561.00
302_L392_M4.6091.00
363_M415_A4.5081.00
24_I299_A4.1861.00
96_G222_L4.1541.00
171_G180_G4.1401.00
365_G382_T3.5451.00
103_R240_R3.5271.00
105_I230_S3.3640.99
224_S246_G3.3150.99
338_L421_T3.2010.99
363_M411_V3.1010.99
332_S364_N2.8850.98
108_Y333_L2.8800.98
37_Y41_V2.7560.97
53_Q149_D2.6040.96
170_P215_G2.5680.96
112_V291_L2.5460.96
356_A408_S2.4800.95
323_P427_Y2.3960.94
312_V360_G2.3300.93
359_I411_V2.3200.93
396_L421_T2.2860.92
350_T393_W2.2360.91
49_T258_N2.2120.91
119_L199_M2.1790.90
50_S288_Q2.1690.90
96_G117_L2.1500.90
88_L259_N2.1250.89
254_S257_A2.0880.88
152_G292_T2.0680.88
171_G259_N2.0570.87
60_I356_A2.0330.87
102_E109_T2.0290.87
100_V225_N1.9780.85
304_A308_M1.9670.85
171_G182_H1.9610.85
44_A105_I1.9540.84
361_A386_L1.9380.84
379_M383_L1.9270.84
149_D152_G1.9150.83
152_G323_P1.8920.82
152_G363_M1.8190.80
220_M278_F1.7960.79
41_V282_V1.7940.79
411_V415_A1.7800.78
322_H426_W1.7800.78
293_D395_L1.7570.77
398_S401_S1.7530.77
293_D297_K1.7470.77
334_V357_S1.7400.77
342_A413_A1.7300.76
392_M396_L1.7270.76
376_C390_G1.7130.75
19_L22_I1.7060.75
251_W322_H1.6900.74
74_D95_D1.6830.74
392_M421_T1.6810.74
75_K131_L1.6490.73
50_S151_R1.6380.72
33_E37_Y1.6380.72
41_V45_I1.6330.72
239_K250_H1.6100.71
279_S287_D1.6040.70
391_V409_V1.5850.69
9_K328_L1.5660.69
98_Q224_S1.5630.68
360_G421_T1.5590.68
33_E279_S1.5520.68
116_D202_N1.5490.68
41_V44_A1.5190.66
358_L362_I1.5170.66
338_L392_M1.4990.65
72_E79_R1.4980.65
159_P183_I1.4960.65
411_V426_W1.4850.64
95_D223_T1.4640.63
55_L98_Q1.4570.63
108_Y303_I1.4520.62
25_M29_Q1.4410.62
306_T395_L1.4380.62
90_E124_D1.4340.61
90_E216_R1.4270.61
63_P400_D1.4260.61
129_S136_I1.4130.60
41_V106_G1.4080.60
231_F242_V1.4050.60
121_A161_V1.3970.59
302_L378_S1.3800.58
161_V197_L1.3800.58
253_S256_F1.3650.58
44_A138_L1.3540.57
301_L372_L1.3520.57
23_P112_V1.3240.55
41_V110_G1.3160.55
9_K199_M1.3150.55
19_L348_G1.3130.55
41_V144_V1.3030.54
103_R302_L1.3020.54
336_F367_Y1.2960.54
249_A336_F1.2920.53
350_T354_I1.2900.53
201_L316_L1.2870.53
40_D62_I1.2830.53
41_V308_M1.2810.53
151_R352_A1.2720.52
211_V279_S1.2670.52
148_G291_L1.2660.52
38_R287_D1.2630.52
180_G215_G1.2620.52
316_L361_A1.2590.51
226_W422_R1.2560.51
224_S399_A1.2550.51
53_Q203_L1.2530.51
93_M219_E1.2510.51
211_V408_S1.2490.51
220_M279_S1.2480.51
344_S347_T1.2470.51
180_G259_N1.2450.51
55_L115_S1.2410.50
143_I362_I1.2390.50
327_L344_S1.2310.50
290_Q308_M1.2280.50
113_W217_N1.2260.49
141_P258_N1.2230.49
4_S292_T1.2200.49
153_I171_G1.2110.49
307_F332_S1.2010.48
257_A391_V1.1920.47
56_V212_V1.1870.47
322_H325_Q1.1820.47
60_I97_N1.1800.47
50_S115_S1.1720.46
49_T206_T1.1710.46
323_P426_W1.1690.46
117_L240_R1.1660.46
302_L421_T1.1650.46
53_Q314_E1.1640.46
13_L107_I1.1640.46
122_D196_K1.1560.45
396_L422_R1.1550.45
342_A407_T1.1520.45
335_M410_L1.1490.45
120_K198_N1.1490.45
112_V356_A1.1470.45
27_I292_T1.1400.44
170_P218_S1.1390.44
303_I337_Y1.1360.44
299_A337_Y1.1330.44
215_G255_W1.1290.44
103_R112_V1.1210.43
49_T112_V1.1210.43
33_E113_W1.1200.43
151_R329_V1.1190.43
57_G402_A1.1140.43
325_Q346_H1.1070.42
149_D395_L1.1010.42
72_E77_V1.1000.42
235_F342_A1.0990.42
306_T385_L1.0990.42
216_R278_F1.0970.42
53_Q58_P1.0920.42
400_D420_V1.0910.42
338_L396_L1.0890.41
348_G395_L1.0840.41
313_F319_Q1.0830.41
253_S258_N1.0820.41
62_I87_W1.0820.41
40_D335_M1.0800.41
232_L281_A1.0790.41
316_L424_I1.0740.41
24_I352_A1.0690.40
216_R292_T1.0640.40
339_L411_V1.0600.40
103_R341_L1.0580.40
50_S299_A1.0560.40
24_I301_L1.0450.39
58_P152_G1.0420.39
422_R427_Y1.0420.39
68_Y81_R1.0410.39
297_K410_L1.0400.39
333_L410_L1.0360.38
64_V305_L1.0360.38
195_L243_S1.0250.38
149_D171_G1.0210.38
246_G399_A1.0190.37
108_Y404_L1.0180.37
89_P180_G1.0170.37
381_F427_Y1.0160.37
331_L339_L1.0050.37
120_K129_S1.0020.37
62_I327_L1.0020.37
162_N283_T1.0010.37
44_A48_S0.9970.36
290_Q293_D0.9970.36
87_W128_L0.9960.36
206_T364_N0.9900.36
260_L337_Y0.9900.36
50_S381_F0.9890.36
206_T410_L0.9830.36
33_E121_A0.9790.35
92_L356_A0.9780.35
96_G242_V0.9730.35
260_L276_P0.9730.35
88_L260_L0.9720.35
235_F257_A0.9710.35
14_F181_V0.9670.35
13_L16_A0.9660.35
224_S280_V0.9640.35
121_A279_S0.9620.34
33_E44_A0.9590.34
66_E83_F0.9580.34
57_G218_S0.9560.34
242_V390_G0.9540.34
49_T204_S0.9530.34
324_M347_T0.9480.34
312_V356_A0.9480.34
160_E165_A0.9460.34
222_L360_G0.9400.33
363_M426_W0.9320.33
287_D363_M0.9320.33
292_T323_P0.9300.33
289_Y389_D0.9300.33
145_I198_N0.9230.32
9_K287_D0.9220.32
9_K420_V0.9210.32
300_I427_Y0.9200.32
59_L306_T0.9170.32
185_L355_I0.9080.32
306_T410_L0.9030.31
33_E311_F0.9020.31
353_W389_D0.8980.31
6_L344_S0.8880.31
50_S256_F0.8870.31
168_I424_I0.8860.30
27_I209_L0.8840.30
50_S360_G0.8840.30
106_G283_T0.8800.30
346_H367_Y0.8800.30
110_G121_A0.8790.30
287_D323_P0.8770.30
57_G92_L0.8760.30
313_F343_L0.8750.30
214_G352_A0.8740.30
328_L341_L0.8740.30
76_T379_M0.8730.30
343_L348_G0.8710.30
256_F290_Q0.8700.30
168_I319_Q0.8690.30
371_V405_L0.8680.30
150_A257_A0.8670.30
144_V182_H0.8650.29
193_Q412_V0.8650.29
20_L333_L0.8640.29
255_W258_N0.8630.29
288_Q348_G0.8620.29
8_W13_L0.8620.29
89_P402_A0.8600.29
80_K120_K0.8600.29
282_V301_L0.8590.29
118_T200_A0.8580.29
360_G368_L0.8560.29
90_E350_T0.8560.29
49_T394_G0.8550.29
64_V393_W0.8530.29
120_K386_L0.8520.29
215_G262_E0.8510.29
54_K143_I0.8500.29
366_I419_F0.8470.29
371_V397_N0.8460.29
230_S312_V0.8460.29
310_F323_P0.8450.28
153_I225_N0.8440.28
145_I168_I0.8430.28
31_I341_L0.8420.28
333_L385_L0.8410.28
148_G313_F0.8380.28
360_G393_W0.8380.28
63_P371_V0.8350.28
287_D372_L0.8340.28
53_Q152_G0.8320.28
171_G367_Y0.8280.28
204_S258_N0.8270.28
228_H285_P0.8260.28
99_N383_L0.8220.27
241_E245_S0.8220.27
199_M280_V0.8210.27
112_V392_M0.8200.27
106_G286_A0.8190.27
100_V328_L0.8170.27
64_V413_A0.8150.27
145_I181_V0.8140.27
332_S389_D0.8140.27
15_G174_L0.8130.27
280_V330_G0.8110.27
368_L381_F0.8100.27
260_L395_L0.8100.27
151_R333_L0.8090.27
199_M310_F0.8090.27
49_T121_A0.8070.27
321_L397_N0.8060.27
10_M199_M0.8060.27
341_L364_N0.8060.27
113_W353_W0.8060.27
312_V357_S0.8050.27
413_A417_M0.8040.27
287_D290_Q0.8000.26
97_N248_Q0.8000.26
16_A307_F0.7970.26
413_A421_T0.7940.26
30_V37_Y0.7920.26
24_I295_A0.7920.26
58_P92_L0.7900.26
160_E163_G0.7900.26
258_N262_E0.7890.26
48_S409_V0.7890.26
9_K173_G0.7890.26
114_H299_A0.7840.26
228_H399_A0.7820.26
20_L27_I0.7790.25
143_I332_S0.7790.25
376_C387_L0.7760.25
103_R108_Y0.7760.25
180_G414_L0.7740.25
37_Y45_I0.7720.25
369_Q378_S0.7690.25
50_S258_N0.7690.25
83_F393_W0.7680.25
335_M368_L0.7650.25
378_S382_T0.7640.25
125_V194_N0.7640.25
88_L264_F0.7630.25
56_V395_L0.7620.25
302_L389_D0.7610.25
241_E357_S0.7610.25
9_K329_V0.7580.24
333_L417_M0.7570.24
72_E387_L0.7570.24
80_K379_M0.7560.24
16_A215_G0.7550.24
218_S348_G0.7550.24
231_F247_F0.7530.24
88_L337_Y0.7510.24
302_L341_L0.7490.24
100_V261_G0.7490.24
13_L264_F0.7460.24
223_T245_S0.7460.24
19_L275_F0.7450.24
331_L416_G0.7440.24
283_T363_M0.7430.24
336_F422_R0.7410.24
324_M413_A0.7410.24
112_V290_Q0.7400.24
222_L329_V0.7380.24
228_H360_G0.7380.24
354_I361_A0.7370.24
73_E355_I0.7360.24
108_Y337_Y0.7350.24
29_Q143_I0.7340.23
224_S235_F0.7320.23
77_V248_Q0.7320.23
342_A402_A0.7310.23
41_V337_Y0.7300.23
168_I316_L0.7290.23
312_V421_T0.7260.23
232_L235_F0.7240.23
302_L400_D0.7190.23
33_E168_I0.7160.23
27_I334_V0.7150.23
293_D372_L0.7140.23
20_L330_G0.7130.23
163_G244_E0.7130.23
86_F256_F0.7090.22
359_I363_M0.7080.22
367_Y421_T0.7060.22
314_E328_L0.7050.22
5_P398_S0.7040.22
121_A168_I0.7040.22
310_F372_L0.7040.22
305_L338_L0.7030.22
68_Y383_L0.7030.22
119_L304_A0.7010.22
244_E428_A0.7000.22
50_S249_A0.6980.22
368_L394_G0.6980.22
161_V195_L0.6970.22
192_K196_K0.6940.22
9_K387_L0.6930.22
204_S385_L0.6920.22
258_N261_G0.6920.22
323_P422_R0.6920.22
20_L303_I0.6900.22
21_L29_Q0.6880.22
325_Q427_Y0.6880.22
243_S248_Q0.6870.22
197_L279_S0.6870.22
75_K379_M0.6860.21
22_I26_L0.6840.21
328_L360_G0.6830.21
224_S356_A0.6830.21
50_S204_S0.6820.21
193_Q361_A0.6820.21
88_L108_Y0.6810.21
62_I91_S0.6800.21
295_A299_A0.6800.21
368_L409_V0.6790.21
243_S362_I0.6770.21
23_P103_R0.6770.21
162_N244_E0.6760.21
361_A370_A0.6750.21
115_S337_Y0.6740.21
65_T97_N0.6730.21
60_I217_N0.6720.21
392_M409_V0.6710.21
95_D221_T0.6690.21
251_W400_D0.6670.21
30_V407_T0.6660.21
18_L80_K0.6660.21
329_V427_Y0.6650.21
264_F341_L0.6640.21
165_A354_I0.6630.21
362_I412_V0.6630.21
181_V423_N0.6630.21
31_I278_F0.6610.21
61_A144_V0.6610.21
149_D360_G0.6610.21
171_G215_G0.6600.20
322_H425_D0.6600.20
399_A417_M0.6590.20
147_V314_E0.6590.20
91_S132_N0.6580.20
101_E243_S0.6580.20
152_G310_F0.6580.20
251_W325_Q0.6560.20
53_Q180_G0.6540.20
335_M414_L0.6540.20
246_G422_R0.6530.20
336_F346_H0.6520.20
44_A87_W0.6520.20
199_M306_T0.6500.20
76_T354_I0.6500.20
99_N225_N0.6490.20
393_W422_R0.6490.20
45_I107_I0.6470.20
218_S321_L0.6450.20
107_I115_S0.6440.20
247_F356_A0.6430.20
290_Q337_Y0.6420.20
44_A279_S0.6420.20
186_P198_N0.6410.20
26_L31_I0.6410.20
285_P372_L0.6410.20
310_F371_V0.6400.20
257_A260_L0.6390.20
162_N365_G0.6370.20
28_R296_T0.6360.20
87_W190_W0.6350.20
347_T351_V0.6340.20
335_M416_G0.6340.20
229_P330_G0.6330.19
309_A328_L0.6330.19
206_T295_A0.6330.19
260_L348_G0.6320.19
39_S163_G0.6320.19
162_N223_T0.6310.19
224_S310_F0.6300.19
7_F306_T0.6300.19
198_N379_M0.6280.19
120_K223_T0.6270.19
280_V344_S0.6260.19
57_G240_R0.6240.19
55_L208_D0.6240.19
37_Y40_D0.6230.19
226_W249_A0.6230.19
134_P387_L0.6230.19
320_R427_Y0.6230.19
223_T248_Q0.6230.19
50_S308_M0.6220.19
254_S410_L0.6220.19
106_G301_L0.6210.19
100_V342_A0.6200.19
197_L216_R0.6190.19
191_R194_N0.6190.19
286_A315_T0.6170.19
240_R327_L0.6150.19
60_I87_W0.6120.19
283_T411_V0.6120.19
413_A428_A0.6100.19
206_T381_F0.6100.19
290_Q397_N0.6090.19
218_S279_S0.6070.19
107_I400_D0.6070.19
360_G411_V0.6060.18
147_V203_L0.6060.18
55_L119_L0.6060.18
236_L264_F0.6030.18
229_P240_R0.6010.18
57_G246_G0.6000.18
200_A383_L0.6000.18
152_G344_S0.6000.18
76_T287_D0.6000.18
360_G363_M0.5930.18
188_G219_E0.5920.18
108_Y281_A0.5910.18
76_T386_L0.5910.18
9_K340_L0.5900.18
199_M355_I0.5890.18
360_G392_M0.5870.18
308_M417_M0.5860.18
4_S344_S0.5860.18
108_Y310_F0.5850.18
336_F421_T0.5850.18
111_Q398_S0.5840.18
310_F422_R0.5840.18
320_R331_L0.5830.18
42_E278_F0.5820.18
53_Q171_G0.5820.18
168_I199_M0.5800.18
28_R211_V0.5790.18
14_F204_S0.5780.18
100_V107_I0.5780.18
127_R234_D0.5770.17
20_L305_L0.5760.17
113_W282_V0.5750.17
26_L414_L0.5750.17
231_F237_P0.5750.17
375_W393_W0.5740.17
94_V238_A0.5730.17
394_G405_L0.5720.17
297_K313_F0.5720.17
191_R243_S0.5720.17
8_W27_I0.5720.17
61_A393_W0.5700.17
357_S361_A0.5700.17
43_D164_T0.5690.17
37_Y44_A0.5690.17
49_T308_M0.5680.17
96_G115_S0.5670.17
194_N223_T0.5660.17
94_V218_S0.5640.17
8_W393_W0.5610.17
76_T99_N0.5600.17
282_V317_T0.5600.17
295_A399_A0.5590.17
180_G282_V0.5580.17
81_R129_S0.5580.17
149_D203_L0.5580.17
61_A86_F0.5570.17
303_I340_L0.5550.17
103_R142_F0.5530.17
356_A370_A0.5520.17
198_N351_V0.5520.17
111_Q284_T0.5480.17
189_D242_V0.5480.17
154_G299_A0.5480.17
21_L386_L0.5470.16
138_L413_A0.5460.16
55_L416_G0.5460.16
380_L383_L0.5460.16
109_T424_I0.5450.16
158_A355_I0.5430.16
212_V277_A0.5430.16
50_S235_F0.5430.16
350_T397_N0.5410.16
258_N276_P0.5410.16
103_R218_S0.5400.16
143_I185_L0.5400.16
44_A218_S0.5390.16
195_L252_Q0.5390.16
59_L316_L0.5380.16
63_P138_L0.5380.16
90_E366_I0.5380.16
337_Y361_A0.5360.16
146_S356_A0.5350.16
90_E217_N0.5350.16
141_P262_E0.5340.16
39_S112_V0.5330.16
108_Y138_L0.5330.16
243_S424_I0.5320.16
379_M408_S0.5310.16
214_G423_N0.5300.16
39_S423_N0.5290.16
293_D360_G0.5280.16
59_L410_L0.5280.16
181_V394_G0.5270.16
23_P401_S0.5260.16
186_P189_D0.5250.16
149_D314_E0.5250.16
220_M386_L0.5240.16
261_G264_F0.5230.16
92_L218_S0.5220.16
60_I151_R0.5210.16
346_H402_A0.5190.16
133_A354_I0.5190.16
66_E398_S0.5190.16
354_I373_K0.5170.16
163_G178_G0.5170.16
15_G120_K0.5160.16
193_Q277_A0.5160.16
368_L398_S0.5160.16
17_V181_V0.5150.15
331_L341_L0.5150.15
111_Q228_H0.5130.15
170_P255_W0.5130.15
92_L335_M0.5120.15
15_G130_E0.5120.15
38_R103_R0.5110.15
391_V398_S0.5100.15
339_L408_S0.5100.15
332_S357_S0.5090.15
36_D43_D0.5080.15
321_L324_M0.5080.15
310_F321_L0.5080.15
96_G311_F0.5080.15
57_G89_P0.5070.15
48_S338_L0.5070.15
69_T374_G0.5060.15
152_G203_L0.5060.15
303_I397_N0.5060.15
38_R152_G0.5060.15
143_I245_S0.5060.15
231_F280_V0.5050.15
143_I423_N0.5040.15
305_L340_L0.5040.15
310_F368_L0.5040.15
107_I256_F0.5040.15
85_H138_L0.5040.15
206_T306_T0.5040.15
404_L417_M0.5030.15
22_I379_M0.5020.15
151_R323_P0.5020.15
52_P221_T0.5010.15
308_M381_F0.5010.15
109_T287_D0.5010.15
371_V377_N0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4he8J 1 0.2733 68.1 0.975 Contact Map
4aw7A 1 0.3089 23 0.981 Contact Map
3rkoJ 1 0.2911 20.1 0.982 Contact Map
3b5dA 2 0.2222 11.9 0.984 Contact Map
4x5mA 2 0.1822 9.4 0.984 Contact Map
4qtnA 3 0.2756 9.1 0.985 Contact Map
4j05A 3 0.3644 9.1 0.985 Contact Map
1pw4A 1 0.4356 4.9 0.986 Contact Map
4qncA 2 0.1556 4.9 0.986 Contact Map
4c7rA 3 0.1578 4.4 0.987 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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