GREMLIN Database
CREB - Transcriptional regulatory protein CreB
UniProt: P08368 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11218
Length: 229 (205)
Sequences: 79335 (57500)
Seq/√Len: 4016.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_A32_V3.6881.00
16_A34_E3.2841.00
20_V32_V3.2151.00
9_V39_V2.7461.00
40_L68_Q2.7111.00
37_L59_D2.5071.00
31_E48_P2.4281.00
36_G60_I2.3541.00
60_I68_Q2.3181.00
44_R72_L2.3141.00
35_R59_D2.2531.00
5_T31_E2.1201.00
22_M108_P2.0781.00
31_E42_K2.0691.00
26_E112_C2.0591.00
33_F42_K2.0181.00
5_T29_A2.0171.00
20_V24_Q1.9931.00
31_E46_Q1.9861.00
56_G84_R1.9251.00
34_E38_P1.8581.00
53_L65_L1.8151.00
193_R196_D1.7831.00
66_C78_V1.7701.00
90_R110_E1.7591.00
35_R38_P1.7431.00
80_F93_G1.7001.00
7_W33_F1.6871.00
68_Q72_L1.6801.00
67_R96_I1.6581.00
70_L99_D1.6581.00
158_Y161_L1.6521.00
42_K46_Q1.6291.00
176_R196_D1.6191.00
80_F98_A1.5941.00
36_G65_L1.5871.00
60_I64_E1.5651.00
4_E119_L1.5541.00
87_E107_S1.5371.00
164_K168_K1.5371.00
100_D114_R1.5291.00
61_S64_E1.5191.00
165_T182_S1.4981.00
43_A69_L1.4951.00
42_K45_K1.4811.00
23_L115_V1.4711.00
68_Q71_A1.4511.00
51_M76_L1.4451.00
84_R89_D1.4251.00
174_W182_S1.4151.00
37_L60_I1.4091.00
198_H201_T1.3991.00
175_S178_Q1.3841.00
66_C80_F1.3801.00
136_H149_F1.3801.00
13_Q34_E1.3421.00
169_S172_R1.3381.00
64_E67_R1.3371.00
40_L65_L1.3281.00
79_L118_L1.3251.00
50_V115_V1.3031.00
42_K48_P1.2981.00
99_D121_R1.2661.00
55_V63_F1.2651.00
99_D118_L1.2641.00
5_T46_Q1.2601.00
63_F93_G1.2531.00
165_T169_S1.2451.00
40_L60_I1.2281.00
10_E16_A1.2161.00
41_D45_K1.2111.00
73_H76_L1.2111.00
9_V57_L1.2081.00
11_D54_D1.2021.00
28_F116_R1.1971.00
112_C116_R1.1891.00
159_E205_K1.1851.00
160_F164_K1.1851.00
92_L96_I1.1841.00
178_Q182_S1.1681.00
38_P41_D1.1561.00
53_L66_C1.1481.00
38_P42_K1.1471.00
7_W48_P1.1391.00
33_F39_V1.1331.00
86_E89_D1.1291.00
55_V80_F1.1221.00
63_F92_L1.1181.00
37_L41_D1.1141.00
7_W39_V1.1081.00
26_E116_R1.0921.00
138_E147_S1.0891.00
6_V28_F1.0751.00
87_E91_L1.0691.00
177_Q192_D1.0611.00
145_Q152_P1.0591.00
113_A117_T1.0591.00
7_W42_K1.0491.00
27_G116_R1.0481.00
133_R138_E1.0451.00
91_L95_E1.0341.00
39_V65_L1.0301.00
165_T174_W1.0271.00
33_F38_P1.0251.00
40_L44_R1.0251.00
197_T200_K1.0201.00
8_L19_L1.0171.00
110_E113_A1.0151.00
140_N143_A1.0151.00
193_R197_T1.0141.00
88_V92_L1.0091.00
50_V119_L1.0091.00
95_E116_R1.0071.00
161_L164_K1.0031.00
4_E28_F0.9991.00
17_D32_V0.9951.00
67_R92_L0.9861.00
208_A218_T0.9791.00
51_M69_L0.9781.00
194_T198_H0.9741.00
14_G18_T0.9631.00
39_V43_A0.9561.00
13_Q17_D0.9511.00
141_E164_K0.9451.00
90_R103_A0.9381.00
55_V61_S0.9241.00
9_V33_F0.9231.00
157_R161_L0.9211.00
20_V30_V0.9201.00
66_C96_I0.9161.00
53_L78_V0.9131.00
5_T49_D0.9091.00
63_F96_I0.9061.00
87_E90_R0.9051.00
7_W31_E0.9051.00
174_W178_Q0.9031.00
19_L81_L0.9001.00
51_M78_V0.8941.00
7_W43_A0.8931.00
41_D44_R0.8831.00
64_E68_Q0.8731.00
53_L80_F0.8701.00
9_V51_M0.8691.00
139_L167_L0.8651.00
66_C98_A0.8641.00
162_L166_L0.8631.00
17_D20_V0.8611.00
79_L114_R0.8601.00
199_I203_R0.8601.00
118_L121_R0.8551.00
92_L95_E0.8511.00
77_P99_D0.8491.00
21_Y25_Q0.8491.00
13_Q16_A0.8481.00
85_S103_A0.8431.00
52_I111_V0.8381.00
207_R210_N0.8371.00
147_S152_P0.8361.00
55_V89_D0.8331.00
65_L69_L0.8331.00
172_R178_Q0.8301.00
192_D196_D0.8281.00
165_T179_L0.8221.00
108_P112_C0.8211.00
139_L160_F0.8191.00
110_E114_R0.8041.00
5_T48_P0.8021.00
193_R200_K0.7931.00
28_F112_C0.7911.00
52_I115_V0.7901.00
55_V84_R0.7851.00
43_A48_P0.7841.00
89_D92_L0.7841.00
15_I106_F0.7811.00
67_R71_A0.7781.00
57_L65_L0.7781.00
43_A76_L0.7751.00
144_A161_L0.7741.00
177_Q181_D0.7721.00
4_E123_K0.7711.00
60_I65_L0.7711.00
43_A73_H0.7701.00
176_R192_D0.7671.00
142_P172_R0.7661.00
178_Q181_D0.7661.00
91_L109_R0.7631.00
201_T204_A0.7601.00
81_L106_F0.7531.00
52_I81_L0.7491.00
200_K204_A0.7471.00
107_S110_E0.7411.00
165_T168_K0.7401.00
77_P121_R0.7381.00
17_D21_Y0.7361.00
19_L111_V0.7351.00
161_L165_T0.7341.00
119_L122_V0.7331.00
131_V138_E0.7331.00
36_G40_L0.7301.00
117_T120_R0.7281.00
8_L30_V0.7261.00
156_T205_K0.7251.00
9_V65_L0.7231.00
88_V109_R0.7211.00
106_F111_V0.7151.00
197_T201_T0.7131.00
36_G59_D0.7121.00
56_G83_A0.7091.00
40_L43_A0.6921.00
69_L78_V0.6921.00
114_R118_L0.6911.00
22_M112_C0.6871.00
100_D117_T0.6871.00
36_G57_L0.6761.00
117_T122_V0.6751.00
43_A51_M0.6731.00
6_V50_V0.6721.00
47_V73_H0.6681.00
10_E57_L0.6671.00
18_T22_M0.6661.00
40_L72_L0.6661.00
77_P125_F0.6651.00
69_L74_P0.6601.00
75_A125_F0.6591.00
44_R68_Q0.6591.00
203_R208_A0.6581.00
94_L114_R0.6551.00
52_I79_L0.6531.00
93_G98_A0.6511.00
122_V126_S0.6501.00
95_E113_A0.6491.00
70_L77_P0.6491.00
190_T195_V0.6491.00
8_L20_V0.6471.00
196_D199_I0.6461.00
144_A160_F0.6391.00
77_P119_L0.6381.00
6_V23_L0.6351.00
8_L32_V0.6281.00
16_A20_V0.6271.00
109_R113_A0.6271.00
106_F110_E0.6261.00
90_R107_S0.6251.00
4_E49_D0.6241.00
63_F89_D0.6241.00
137_F148_W0.6241.00
168_K182_S0.6211.00
87_E109_R0.6181.00
147_S150_D0.6151.00
136_H148_W0.6111.00
55_V93_G0.6081.00
12_E83_A0.6071.00
44_R73_H0.6061.00
12_E15_I0.6051.00
79_L100_D0.6041.00
168_K174_W0.6041.00
15_I18_T0.6021.00
156_T159_E0.6021.00
116_R120_R0.5951.00
54_D104_K0.5951.00
22_M26_E0.5901.00
66_C70_L0.5901.00
166_L199_I0.5861.00
70_L76_L0.5821.00
148_W209_I0.5811.00
77_P122_V0.5811.00
158_Y198_H0.5801.00
53_L69_L0.5711.00
75_A124_K0.5701.00
23_L28_F0.5701.00
133_R136_H0.5701.00
169_S182_S0.5701.00
11_D82_T0.5671.00
159_E162_L0.5651.00
38_P59_D0.5621.00
199_I211_P0.5611.00
88_V91_L0.5601.00
35_R57_L0.5601.00
207_R215_P0.5591.00
113_A116_R0.5571.00
148_W207_R0.5561.00
134_I137_F0.5551.00
139_L146_I0.5501.00
128_P131_V0.5481.00
191_Y194_T0.5471.00
11_D57_L0.5471.00
53_L57_L0.5411.00
136_H140_N0.5351.00
172_R179_L0.5331.00
18_T21_Y0.5311.00
82_T90_R0.5281.00
69_L76_L0.5281.00
21_Y24_Q0.5261.00
91_L94_L0.5241.00
148_W208_A0.5231.00
172_R182_S0.5221.00
8_L16_A0.5211.00
82_T104_K0.5181.00
6_V115_V0.5161.00
137_F146_I0.5141.00
24_Q30_V0.5111.00
43_A65_L0.5081.00
141_E168_K0.5071.00
109_R112_C0.5061.00
140_N145_Q0.5051.00
43_A74_P0.5021.00
24_Q29_A0.5021.00
166_L169_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ys7A 2 0.9825 100 0.17 Contact Map
3r0jA 2 0.9651 100 0.173 Contact Map
4b09A 2 0.9214 100 0.174 Contact Map
2gwrA 1 0.9738 100 0.18 Contact Map
2oqrA 2 0.9782 100 0.193 Contact Map
1kgsA 1 0.9563 100 0.195 Contact Map
4kfcA 2 0.9782 100 0.195 Contact Map
3q9sA 1 0.917 100 0.223 Contact Map
1p2fA 1 0.9476 100 0.225 Contact Map
2hqrA 2 0.9432 100 0.225 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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