GREMLIN Database
MUTT - 8-oxo-dGTP diphosphatase
UniProt: P08337 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10626
Length: 129 (119)
Sequences: 4617 (3309)
Seq/√Len: 303.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_N17_E3.3061.00
55_Q61_T2.9661.00
22_R101_P2.6671.00
45_T48_Q2.5981.00
22_R100_Q2.3941.00
20_I113_D2.3251.00
40_I49_A2.2621.00
106_S109_G2.2301.00
32_K114_D2.1611.00
5_Q81_T2.1461.00
19_F102_G2.0541.00
9_G50_V2.0351.00
54_L62_P2.0171.00
105_M113_D1.9991.00
20_I115_F1.9791.00
20_I105_M1.9251.00
63_Q88_E1.8151.00
24_A27_A1.7571.00
17_E106_S1.7371.00
69_E125_K1.7181.00
26_D30_A1.7151.00
61_T91_E1.7111.00
109_G112_A1.6601.00
12_R86_L1.6341.00
5_Q83_W1.5451.00
60_I89_R1.5291.00
46_P85_W1.5131.00
40_I46_P1.4931.00
59_G97_K1.4881.00
51_V55_Q1.4521.00
7_A49_A1.4451.00
59_G95_W1.4011.00
9_G54_L1.3871.00
74_E79_H1.3671.00
21_T102_G1.3541.00
89_R92_G1.3311.00
65_F88_E1.3231.00
72_E81_T1.3141.00
8_V84_F1.2961.00
63_Q90_W1.2771.00
10_I68_F1.2371.00
24_A30_A1.2291.00
32_K117_P1.2271.00
16_N107_L1.2021.00
103_E113_D1.1951.00
51_V64_H1.1901.00
7_A46_P1.1771.00
21_T99_G1.1721.00
70_K81_T1.1631.00
11_I54_L1.1511.00
47_E51_V1.1471.00
29_M32_K1.1471.00
67_L83_W1.1441.00
70_K83_W1.0761.00
68_F86_L1.0521.00
32_K116_P1.0461.00
96_G99_G1.0411.00
67_L70_K1.0411.00
55_Q59_G1.0391.00
96_G102_G1.0181.00
72_E79_H1.0161.00
31_N100_Q1.0011.00
27_A98_E0.9941.00
121_P124_A0.9821.00
53_E57_E0.9791.00
94_P102_G0.9671.00
48_Q51_V0.9621.00
9_G87_V0.9521.00
25_A31_N0.9491.00
29_M116_P0.9331.00
115_F119_N0.9301.00
60_I94_P0.9281.00
63_Q89_R0.9271.00
7_A50_V0.9241.00
66_S86_L0.8981.00
67_L85_W0.8951.00
62_P87_V0.8941.00
50_V85_W0.8851.00
12_R16_N0.8711.00
84_F122_V0.8691.00
116_P119_N0.8681.00
62_P65_F0.8681.00
35_F84_F0.8591.00
25_A30_A0.8491.00
46_P83_W0.8481.00
54_L60_I0.8431.00
111_N124_A0.8421.00
24_A100_Q0.8291.00
22_R31_N0.8281.00
87_V90_W0.8231.00
25_A100_Q0.8041.00
10_I84_F0.7941.00
120_E124_A0.7931.00
103_E109_G0.7880.99
51_V61_T0.7880.99
19_F60_I0.7870.99
47_E85_W0.7770.99
24_A98_E0.7700.99
12_R18_I0.7690.99
68_F125_K0.7630.99
69_E122_V0.7500.99
65_F86_L0.7490.99
22_R33_L0.7470.99
54_L87_V0.7370.99
58_V102_G0.6980.99
5_Q46_P0.6950.99
17_E109_G0.6900.99
115_F123_I0.6770.98
75_F78_R0.6770.98
61_T90_W0.6700.98
50_V87_V0.6690.98
64_H89_R0.6670.98
27_A30_A0.6600.98
33_L92_G0.6600.98
64_H88_E0.6590.98
96_G100_Q0.6590.98
78_R82_L0.6520.98
34_E99_G0.6500.98
5_Q40_I0.6500.98
33_L105_M0.6480.98
58_V94_P0.6430.98
51_V65_F0.6410.98
69_E84_F0.6380.98
23_R34_E0.6370.98
73_Y80_I0.6360.98
91_E94_P0.6320.98
50_V54_L0.6310.98
34_E80_I0.6300.98
71_L82_L0.6260.97
55_Q97_K0.6220.97
8_V35_F0.6150.97
35_F116_P0.6130.97
51_V62_P0.6110.97
119_N122_V0.6100.97
53_E56_E0.6020.97
66_S88_E0.6020.97
34_E119_N0.6010.97
35_F82_L0.6010.97
12_R88_E0.5990.97
21_T50_V0.5970.97
64_H85_W0.5960.97
13_N16_N0.5840.96
64_H87_V0.5840.96
75_F118_A0.5810.96
47_E65_F0.5800.96
18_I110_L0.5780.96
21_T96_G0.5720.96
111_N120_E0.5690.96
30_A100_Q0.5690.96
29_M77_D0.5670.96
33_L101_P0.5660.95
74_E77_D0.5650.95
116_P122_V0.5610.95
64_H67_L0.5590.95
89_R94_P0.5590.95
21_T58_V0.5570.95
105_M109_G0.5560.95
34_E39_K0.5550.95
35_F119_N0.5550.95
80_I83_W0.5510.95
13_N93_E0.5480.95
75_F80_I0.5470.95
18_I35_F0.5470.95
8_V34_E0.5460.95
39_K57_E0.5450.94
60_I92_G0.5440.94
106_S110_L0.5400.94
117_P120_E0.5330.94
65_F85_W0.5300.94
23_R39_K0.5260.93
6_I119_N0.5260.93
63_Q91_E0.5230.93
34_E82_L0.5190.93
19_F58_V0.5150.93
44_E49_A0.5130.93
114_D117_P0.5130.93
37_G84_F0.5030.92
11_I87_V0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mutA 1 1 100 0.252 Contact Map
3gwyA 2 0.9922 100 0.268 Contact Map
2rrkA 1 0.9922 99.9 0.283 Contact Map
4v14A 1 0.9612 99.9 0.294 Contact Map
3hhjA 1 0.9767 99.9 0.295 Contact Map
3eesA 2 0.9845 99.9 0.296 Contact Map
3r03A 2 1 99.9 0.302 Contact Map
3q93A 1 0.9767 99.9 0.306 Contact Map
3fspA 1 0.969 99.9 0.31 Contact Map
1x51A 1 1 99.9 0.319 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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