GREMLIN Database
PYRF - Orotidine 5'-phosphate decarboxylase
UniProt: P08244 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10809
Length: 245 (224)
Sequences: 2657 (1705)
Seq/√Len: 113.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_D64_R3.4221.00
100_A126_A3.2511.00
25_N28_D3.1561.00
62_Q94_W3.0711.00
229_D232_Q3.0341.00
135_A147_P2.4381.00
134_E202_R2.4321.00
170_A205_M2.3801.00
56_Q59_R2.3631.00
102_G106_M2.3211.00
104_A140_D2.2691.00
107_M163_L2.2451.00
177_K216_D2.2451.00
227_S233_T2.2171.00
104_A108_T2.1291.00
82_A112_E2.0831.00
105_R202_R2.0751.00
30_L60_E2.0481.00
17_V220_I2.0081.00
196_S223_P1.9811.00
111_R115_V1.9381.00
208_E240_S1.9281.00
47_K51_T1.8751.00
26_R60_E1.8561.00
159_Q181_G1.8481.00
205_M213_A1.8431.00
231_A235_K1.7931.00
177_K186_L1.7891.00
135_A139_V1.7801.00
208_E212_S1.7451.00
193_P196_S1.7381.00
193_P223_P1.7171.00
209_Q212_S1.6901.00
23_Y32_F1.6791.00
104_A160_K1.6631.00
152_E179_V1.6391.00
232_Q236_A1.6391.00
74_F88_A1.5991.00
32_F36_I1.5781.00
135_A146_S1.5751.00
138_L143_M1.5731.00
176_F186_L1.5681.00
105_R108_T1.5681.00
215_V218_M1.5671.00
82_A113_A1.5511.00
104_A161_C1.5431.00
105_R137_D1.5431.00
146_S149_D1.5401.00
26_R53_F1.4941.00
18_V42_R1.4631.00
83_H86_A1.4621.00
134_E137_D1.4561.00
49_M53_F1.4501.00
85_V96_V1.4461.00
52_L87_A1.4351.00
39_R235_K1.4291.00
33_V43_L1.3971.00
195_G236_A1.3881.00
209_Q213_A1.3811.00
156_A179_V1.3741.00
168_C186_L1.3481.00
115_V121_A1.3351.00
193_P237_I1.3331.00
170_A191_I1.3301.00
145_L149_D1.3111.00
188_T215_V1.2980.99
104_A157_L1.2970.99
17_V234_L1.2960.99
125_I163_L1.2960.99
67_D94_W1.2910.99
159_Q180_F1.2870.99
123_L185_K1.2810.99
45_V61_L1.2630.99
198_A204_I1.2620.99
145_L153_R1.2470.99
28_D31_A1.2460.99
20_A221_G1.2290.99
186_L216_D1.2290.99
79_N83_H1.2180.99
236_A240_S1.2110.99
121_A164_D1.2100.99
26_R30_L1.2090.99
35_K229_D1.2020.99
97_N127_V1.1900.99
49_M57_F1.1880.99
142_G153_R1.1720.99
173_A215_V1.1590.99
31_A35_K1.1490.99
35_K230_P1.1480.99
129_V133_M1.1310.99
43_L66_F1.1270.99
235_K239_A1.1240.99
174_V213_A1.1230.99
81_A110_A1.1220.99
19_V225_T1.1160.98
133_M137_D1.1150.98
173_A186_L1.0880.98
129_V150_Y1.0860.98
81_A106_M1.0860.98
166_V184_F1.0850.98
18_V217_Y1.0840.98
30_L34_D1.0830.98
101_S154_L1.0810.98
211_L218_M1.0770.98
111_R121_A1.0740.98
51_T74_F1.0740.98
97_N125_I1.0640.98
195_G199_G1.0630.98
83_H87_A1.0540.98
123_L164_D1.0540.98
59_R63_Q1.0520.98
61_L66_F1.0450.98
26_R57_F1.0440.98
199_G226_Q1.0430.98
98_V107_M1.0420.98
137_D140_D1.0420.98
95_M123_L1.0400.98
176_F180_F1.0340.97
70_L93_V1.0290.97
185_K216_D1.0280.97
42_R67_D1.0170.97
150_Y154_L1.0160.97
139_V144_T1.0010.97
139_V145_L0.9940.97
41_C66_F0.9850.97
232_Q235_K0.9840.97
19_V40_D0.9830.97
40_D234_L0.9800.97
95_M125_I0.9790.96
148_A175_R0.9760.96
97_N107_M0.9760.96
24_H28_D0.9700.96
236_A239_A0.9660.96
108_T112_E0.9640.96
199_G223_P0.9630.96
83_H226_Q0.9580.96
109_A113_A0.9560.96
109_A112_E0.9560.96
81_A102_G0.9550.96
17_V241_L0.9540.96
101_S150_Y0.9530.96
42_R95_M0.9480.96
101_S129_V0.9470.96
98_V124_L0.9290.95
168_C176_F0.9260.95
156_A180_F0.9230.95
74_F81_A0.9210.95
111_R164_D0.9200.95
211_L241_L0.9170.95
60_E63_Q0.9040.95
85_V114_L0.9030.94
233_T236_A0.8990.94
48_E83_H0.8990.94
152_E175_R0.8950.94
166_V186_L0.8880.94
52_L90_D0.8870.94
82_A86_A0.8820.94
58_V91_L0.8800.94
105_R109_A0.8680.93
205_M209_Q0.8680.93
58_V68_I0.8670.93
152_E156_A0.8640.93
50_F72_L0.8620.93
100_A158_T0.8530.93
218_M241_L0.8530.93
101_S133_M0.8520.93
17_V238_N0.8480.92
111_R124_L0.8460.92
35_K231_A0.8430.92
142_G145_L0.8350.92
74_F84_A0.8340.92
48_E225_T0.8320.92
39_R231_A0.8280.92
41_C234_L0.8210.91
107_M161_C0.8140.91
171_Q205_M0.8120.91
47_K84_A0.8110.91
126_A163_L0.8100.91
50_F55_P0.8070.90
68_I93_V0.8050.90
174_V178_Q0.8010.90
119_K122_P0.8010.90
53_F57_F0.7970.90
45_V49_M0.7960.90
125_I187_V0.7950.90
126_A158_T0.7940.90
198_A202_R0.7890.89
194_Q240_S0.7890.89
104_A107_M0.7890.89
51_T88_A0.7870.89
29_A49_M0.7820.89
175_R179_V0.7780.89
156_A160_K0.7770.89
15_S41_C0.7760.89
96_V114_L0.7760.89
16_P211_L0.7710.88
100_A151_A0.7700.88
19_V32_F0.7650.88
224_V234_L0.7600.88
95_M217_Y0.7570.87
42_R94_W0.7520.87
87_A90_D0.7510.87
231_A234_L0.7500.87
23_Y29_A0.7500.87
43_L61_L0.7440.87
127_V130_L0.7430.86
15_S67_D0.7400.86
169_S172_E0.7380.86
37_D43_L0.7370.86
85_V110_A0.7340.86
223_P237_I0.7280.85
75_H133_M0.7260.85
128_T166_V0.7250.85
158_T163_L0.7250.85
23_Y225_T0.7230.85
21_L45_V0.7220.85
30_L33_V0.7210.85
143_M150_Y0.7100.84
100_A154_L0.7050.83
39_R238_N0.7030.83
141_L150_Y0.7000.83
180_F184_F0.6980.83
21_L33_V0.6980.83
26_R56_Q0.6950.83
234_L238_N0.6920.82
152_E180_F0.6920.82
145_L150_Y0.6890.82
207_P218_M0.6890.82
32_F43_L0.6850.82
38_P231_A0.6830.81
84_A87_A0.6800.81
97_N184_F0.6780.81
101_S143_M0.6750.81
57_F60_E0.6740.81
18_V187_V0.6710.80
78_P106_M0.6630.80
36_I231_A0.6620.79
129_V154_L0.6580.79
186_L217_Y0.6560.79
193_P240_S0.6550.79
85_V113_A0.6530.78
150_Y153_R0.6520.78
110_A113_A0.6520.78
27_D31_A0.6480.78
82_A109_A0.6480.78
27_D30_L0.6460.78
36_I234_L0.6440.78
175_R178_Q0.6440.78
74_F85_V0.6400.77
32_F230_P0.6400.77
21_L61_L0.6360.77
37_D66_F0.6330.76
85_V124_L0.6310.76
40_D238_N0.6290.76
229_D233_T0.6260.76
185_K217_Y0.6250.75
47_K88_A0.6240.75
177_K217_Y0.6230.75
33_V53_F0.6220.75
34_D38_P0.6130.74
125_I167_V0.6070.73
45_V57_F0.6020.73
19_V224_V0.6010.73
30_L64_R0.6010.73
220_I237_I0.6000.72
95_M187_V0.5990.72
237_I240_S0.5990.72
19_V41_C0.5960.72
48_E80_T0.5940.72
55_P91_L0.5920.71
140_D157_L0.5890.71
60_E64_R0.5830.70
166_V180_F0.5830.70
173_A188_T0.5810.70
58_V62_Q0.5780.70
107_M158_T0.5770.70
148_A171_Q0.5750.69
50_F87_A0.5740.69
21_L29_A0.5720.69
29_A57_F0.5720.69
86_A109_A0.5700.69
133_M154_L0.5690.68
95_M167_V0.5680.68
115_V119_K0.5670.68
196_S199_G0.5660.68
166_V176_F0.5610.67
195_G240_S0.5610.67
42_R66_F0.5590.67
137_D202_R0.5590.67
48_E86_A0.5580.67
55_P58_V0.5570.67
32_F35_K0.5570.67
152_E178_Q0.5530.66
114_L124_L0.5520.66
70_L88_A0.5500.66
47_K74_F0.5500.66
207_P237_I0.5480.66
171_Q204_I0.5480.66
37_D40_D0.5470.65
138_L147_P0.5460.65
57_F61_L0.5460.65
33_V61_L0.5450.65
159_Q184_F0.5440.65
111_R163_L0.5440.65
76_D80_T0.5420.65
133_M150_Y0.5410.65
40_D43_L0.5400.64
79_N82_A0.5400.64
17_V170_A0.5370.64
159_Q183_E0.5350.64
75_H101_S0.5340.64
89_A92_G0.5320.63
124_L163_L0.5300.63
86_A113_A0.5290.63
106_M130_L0.5280.63
56_Q63_Q0.5280.63
18_V95_M0.5270.63
100_A107_M0.5250.62
163_L166_V0.5200.62
103_G154_L0.5200.62
53_F56_Q0.5200.62
169_S203_R0.5190.61
136_S140_D0.5180.61
150_Y176_F0.5170.61
45_V50_F0.5160.61
24_H83_H0.5150.61
30_L57_F0.5140.61
195_G198_A0.5100.60
51_T87_A0.5080.60
62_Q92_G0.5060.59
31_A34_D0.5060.59
108_T160_K0.5040.59
220_I234_L0.5020.59
228_V232_Q0.5010.59
49_M52_L0.5000.59
112_E115_V0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gdmA 2 0.9469 100 0.316 Contact Map
1eixA 2 0.9469 100 0.343 Contact Map
3tr2A 2 0.9061 100 0.345 Contact Map
3ldvA 2 0.9469 100 0.347 Contact Map
3qw4B 4 0.9143 100 0.364 Contact Map
3g3dA 2 0.9347 100 0.365 Contact Map
3r89A 2 0.9429 100 0.367 Contact Map
3v75A 2 0.9306 100 0.372 Contact Map
3ewwA 2 0.9347 100 0.373 Contact Map
3qw3A 2 0.902 100 0.376 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0094 seconds.